Psychopharmacology and Psychiatry Updates

In this episode, we delve into the use of clozapine for treatment-resistant psychosis and mood disorders. When should clinicians consider clozapine, and what do expert guidelines recommend? Dr. Brian Miller guides us through the evidence and best practices for utilizing this powerful but often underused medication.

Faculty: Brian Miller, M.D. Host: Richard Seeber, M.D.

In this episode, we explore the role of lithium in treating pediatric bipolar disorder and conduct disorder. Is lithium a viable option for managing these complex conditions in children and adolescents, or are other medications more effective?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we explore real-world clinical cases demonstrating how broad-spectrum micronutrients can complement existing interventions for ADHD, emotional dysregulation, and mood instability. Can close monitoring and expert guidance optimize the integration of nutritional supplementation with pharmacologic treatments to create a harmonious, personalized approach?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the groundbreaking FDA approval of zuranolone, the first oral medication specifically targeting postpartum depression. Could zuranolone's novel mechanism of action as an allopregnanolone agonist herald a new era of rapid-onset, targeted treatments for this debilitating condition affecting 1 in 8 new mothers?

Faculty: Vivien Burt, M.D. Host: Richard Seeber, M.D.

In this episode, we explore practical clinical tips for using broad-spectrum micronutrient supplements to treat mental health conditions. Can an individual's nutritional needs surpass population standards?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

In this episode, we examine whether first-trimester exposure to the antipsychotic olanzapine increases the risk of major fetal malformations. Does stopping medication abruptly also carry risks?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the safety considerations of using broad-spectrum micronutrient formulas in mental disorder treatment, mainly how these supplements can interact with other medications. Is it safe to use these formulas alongside anesthesia during surgery?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

In this episode, we explore the potential of NSAIDs in delirium prevention. However, NSAIDs come with risks, such as GI bleeding or kidney injury. Can NSAIDs really help prevent delirium, and if so, how?

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.

In this episode, we explore the unconventional yet promising treatment modality of using broad-spectrum micronutrient formulas in mental health care. We discuss the research and clinical trials that have been undertaken to test combinations of vitamins and minerals, focusing on their safety and efficacy. What are the potential side effects of using broad-spectrum micronutrient formulas?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss an insightful study by Strawn et al. that utilized a mega-analysis approach, combining data on over 900 MDD patients across lifespan treatment trials to elucidate differences in antidepressant treatment outcomes based on patient age. Does antidepressant efficacy differ across developmental stages—children, adolescents, and adults?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

What are some common signs that suggest a cancer patient may be developing delirium? In this episode, we explore the complex issue of delirium in advanced cancer patients. We discuss important considerations regarding medication management, the importance of distinguishing terminal from reversible delirium, and the role of antipsychotics and benzodiazepines in treatment.

Faculty: Jaroslava Salman, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the treatment of agranulocytosis or neutropenia in patients on clozapine therapy, a rare yet serious scenario that clinicians may encounter. We delve into the possibility of rechallenging clozapine treatment after such an event and explore the use of colony-stimulating factors. What's the likelihood of agranulocytosis while prescribing clozapine long term?

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the management of anxiety in cancer patients, including the effective psychotherapeutic interventions and pharmacologic options for treating anxiety in this vulnerable group. The episode also touches on the importance of cultural sensitivity and patient education when managing anxiety in cancer patients.

Faculty: Jaroslava Salman, M.D. Host: Richard Seeber, M.D.

In this podcast episode, Dr. David Rosenberg explores practical strategies to asess and manage common antidepressant side effects in the pediatric population. Get useful takeaways regarding activation, insomnia, withdrawal symptoms, and more.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this podcast episode, Jaroslava Salman, M.D., discusses the treatment options for depressed patients with cancer. Stay a step ahead in your practice with practical tips on which psychotherapies are helpful, which antidepressants to use and for how long, what to be mindful of, and even insights into prescribing stimulants.

Faculty: Jaroslava Salman, M.D. Host: Richard Seeber, M.D.

In this podcast episode, Dr. Vivien Burt delves into a study on brexanolone for women with postpartum depression, anxiety, and insomnia. Listen in and find out the effect and time frame of brexanolone on these symptoms.

