The EMJ Podcast: Insights For Healthcare Professionals

This podcast episode dives into the screening and management of Duchenne muscular dystrophy, as well as diversity in genetic databases, and treating neuromuscular disorders. Jonathan is joined by Madhuri Hegde, Senior Vice-President & Chief Scientific Officer at Revvity, Inc., to talk about innovation in genomic testing.

Use the following timestamps to navigate our episode!

(00:00)-Introduction 

(03:54)-Entering into genomic technologies

(05:13)-Duchenne muscular dystrophy

(10:47)-Revvity and genome sequencing

(13:13)-Ultrarapid genomic testing (urWGS)

(15:18)-LANTERN project

(17:42)-Lack of diversity in genetic databases

(20:06)-New developments in genetics

(22:19)-COVID-19 testing laboratories

(27:27)-Madhuri’s wishes for healthcare

Jonathan is joined by Joshua Makower, Director and Co-Founder of the Stanford Byers Center for Biodesign, Stanford University, California, USA. The pair navigate fascinating themes, from Makower’s passion for music and his band, Still Trust, to innovative strategies for controlling rising healthcare costs through innovation. Makower offers perspectives on AI in healthcare, and the associated challenges with regulating these new technologies.

Use the following timestamps to navigate the topics discussed in this episode:

(00:00)-Introduction 

(03:05)-A passion for music 

(06:11)-From the Massachusetts Institute of Technology (MIT) to medical school 

(08:50)-The Biodesign process 

(19:37)-Driving technology from mind to marketplace 

(23:25)-Doctors engaging with industry 

(27:52)-The ExploraMed incubator 

(31:07)-Josh’s current work 

(34:27)-The importance of failure 

(36:16)-Perspectives on artificial intelligence in healthcare 

(39:05)-Healthcare innovation horizons 

(40:37)-Medical technology regulation 

(46:00)-Josh’s three wishes for the future of healthcare 

In this bonus episode of the EMJ podcast, host Sue Saville, a medical correspondent, discusses the latest advancements in access and hemostasis for coronary and other procedures via the distal radial route. Joined by Pavan Najran, clinical lead for interventional radiology and Consultant Clinical and Interventional Radiologist, The Christie Hospital NHS Foundation Trust, Manchester, UK, they further explore the benefits of the distal radial method, emphasizing reduced vascular complications, improved patient comfort, and shorter haemostasis time. Najran highlights the ergonomic advantages, dispels misconceptions, and shares insights from trials and personal experience, showcasing the potential for distal radial access to become the preferred approach.

Pavan Najran, is a clinical lead for interventional radiology and Consultant Clinical and Interventional Radiologist, The Christie Hospital NHS Foundation Trust, Manchester, UK.

The publication of this podcast was funded by Merit Medical. Dr Najran is a consultant to Merit Medicall.

The suggestions and other information, which may include both Merit and third-party products, are for the practitioner’s convenience and for general information purposes only. This information does not constitute medical or legal advice, nor is it meant to endorse or guarantee the suitability of any of the referenced products or methods for any specific patient or procedure. Before using, refer to the Instructions for Use (IFU) for indications, contraindications, warnings, precautions, and directions for use.

This podcast explores the fascinating world of artificial intelligence and advances on the horizon in oncology. Jonathan and Sofia Merajver, Michigan Medicine, Ann Arbor, USA, discuss vaccine hesitancy, the promise of artificial intelligence in generating large datasets, and non-small cell lung cancer, before concluding with her three wishes for healthcare.

Use the following tiestamps tot navigate the episode! 

(00:00)-Introduction

(00:46)-Breast cancer vaccine hesitancy

(07:38)-Advances on the horizon to prevent, protect, and treat malignancies

(09:30)-Hospitals in areas of conflict

(12:20)-Artificial intelligence

(17:28)-Non-small cell lung cancer

(23:10)-Sofia’s three wishes for healthcare

This podcast explores the genetic determinants and mechanisms of breast and ovarian cancer. Jonathan and Sofia Merajver, Michigan Medicine, Ann Arbor, USA, discuss brain metastases, the severity of inflammatory breast cancer, and the movement of cancers through tissue.

Use the following timestamps to navigate this episode!

(00:00)-Introduction

(02:27)-Sofia’s journey into medicine

(04:10)-Personal stakes

(05:09)-Not being your doctor

(06:58)-Genes in inflammatory breast cancer

(10:58)-RHO proteins

(12:52)-Brain metastasis

(17:33)-Crossing the blood–brain barrier

(22:11)-Aggressive phenotypes of breast cancer

(24:18)-Chemoprevention in breast cancer

This podcast explores the mOm Incubator, the importance of collaboration with healthcare professionals when designing medical devices, and the environmental impact of healthcare. Jonathan is joined by James Roberts, co-founder and CEO of mOm Incubators Ltd., a MedTech start-up on a mission to provide global access to high-quality healthcare. The pair discuss how the mOm incubator compares to traditional incubators, and the problems it solves.

Use the following timestamps to navigate this episode!

(00:00)-Introduction

(02:11)-Sparking interest in medical innovation

(04:11)-Navigating a medical device start-up

(07:03)-Unveiling the mOm incubator

(10:19)-The value of input from HCPs in device development

(13:04)-Delivering a simple yet low-risk device

(16:14)-Supplying mOm incubators to Ukraine

(20:16)-Considering the environmental impacts of medical devices

(23:30)-James’ proudest achievements

(26:58)-Looking to the future

(28:48)-Transport for London’s map of engineering icons

(31:09)-Three wishes for the future of healthcare

In this final episode of the series, the discussion focuses on the role of therapeutic drug monitoring and current practices, as well as how treatment decisions are made for patients refractory to anti-TNFs. The guests conclude by discussing the future of anti-TNFs and identifying the remaining gaps in the care of patients with inflammatory bowel disease.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this penultimate episode of the series on anti-TNFs for inflammatory bowel disease, our expert gastroenterologists discuss treatment options for difficult-to-treat Crohn’s disease and ulcerative colitis, including recent views and decision-making.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

Expanding the discussion of the use of anti-TNF biosimilars, in this episode, our expert panel provides insights on switching and the handling of adalimumab biosimilars.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this episode, our expert gastroenterologists consider the importance of anti-TNF biosimilars as a treatment option for inflammatory bowel disease and the corresponding guideline recommendations.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this episode, our experts discuss the use of combination therapy involving anti-TNFs and immunomodulators, with a focus on the synergy and immunogenic effects, clinical trial outcomes, and the conversations that need to be had with patients.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

Our expert gastroenterologists continue their discussion of the side effects and risks of anti-TNFs, including infection, vaccine immunogenicity, and tuberculosis (TB) risk, as well as monitoring approaches.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

Our gastroenterology experts consider the patient's underlying comorbidities when making treatment decisions regarding anti-TNFs. They also evaluate the safety profile and risks, particularly for elderly patients

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this episode, our experts discuss the recommended clinical anti-TNF treatments for inflammatory bowel disease in Europe and the USA and the patient factors that should be considered in patient decision-making.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this episode, our expert gastroenterologists provide a summary of the current ECCO and AGA recommendations for the use of anti-TNFs and insights on potential updates.

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

This introductory episode provides an introduction to the role anti-TNF therapies play in the management of inflammatory bowel disease, ulcerative colitis and Crohn’s disease

This podcast series has been supported by Viatris, who were not involved in the creation of this content.

In this week’s episode, Jonathan and George Bakris, Comprehensive Hypertension Center, University of Chicago, Illinois, USA, chat about hypertension and renal denervation.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(00:40)-Renal denervation Vs drugs in development for resistant hypertension

(06:06)-Get with the guidelines

(11:05)-Disparities in kidney disease incidence

(16:25)-Novel diabetes drugs

(19:42)-Remaining challenges in treating hypertension

(26:30)-Three wishes for healthcare

This podcast is supported by Medtronic.

This podcast episode, moderated by George Cooper, provides an exploration of the latest European Society of Hypertension (ESH) guidance on the use of renal denervation in uncontrolled hypertension management.

