Gut Podcast

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Ming-Hua Zheng from the MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, and the Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China, on the paper "Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement" published in paper copy in Gut in October 2026. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Muyiwa Awoniyi, who is an Clinical Staff Transplant Hepatologist and Assistant Professor from the Department of Gastroenterology, Hepatology and Nutrition, Digestive Disease Institute, Hepatology Section, Department of Inflammation and Immunity, Cleveland Clinic Research Institute in Cleveland, Ohio, USA, on the paper "Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model" published in paper copy in Gut in September 2026. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Soeren Ocvirk, from the Research Group WESTGUT, ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany and the Gnotobiology Research Unit, German Institute of Human Nutrition Potsdam, Nuthetal, Germany, on the paper "Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer" published in paper copy in Gut in August 2026 Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Seong Ho Jeong, Assistant professor in the Department of Neurology, Yongin Severance Hospital, Yonsei University Healthcare System, Yongin-si, and the Department of Neurology, Yonsei University College of Medicine, Seoul, The Republic of Korea, on the paper "DPP-4 inhibitor alleviates gut-brain axis pathology in Parkinson’s disease" published in paper copy in Gut in July 2026 (https://gut.bmj.com/content/75/7/1307).   Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Wei Wang from the Department of Gynaecology and Obstetrics, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China and the Department of Gynaecology, Shanghai Key Laboratory of Maternal Foetal Medicine, Shanghai Institute of Maternal-Foetal Medicine and Gynaecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China, on the paper "Intraperitoneal translocation of gut microbiota induces NETosis and promotes endometriosis" published in paper copy in Gut in June 2026. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Amanda Muir from the Department of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA, on the paper "FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis" published in paper copy in Gut in May 2026. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Shanshan Wu from the Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China, and Professor Yuanjie Pang from Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China, on the paper "Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts" published in paper copy in Gut in April 2026.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Xiaolong Qi from Centre of Liver Disease, Zhongda Hospital, Southeast University, Nanjing, China on the paper "Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes" published in paper copy in Gut in March 2026.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://bit.ly/4rRJeUI).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Zhi-Gang She from the State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute; School of Pharmacy; First Affiliated Hospital, Gannan Medical University, Ganzhou, China. Professor She is also the Deputy Director of the Department of Cardiology, Renmin Hospital of Wuhan University. Professor She is interviewed on the paper "Discovery of a carboxyl fullerene derivative as a new lipid droplet regulator inhibiting MASLD" published in paper copy in Gut in February 2026. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Jun Li from the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China on the paper "Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies" published in paper copy in Gut in January 2026.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Fernando Lucas-Ruiz from the Biomedical Research Institute of Murcia, Murcia, Spain on the paper "Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes" published in paper copy in Gut in December 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Jyh-Ming Liou from Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan on the paper "Screening and eradication of Helicobacter pylori for gastric cancer prevention: Taipei Global Consensus II" published in paper copy in Gut in November 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Christian Schulz from the Medical Department 2, LMU Munich, Munich, Germany on the paper "Helicobacter pylori antibiotic resistance: a global challenge in search of solutions" published in paper copy in Gut in October 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Chengwei Tang and Associate Professor Zhiyin Huang from the Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China on the paper "Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial" published in paper copy in Gut in September 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Tao Zuo from the Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China, on the paper "Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome" published in paper copy in Gut in August 2025.   Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Yanglin Pan from the State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China, on the paper "Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial" published in paper copy in Gut in July 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Tye-Din from the Immunology Division, Walter and Eliza Hall Institute of Medical Research, and Department of Gastroenterology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia, on the paper "Purified oat protein can trigger acute symptoms linked to immune activation in coeliac disease patients but not histological deterioration" published in paper copy in Gut in June 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Benoit Chassaing and Dr Héloïse Rytter from Microbiome-Host Interactions, INSERM, Institut Pasteur, Université Paris Cité, Paris, France, on the paper "In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier" published in paper copy in Gut in May 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Yao-Chun (Holden) Hsu from School of Medicine and Graduate Institute of Medicine, I-Shou University, Kaohsiung, Taiwan, on the paper "Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B" published in paper copy in Gut in April 2025.   Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Bertram Bengsch and Dr Henrike Salie from the Department of Internal Medicine II, Medical Centre, University of Freiburg, Freiburg, Germany, on the paper "Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma" published in paper copy in Gut in March 2025.