Faculty: Vivien Burt, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. David Rosenberg offers practical insights into treatment optimization for youth with tic disorders. Listen in and find out which treatment modality takes precedence, which factors need to be considered, how long to use medication, and more.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. David Rosenberg expertly addresses the questions on what to do when your adolescent patient has ADHD but uses cannabis. Should you prescribe stiimulants or not? And what if they just want stimulants for better test scores? What do you do? Listen in as Dr. Rosenberg offers useful takeaways to help you with these (all too common) dilemmas.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. David Rosenberg delves into tic disorders and psychiatric comorbidities in youth. This includes ADHD, OCD, anxiety and depression, and disruptive behaviors. Jump in and listen to practical treatment options for these cases, and stay one step ahead in your clinical practice.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

CANMAT presents a spectrum approach to mixed states. In this podcast, Dr. Jim Phelps delves into this and the DSM-5 approach, where mixed states became a specifier that can be added to a diagnosis of unipolar depression, effectively creating a spectrum approach to the diagnosis of mixed mood disorders. So, what’s a clinician to do treatment-wise? Should we or should we not use antidepressants when 4 specific symptoms are present? Find the answer to these and other questions in this podcast.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this podcast episode, Dr. David Rosenberg provides a much-needed understanding of tic disorders in children and adolescents. Listen in to learn what a typical course of this disorder could look like, why you may not need to substitute methylphenidate in these patients, what happens when patients supress tics, and much more.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. David Rosenberg explores a review on metformin for youth on SGAs. Is it effective in mitigating weight gain in this population? And more importantly, should you prescribe it ASAP? Listen in as Dr. Rosenberg answers these questions and others.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. Jim Phelps discusses the issue of diagnosing bipolar disorder within the framework of a mood spectrum. How bipolar should a patient be before switching treatment strategies? Listen in for tips and practical takeaways to answer this question and guide decision making.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this podcast, Dr. Schenck discusses zolpidem-induced sleeping disorder and eating disorder. Listen and find out important tips and considerations, such as this being more common in females, alerting bed partners, being careful with zolpidem doses over 10 mg, and more.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

Cariprazine may be a good option for pediatric patients with schizophrenia and bipolar I disorder. Listen as Dr. Rosenberg summarizes study findings, which may broaden your options with children and adolescents.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

This podcast explores medication associated with sleepwalking and sleep driving, as well as recommendations for clinicians when prescribing them to patients.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

In this episode, we explore whether the olanzapine–samidorphan combination helps with psychosis while halting weight gain. We also look into the cost vs benefit of the combination as well as the metabolic side effects.

Faculty: James Phelps, M.D. Host: Richard Seeber, M.D.

Can melatonin reduce the risk of suicidality, bodily injuries, falls, and accidents in children and adolescents? In this episode, we explore a study that delves into this question. Discover how sleep disturbances impact young individuals' health, development, cognitive skills, emotional regulation, and behavior.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Do you know what sleep-related eating disorder (SRED) is and how it intertwines sleep and eating pathologically? In this episode, we delve into an in-depth analysis of SRED, elucidating its diagnostic criteria, key characteristics of the diagnosis, and some intriguing aspects related to this disorder.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

This episode explores the controversial role of pimavanserin in treating psychosis in Parkinson's disease. How does it compare with quetiapine or clozapine? Sneak peek: All of these medications are effective, yet none distinctly surpasses the others.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Pediatric bipolar disorder treatment has evolved significantly since 2005, moving beyond lithium to several FDA-approved treatments. However, the challenges remain: How do we choose the first-line treatment? How can we mitigate and monitor side effects? In this episode, we discuss the latest practice treatment algorithms for pediatric bipolar disorder.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Can pharmacogenomic testing improve the selection and dosing of antidepressants in patients with MDD? In this episode, we explore the findings of the PRIME Care trial and discuss the clinical significance of these tests. 