Atul Pathak, Princess Grace Hospital, Monaco, joins EMJ to offer key insights on renal denervation.

In this week’s episode, Jonathan and George Bakris, Comprehensive Hypertension Center, University of Chicago, Illinois, USA, discuss the role of music in medical practice, before diving into hypertension and ambulatory blood pressure monitoring. 

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(02:47)-Hoosiers and music

(08:45)-Routes into medicine

(09:47)-Finding hypertension

(13:50)-Ambulatory blood pressure monitoring

(15:10)-White coat hypertension

(16:30)-Lowering your blood pressure

(18:09)-An innocent murmur

(18:59)-Markers of kidney and heart disease

(21:10)-Two most common causes of kidney disease

(23:18)-Arterial stiffness

In this episode, Jonathan chats with Mark Little, Consultant Interventional Radiologist at the Royal Berkshire NHS Foundation Trust, Reading, UK, where he has set up a large embolotherapy research group in addition to his clinical work. The two discuss everything from their shared passion for aviation to developments in prostate artery embolisation.

Use these timestamps to navigate our episode!

(00:00)-Introduction

(02:32)-What led Little to pursue a career in radiology

(09:01)-Prostate artery embolisation

(15:02)-Genicular artery embolisation

(21:40)-Uterine artery embolisation

(24:43)-The TARGET trial: using augmented reality to guide prostate cancer biopsy

(28:05)-The role of AI in radiology

(31:50)-Innovations on the horizon for interventional radiology

(35:23)-Three wishes

In this week’s episode, Jonathan is joined by Stephanie Hanna, a Research Fellow for the Diabetes Research and Wellness Foundation, in the Division of Infection and Immunity, at Cardiff University’s School of Medicine, Wales, UK. In this fascinating episode, the pair discuss all things diabetes, including immunotherapy, the future of diagnosis, and how to predict your diabetes risk.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(01:22)-Getting into Type 1 diabetes (T1D)

(02:23)-Stages of T1D

(05:04)-Biomarkers of T1D

(07:01)-Phenotypic analysis of T and B-cells

(08:24)-Diabetes progression

(10:11)-Immunotherapy for T1D

(14:00)-Challenges in measuring immune response

(16:22)-Some thoughts on artificial intelligence

(18:11)-How to get involved in a study

(19:27)-Checking your own antibody status

(23:51)-Thyroid eye disease

(25:19)-Risks of overlooking T1D

(27:34)-Three wishes for the future of healthcare

Dr Teresa Amaral and Prof Mario Mandalà discuss: The typical patient for whom adjuvant therapy may be considered, and provide details on therapy choices. The long-term advantages of adjuvant treatments, and prospects for the use of biomarkers to help elucidate the best candidates for such therapies. The potential disadvantages of adjuvant therapy, and how more studies are needed to understand if these therapies can impact quality of life and fertility.

This content was fully funded by Novartis Pharma AG

In this bonus episode of the EMJ Podcast, host Brigitte Scott is joined by Ketta Lorusso, Humanitas University, Milan, Italy; and Rob Coleman, Vaniam Group, Chicago, Illinois, USA, who discuss key developments in endometrial cancer research that were presented in 2023.

This podcast was funded by a medical educational grant from GSK, with the purpose of enhancing the fundamental understanding of oncology specialists of key data and the latest advancements in endometrial cancer care. This content is not intended for US Healthcare Professionals.

This week’s episode focuses on innovations in diabetes technology, such as flash glucose monitoring and hybrid closed loop systems. Jonathan and Partha Kar, National Specialty Advisor in Diabetes for the National Health Service (NHS), UK, discuss promising innovations on the horizon, such as immunotherapy, as well as the importance of exercising caution on social media, and Partha’s Type 1 diabetes comic book.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(02:40)-Partha’s love of comic books

(04:30)-Why diabetes?

(06:09)-Promoting technology in Type 1 Diabetes 

(08:25)-Patient responsibility

(10:05)-Labelling patients with diabetes

(11:28)-Hybrid closed loop systems

(14:40)-Impact on the NHS and global healthcare

(16:04)-Pioneering the diabetes ‘super six’ model

(18:02)-Social media and combatting pseudoscience

(21:15)-Considering racism

(24:06)-Diabetes on ‘the big screen’

(27:31)-Game changing drugs for diabetes

(29:40)-Innovation: stem cells and immunotherapy

(31:24)-Partha’s three wishes for healthcare

(32:40)-Concluding remarks

Jonathan is joined by Geraldine Dawson, Director of the Duke Center for Autism and Brain Development, USA. In the second of a two-part episode, the pair discuss face processing in young children with autism, the use of datasets in autism research, and biomarkers for potential treatment.

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction

(00:42)-Digital behaviour phenotyping for the early detection of autism

(07:11)-Research on early autism detection models based on electronic health records

(12:43)-The application of artificial intelligence and computer vision in early autism detection

(15:11)-Brain circuitry, and the techniques and implications of electrophysiological techniques

(20:16)-Three wishes for the future of healthcare

In this week’s episode, Jonathan is joined by Geraldine Dawson, Director of the Duke Center for Autism and Brain Development, and the Duke Autism Clinic, Durham, North Carolina, USA. In the first of a two-part episode, the pair discuss autism screening, the characteristics of autism in infancy, and the benefits of early intervention in social interactions.

Use the following timestamps to navigate the content in this episode:  (00:00)-Introduction (02:15)-What led Dawson to an academic career in psychology and autism (05:09)-How do we characterise being ‘on the spectrum’? (09:29)-Aetiology of autism: genetic and environmental factors (13:20)-Dawson’s early, groundbreaking research into autism symptoms in infancy (17:17)-Why is the incidence of autism increasing? (19:45)-The Early Start Denver Model: early autism interventions (23:24)-Time Magazine’s medical breakthrough of 2012

This week, James Hull, Consultant Respiratory Physician, Royal Brompton Hospital, London, UK, takes Jonathan on a deep dive into respiratory care, from combatting breathlessness to airway collapse in athletes. The pair also discuss the common misconceptions surrounding asthma diagnosis, recent technological advancements, and the potential challenges behind emerging treatments.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(2:17)-What got Hull into medicine?

(03:34)-Relationship between exercise and breathlessness

(06:22)-Anxiety and breathlessness

(10:24)-Optimising respiratory health in elite athletes

(13:52)-RELACS; managing large airway collapse

(16:10)-New methods for diagnosing upper airway problems

(20:09)-New developments in treating asthma

(23:10)-Challenges in respiratory medicine

(25:04)-Respiratory medicine and sports committees

(26:38)-Three wishes for the future of healthcare 

The information contained in this podcast is intended for a European healthcare professional audience for continuing education purposes only. This podcast was supported by Jazz Pharmaceuticals, which  had input into the concept and topic, but not the content of the podcast. The views expressed in this podcast are those of the individual speakers and do not necessarily reflect the views of Jazz Pharmaceuticals.

Lennox–Gastaut syndrome (LGS) is a rare, severe, and progressive childhood-onset epilepsy characterised by recurrent seizures. LGS can be challenging to diagnose due to multiple aetiologies, varying clinical presentation at onset, and a lack of specific biological markers. These challenges can be compounded in adulthood due to the evolving presentation of LGS over time, and incomplete medical histories. In this insightful podcast, experts Steve Chung, University of Arizona, Phoenix, USA; and Rhys Thomas, Royal Victoria Infirmary, Newcastle, UK, explore the identification, diagnosis, and management of LGS in both children and adults based on their experiences in real-life clinical settings.

In this week’s episode, Jonathan is joined by Aleksander Lühr Hansen, Steno Diabetes Center, Copenhagen, Denmark; and Aarhus University Hospital, Denmark. The pair discuss low birthweight and fetal programming, in the context of the associated increased risk of developing conditions like Type 2 diabetes.  