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Jordi Mayneris-Perxachs and Dr Anna Castells-Nobau from the Girona Biomedical Research Centre (IDIBGI), Girona, Spain, on the paper "Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism" published in paper copy in Gut in February 2025. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Suhua Jiang from the Department of Paediatrics, The First People's Hospital of Foshan, Foshan, People's Republic of China and Professor Lin Zhang, Assistant Professor from Department of Anaesthesia and Intensive Care and Lead Scientist, Microbiota I-Center (MagIC) in the Chinese University of Hong Kong, on the paper "Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis" published in paper copy in Gut in January 2025.   A close transcript of this podcast is available at this link: https://bit.ly/40jF5xo    Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Professor Jihui Hao from the Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China, on the paper "CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells" published in paper copy in Gut in December 2024. A close transcript of this podcast is available at this link: https://bit.ly/3Ox8Io2 Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Elena Martín-García and Professor Rafael Maldonado from the Laboratory of Neuropharmacology, Pompeu Fabra University and Hospital del Mar Research Institute, Barcelona, Spain and Professor Jose Manuel Fernández-Real from the Endocrinology, Nutrition, Eumetabolism & Health group, Hospital Trueta of Girona, University of Girona, Girona, Spain on the paper "Gut microbiota signatures of vulnerability to food addiction in mice and humans" published in paper copy in Gut in November 2024. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Mario Dinis-Ribeiro from the Department of Gastroenterology at Porto Comprehensive Cancer Center & RISE—Health Research Network, Porto, Portugal, on the paper "The road to a world-unified approach to the management of patients with gastric intestinal metaplasia: a review of current guidelines" published in paper copy in Gut in October 2024. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Conor McCann from the Department of Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK and Dr Anestis Tsakiridis from the School of Biosciences, The University of Sheffield, Sheffield, UK on the paper "Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue" published in paper copy in Gut in September 2024.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Samuel Huber, from the Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany, on the paper "Protective function of sclerosing cholangitis on IBD" published in paper copy in Gut in August 2024.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Jianping Guo from Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, on the paper "High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT" published in paper copy in Gut in July 2024. A close transcript of this podcast is available at this link: https://bit.ly/3zlcoVF Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Hashem El-Serag from the Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA, on the paper "Serum biomarker signature is predictive of the risk of hepatocellular cancer in patients with cirrhosis" published in paper copy in Gut in June 2024. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Kurtis Budden, from the Immune Health Program, The University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia and Professor Philip Hansbro who is also a conjoint there and the Director of the Centenary Institute and University of Technology Sydney Centre for Inflammation, Sydney, NSW, Australia, on the paper "Faecal microbial transfer and complex carbohydrates mediate protection against COPD" published in paper copy in Gut in May 2024.Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Herbert Tilg who is the Head of Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria on on the Recent Advances in Clinical Practice paper "MASLD: a systemic metabolic disorder with cardiovascular and malignant complications" published in paper copy in Gut in April 2024. Read the paper: https://gut.bmj.com/content/73/4/691 Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Massimo Rugge who is a Honorary Professor of Pathology at the Padova University and Adjunct Professor of Medicine and Gastroenterology at the Baylor College of Medicine in Houston; Professor Peter Malfertheiner who is senior Professor of Medicine at the Ludwig Maximilian University of Munich, Munich, Germany and Professor Robert Genta who is an Adjunct Professor of Pathology and Medicine (Gastroenterology) at Baylor College of Medicine, Houston, Texas, as well as the Chief for Academic Affairs at Fulgent-Inform Diagnostics in Irving, Texas. They are interviewed on the paper "RE.GA.IN.: the Real-world Gastritis Initiative-updating the updates " published in paper copy in Gut in March 2024. Read the paper: https://bit.ly/3IgUggW Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Veronica Witte from the Department of Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany, on the paper "Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial" published in paper copy in Gut in February 2024 and available online - https://gut.bmj.com/content/73/2/298 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Professor Peng Chen, from the Department of Pathophysiology, Southern Medical University, Guangzhou, China, on the paper "Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis" published in paper copy in Gut in January 2024. Read the paper included in the January 2024 issue: https://gut.bmj.com/content/73/1/78 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews a fantastic panel of guests from around the globe including: Professor Bishr Omary from Rutgers University, Piscataway, New Jersey, USA who was the past president of the American Gastroenterological Association Professor Desmond Leddin from Dalhousie University, Halifax, Nova Scotia, Canada and incoming chair of the World Gastroenterology Organization (WGO) climate change and sustainability committee Professor Geoffrey Metz from The University of Melbourne and Monash University, Melbourne, Victoria, Australia and president-elect of the WGO Professor Andrew Veitch from the Department of Gastroenterology, New Cross Hospital, Wolverhampton, UK and president of the British Society of Gastroenterology Professor Guilherme Macedo from the Department of Gastroenterology, Centro Hospitalar de São João, Porto, Portugal and president of the WGO Associate Professor Mai Ling Perman from Fiji National University, Suva, Fiji and the Head of School of Medical Science They are interviewed regarding an exciting 9-commentary series related to digestive health and climate change which is being published in GUT in December 2023. Each commentary summarizes one, or a hybrid, of the nine educational webinars organised by the World Gastroenterology Organisation (WGO). This concise podcast is unusual in that it has the 6 participants who were involved in setting up the WGO webinar course and the commentaries that were developed from this course, and that it highlights an entire commentary series on a very important topic that GUT is very proud to publish. Please read the commentary series here: https://gut.bmj.com/content/72/12/2193 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Jay Pasricha, Chair of the Department of Medicine, Mayo Clinic Arizona, Arizona, USA and Bo Konings, final year medical student and researcher at the Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven University Hospitals, Leuven, Belgium, on the paper "Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases" published in paper copy in Gut in November 2023 and available online: https://gut.bmj.com/content/72/11/2103 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Julia Mayerle and Dr Simon Sirtl from the Department of Medicine II, LMU University Hospital, Munich, Germany, on the paper "Consensus definition of sludge and microlithiasis as a possible cause of pancreatitis" published in paper copy in Gut in October 2023 and available online: https://gut.bmj.com/content/72/10/1919  Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Loris Lopetuso, Department of Medicine and Ageing Sciences, University of Chieti-Pescara, Italy, on the paper "The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease", published in paper copy in Gut in September 2023, and available online: https://gut.bmj.com/content/72/9/1642  Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Thomas Marjot, Hepatology SpR from the Oxford Liver Unit in Oxford University Hospitals and also a Wellcome Trust Clinical Research Training Fellow at the University of Oxford based at the Oxford Centre for Diabetes, Endocrinology and Metabolism, UK, on the paper "Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD" published in paper copy in Gut in August 2023 and available online: https://gut.bmj.com/content/72/8/1607 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Markus Gerhard from the Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Germany, on the paper "Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature" published in paper copy in Gut in July 2023 and available online: https://gut.bmj.com/content/72/7/1258   Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Kathy DelGiorno, from the Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA, on the paper 'It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease' published in paper copy in Gut in June 2023 and available online: https://gut.bmj.com/content/72/6/1211 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Benoit Chassaing, group leader from the “Mucosal microbiota in chronic inflammatory diseases” Team at INSERM and the Université Paris Cité, Paris, France, on the paper 'Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism' published in paper copy in Gut in May 2023 and available online: https://gut.bmj.com/content/72/5/906 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Tine Jess, from the Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine, and Department of Gastroenterology and Hepatology, Aalborg University, Aalborg, Denmark, and Dr Adam S Faye, from the Department of Medicine and Population Health, New York University Langone Health, New York, USA, on the paper 'Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study' published in paper copy in Gut in April 2023 and published online: https://gut.bmj.com/content/72/4/663  Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Rohit Loomba, Professor of Medicine in the Division of Gastroenterology, and Adjunct Professor in the Division of Epidemiology at the University of California San Diego, La Jolla, California, USA on the paper 'Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis' published in paper copy in Gut in March 2023 and available online: https://gut.bmj.com/content/72/3/581 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Fredrik Bäckhed, The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden on the paper '6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice' published in paper copy in Gut in February 2023, and available online: https://gut.bmj.com/content/72/2/314 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut, and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Professor Massimo Rugge, Pathologist at Padova University, Italy, and Adjunct Professor of Medicine at the Baylor College of Medicine in Houston, Texas, USA; and Ms Ludovica Bricca, a student at Padova University, and the youngest researcher involved in the study. They are interviewed on the paper 'Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients' published in paper copy in Gut in January 2023. Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Vineet Ahuja who is from the Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India, on the paper 'Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial' published in paper copy in Gut in December 2022 and available online: https://gut.bmj.com/content/71/12/2401 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients with gastroparesis. Dr Philip Smith, Digital and Education Editor of Gut, interviews Professor Jan Martinek, from the Department of Hepatogastroenterology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic, about his paper on this topic. The article titled 'Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial' is published in paper copy in Gut in November 2022 and available online at: https://gut.bmj.com/content/71/11/2170 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Desmond Leddin, who is from the Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada, on the paper 'Climate change: a survey of global gastroenterology society leadership' published in paper copy in Gut in October 2022 and available online at: https://gut.bmj.com/content/71/10/1929 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Peter Malfertheiner, Gastroenterologist, who is senior Professor of Medicine at the Ludwig Maximilian University of Munich, Munich, Germany, on the paper 'Management of Helicobacter pylori infection—the Maastricht VI/Florence Consensus Report' published in paper copy in Gut in September 2022 and online at: https://gut.bmj.com/content/71/9/1724 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Sugano, Department of Medicine, Jichi Medical University, Tochigi, Japan, about the paper 'Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction'. The article is published in paper copy in Gut in August 2022, and available online: https://gut.bmj.com/content/71/8/1488. Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Professor Peer Bork, Director of the Heidelberg site of the European Molecular Biology Laboratory Heidelberg, Baden, Germany on the paper 'A faecal microbiota signature with high specificity for pancreatic cancer' published in paper copy in Gut in July 2022, and available online: https://gut.bmj.com/content/71/7/1359 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Dr Marietta Iacucci, Associate Professor in Gastroenterology, Institute of Immunology and Immunotherapy, University of Birmingham and Consultant Gastroenterologist, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, on the paper "‘PICaSSO Histologic Remission Index (PHRI) in ulcerative colitis: development of a novel simplified histological score for monitoring mucosal healing and predicting clinical outcomes and its applicability in an artificial intelligence system" published in paper copy in Gut in May 2022, and available online: https://gut.bmj.com/content/71/5/889 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Dr Maria Arechederra, young researcher at the Hepatology Program in the Center for Applied Medical Research (CIMA) from the University of Navarra in Pamplona, Spain, on the paper "Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures" which is published in paper copy in Gut in June 2022, and available online: https://gut.bmj.com/content/71/6/1141 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Rakesh Kalapala, Senior Consultant Gastroenterologist & Therapeutic Endoscopist, Head of GI Motility Lab, Director of Endoscopy at the Center for Obesity & Metabolic Therapy, Member of the International Bariatric and Metabolic Endoscopy Committee, Asian Institute of Gastroenterology Hospitals, Hyderabad, India on the paper 'Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial' which is published in paper copy in Gut in April 2022, and is available here: https://gut.bmj.com/content/71/4/686 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Patrice Cani, Louvain Drug Research Institute, WELBIO, Metabolism and Nutrition, UCLouvain, Brussels, Belgium and Emilie Moens de Hase a PhD student in the same institution. This Gut podcast is focused on the paper "Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice" which is published in paper copy in Gut in March 2022, and is available here: https://gut.bmj.com/content/71/3/534 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Lu from the Department of Respiratory Care, College of Medicine, Fu Jen Catholic University, Taiwan, and Drs Lai and Dr Lin from the Department of Medical Biotechnology and Laboratory Science, and Microbiota Research Center, College of Medicine, Chang Gung University, Taiwan. The Gut podcast is focused on the paper "Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide", which is published in paper copy in Gut in February 2022, and is available here: https://gut.bmj.com/content/71/2/309 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Laurent Azoulay and Dr Devin Abrahami, from the Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, and McGill University, Montreal, Canada. Dr. Abrahami is now a postdoctoral fellow at the Brigham and Women’s Hospital and Harvard Medical School. This Gut podcast is focused on the paper "Proton pump inhibitors and risk of colorectal cancer", which is published in paper copy in Gut in January 2022, and is available here: https://gut.bmj.com/content/71/1/111. Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727). Thank you for listening.