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the role of broad-spectrum micronutrients (BSMs) in managing symptoms of ADHD. We examine the rationale behind opting for alternative therapies for this condition and dissect the outcomes of an RCT involving BSMs for ADHD. Could micronutrients provide a comprehensive strategy for treating ADHD, thereby enhancing overall mental wellness?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

Are you aware that a staggering 80% of ADHD patients report at least 1 side effect from their medication? In this episode, we discuss an analysis that seeks to answer an essential question: Can we predict medication nonadherence in adolescents and young adults with ADHD based on specific side effects?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Did you know that your genes could affect how your brain processes vital nutrients? In this episode, we delve into fascinating research on micronutrient supplementation for mental disorders, such as ADHD. Discover how our genetic makeup might dictate our nutrient needs and how this can influence mental health outcomes.

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

Could antipsychotic switching impact substance use in schizophrenia? In this episode, Dr. Jim Phelps explores the impact of antipsychotics on patients with schizophrenia and substance use disorder. He includes insights from national cohorts and clinical cases and delves into the potential effects of changing from risperidone to clozapine.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Dive into the fascinating world of nutrition's impact on mental health in our latest episode. We explore intriguing studies on the Mediterranean diet's potential to alleviate depressive symptoms. Can a shift in dietary habits truly improve mental health?

Faculty: Amelia Villagomez, M.D. Host: Richard Seeber, M.D.

In this episode, we explore a pressing problem in pediatric psychiatry: The disparities in the use of pharmacologic restraints. How can we address these biases in our healthcare system? What role do behavioral interventions play in reducing the need for these measures?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the causes of clozapine-induced orthostasis. Although some patients may develop tolerance, it can limit titration and potentially obstruct patients from reaching the plasma level where they respond well to the medication. There are practical management strategies for orthostasis, including slow titration based on patient complaints and encouraging fluid intake, among others.

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the potential of lavender extract, Silexan, as an alternative treatment for anxiety and insomnia with Dr. Jim Phelps. Is it truly a promising solution free from dependency and withdrawal symptoms or just an effective placebo?

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we explore a common yet severe side effect of clozapine: Constipation. Why does this drug cause such drastic changes in colonic transit times, and how can we manage it effectively?

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss a comprehensive study on the potential cardiovascular risks of ADHD medication. Although these medications pose minimal risk for those without preexisting conditions, there seems to be an elevated risk for those with preexisting cardiovascular diseases. Should we confidently prescribe these medications?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the problem of sialorrhea or excessive salivation in patients on clozapine. Why does this occur, and how can it be managed? Join us as Dr. Jonathan Meyer shares his expertise on this unique side effect.

Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, M.D.

Can a simple lab test guide our choice of antidepressants? Explore the intriguing link between inflammation, measured by C-reactive protein (CRP) levels, and the effectiveness of certain antidepressants in this episode.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Could ketamine be the breakthrough we need in treating adolescent depression? Join us in this episode as we explore the potential of ketamine therapy and its rapid antidepressant effects. Also, learn how ketamine works, its safety profile, and why it's not quite ready for mainstream use in adolescents.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we dive into the puzzling case of a 67-year-old man experiencing violent moving nightmares. Is it rapid eye movement sleep behavior disorder, frequent and recurring nightmares, night terrors, PTSD, or another parasomnia? Tune in as we explore potential diagnoses with our expert Dr. Carlos Schenck.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into a new horizon in the management of acute agitation. We discuss dexmedetomidine, a drug that's been around since 1999, recently reformulated into a sublingual film and FDA approved for treating agitation associated with schizophrenia or bipolar I or II disorder. We explore the results from a recent randomized trial and its potential for transforming psychiatric care. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we dive into rapid eye movement sleep behavior disorder (RBD). Did you know that RBD's prevalence is on par with schizophrenia in middle-aged and older adults? Tune in as we explore the prevalence, assessment, and management of RBD, a condition that is not only a sleep disorder but a potential harbinger of severe neurological conditions, like Parkinson's Disease and Dementia with Lewy Bodies.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

In this episode, we dive deep into the effects of ADHD medication on anxiety and depressive symptoms in children and adolescents. Can these medications significantly exacerbate symptoms of anxiety or depression? Or do these symptoms arise more from the underlying condition of ADHD? We will delve into these critical questions and more through a thorough exploration of a comprehensive meta-analysis.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve deep into the diagnostic mysteries of RBD, the need for video polysomnography, and the mechanisms leading to RBD. Whether you are a veteran or new to the field, this episode promises to deepen your understanding of RBD.