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction 

(01:50)-Alexander’s route in medicine and diabetes 

(03:50)-Research on low birthweight 

(05:44)-Fetal programming 

(10:11)-The ‘thrifty phenotype’ 

(12:55)-Low birthweight and Type 2 diabetes development 

(19:45)-Alexander’s experiences in Tanzania 

(24.06)-Adverse pregnancy outcomes and incident heart failure 

(27.19)-The translational Type 2 diabetes research group 

(30:00)-Projects for the future 

(33.01)-Three wishes 

Jonathan is joined by Simon Fleming, orthopaedic surgeon, Royal North Shore Hospital, Sydney, Australia, and Fellow of the Royal College of Surgeons of England. Passionate about improving the quality and culture of healthcare, Simon discusses advocating for increased education standards, and his groundbreaking work to drive out bullying, discrimination, and harassment in healthcare.  

Use the following timestamps to navigate the content in this episode:  

(00:00)-Introduction 

(02:12)-Fleming the orthopod  

(08:05)-Training and practicing in Britain and Australia 

(13:40)-Similarities and dissimilarities 

(15:56)-Rocking the boat  

(21:28)-Bullying and discriminatory behaviours in healthcare 

(23:11)-The BOTA census 

(26:09)-TEDx NHS 

(29:14)-Holding sexual predators accountable  

(34:00)-Pronouns 

(37:35)-#OrthoTwitter  

(40:35)-Flawed assessment in healthcare 

(43:46)-Influencing the next generation 

(46:36)-Three wishes for the future of healthcare 

The publication of this podcast was funded by CSL Behring. The views and opinions expressed are exclusively those of the speakers.

In this section, the panel considers the diagnostic tools and approaches available for healthcare professionals to use for suspected idiopathic pulmonary fibrosis (IPF). The discussion is directed towards the expertise of Prof. Luca Richeldi, who emphasises the importance of knowledge, education, and medical examination approaches for addressing the unmet medical needs associated with the awareness of, and diagnostic delays of IPF.

The publication of this podcast was funded by CSL Behring. The views and opinions expressed are exclusively those of the speakers.

In this section, which is directed towards the expertise of Prof. McElvaney, the discussion focuses specifically on the relevance of detecting and diagnosing Alpha 1 Antitrypsin Deficiency (AATD) for lung diseases, as well as consideration of other diagnostic techniques and standards of care options for patients with AATD.

In this podcast episode exploring a novel radioisotope treatment for non-melanoma skin cancer, our moderator, Sue Saville, hosts two experts in skin cancer and oncological nuclear medicine.

This podcast has been sponsored by OncoBeta, a medical device company specialising in innovative epidermal radioisotope therapies.

In this week’s episode, Jonathan is joined by Jane Barratt, Secretary General of the International Federation on Ageing (IFA), an international non-governmental organisation that works with the United Nations (UN) and its agencies. The pair discuss global perceptions of ageing, approaches to elderly care around the world, and increasing inequity in service accessibility. 

Use the following timestamps to navigate the content in this episode:  

(00:00)-Introduction 

(02:11)-Jane’s passion for population aging and disability 

(04:23)-Our obsession with age! 

(06:56)-Considering the quality of life of elderly people 

(09:20)-The importance of human companionship 

(11:07)-Global and societal variations in the standard of care for the elderly 

(15:20)-Aiming for a ‘kinder’ society 

(16:47)-International Federation on Aging 

(19:13)-COVID and vaccination denial 

(24:30)- Successful care programmes in Scandinavia and China 

(26:40)-Life course approach to vaccination 

(28:32)-Programme and policy creation centered around the elderly 

(31:43)-Petitioning healthcare professionals  

(34:36)-Jane’s three wishes for healthcare  

Jonathan is joined by Elizabeth Macintyre, President-Elect and Board Member of the Biomedical Alliance, Europe; and Past President of the European Haematology Association (EHA). The pair delve into the world of haematology, focusing on Macintyre’s research towards equal access, haematological diagnostics, and her presidency during the COVID-19 pandemic. 

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction 

(01:39)-Macintyre’s route into medicine  

(04:13)-Haematology in Europe, and leading the EHA  

(08:30)-Diagnostics in haematological malignancies 

(10:18)-Changes to congress following COVID-19 

(14:12)-Coffee conversations  

(15:36)-Madrid 2024 

(18:42)-Jonathan speaks French  

(24:07)-Medical politics and economics 

(30:00)-Accessing new treatments  

(35:43)-Three wishes for the future of healthcare  

This week’s episode spotlights epilepsy, exploring research in the field, and global perspectives on this condition. Jonathan is joined by Maeike Zijlmans, who discusses the electrical activity in the brain which is causative for this disorder; seizures and loss of consciousness; and the more unknown aetiologies of epilepsy.

Maeike Zijlmans, Neurologist and Professor, University Medical Center Utrecht, and Stichting Epilepsie Instellingen Nederland, Heemstede, both in the Netherlands, shares valuable insights into her work studying both generalised and focal epilepsy, the longevity of this disease, and exciting treatment options.

Use the following timestamps to navigate the content in this episode

(00:00)-Introduction

(02:38)-Why neurology and later epilepsy research?

(03:26)-Global perspectives on epilepsy research and clinical practice

(06:30)-Aetiologies and treatment journeys associated with epilepsy

(10:29)-Raising awareness

(15:58)-Spotlighting electroencephalogram in the context of epilepsy

(18:26)-High-frequency oscillations

(21:23)-Signal analysis and phase amplitude coupling to generate an individual epileptic ‘signature’

(24:38)-Intraoperative electrocorticography in people with brain tumours

(26:40)-Surgical approaches to treating epilepsy

(29:20)-Next-generation taskforce for the International League Against Epilepsy

(31:14)-Machine learning and artificial intelligence

(34:05)-Three wishes for the future of healthcare

This week, Jonathan is joined by Michael Reardon, Houston Methodist Hospital, Texas, USA, to explore developments in treating coronary artery disease, as well as his work on various clinical trials in interventional radiology. Reardon discusses his extensive experience in performing heart surgery, focusing especially on transcatheter aortic valve implantation and transcatheter mitral valve replacements.

Follow the timestamps below!

(00.00)-Introduction

(03.09)-Michael’s inspiration for pursuing a career in cardiothoracic surgery

(04.21)-‘The TAVI Revolution’: advances in cardiac surgery

(10.15)-The Evolut Low-Risk and CoreValve trials

(11.12)-The ARISE Type A stent graft trial

(14.31)-Transcatheter mitral valve replacement: the Cephea and Apollo TMVR trials

(19.33)-Treatment of cardiac tumours

(22.33)-Cardiac tumour removal procedure

(24.51)-Structural heart disease and catheter-based treatment approaches

(26.50)-Latest advances in minimally invasive techniques in cardiac surgery

(28.52)-Risks and complications associated with complex cardiac procedures

(31.35)-Three wishes for the future of healthcare

This week’s episode explores broken heart syndrome, cardiomyocytes, and regenerative medicine. Jonathan is joined by Sian Harding, Emeritus Professor of Cardiac Pharmacology at the National Heart and Lung Institute (NHLI) at Imperial College London, UK, to discuss the relationship between emotions and heart function, as well as her research into regenerative medicine, including pluripotent stem cells, gene editing, and engineered heart tissue patches.

Use the following timestamps to navigate the content in this episode:

(00.00)-Introduction

(02.25)-What led Sian to a career in cardiology?

(03.45)-Introduction to cardiomyocytes

(05.53)-How has knowledge of cardiomyocytes changed over time?

(07.46)-Broken heart syndrome

(16.31)-Regenerative medicine in cardiology

(20.18)-Engineered heart tissue patches

(24.40)-Sian’s work in the House of Commons

(27.26)-The use of stem cells in cardiology

(29.39)-Gene editing

(32.08)-Three wishes for the future of healthcare

In this bonus episode of the EMJ Podcast, host Brigitte Scott is joined by Ketta Lorusso, Associate Professor of Obstetrics and Gynaecology, Catholic University of Rome, Italy; and Brad Monk, Professor, University of Arizona College of Medicine, USA, who discuss key research findings in endometrial cancer, as presented at the European Society for Gynecologic Oncology (ESGO) Congress 2023, which took place from 28th September–1st October 2023 in Istanbul, Türkiye.

The publication of this podcast was funded by a medical educational grant from GSK.