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Professor Cao, Associate Professor of Surgery, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri. This Gut podcast is focused on the paper "Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women", which is published in paper copy in Gut in December 2021, and is available here: https://gut.bmj.com/content/70/12/2330.

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. The guideline discussed in this podcast is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Marco del Chiaro, from The European Study Group on Cystic Tumours of the Pancreas. And read the details of the guidelines on the Gut website: https://gut.bmj.com/content/67/5/789.

Clostridium difficile (C. difficile, C. diff or CDI) is a bacterium associated with the intake of antibiotics which causes diarrhoea. It is easily spread to others, both in hospital and a household environments. C. Diff infections are generally treated with antibiotics. Recurrent infection is successfully treated with faecal microbiota transplantation (FMT), however the underlying mechanism of action is not well defined. This study identified a key role of the virome within the transferred stool on treatment responses. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Siew Ng (The Chinese University of Hong Kong, China), who's the leading author of the Open Access paper “Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome”, included in the April 2018’s Gut issue (gut.bmj.com/content/67/4/634).

Prioritising research and funding could have a significant impact on reducing colorectal cancer disease burden over the next 5 years. The conclusions are included in a study recently published by Gut titled “Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer” and expanded in this podcast. In conversation with the journal’s Education Editor Mairi McLean, the leading author of the study, Mark Lawler, identifies 15 critical research gaps which prioritisation and resolution could improve patient outcomes. Professor Mark Lawler works at the Centre for Cancer Research and Cell Biology, Queen’s University Belfast, UK. For more details on this Open Access article included in the January 2018 issue of Gut, visit http://gut.bmj.com/content/67/1/179.

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Matias Avila and Carmen Berasai, University of Navarra, Pamplona, Spain. They discuss their published paper "Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration". Full article >> http://gut.bmj.com/content/66/10/1818.info

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Fergus Shanahan, Professor and Chair of the Department of Medicine at University College Cork. They discuss his recent paper in Gut entitled "Feeding the microbiota: transducer of nutrient signals for the host" Full text - http://gut.bmj.com/content/early/2017/06/29/gutjnl-2017-313872

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Benoit Chassaing, Georgia State University - Center for Inflammation, Immunity and Infection, about his recently published paper "Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation". Full paper>> http://gut.bmj.com/content/66/8/1414

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Giovanni Cammarota and Gianluca Ianiro from the Agostino Gemelli University. They discuss the April editors choice paper "European consensus conference on faecal microbiota transplantation in clinical practice". Full paper >> http://gut.bmj.com/content/early/2017/01/13/gutjnl-2016-313017

In this episode Mairi McLean, Education Editor for Gut, talks to Dr Katja Breitkopf-Heinlein, Medical Faculty Mannheim, Heidelberg University, about her recently published paper "BMP-9 interferes with liver regeneration and promotes liver fibrosis". Full paper >> http://gut.bmj.com/content/66/5/939

In this podcast Mairi McLean talks to Professor Jon Rhodes about his recently published paper "Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?" Full paper >> http://gut.bmj.com/content/66/2/362

In this episode Mairi McLean talks to Herbert Tilg about his recently published paper "Gut microbiome and liver diseases". Full paper >> http://gut.bmj.com/content/65/12/2035.long

In this podcast Mairi McLean interviews Dr Gianluca Ianiro about the editors choice paper "Antibiotics as deep modulators of gut microbiota: between good and evil." Full paper >> http://gut.bmj.com/content/65/11/1906.full?sid=4929814b-b6f1-43d2-9af1-964357aa664c

In this episode Mairi McLean talks to Professor Fock about his recently published paper; "Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus" Full paper >> http://gut.bmj.com/content/65/9/1402.full?sid=13ba6d1c-8c84-4ae9-9cd3-0bab0fa2b3a9

In this track Mairi McLean talks to Hasim El-Serag about the recent paper "Surveillance endoscopy is associated with improved outcomes of oesophagealadenocarcinoma detected in patients with Barrett's oesophagus."