Faculty: Carlos Schenck, M.D. Host: Richard Seeber, M.D.

Are we missing a vital piece in the schizophrenia treatment puzzle? In this episode, we explore the intriguing and controversial role of N-acetylcysteine (NAC) in schizophrenia. We dive deep into the evidence, the theories, and the ongoing debates about this seemingly simple over-the-counter supplement. Could NAC be the key to unlocking better outcomes for those with schizophrenia, or is it just another dead end?

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

How can N-acetyl cysteine (NAC) and S-adenosyl methionine (SAMe) be effectively integrated into child and adolescent psychiatric treatment? In this episode, we dive deep into the world of NAC and SAMe and explore their potential applications, dosage, side effects, and more.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

How has the use of antipsychotics among children and adolescents been affected by the COVID-19 pandemic in the United States? In this episode, we delve into pandemic-induced trends in youth psychotropic prescriptions. Uncover how COVID-19 reshaped mental health services and psychopharmacology among young individuals.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Can nature’s remedies hold the key to mental well-being in our youth? In this episode, we delve into the potential uses and limitations of St. John’s wort and valerian in child and adolescent psychiatry and, most importantly, their evidence in treating psychiatric disorders in this population.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Have you ever pondered the mystery behind the effectiveness of different SSRI dosing strategies for premenstrual dysphoric disorder (PMDD)? In this episode, we delve deep into the complex world of PMDD treatments, focusing on the intriguing comparison between intermittent luteal phase dosing and continuous dosing of serotonergic antidepressants.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Have you ever wondered how natural remedies like omega-3 fatty acids might influence child and adolescent psychiatry? In this episode, we delve into the intriguing world of omega-3 fatty acids and their potential role in treating various psychiatric disorders in children and adolescents, such as major depressive disorder, bipolar disorder, ADHD, and ASD.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

 Have you ever wondered about the safety and effectiveness of ADHD medications in preschoolers? In this episode, we discuss a pioneering double-blind, fixed-dose study exploring the use of lisdexamfetamine in children aged 4–5 years. We delve into the nuances of this complex topic, from the increasing trend of psychotropic medication use in young children, to the unique characteristics that distinguish lisdexamfetamine from other amphetamine medications.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the intriguing world of ginkgo biloba and its potential role in treating ADHD in children and adolescents. Can this ancient herbal remedy offer a valuable alternative or adjunctive therapy?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the intriguing world of COVID-19's long-term effects in psychiatry. We explore a groundbreaking study that examines the duration of COVID-associated psychiatric disorders and variations in susceptibility by age. How long do these disorders persist, and are certain age groups more affected?

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, you'll discover the preferred second-generation antipsychotics for augmenting treatment for obsessive-compulsive disorder: Risperidone and aripiprazole. We discuss their effectiveness and important considerations when choosing between them. What factors should clinicians weigh when deciding on an augmentation strategy?

Faculty: David Osser, M.D. Host: Richard Seeber, M.D.

In this episode, we focus on the challenges faced in metabolic monitoring of youth receiving second-generation antipsychotics (SGAs), including the strategies to overcome these barriers and ensure the long-term health of young patients on SGAs.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we delve into the potential outcomes after the first SSRI trial for OCD. With SSRIs being a first-line treatment, understanding response patterns is crucial. What course of action should be taken when patients exhibit significant symptom improvement, partial relief, or no response? Discover when to discontinue, switch, or augment treatment.

Faculty: David Osser, M.D. Host: Richard Seeber, M.D.

In this episode, Dr. Richard Seeber and his special guests, Dr. Lorena Rodriguez and Dr. Paz Badia, discuss the topics covered in the APA Annual Meeting 2023, from technology in mental health practice to the use of cognitive–behavioral therapy for suicide prevention. Get ready to explore topics like ECT, ADHD, women's health, and much more. How can the integration of technology revolutionize mental health practice? Faculty: Paz Badia, M.D. and Lorena Rodríguez, M.D. Host: Richard Seeber, M.D.