Jonathan is joined by António Almeida, President of the European Hematology Association (EHA); and Professor and Director of the Clinical Haematology Service, Hospital da Luz, Lisbon, Portugal, to discuss his highlights since becoming EHA President. The pair cover the three pillars of EHA, the anticipated topics for the 2024 congress, and how Almeida has implemented a brand-new medical school, as well as much more.  

 Use the following timestamps to navigate the content in this episode:

(00.00)-Introduction (01:55)-Almeida’s new medical school (03:35)-EHA Master Class peer-based learning and modern medical education (09:00)-Presidential highlights  (11:50)-EHA’s three pillars in the coming year (16:05)-EHA 2024 in Madrid (20:15)-Research in myeloproliferative and myelodysplastic syndromes (23:00)-Clinical trial updates in myelodysplastic syndromes and chronic myeloid leukaemia (26:50)-Changes over the course of Almeida’s career (31:30)-Treatment advances on the horizon (32:50)-CRISPR to treat sickle cell disease and β-thalassaemia (36:30)-Three wishes for the future of healthcare 

This episode discusses the wide range of applications of radiology, from detecting conditions that mimic cancer in pregnancy to enabling the detection of abuse in elderly patients. Refky Nicola, Associate Professor in the Department of Radiology at the State University of New York Upstate Medical University (SUNY), Syracuse, USA, joins Jonathan to discuss the Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer and the development of AI in radiology. 

Use the following timestamps to navigate the topics discussed in this episode:

(00.00)-Introduction

(02.26)-What inspired Nicola to pursue a career in radiology

(04.07)-What led to Nicola migrating from emergency to abdominal radiology

(05.25)-Mimics of cancer in pregnancy

(07.13)-The Vesical Imaging Reporting and Data System in bladder cancer

(09.12)-Pitfalls of right upper quadrant ultrasound

(11.10)-Rare COVID-19 vaccine multiorgan complications

(15.40)-Role of the radiologist in detecting abuse in elderly patients

(18.35)-Use of AI in radiology

(19.54)-Three wishes

This week, Jonathan is joined once more by Neil Patel, Neonatologist and Clinical Innovation Director at the Royal Hospital for Children in Glasgow, UK, to explore innovations in neonatology. In this episode, Patel discusses his work in revolutionising neonatal care by embracing the use of video messaging in order to promote family involvement, and Patel’s vision to open a centre for innovation at the Royal Hospital.

Use the following timestamps to navigate the topics discussed in this episode:

(00:00)-Introduction 

(00:34)-vCreate and the challenges of introducing medical innovations 

(09:30)-Opening a Centre for Innovation in Glasgow 

(13:27)-Challenges in maternal and neonatal care 

(17:03)-Three wishes for the future of healthcare 

In this final episode, the experts consider the patient perspective of managing type 2 diabetes and its complications while tailoring treatment approaches to individual characteristics. They also consider the patient's needs with a focus towards incretin/gut hormones and providing practical insights for healthcare practice.

This podcast is provided by EMJ and was supported by independent funding from Eli Lilly and Company, who did not influence the content of it. This educational activity is intended for an audience of non-US healthcare professionals.

Prof Michael Nauck

Head of Clinical Research at the Diabetes Division Medical Department of St. Josef-Hospital, Ruhr-University in Bochum, Germany.

Professor Nauck’s research interests include the pivotal role of gastrointestinal peptide hormones, including incretins, in both the physiological and therapeutic regulation of metabolism, as well as in the pathophysiology of type 2 diabetes. His groundbreaking contributions have been significant in shaping the treatment landscape of type 2 diabetes. He has played a pivotal role in developing novel therapeutic agents based on anti-diabetic properties of the gut hormone including GLP-1 (or Glucagon-like peptide-1).

His extensive scholarly output is underscored by numerous publications, and his outstanding scientific contributions have been honoured with several awards and accolades, including the Paul Langerhans Medal (2012) bestowed by the German Diabetes Association, and the Claude Bernard Medal from the European Association for the Study of Diabetes in 2022.

Dr. Priya Manjoo

Clinical Assistant Professor in the Division of Endocrinology at the University of British Columbia in Canada. 

Dr Manjoo is a diplomat of the American Board of Obesity Medicine and a Certified Specialist in Hypertension Medicine. She is also the director of the CardioMetabolic Collaborative Clinic located in Victoria, British Columbia, Canada and a member of the Victoria Lipid Clinic. She is a co-author of the Pharmacotherapy Section of the 2020 Canadian Adult Obesity Clinical Practice guidelines, as well as the 2022 chapter update and is an author of the 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia in Adults. Dr. Manjoo is a key opinion leader in the realms of diabetes, dyslipidaemia, and obesity management. Her invaluable contributions significantly contribute to advancing our understanding of these critical medical concepts.

This week, Jonathan is joined by Neil Patel, Neonatologist and Clinical Innovation Director at the Royal Hospital for Children in Glasgow, UK, to explore innovations in neonatology. Patel discusses his work on diaphragmatic hernia, a condition that requires multidisciplinary input and lifelong care. He further explains his role with the Scottish Women’s and Children’s Health Innovation Consortium, and the potential of the mOm Incubator for thermal regulation in newborns.

(00.00)-Introduction

(02.43)-Heart function through the medium of dance

(04.20)-Neil's route into paediatric medicine

(08.05)-Diaphragmatic hernia

(12.21)-Interests in innovation

(17.55)-mOm Incubators

(21.49)-Crossing the valley of doom

Antoni Chan, Consultant Rheumatologist and Associate Medical Director at the Royal Berkshire NHS Foundation Trust, Reading, UK, and Jonathan discuss digital healthcare technology and remote monitoring, and how they have impacted the field of rheumatology. Chan provides further detail, exploring how virtual multidisciplinary teams are used in the field, and touches on the digital tools and wearables that can be used to track patients with chronic conditions.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(02:10)-What first led Antoni into medicine

(03:14)-Antoni’s specific interests in rheumatology and ankylosing spondylitis

(05:51)-Antoni’s doctoral thesis

(07:20)-Referrals and collaboration in primary care

(09:04)-The impacts of digital healthcare technology in rheumatology

(12:11)-Specific digital tools and wearables showing promise in the management of chronic conditions

(14:05)-Using technology to improve collaboration with healthcare professionals, and communication with patients

(16:12)-The future of digital healthcare in rheumatology: trends and anticipations

(17:23)-Artificial intelligence and machine learning algorithms

(18:27)-Three wishes for the future of healthcare

In this episode, the experts focus on incretin hormones, their clinical benefits, and therapeutic approaches, providing valuable insights into incretin-based therapies, and the perspectives of the EASD-ADA guidelines and when it is clinically appropriate to start prescribing incretins for blood glucose control.

This podcast is provided by EMJ and was supported by independent funding from Eli Lilly and Company, who did not influence the content of it. This educational activity is intended for an audience of non-US healthcare professionals.

Prof Michael Nauck

Head of Clinical Research at the Diabetes Division Medical Department of St. Josef-Hospital, Ruhr-University in Bochum, Germany.

Professor Nauck’s research interests include the pivotal role of gastrointestinal peptide hormones, including incretins, in both the physiological and therapeutic regulation of metabolism, as well as in the pathophysiology of type 2 diabetes. His groundbreaking contributions have been significant in shaping the treatment landscape of type 2 diabetes. He has played a pivotal role in developing novel therapeutic agents based on anti-diabetic properties of the gut hormone including GLP-1 (or Glucagon-like peptide-1).

His extensive scholarly output is underscored by numerous publications, and his outstanding scientific contributions have been honoured with several awards and accolades, including the Paul Langerhans Medal (2012) bestowed by the German Diabetes Association, and the Claude Bernard Medal from the European Association for the Study of Diabetes in 2022.

Dr. Priya Manjoo

Clinical Assistant Professor in the Division of Endocrinology at the University of British Columbia in Canada. 

