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Tinnitus Talk is a podcast about all things tinnitus. We aim to engage and inform you, bringing you fresh insights and updates on research, treatments, personal experiences and public awareness. Our hosts (who all have tinnitus themselves) interview tinnitus researchers, healthcare providers and advocates. We bring you real life stories from tinnitus patients. And we’ll update you on the latest developments in the field and in the patient community. Tinnitus Talk is a brand owned by Tinnitus Hub. Visit TinnitusTalk.com to join our online patient forum!
- 23 - Good Tinnitus Science, Bad Tinnitus Science
We often talk about the lack of research and funding for tinnitus. But what about the quality of research? Do tinnitus sufferers benefit from the research that is conducted? In reality, many studies are conducted improperly, thus giving misleading results and false promises for patients.
During this episode, we dive deep into concepts like research design, patient selection, outcome measures, statistical analysis, and everything else required for high-quality studies. We focus on studies that assess tinnitus interventions; in other words, studies that measure the effectiveness of new treatments. How do we ensure that such studies generate valuable information for patients?
We discuss these topics with Inge Stegeman, an epidemiologist from the University of Utrecht, and Jorge Simões, Assistant Professor in data science and mental health at the University of Twente.
(00:00) Why Is This Topic Important?
(16:15) Things That Can Go Wrong in Designing a Study
(24:55) How Do We Measure the Success of Clinical Trials?
(35:54) Open Science and the Importance of Being Systematic
(39:24) Breaking Out of Research Silos
(46:04) The Importance of Negative Results
(49:43) Being Honest About Study Outcomes
(55:59) Reasons for Optimism
(58:39) Unifying Tinnitus Research
Become a Tinnitus Talk Podcast Patron at https://moretinnitustalk.com for bonus content, video interviews, Ask an Expert series, and more!
Sat, 13 Apr 2024 - 1h 12min - 22 - Revisiting a Friend of Tinnitus Talk - Dr. Josef Rauschecker
We revisited with an old friend of the podcast: Dr. Josef Rauschecker. He was our first ever guest – go back and listen to that episode! – who came up with the famous 'gating' theory of tinnitus.
Josef’s gating theory poses that while neural ‘noise’ may arise in the ear and lower brain regions due to hearing loss, this noise is typically cancelled out further up the auditory pathway. For most people at least, but not for those experiencing tinnitus.
We speak to Josef in person at his office in Georgetown University about how his theory has evolved, his views on psychological treatments for tinnitus, why animal studies for tinnitus often fail, and how we can quickly get new tinnitus medications to market.
(00:00) Introduction
(02:23) Explaining the 'Gating' Theory
(06:55) Tinnitus Disorder
(09:31) Recent Insights from MRI Studies
(12:06) Psychological Treatments for Tinnitus
(15:49) Animal Models to Cure Tinnitus
(21:04) Speeding Up New Treatments
(27:08) Lidocaine Cures Tinnitus?
(30:18) New Funding Opportunities
Become a Tinnitus Talk Podcast Patron at https://moretinnitustalk.com for bonus content, video interviews, Ask an Expert series, and more!
Wed, 10 Jan 2024 - 34min - 21 - Can Sound Silence Tinnitus?Wed, 25 Jan 2023 - 1h 22min
- 20 - The Man Who Donated a Million Dollars to Tinnitus ResearchSun, 22 May 2022 - 59min
- 19 - It’s the Data, Stupid! - Christopher Cederroth and David StockdaleMon, 07 Feb 2022 - 1h 30min
- 18 - Tinnitus Realities - Steve and SeanThu, 04 Nov 2021 - 1h 44min
- 17 - Tinnitus, Ingrained in the Brain? - Prof. Dirk De RidderSat, 21 Aug 2021 - 1h 37min
- 16 - The Sound of Science - OtonomyWed, 26 May 2021 - 1h 36min
- 15 - Objectifying Tinnitus - The Bionics InstituteTue, 09 Feb 2021 - 1h 02min
- 14 - Visual Snow and Tinnitus - Phantom PhenomenaWed, 07 Oct 2020 - 1h 23min
- 13 - Tinnitus and the Power of Prediction - Dr. Will Sedley
This episode will give you a deeper understanding of the different models that explain the brain mechanisms underlying tinnitus. Dr Will Sedley outlines his own theory, based on predictive processing. We also cover issues like how to develop an objective marker of tinnitus and the thorny topic of whether tinnitus subtypes really exist or not.