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In this episode, we delve into the fascinating world of microdosing psilocybin. A recent randomized trial examined the effects of microdosing using various outcome measures. Surprisingly, the acute effects were significantly more intense for the active dose but only when participants correctly identified their experimental condition.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

What factors should clinicians consider when choosing an SSRI for treating patients with OCD? In this episode, we dive into the first-line treatment for OCD: SSRIs. Discover the most effective SSRIs for treating OCD, recommended doses, and potential adverse effects.

Faculty: David Osser, M.D. Host: Richard Seeber, M.D.

Are there any particular situations where nonstimulant medications may be especially effective for ADHD? In this episode, we discuss nonstimulant treatments for ADHD. Although stimulants are commonly used for ADHD, nonstimulant options like atomoxetine, viloxazine, clonidine, and guanfacine have been FDA approved and can be equally effective in certain populations. Listen in as we share clinical pearls on how to tailor treatments for each patient's unique needs.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we share insights into the comorbidities and other considerations that can impact the treatment algorithm for OCD. From the risks of medication use in pregnant women, to the challenges of treating OCD in patients with comorbid bipolar disorder, this episode provides valuable clinical pearls for clinicians looking to improve their approach to treating OCD.

Faculty: David Osser, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss rapid cycling bipolar disorder and its treatment, focusing on the use of the combination of lamotrigine and lithium. We also highlight the importance of checking thyroid status and tapering antidepressants in patients with rapid cycling.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the potential use of melatonin as a safe and effective pharmacotherapy for sleep disturbances in children with ADHD and ASD. Did you know that up to 80% of children with ASD experience sleep disorders? Listen in to learn how melatonin can help improve sleep onset and duration in these patients. Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Which medications are safe and effective for treating nonsuicidal self-injury (NSSI) in children and adolescents? In this episode, we discuss the use of psychotropic medications in treating NSSI, which is becoming increasingly common in this population and can predict future suicide attempts.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

This episode discusses D-cycloserine’s potential indications and administration in children and adolescents, including the evidence for anxiety disorders, OCD, ASD, and PTSD. It also mentions the dosage, administration, benefits, and side effects of D-cycloserine in youth.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Antidepressants are commonly used to treat depression, but how effective are they? In this episode, we discuss the concept of the minimal clinically important difference (MCID) and how it can be applied to assess antidepressant efficacy in treating depression. Specifically, knowing MCID estimates helps to shed light on recent controversies regarding antidepressant efficacy.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

What is the role of memantine in pediatric populations? This episode discusses memantine’s potential indications and administration in children and adolescents, an explanation of the theory of glutamatergic dysregulation, and the evidence of memantine for ASD, OCD, and mood disorders.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we examine the tolerability, safety, and effectiveness of low-dose olanzapine in adolescents with anorexia nervosa (AN). Learn about the potential benefits and risks of using olanzapine in AN patients and the importance of a multidisciplinary approach in treating this challenging population.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the potential uses and challenges of naltrexone in children and adolescents while addressing the limited and conflicting evidence. We also examine the dosage, side effects, and important considerations for using naltrexone in young populations.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Would a slower lamotrigine titration rate decrease the likelihood of developing the dreaded lamotrigine-associated rash? This episode discusses the possible advantages of slower lamotrigine titration rates, tips for managing benign rashes, and when to rechallenge lamotrigine.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we dive into a topic that's especially relevant for those working with older adults: The use of benzodiazepines and sedative-hypnotics. We explore the unique considerations of prescribing these medications to geriatric patients and the importance of deprescribing them when possible.

Faculty: Lauren Gerlach, D.O. Host: Richard Seeber, M.D.

In this episode, we delve into lithium's efficacy and potential long-term effects in younger patients and what clinicians should carefully monitor in this population.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Are mood stabilizers the right choice for elderly patients? This episode discusses key insights about using mood stabilizers in the geriatric population, including side effects and monitoring for lithium, valproic acid, lamotrigine, carbamazepine, and gabapentinoids.

Faculty: Lauren Gerlach, D.O. Host: Richard Seeber, M.D.