Dr Manjoo is a diplomat of the American Board of Obesity Medicine and a Certified Specialist in Hypertension Medicine. She is also the director of the CardioMetabolic Collaborative Clinic located in Victoria, British Columbia, Canada and a member of the Victoria Lipid Clinic. She is a co-author of the Pharmacotherapy Section of the 2020 Canadian Adult Obesity Clinical Practice guidelines, as well as the 2022 chapter update and is an author of the 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia in Adults. Dr. Manjoo is a key opinion leader in the realms of diabetes, dyslipidaemia, and obesity management. Her invaluable contributions significantly contribute to advancing our understanding of these critical medical concepts.

Join Jonathan as he welcomes back Greg Marcus, Endowed Professor of Atrial Fibrillation, and Professor of Residence (Medicine) at the University of California, San Francisco, USA. They discuss how ethnicities need to be researched with regard to atrial fibrillation, including how adverse outcomes differ depending on an individual’s ethnicity. They also talk about digital health, and how AI devices encourage people to become more aware of their own health.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(00:37)-The economics of cardiac disease prevention and cardiac devices

(05:00)-Genetic risk across ethnic groups

(07:54)-Atrial fibrillation detected by smart watches

(12:05)-AI in cardiology

(12:49)-A new energy for common catheter ablation

(15:14)-Personalised medicine

(16:53)-Advice for young cardiologists

(20:59)-Three wishes for the future of healthcare

The publication of this podcast was funded by QIAGEN.

Tune in to our latest podcast for valuable insights on non-small cell lung cancer (NSCLC). Esteemed contributors to this discussion include Terri Conneran, a Patient Advocate and founder of KRAS Kickers, and Colin Lindsay, a Clinical Senior Lecturer and Honorary Consultant in Thoracic Medical Oncology at The Christie in Manchester, UK. Both experts underscore the pivotal importance of biomarkers, diagnostic technologies, and collaborative efforts in enhancing survivorship.

During this episode, you'll hear about the need for early biomarker testing in NSCLC, along with a forward-looking exploration of the field's future. Lindsay offers an overview of the current treatment landscape for NSCLC, shedding light on issues like late diagnosis and targeted therapies, as well as outlining next-generation sequencing and liquid biopsy as tools to enhance NSCLC testing. Patient experiences are explored, with Conneran sharing her personal journey with diagnosis and treatment.

Terri Conneran – Patient Advocate and Founder of KRAS Kickers, Charlotte, North Carolina. United States.

Colin Lindsay - Clinical Senior Lecturer and Honorary Consultant in Thoracic Medical Oncology at The Christie, Manchester

In this episode, the experts dive deeper into the mechanisms and physiological targets through which incretin hormones work (GLP-1), ensuring the harmonious balance of glucose metabolism and appetite regulation. They explore the intricate molecular pathways and unveil the physiological effects that arise from the actions of these messengers.

This podcast is provided by EMJ and was supported by independent funding from Eli Lilly and Company, who did not influence the content of it. This educational activity is intended for an audience of non-US healthcare professionals.

Prof Michael Nauck

Head of Clinical Research at the Diabetes Division Medical Department of St. Josef-Hospital, Ruhr-University in Bochum, Germany.

Professor Nauck’s research interests include the pivotal role of gastrointestinal peptide hormones, including incretins, in both the physiological and therapeutic regulation of metabolism, as well as in the pathophysiology of type 2 diabetes. His groundbreaking contributions have been significant in shaping the treatment landscape of type 2 diabetes. He has played a pivotal role in developing novel therapeutic agents based on anti-diabetic properties of the gut hormone including GLP-1 (or Glucagon-like peptide-1).

His extensive scholarly output is underscored by numerous publications, and his outstanding scientific contributions have been honoured with several awards and accolades, including the Paul Langerhans Medal (2012) bestowed by the German Diabetes Association, and the Claude Bernard Medal from the European Association for the Study of Diabetes in 2022.

Dr. Priya Manjoo

Clinical Assistant Professor in the Division of Endocrinology at the University of British Columbia in Canada.  

Dr Manjoo is a diplomat of the American Board of Obesity Medicine and a Certified Specialist in Hypertension Medicine. She is also the director of the CardioMetabolic Collaborative Clinic located in Victoria, British Columbia, Canada and a member of the Victoria Lipid Clinic. She is a co-author of the Pharmacotherapy Section of the 2020 Canadian Adult Obesity Clinical Practice guidelines, as well as the 2022 chapter update and is an author of the 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia in Adults. Dr. Manjoo is a key opinion leader in the realms of diabetes, dyslipidaemia, and obesity management. Her invaluable contributions significantly contribute to advancing our understanding of these critical medical concepts.

In this final episode, Solomon Tesfaye and Oliver Binns-Hall explore the dynamic landscape of the recognition and treatment of diabetic neuropathy across diverse clinical realities in various countries. They discuss the challenges, and solutions that can help improve the management of diabetic neuropathy in different healthcare settings worldwide. 

This content has been supported by Viatris

In this third episode, Solomon Tesfaye and Oliver Binns-Hall consider the transformative potential for diabetic neuropathy care. They identify the importance of integrated patient care and the need for early-stage screening and diagnosis, discussing the evolving role of the podiatrist, and the need for a well co-ordinated foot care service. They also consider innovative screening solutions and the improvements needed in the chronic management of this condition.

This content has been supported by Viatris

This week, Jonathan is joined by Greg Marcus, Endowed Professor of Atrial Fibrillation and Professor of Residence (Medicine) at the University of California, San Francisco, USA, to explore advances in the field of electrophysiology, and how substances such as coffee, alcohol, and cannabis have an effect on cardiac arrythmias, physical activity, and sleep. They further dive into the aims and results of the Health eHeart study, and how technology such as smartwatches can be used in heart disease.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(04:01)-What inspired Greg to get into medicine, and specifically into cardiology and electrophysiology

(06:30)-Electrophysiology 101

(09:10)-Coffee’s effects on cardiac arrhythmias

(15:31)-Shifts in metabolism triggered by ageing

(16:35)-The MARY-JANE Cannabis and Heart Rhythm trial

(20:09)-Effects of alcohol on heart outcomes

(26:01)-Aims and discoveries of the Health eHeart study

In this episode, Jonathan is joined by Brian Van Tine, Professor of Medicine in medical oncology and Professor of Paediatrics at the Washington University School of Medicine (WUSM) in St. Louis, Missouri, USA, to provide an overview of his clinical interest in soft tissue and bone sarcomas. The pair explore immunotherapy, specifically monoclonal antibodies and immune checkpoint blockade, and further dive into metabolomics and its relevance to oncology.  

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction 

(03:50)-Brian’s inspiration for pursuing oncology 

(04:43)-The rare tumour world and sarcomas 

(06:13)-Immunotherapy trials

(09:21)-Treatment options for advanced alveolar soft part sarcoma 

(13:52)-Genetic mutations in malignant diseases 

(17:13)-Argininosuccinate synthetase 1

(22:49)-Metabolomics

(25:55)-Anthracycline-associated cardiotoxicity in patients with soft tissue sarcoma 

(28:40)-Treatments available for soft tissue tumours 

(31:49)-Three wishes

Tune in for a fascinating discussion with Jørgen Bjerggaard Jensen, Department of Urology, Aarhus University, Denmark, as he explores recent breakthroughs in non-muscle-invasive bladder cancer (NMIBC) management through mitomycin C (MMC) chemoresection. Jensen addresses the critical need to advance NMIBC management, underscoring its unique status as a disease of field cancerisation. Delving into the study’s main findings, Jensen discusses the efficacy of MMC chemoresection and the potential effectiveness in both low-grade and high-grade Ta tumours. Safety and tolerability aspects are also examined, highlighting the promise this intervention holds for patients and urologists alike. This content was funded by medac GmbH.

Two experts in medical oncology explore the latest developments in metastatic colorectal cancer in this episode of the EMJ podcast. Elena Élez, Vall d’Hebron University Hospital and Vall d’Hebron Institute of Oncology, Barcelona, Spain; and Michel Ducreux, Gustave Roussy, Villejuif, France, and Paris-Saclay University, France, discuss current treatment guidelines for patients with mCRC BRAF V600E mutation.