In this podcast Dr Mairi McLean talks to Dr Sonia Friedman about the May editors choice paper "Live birth and adverse birth outcomes in women with ulcerative colitis and Crohn's disease receiving assisted reproduction: a 20-year nationwide cohort study". Full text > http://gut.bmj.com/content/65/5/767.full

In this podcast Dr Mairi McLean talks to Dr Mark Smits and Dr Djuna Cahen about their editors choice paper "GLP-1 based therapies: clinical implications for gastroenterologists"

In this podcast Dr Mairi McLean talks to Professor Dirk Haller about his editors choice paper "Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence." Read the full paper >> http://gut.bmj.com/content/65/2/225.full

In this podcast Dr Mairi McLean talks to Dr Christoph Gasche about his editors choice paper "Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2loxP/loxP Villin-Cre mice." Full paper >> http://gut.bmj.com/content/64/12/1905.full

In this podcast Dr Mairi McLean talks to Dr Joanna Jalanka about her recently published article in Gut entitled "Effects of bowel cleansing on the intestinal microbiota". They discuss what was already known in the field and what has since been discovered, and how long these effects last and how the microbiota were measured.

Mairi McLean talks to Thaddeus S Stappenbeck, Department of Pathology and Immunology, Washington University School of Medicine, about his paper: Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Read the full paper: http://goo.gl/xeWDHz

Helicobacter pylori strains that express the a protein that increases the risk of gastric cancer. However, the precise mechanisms through which the cancer risk is heightened have not been fully investigated and understood. In this podcast Dr Mairi McLean talks to Dr Lydia Wroblewski from the Vanderbilt University School of Medicine about the study her group conducted to define mechanisms through which H. pylori modulates expression of the cancer-associated tight junction protein claudin-7. To read the full paper please visit http://gut.bmj.com/content/64/5/720.full

Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in 1996 and have been refined in subsequent years. More recently the International Club of Ascites (ICA)redefined the criteria to reach a new definition of acute kidney injury (AKI) in patients with cirrhosis. Dr Mairi McLean speaks to lead author Professor Paolo Angeli from the University of Padova about the scientific evidence supporting the new approach to the diagnosis and treatment of acute kidney injury.Read the full article >> http://gut.bmj.com/content/64/4/531.full

Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. Dr Mairi McLean speaks to Dr Toshikazu Ushijima about his study investigating these defects and the association with gastric cancer.

The genetic basis of inflammatory bowel disease (IBD) is incompletely understood, and the aim of a recent study in Gut was to identify rare genetic variants involved in the pathogenesis of IBD. Mairi McLean speaks to authors Sebastian Zeissig, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, and Andre Franke, Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, to hear what they found. Read the full paper: http://gut.bmj.com/content/64/1/66.full

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. Now a paper in Gut has examined in detail the distribution of the full range of cell lineages within the human stomach. Mairi McLean talks to authors James Goldenring, Eunyoung Choi and Joseph Roland, all Vanderbilt University School of Medicine, Nashville, Tennessee. Read the full paper: http://gut.bmj.com/content/63/11/1711.full

Mairi McLean talks to Krisztina Gecse about the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Read the related article: http://gut.bmj.com/content/63/9/1381.full

The identification of a distinct syndrome, designated eosinophilic oesophagitis (EoE), with its own clinical and histopathological characteristics, was first described in the early 1990s. Meanwhile intense research has uncovered many molecular, immunological and clinical aspects of this chronic-inflammatory disorder. In this podcast, Mairi McLean talks to Professor Alex Straumann, Swiss EoE Clinic and EoE Research Network, about the basic and clinical insights of EoE gathered during the last few years. Read Professor Straumann's update on the topic: http://goo.gl/0B6h14