Mon, 07 Sep 2020 - 1h 20min - 12 - Hearing Lost and Found - Frequency Therapeutics
This is your chance to learn all about the hearing regeneration treatment FX-322 being developed by Frequency Therapeutics. We spoke with Carl LeBel about the promising results of their Phase 1 trial, the potential benefits for tinnitus, why speech intelligibility should be the primary measure of hearing, and when the drug might reach the market.
Fri, 24 Jul 2020 - 1h 31min - 11 - Reviving Retigabine for Tinnitus - Thanos Tzounopoulos, PhD
A drug to quieten your tinnitus, that’s what Thanos Tzounopoulos, PhD, is working on. The drug targets potassium ion channels in the brain. These channels – or so the theory goes – are compromised in tinnitus patients, thus triggering the neural hyperactivity perceived as tinnitus. In spite of trials and tribulations in getting the drug ready for clinical trials, Thanos is optimistic about his chances for success.
Sun, 24 May 2020 - 1h 03min - 10 - Coronavirus Special: Tinnitus in Times of Quarantine
In this special compilation episode, you’ll hear from four people with tinnitus, as well as a researcher and an audiologist, about tinnitus experiences during the Coronavirus crisis. How has the stress of the crisis impacted people’s tinnitus? Can the Coronavirus cause tinnitus to aggravate? What kind of support is available for people struggling during this time?
Wed, 22 Apr 2020 - 52min - 9 - Healing Hearing, Silencing Tinnitus? - Hough Ear Institute
Tinnitus Talk spoke with the Hough Ear Institute, a non-profit research organization that focusses on restoring hearing. They are working on two hearing regeneration treatments that could very well have benefits for tinnitus sufferers. In this episode, we spoke with Dr. Richard Kopke and Justin DeMoss. They explain the mechanisms behind their treatments and how hearing restoration can be achieved. They take us through the different phases of research and development required to get new drugs to market, and some of the challenges faced along the way. Of course, we also touch on the topic of whether restoring hearing could cure tinnitus. The episode includes an announcement about an exciting new partnership with pharmaceutical company Oblato to take Hough’s hearing loss pill through the next phases of clinical trial and assess its potential for tinnitus.
Tue, 11 Feb 2020 - 1h 16min - 8 - Transforming Hyperacusis Research - Bryan Pollard
Tinnitus Talk spoke with Bryan Pollard, the president of Hyperacusis Research Limited, based in Boston. Bryan himself suffers from hyperacusis, which he believes is due to sound exposure from a loud woodchipper several years ago. In this episode, Bryan talks about his personal experience with hyperacusis, and how this drove him to start Hyperacusis Research to raise funds for scientific research. We spoke about the concept of pain hyperacusis and how it only recently became recognized due to the scientific breakthrough proving that the cochlea has pain receptors. Bryan also gives advice to hyperacusis patients regarding treatment options. And of course, we spoke about the most exciting new research developments.
Sat, 14 Dec 2019 - 1h 15min - 7 - Neuromod's Lenire - Treating Tinnitus the Bimodal Way
It’s been the talk of the town on the Tinnitus Talk forum for the past few months: the launch of Neuromod’s Lenire treatment for tinnitus. We got a chance to sit down with their CEO Dr. Ross O’Neill and ask him everything (well, nearly) you want to know about this device. It’s an extra-long episode, because so many questions were raised on our forum about Lenire – the thread has been viewed over half a million times – that we felt we needed to do our best to gather as many answers as possible. In the episode, Hazel and Ross talk about the basic principles of the treatment, its effectiveness, and risks. We also covered clinical trial results and go in-depth on what the treatment actually looks like. We clarify whom Lenire is suitable for, and Ross makes some projections about future roll-out of the device.
Sat, 09 Nov 2019 - 1h 49min - 6 - Clinical Guidelines for Tinnitus - Status Quo or Way Forward?
What is the current state of evidence in favour or against tinnitus treatments on the market? Which treatments have been thoroughly tested and which require more testing? What should doctors and patients learn from this? And how should this inform new tinnitus research? These are all questions answered in this episode! Tinnitus Talk spoke with Rilana Cima and Derek Hoare, two of the co-authors of the European Clinical Practice Guidelines for Tinnitus, which were published earlier this year. Clinical Guidelines are recommendations for healthcare professionals on how to diagnose and treat a medical condition, based on currently available evidence. The episode makes clear that the vast majority of treatments currently on the market have not been sufficiently studied to tell one way or the other how effective and safe they are. There is a dire lack of thorough clinical trial data available, which severely hinders clinical management of tinnitus. Doctors are often not aware of different treatment options, and patients have to find their own way through the system. If you are currently seeking medical treatment for tinnitus, make sure you are aware of any relevant Clinical Guidelines.