This podcast has been funded by Pierre Fabre; the position and discussions might not represent the position of Pierre Fabre.

Michelle Kelly-Irving, Director of Research at the Center for Epidemiology and Population Health Research, Faculty of Medicine, Paul Sabatier University, Toulouse, France, joins Jonathan to discuss social, economic, minority, and gender inequalities across healthcare systems and the life-course; her epidemiological research projects; and the concept of the exposome, highlighting  how environmental exposures impact biology and human health.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(02:12)-A diverse upbringing and disciplinary mix

(04:20)-Social determinants of biology

(06:12)- The exposome

(09:26)-Falling down the rabbit hole

(11:47)-Gender and health inequalities

(15:00)-Man flu!

(19:52)-Social deprivation and COVID

(25:35)-Health trajectories and influencing people earlier in life

(28:16)-Three wishes

In this second podcast, Kevin Boehnke and Dan Clauw consider the experiences of the healthcare professional when it comes to treating fibromyalgia. They emphasise the significance of shared decision-making between both the patient and practitioner. They also explore the available treatment options, and consider the role of non-pharmacological approaches in managing this condition.

Dr Kevin Boehnke

Research Assistant Professor, Department of Anaesthesiology and the Chronic Pain and Fatigue Research Centre, University of Michigan Medical School, Ann Arbor, USA

Dr Boehnke received his doctorate from the University of Michigan School of Public Health in Environmental Health Sciences in 2017. Dr Boehnke’s current research focuses on therapeutic applications of cannabis and psychedelics where his goal is to rigorously assess appropriate use of these substances and to help address the public health harms caused by their criminalisation. He is also a yoga instructor and he himself lives with fibromyalgia.

Professor Daniel Clauw

Professor of Anasthesiology, Internal Medicine of Rheumatology and Psychiatry, and the Chronic Pain and Fatigue Research Centre, University of Michigan Medical School, Ann Arbor, USA

Professor Clauw serves as Director of the Chronic Pain and Fatigue Research Centre at the University of Michigan, USA and co-directs the Research Development Core and Pre-Doctoral Programs. His research is committed to clinical care and research into the central nervous system. He is an international expert in chronic pain disorders, such as fibromyalgia, where he incorporates a multitude of methods ranging from patient-reported outcomes to functional and chemical neuroimaging, and phenotyping, and as such, has been critical in helping elucidate the importance of the central nervous system in chronic pain conditions.

This content has been supported by Viatris

In this episode, the experts provide an understanding of the intricate role gut hormones play in glucose and appetite regulation. Also, to shed light on the vital role played by these nutrient-stimulated hormones, and their profound influence on energy, glucose regulation and their intricate interactions with target tissues.

This podcast is provided by EMJ and was supported by independent funding from Eli Lilly and Company, who did not influence the content of it. This educational activity is intended for an audience of non-US healthcare professionals.

Byungyol ‘Bill’ Chun, Owner of Women’s Healthcare of Woburn, Massachusetts, USA, Founder of Women Only Organics (WOO), and Co-founder of Doc & Doula, joins Jonathan to discuss the menopause, abortion, and the profit-based healthcare system in the USA. 

You can find more information about doulas, which are discussed during this podcast, on the Doulas for Everyone website.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction  

(02:50)-Born to be an OBGYN  

(05:00)-Training in Boston City Hospital  

(06:00)-Caesarean-section and induction of labour in 2023  

(07:30)-Shortage of OBGYNs  

(09:00)-State of women’s health  

(11:25)-Positive patient and doctor interaction  

(15:30)-Inside information on women’s healthcare

(17:20)-The taboo on menopause

(21:20)-Six reasons why women’s healthcare is a disaster

(25:20)-CBD in women’s healthcare  

(30:39)-Access to abortion  

(36:25)-Doc & Doula to empower women  

(41:20)-Ask Bill

(42:30)-Three wishes

This week, Jennifer Dixon joins Jonathan to share the mission of The Health Foundation, which she is Chief Executive Office of. The pair discuss the resource allocation formula that was created, taking into account the needs of the population, as well as the future of national strategy in health and healthcare. They further explore underfunding in the National Health Service (NHS), and the importance of investing in community care.  

Use the following timestamps to navigate the content in this episode: 

(00:00)-Introduction 

(02:05)-Dixon’s route into medicine  

(03:57)-The Health Foundation 

(08:00)-Future strategies for national healthcare systems  

(14:05)-’The thermostat is set too cold’, Europe versus the USA  

(18:32)-Dixon’s publications  

(24:40)-Telehealth and artificial intelligence as tools in healthcare  

(26:50)-’Money is too tight to mention’ and the NHS as a ‘political hot potato’ 

(32:24)-The highs and lows with global healthcare provision  

(24:40)-Future services 

(37:46)-Use of social media and Dixon’s ‘a-ha!’ moments  

(42:08)-Dixon’s three wishes 

In this episode, Jonathan is once again joined by Vikram Talaulikar, Associate Specialist in reproductive medicine at the University College London Hospitals (UCLH) NHS Foundation Trust, UK, to explore different treatment options for menopause, including lifestyle changes, alternative medicine, hormone replacement therapy, and non-hormonal treatments. They further dive into the symptoms, diagnosis, and treatment of polycystic ovary syndrome, and implications of oestrogen deficiency.

Use the following timestamps to navigate the topics in this episode:

(00:00)-Introduction

(00:43)-Treatments for menopause: benefits and side effects

(11:30)-Reasons for, and impact of, perimenopause

(16:18)-Polycystic ovary syndrome 101

(22:29)-Oestrogen deficiency and its implications

(25:53)-Three wishes for the future of healthcare

In the first episode, Solomon Tesfaye and Ollie Binns-Hall explore the pressing issue of the diabetes epidemic and its most prevalent microvascular complication: neuropathy. They discuss the identification and characterisation of these critical aspects of diabetes and explore the causes, symptoms, and challenges of diagnosing neuropathy within the broader context of diabetes.

This content has been supported by Viatris

In the second episode, Solomon Tesfaye and Ollie Binns-Hall unravel the intricate relationship between diabetes and pain. They focus on the current approaches to identifying diabetic peripheral neuropathy and explore the risk factors, and current detection and management approaches, identifying the challenges associated with managing this multifaceted condition.

This content has been supported by Viatris

This podcast, featuring Dr. João Neves, a pediatrician and Associate Professor at Nova Medical School in Lisbon, Portugal, who has a Ph.D. in immunology, also Head of the Paediatrics Department at the Hospital da Luz in Lisbon, will delve into the intricacies of RSV, exploring its structure, transmission, symptoms, its impact on both healthy and at-risk infants, the epidemiology surrounding it, its seasonality, and its relationship with the ongoing COVID pandemic.

This podcast was organized and funded by Sanofi. The statements are reflecting the opinion of the expert interviewed based on his clinical experience

MAT-GLB-2301791

Vikram Talaulikar, Associate Specialist in reproductive medicine at the University College London Hospitals (UCLH) NHS Foundation Trust, UK, joins Jonathan to discuss menopause symptoms, how these can differ depending on ethnicity, how they vary over time, and possible treatments.

Use the following timestamps to navigate the topics in this episode:

(00:00)-Introduction

(02:38)-Vikram’s inspiration in pursuing his career

(04:00)-Explaining perimenopause and menopause

(08:21)-Ethnic differences in experience of menopause, and areas where further research is needed

(13:22)-Post-menopause: the most productive years of a woman’s life?

(20:15)-What GPs and specialists need to understand about the field

In this first podcast, Kevin Boehnke and Dan Clauw delve into the patient’s perspective regarding the burden of fibromyalgia. They explore the impact of fibromyalgia on a person’s life, with Kevin sharing his personal experiences. Both experts also evaluate the significance of non-pharmaceutical treatment options for managing this condition.

