Medscape InDiscussion: Myasthenia Gravis

Drs Nicholas Silvestri and Kelly Gwathmey discuss how exercise and other modifiable lifestyle factors can influence how patients experience the burden of myasthenia gravis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/990462). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Evidence-based Practice in Rehabilitation of Myasthenia Gravis. A Systematic Review of the Literature https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739309/

Drugs That Induce or Cause Deterioration of Myasthenia Gravis: An Update https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038781/

The Humanistic Burden of Myasthenia Gravis: A Systematic Literature Review https://pubmed.ncbi.nlm.nih.gov/35486970/

Outcome Measures in Clinical Trials of Patients With Myasthenia Gravis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793650/

Drs Nicholas Silvestri and Gil Wolfe get right to the point about when and why thymectomy may be considered as an evidence-based option for treatment of myasthenia gravis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/990461). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Long-term Effect of Thymectomy Plus Prednisone Versus Prednisone Alone in Patients With Non-thymomatous Myasthenia Gravis: 2-year Extension of the MGTX Randomised Trial https://pubmed.ncbi.nlm.nih.gov/30692052/

Randomized Trial of Thymectomy in Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/27509100/

The Short and Long-term Effects of Open vs Minimally Invasive Thymectomy in Myasthenia Gravis Patients: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/36539629/

Prognostic Factors for Conversion to Generalization in Ocular Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/34106649/

Development of a Model Care Pathway for Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/34770107/

Drugs That Induce or Cause Deterioration of Myasthenia Gravis: An Update https://pubmed.ncbi.nlm.nih.gov/33917535/

Drs Nicholas Silvestri and James "Chip" Howard discuss newer and novel myasthenia gravis tools to personalize treatment, including complement inhibitors, FcRn antagonists, biomarkers, and more.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/990460). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Safety and Efficacy of Eculizumab in Refractory Generalized Myasthenia Gravis (REGAIN Study) https://clinicaltrials.gov/ct2/show/NCT01997229

Safety and Efficacy of Eculizumab in Anti-acetylcholine Receptor Antibody-positive Refractory Generalised Myasthenia Gravis (REGAIN): A Phase 3, Randomised, Double-blind, Placebo-controlled, Multicentre Study https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30369-1/fulltext

ULTOMIRIS® (Ravulizumab-cwvz) Approved in the US for Adults With Generalized Myasthenia Gravis https://www.astrazeneca-us.com/media/press-releases/2022/ultomiris-approved-in-the-us-for-adults-with-generalized-myasthenia-gravis.html

UCB Announces US FDA Acceptance of New Drug Application and EMA MAA Validation for Zilucoplan for the Treatment of Generalized Myasthenia Gravis in Adult Patients https://www.prnewswire.com/news-releases/ucb-announces-us-fda-acceptance-of-new-drug-application-and-ema-maa-validation-for-zilucoplan-for-the-treatment-of-generalized-myasthenia-gravis-in-adult-patients-301676223.html

Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody–positive Generalized Myasthenia Gravis https://www.tandfonline.com/doi/full/10.1080/13543784.2021.1897567

Drs Nicholas Silvestri and Neelam Goyal lay out pathways for successful routine treatment of myasthenia gravis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/990458). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Adverse Side Effects Associated With Corticosteroid Therapy: A Study in 39 Patients With Generalized Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/34707081/

The History of Acetylcholinesterase Inhibitors in the Treatment of Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/32918950/

FcRn Inhibitors: A Novel Option for the Treatment of Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/36751773/

Ravulizumab: A Review in Generalised Myasthenia Gravis https://pubmed.ncbi.nlm.nih.gov/37166620/

Safety and Efficacy of Eculizumab in Anti-acetylcholine Receptor Antibody-positive Refractory Generalised Myasthenia Gravis (REGAIN): A Phase 3, Randomised, Double-blind, Placebo-controlled, Multicentre Study https://pubmed.ncbi.nlm.nih.gov/29066163/

Drs Nicholas Silvestri and Carolina Barnett-Tapia discuss what you need to know about immunopathogenesis and diagnosis for this relatively rare condition.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989800). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196750/

Complement Inhibitor Therapy for Myasthenia Gravis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283905/

Spotlight on MuSK Positive Myasthenia Gravis: Clinical Characteristics, Treatment and Outcomes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895578/

A Radioimmunoassay for the Quantitative Evaluation of Anti-human Acetylcholine Receptor Antibodies in Myasthenia Gravis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541026/