Mon, 19 Aug 2019 - 47min - 5 - Hearing In, Tinnitus Out - Prof. Marcelo Rivolta
What are stem cells and how can stem cells treat hearing loss? What’s going on with human trials for hearing regeneration? When can we expected new treatments on the market? And will regenerating hearing resolve tinnitus? These kinds of questions will be answered in this podcast! Tinnitus Talk spoke with Marcelo Rivolta, professor of Sensory Stem Cell Biology at the University of Sheffield. He explains the basic concepts of stem cells and the different approaches to hearing regeneration. It’s fascinating science, but there are a number of roadblocks to be cleared before patients can benefit. Marcelo also announces that he received a research grant and used it to start a biotechnology company called Rinri. If you want to stay up to date with the progress of Rinri, please visit https://rinri-therapeutics.com The interview with Marcelo was conducted by Steve Harrison (Tinnitus Talk) and David Stockdale (British Tinnitus Association). As added bonus material at the end, Hazel and Markku discuss the Tinnitus Talk podcast ‘behind the scenes.’ Visit the Tinnitus Talk Podcast at https://www.tinnitustalk.com/podcast/
Fri, 28 Jun 2019 - 59min - 4 - Tinnitus Management: Who Cares? - Richard Tyler, PhD
How can clinicians and patients work together? Why is tinnitus sub-typing important? Does loudness matter? What does habituation really mean? What different forms of counselling and treatment are available for tinnitus? These are some of the questions addressed in this episode. Tinnitus Talk spoke with Richard Tyler, from the University of Iowa. His career in tinnitus spans many decades. He has vast experience in both tinnitus research and patient care and is passionate about connecting those two worlds. Richard also talks about the annual conference on tinnitus management that he is organising this year for the 27th time in Iowa. The conference is open to patients.
Thu, 30 May 2019 - 57min - 3 - Tinnitus, The Musician's Curse? - CJ Wildheart
How do musicians deal with the fact that they are especially prone to getting tinnitus? Is there enough awareness on this? These are some of the questions addressed in this episode. Tinnitus Talk spoke with CJ Wildheart, professional rock musician with tinnitus, and guitarist for The Wildhearts. He talks candidly about how live and loud playing for many years caused his tinnitus, how this has affected his musical career, and the care he now takes to protect his ears. We were lucky to have Ed (known as Ed209 on the Tinnitus Talk support forum) arrange and conduct the interview with CJ. Ed is himself a professional music teacher, and in the second half of this episode, our podcast host Sean spoke with him about his personal experiences, musicians and tinnitus, and questions around noise protection.
Tue, 30 Apr 2019 - 1h 00min - 2 - A World Without Tinnitus - David Stockdale (British Tinnitus Association)
Tinnitus Talk spoke with David Stockdale, the chief executive of the British Tinnitus Association (BTA). We’re very excited to have David on for episode 2 of our podcast series! David frequently visits TinnitusTalk.com and engages with the tinnitus community through us and other channels. His dedication and drive to represent the needs of the community clearly shines through in this interview. David talks about his drive to accomplish the BTA’s vision: “A world where no one suffers from tinnitus.” We also addressed questions like: How can tinnitus associations move the research field forward? How do they convey the tinnitus experience to the broader public? What are the pros and cons of promoting certain treatments?
Sun, 03 Mar 2019 - 1h 01min - 1 - In Search of a Tinnitus Cure - Dr. Josef Rauschecker
Tinnitus Talk spoke with Dr. Rauschecker, one of most eminent researchers on tinnitus. We’re excited to launch our podcast series with this highly engaging interview, a must for anyone who wants to understand how tinnitus works in the brain and how we can get to a cure. The interview covers a range of topics, from Dr. Rauschecker’s own experience with tinnitus to his theories on how tinnitus manifests in the brain and links with other brain disorders like depression. We also talked about the dire lack of funding for (cure focused) tinnitus research, and the role that patient communities can play in resolving this.
Fri, 25 Jan 2019 - 1h 23min
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