Dr Kevin Boehnke

Research Assistant Professor, Department of Anaesthesiology and the Chronic Pain and Fatigue Research Centre, University of Michigan Medical School, Ann Arbor, USA

Dr Boehnke received his doctorate from the University of Michigan School of Public Health in Environmental Health Sciences in 2017. Dr Boehnke’s current research focuses on therapeutic applications of cannabis and psychedelics where his goal is to rigorously assess appropriate use of these substances and to help address the public health harms caused by their criminalisation. He is also a yoga instructor and he himself lives with fibromyalgia.

Professor Daniel Clauw

Professor of Anasthesiology, Internal Medicine of Rheumatology and Psychiatry, and the Chronic Pain and Fatigue Research Centre, University of Michigan Medical School, Ann Arbor, USA

Professor Clauw serves as Director of the Chronic Pain and Fatigue Research Centre at the University of Michigan, USA and co-directs the Research Development Core and Pre-Doctoral Programs. His research is committed to clinical care and research into the central nervous system. He is an international expert in chronic pain disorders, such as fibromyalgia, where he incorporates a multitude of methods ranging from patient-reported outcomes to functional and chemical neuroimaging, and phenotyping, and as such, has been critical in helping elucidate the importance of the central nervous system in chronic pain conditions.

This content has been supported by Viatris

In the second part of this podcast, Jonathan and Mark de Boer, current president of the Dutch Working Party on Antibiotic Policy (SWAB) focus on the ‘marathon’ of antimicrobial resistance and common misconceptions surrounding this topic . De Boer  then outlines the future of infectious disease management, highlighting the crucial role of healthcare professionals, policy makers, and the general public in combatting the ‘slow pandemic’. 

Use the following timestamps to navigate the topics in this episode:

(00:00)-Introduction (00:42)-Antimicrobial stewardship to combat the rise of resistant infections (05:06)-Main findings from de Boer’s study on antibiotic prescriptions in primary care (08:57)-Research in evolving epidemiology of antimicrobial resistance (11:29)-Common misconceptions made by healthcare professionals and the public (13:40)-The ‘marathon’ of antimicrobial resistance and perceptions of antibiotics (15:53)-Future of infectious disease management and antibiotic policy (19:41)-Three wishes for global healthcare

Article 'Trends in antibiotic selection pressure generated in primary care and their association with sentinel antimicrobial resistance patterns in Europe': https://academic.oup.com/jac/article/78/5/1245/7099685

Article 'The Dutch Working Party on Antibiotic Policy (SWAB) guideline for the approach to suspected antibiotic allergy': https://www.sciencedirect.com/science/article/pii/S1198743X23001787?via%3Dihubhttps://pubmed.ncbi.nlm.nih.gov/37068548/

Survey discussed: https://academic.oup.com/cid/search-results?page=1&q=westgeest&fl_SiteID=5269&SearchSourceType=1&allJournals=1#google_vignette

This week, Jonathan is joined by Mark de Boer, Professor of Infectious Diseases at Leiden University Medical Center (LUMC), the Netherlands, and the current president of the Dutch Working Party on Antibiotic Policy (SWAB). The pair explore the global scale of the “slow pandemic” of antimicrobial resistance, the learning curve of the COVID-19 pandemic, and how we can prepare for future infectious disease management. They also discuss disinformation, the importance of collaboration, and implications for patient care following prosthetic joint infection. 

 Use the following timestamps to navigate the topics in this episode:

(00:00)-Introduction 

(02:27)-Why medicine and infectious diseases  

(05:18)-The scale of antibiotic resistance 

(09:52)-Antibiotics use in the food industry 

(11:30)-International collaborations  

(15:00)-Lessons learnt from hospitalised COVID-19 patients  

(20:10)-Future infectious disease management and policy 

(22:47)-Prosthetic joint infection 

Prof. Torsten Witte, Director of the Dept. of Rheumatology and Clinical Immunology at the Hannover Medical School in Germany, Prof. Andrea Rubbert-Roth, Chief physician and deputy clinic head at the Clinic of Rheumatology, Canton Hospital, St. Gallen, Switzerland and Dr. Alessandro Giollo, lead of refractory arthritis, synovial biopsy and osteoporosis clinics at the Rheumatology Unit, Department of Medicine, University of Padova, in Italy delve into the latest advancements and offer perspectives in the management of rheumatoid arthritis with a specific focus on optimising methotrexate.

This podcast has been funded by Medac Gm-bh.

Evgenia Koutsouki, EMJ Editor, pulls together her favourite moments from the last quarter of the EMJ Podcast. Over the summer, our podcast welcomed an array of great guests, who discussed a multitude of topics, including the links between climate change and mental health, robotic surgery, and disparities in healthcare.

Use the following timestamps to navigate this episode:

(00:00)-Introduction

(00:35)-Richard Cohen discusses the benefits of robotic surgery

(01:37)-Arthur Burnett stresses the importance of the HPV vaccine in urology

(03:02)-Arthur Burnett on the impacts that healthcare disparities have upon survival rates

(03:29)-Samuel Washington speaks about financial barriers impacting outcomes for patients

(04:20)-Christine Ko talks about factors affecting the commonality of skin cancers

(05:16)-Christine Ko goes on to talk about visual perception in dermatology

(06:13)-Eva Parker emphasises the intersectionality between dermatological diseases, mental health, and climate change

(07:42)-Michela Starace questions the quality of life and mental health for patients with alopecia areata

(09:00)-Michela Starace discusses JAK inhibitors in the treatment of alopecia

(10:33)-Morag Griffin provides details on the rare condition paroxysmal nocturnal haemoglobinuria

(11:51)-Morag Griffin stresses the importance of international collaboration in rare diseases

(13:00)-Mark Sullivan highlights the difficulties of finding funding, and how this affects drug development

(14:12)-Mark Sullivan talks about access to healthcare as a fundamental human right

Silke Gillessen, Director of the Oncology Institute of Southern Switzerland, Bellinzona, Switzerland, joins Jonathan to discuss her specialty of genitourinary oncology, and why personalised and precise treatment is so vital. 

Listen to the following timestamps to navigate the content in this episode:

(00:00)-Introduction 

(03:10)-Gillessen’s origin story 

(04:25)-Differences and similarities in access to care between countries 

(06:26)-Inspiration to start the medical oncology unit for genitourinary cancer Kantonsspital St. Gallen 

(08:16)-Gillessen’s experience in the UK 

(11:00)-How evidence-based medicine can best influence adoption of ESMO guidelines 

(14:18)-The meaning of precision oncology and novel treatments for prostate, testicular, and penile cancers 

(17:17)-How ESMO can help support patients dealing with a cancer diagnosis 

(20:47)-Treatment for patients with castration-resistant prostate cancer 

(23:52)-Optimising treatment for metastatic prostate cancer 

(25:51)-Molecular targeted drugs and immunotherapy in prostate cancer 

(27:40)-Three wishes

This week, Jonathan is joined by Sophie Lanzkron, Professor of Medicine in the Division of Hematology at the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. The pair explores sickle cell disease and advancements in its treatment, including hydroxyurea and blood transfusions, as well as advancements in haplotype transplant and gene therapy. They further discuss challenges in diagnosis and treatment, and how the condition affects quality of life.

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction

(02:33)-Inspiration to work in haematology and sickle cell disease

(05:00)-Sickle cell disease: what is it and how does it affect quality of life

(08:30)-Efficiency and use of hydroxyurea

(13:00)-Infusion clinic outcomes versus emergency department outcomes

(16:08)-Treating patients with sickle cell disease by blood transfusions

(17:40)-Global prevalence and burden of sickle cell disease

(20:20)-Challenges faced by patients during diagnosis and treatment

(23:53)-Novel sickle cell disease healthcare delivery model

(26:27)-Perfecting treatment for sickle cell disease

(29:15)-Research focus in the future

(31:22)-Lanzkron’s three wishes for the future

This week, Jonathan is joined by Drew Bird, Director of the Food Allergy Center at Children’s Health, Dallas, Texas, USA, to dive into environmental factors that have led to the increase in allergies, including peanut allergy, and oral immunotherapy as a treatment for allergies. The pair further discuss misconceptions and misinformation around allergies, and which allergies need more attention.