Inflammatory bowel disease is driven by a seemingly aberrant immune response to the gut microbiota with disease development dictated by genetics and environmental factors. A model exemplifying this notion is work by Andrew Gewirtz, Center for Inflammation, Immunity, & Infection, Georgia State University, and colleagues, demonstrating that colonisation of adherent-invasive Escherichia coli (AIEC) during microbiota acquisition drove chronic colitis in mice lacking the flagellin receptor TLR5 (T5KO). They have now published a paper in Gut hypothesising that AIEC instigates chronic inflammation by increasing microbial lipopolysaccharide and flagellin levels, and investigating how AIEC colonisation might instigate colitis in T5KO mice. Mairi McLean talks to Dr Gerwitz about their findings. Read the full paper (for free): http://gut.bmj.com/content/63/7/1069.full

Despite the success of hepatitis B virus vaccination in preventing new infection in endemic areas, chronic hepatitis B still poses a heavy burden globally. There are approximately 350 million carriers in the world, with an estimated 60 000 persons dying annually of hepatitis B-related cirrhosis and hepatocellular carcinoma. In a study recent published in Gut, Professor Man-Fung Yuen, Department of Medicine, The University of Hong Kong, and colleagues, report the results of viral suppression and safety of two doses of besifovir, with entecavir as a comparator in treatment-naive subjects for 48 weeks. He talks to Mairi McLean about the findings. Read the full paper: Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B http://gut.bmj.com/content/63/6/996.full

Mairi McLean talks to Robin Spiller, NIHR Nottingham Digestive Diseases Biomedical Research Unit, and David Tooth, School of Biomedical Sciences, University of Nottingham, about their paper: Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit.Read the full article: http://goo.gl/0OIP34

Mairi McLean talks to Andres Acosta and Barham K Abu Dayyeh, both Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, about their review on the management of obesity.Read the full paper: http://goo.gl/V37xaq

Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. Along with colleagues, Simon Eaton and Paolo De Coppi, both from University College London Institute of Child Health, have tested the hypothesis that amniotic fluid stem (AFS) cells exerted a beneficial effect in a neonatal rat model of NEC.Mairi McLean discusses their findings with them.Read the full paper:Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism http://goo.gl/EFUuN0

Gut's education editor Mairi McLean discusses highlights from the guidelines on the diagnosis and management of Barrett's oesophagus with authors Rebecca Fitzgerald and Massimiliano di Pietro, both from the MRC Cancer Unit, University of Cambridge.Read the full paper here: http://bit.ly/1kkPkVW

Mairi McLean talks to Markus Peck-Radosavljevic, Division of Gastroenterology & Hepatology, Medical University Vienna, about his study looking at carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol.Read the full paper here: bit.ly/1991biw

Mairi McLean talks to Anna Paterson and Rebecca Fitzgerald, both MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, about their study investigating whether a receptor tyrosine kinase (RTK) array could be used to select the most effective therapeutic strategies in molecularly heterogeneous oesophago-gastric adenocarcinomas.Read the full paper here: bit.ly/1acACwz

Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease.In this podcast Mairi McLean, Gut education editor, talks to Professor Yoshiro Niitsu from Sapporo Medical University School of Medicine about his manuscript about the potential for therapeutic use of siRNA in the treatment of pancreatic fibrosis.Read the full research online:http://gut.bmj.com/content/62/9/1328

Mairi McLean talks to Patrick Tan, associate professor, Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, and Heike Grabsch, Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, about their genomic meta-analysis to identify predictors of survival in patients with gastric cancer.See also: Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer http://goo.gl/Rw8lx6

Mairi McLean talks to Emeran Mayer, Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, UCLA, about his paper: An update on the use and investigation of probiotics in health and disease.Read the full paper here: http://bit.ly/11ghKss

In this podcast, Mairi McLean interviews Julián Panés and Azucena Salas, both from the Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBER-EHD in Barcelona, Spain. They disuse their recent article, looking at transcription in the intestinal mucosa of patients with ulcerative colitis.read the full article online: http://tinyurl.com/n3uy6d4

Mairi McLean talks to Philip Rosenstiel, Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, and Stefan Schreiber, University Hospital Schleswig-Holstein, Kiel, about their paper: mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn’s disease http://bit.ly/11FU0Qw.

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol http://bit.ly/10dtab8.