Do you have a patient suffering from postpartum depression? In this episode, we discuss a new study on light therapy as a potential treatment for postpartum depression, including the response rate, adverse effects, and effects on sleep quality.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

This episode discusses some strategies for starting antidepressants in the elderly, the important role of titrating doses, the efficacy of SSRIs, the side effects and drug–drug interactions of different medications, and clinical tips for using SSRIs and SNRIs in this population.

Faculty: Lauren Gerlach, D.O. Host: Richard Seeber, M.D.

Is duloxetine a viable option for youth with MDD? In this episode, we discuss the need for additional medication options in youth with depression as well as an RCT of duloxetine to assess its efficacy and a label extension trial to evaluate its long-term safety.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

What are the most common challenges when prescribing psychotropics to older adults? This episode discusses the challenges in prescribing psychotropics to the geriatric population, such as poor medication adherence and the risks of inappropriate prescribing. It also introduces a clinical case and emphasizes the importance of medication reconciliation.

Faculty: Lauren Gerlach, D.O. Host: Richard Seeber, M.D.

In this episode, we discuss an updated review of 11 studies that seek to evaluate the effect of antidepressants on the risk of hip and vertebral bone fractures. Although the overall effect size seems large, the absolute risk increase might be small.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Are antidepressants effective for managing explosive behavior? In this episode, we discuss the efficacy of antidepressants and mood stabilizers for managing explosive behavior, including some proposed doses of lithium and divalproex sodium, and the indications for using antidepressants.

Faculty: Carrie Vaudreuil, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss a meta-analysis that included 6 million patients to assess whether pharmacotherapy increases the risk of substance use or misuse, specifically the risk of using stimulant medications in children with ADHD.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the SGAs with the most evidence for explosive behavior, their side effects, and monitoring recommendations. We also address the reasons for considering other SGAs and clarify which FGA has the most evidence for aggression.

Faculty: Carrie Vaudreuil, M.D. Host: Richard Seeber, M.D.

Should we start prescribing metformin to our patients on clozapine? In this episode, we discuss several articles on the efficacy of clozapine in preventing clozapine-induced weight gain, including some evidence on when metformin is more effective.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the management of acute aggression in children and adolescents, including therapeutic support for explosive behavior, psychosocial crisis management techniques, and the medications used for acute aggression.

Faculty: Carrie Vaudreuil, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss whether early nonresponse in adolescents with first-episode psychosis predicts longer-term nonresponse and nonremission. We also explain when it is most likely that symptom improvement occurs and some other considerations when there is nonresponse.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the differential diagnosis of explosive behavior in children and adolescents, including the differences in these behaviors when they are associated with mood or anxiety disorders and disruptive behavior disorders.

Faculty: Carrie Vaudreuil, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the long-term follow-up of psychosis and schizophrenia in children and adolescents, including predictors of poor long-term outcomes and the comorbidities associated with schizophrenia in adults.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss a recent systematic umbrella review of the evidence behind the serotonin theory of depression and the controversy this review has generated. We explore the evidence presented regarding the interplay between serotonin and depression and present concrete steps to address several concerns generated by the review.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

Is there an association between SSRIs and type 2 diabetes in children and adolescents? In this episode, we discuss whether there is an association. We also explain whether there is an intraclass risk among different SSRIs.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss additional clinical tips for treating schizophrenia in children and adolescents, including the considerations for selecting antipsychotics, recommendations for nonresponse, and when to use clozapine.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we review the current literature on the association between exercise and the risk for depression. Specifically, how much physical activity is associated with a lower risk for depression? We also discuss the World Health Organization recommendations for the ideal range of physical activity.

Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss treatment options for managing psychosis and schizophrenia in children and adolescents, including the FDA-approved antipsychotics for this population. We also explain medication dosing guidelines and monitoring recommendations. 

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

Are antidepressants in adolescent depression associated with an increased risk for suicidality? In this episode, we discuss the particularities of adolescent depression, including some statistics and the risk of suicide when using antidepressants in this population.

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.

In this episode, we discuss the diagnosis of psychotic symptoms in children and adolescents, including the differences between primary and secondary psychosis and the rating scales for assessing these symptoms. 

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.