Use the following timestamps to navigate the topics discussed in this episode:

(00:00)-Introduction

(02:28)-Bird’s career in paediatric allergy and immunology

(04:50)-Misconceptions in the field

(08:47)-Using food proteins for immunotherapy

(11:53)-Bird’s role as Director of the Food Allergy Center at Children’s Health

(16:46)-Unmet needs in paediatric food allergies

(18:05)-The PALISADE Study

(19:39)-Food protein-induced enterocolitis syndrome

(21:46)-Environmental factors and emerging allergies

(26:36)-Innovations in the allergy and immunology field

(30:51)-Advocating for young patients to promote effective healthcare

(33:15)-Bird’s three wishes for the future of healthcare

Prof Bird has the following disclosures: Consultant for AllerGenis, Allergy Therapeutics, Ltd, Before Brands, DBV Technologies, FARE, Genentech, HAL Allergy, Novartis, and Nutricia; and has received grant funding (institution) from Aimmune, Astellas, DBV Technologies, FARE, Genentech, NIH NIAID, Novartis, Regeneron and Siolta.

Mark Sullivan, Medicines for Global Health (MDGH), Melbourne, Australia, joins Jonathan to discuss global health inequality, the difficulties in finding funding as a Managing Director of a not-for-profit pharmaceutical company, and infectious diseases such as Hanson’s disease and river blindness.

Use the following timestamps to navigate the podcast topics:

(00:00)-Introduction 

(01:55)-What led Sullivan into biochemistry and microbiology 

(03:04)-Sullivan’s subsequent career in Pharma  

(04:36)-The world’s only non-profit biopharmaceutical company 

(7:28)-Approval of moxidectin 

(14:15)-Hansen’s Disease: causes, host response, and treatment 

(19:04)-Innovative medicines to treat the diseases of low- and middle-income countries 

(22:20)-How to tackle the enormous expenditure in low- and middle-income countries 

(30:56)-Product development partnerships 

(34:37)-How healthcare professionals can help 

(37:25)-Three wishes to improve global healthcare 

Speaker: Prof. Dominic Stoop

Topic: “Did you know!” The cycle-to-cycle variability can be influenced by Progesterone

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Dominic Stoop

Topic: “Did you know!” The lower limit of Progesterone that needs supplementation?

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Nikolaos Polyzos.

Topic: “Did you know!” You can also plan natural cycles with the use of Progesterone – NPP?

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Nikolaos Polyzos.

Topic: “Did you know!” That you can stimulate at any time of the cycle, even in the luteal phase

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Peter Humaidan.

Topic: “Did you know!” The optimal cut-off level of serum progesterone in the adenomyosis/endrometriosis patient is for times higher than that in a “normal patient”

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Petra Stute.

Topic: “Did you know!” Many menopausal women suffer from brain fog.

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Petra Stute.

Topic: “Did you know!” Taking oral estradiol has increased risk of venous thromboembolism but not with transdermal estradiol

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Andrea Genazzani.

Topic: “Did you know!” You can continue hormane therapy as long as the patient is symptomatic?

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Andrea Genazzani.

Topic: “Did you know!” Body-identical hormones like estradiol and micronized progesterone are approved, regulated and monitored for purity, efficacy and safety by regulatory agencies unlike compounded bio-identical hormones prepared by compounding pharmacists

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Tommaso Simoncini.

Topic: “Did you know!” It is possible to start menopause hormone therapy if you have symptoms and indications for that, even at later stages?

This podcast was sponsored by Besin Healthcare

Speaker: Prof. Tommaso Simoncini.

Topic: “Did you know!” Hormone therapy remains the most effective treatment for vasomotor symptoms and the genitourinary syndrome of menopause?

This podcast was sponsored by Besin Healthcare

This week, Jonathan is joined by Kevin Tracey, Feinstein Institutes for Medical Research, Manhasset, New York, USA, to explore bioelectronic medicine; its use in the treatment of inflammation, including rheumatoid arthritis; and its future. The pair further dives into the vagus nerve and the link between vagotomy and Parkinson’s disease, and the use of monoclonal anti-TNF antibodies to treat septic shock. 

Use the following timestamps to navigate the content in this episode:

(00:00)-Introduction 

(02.36)-Tracey’s origin story and route into medicine  

(04.46)-Defining bioelectronic medicine  

(07.15)-Septic shock and monoclonal anti-TNF antibodies  

(10:10)-The vagus nerve and 1493 

(22:15)-Vagotomy and Parkinson’s disease  

(26:32)-Optogenetics 

(29:52)-Replacing pharmaceuticals with bioelectronics  

(32:59)-Saving lives with vagus nerve stimulation to treat inflammation 

(35:01)-Cancer neuroscience  

(36:52)-Tracey’s three wishes for improving his field of specialty 

Michela Starace, Department of Medical and Surgical Sciences, University of Bologna, Italy, joins Jonathan to discuss hair loss and its impact on the lives of patients. They also explore how symptoms of conditions can present in nails, and how to treat benign nail tumours.

Use the following timestamps to navigate the topics discussed in this episode:

(00:00)-Introduction

(01:53)-What led Starace into medicine, and the field of dermatology

(03:20)-Alopecia areata, the role of JAK inhibitors, and adverse treatment events

(06:40)-Commonality of alopecia areata, and its recent reclassification as an autoimmune disease

(07:35)-Health-related quality of life and psychosocial anxiety in patients with hair loss

(10:03)-Recommendations for the treatment of female androgenetic alopecia

(12:03)-The role of trichoscopy in diagnostics

(14:36)-Onychoscopy in the diagnosis of nail disorders

(17:58)-The International Nail Society’s hopes for the future

(19:00)-Atopic dermatitis in adolescents

(20:08)-Presentation and treatment of benign nail unit tumours

(23:32)-Doctor-patient relationship in dermatology

(25:23)-Innovations in the field

(26:57)-Three wishes for the future of healthcare

This podcast episode explores the increasing global burden of dengue disease, focusing on changing demographics in endemic areas and the mounting risk of the disease in traditionally non-endemic areas. Moderated by Sue Saville, an independent health journalist, experts Tikki Pangestu, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, and João Bosco Siqueira, Federal University of Gois, Brazil, discuss the dangers of arboviral diseases, their impact on the healthcare ecosystem, and prevention strategies.

This podcast was funded by Merck Sharp & Dohme LLC

This week, Jonathan is joined by Eva Parker, Assistant Professor of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. They explore the impact of climate change on dermatological diseases such as skin cancer, atopic dermatitis, and psoriasis. The pair also discuss how the skin is affected by rising temperatures, ultraviolet radiation, and air pollution, and further dive into diversity and inclusion in the dermatology field, and how political issues can affect healthcare.

Use the following timestamps to navigate the topics discussed in this episode:

(00:00)-Introduction 

(02:45)-Impact of climate change on dermatology and the skin 

(04:23)-Encouraging more people to take skin cancer seriously 

(06:30)-American Academy of Dermatology (AAD) Expert Resource Group (ERG) on Climate Change and Environmental Affairs 

(07:54)-Revelations being published 

(11:05)-Health issues as a political issue 

(12:40)-Impact of climate change atopic dermatitis and mental health comorbidities 

(15:09)-Minimising our impact on climate change 

(18:40)-Chagas disease 

(22:48)-How skin colours affects skin presentations 

(24:50)-Diversity, equality, and inclusion in healthcare and dermatology

(27:25)-Three wishes for healthcare 

This podcast episode explores new advances in treating obstructive hypertrophic cardiomyopathy (HCM) and the role of myosin inhibitors, and provides an overview of the EXPLORER-HCM and VALOR-HCM clinical trials.

Iacopo Olivotto, University of Florence, Italy, first discusses unmet medical needs, specifically regarding the unmet needs of patients and gaps in current treatment methods. The discussion then centres around the mechanism of action of myosin inhibitors, a first-in-class drug for HCM, recently approved by the European Medicines Agency (EMA).

The findings of current clinical trials are outlined, with results being linked to a reduced need for septal reduction therapy, in addition to improved quality of life for patients. Finally, case studies are presented, discussing the impact of treatments on the lives of patients with HCM, and how to best integrate new treatments into current practice.