Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

When we think of computers, we think of machines running on some kind of silicon chips. But the idea is more general: at heart, a computer is any object that takes in input, processes information, and produces output. Taking inspiration from biology, it is interesting to imagine building computers out of DNA -- a molecule that can store and process information, and is even programmable. Erik Winfree is one of the leading scientists who are using DNA to build tiny computers and even robots that can perform a number of tasks, with important implications for future biology and medicine.

Blog post with transcript: https://preposterousuniverse.com/podcast/2026/10/26/372-erik-winfree-on-dna-robots-and-computers/

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Erik Winfree received his Ph.D. in computation and neural science from the California Institute of Technology. He is currently Professor of Computer Science, Computation and Neural Systems, and Bioengineering at Caltech. Among his awards are the Tulip Prize in DNA Computing, the Feynman Prize for nanotechnology, the MacArthur Fellowship, and fellowship in the American Association for the Advancement of Science.

Humanity is merely one species out of millions living on Earth, but we have a disproportionate impact on the rest of the biosphere. Recent transformations have accelerated that impact, but in fact it stretches back to the earliest days in human history. In his new book The Last Animal: Human History and the Fate of Life on Earth from the Ice Age to the Sixth Extinction, historian Kyle Harper traces how humans have impacted the rest of the planet, from extinction events to much more subtle changes.

Blog post with transcript: https://preposterousuniverse.com/podcast/2026/10/19/371-kyle-harper-on-how-humans-have-shaped-life-on-earth/

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Kyle Harper received a Ph.D. in history from Harvard University. He is currently the G.T. and Libby Blankenship Chair in the History of Liberty, Professor of Classics and Letters, Senior Advisor to the President, and Provost Emeritus at the University of Oklahoma, and an external faculty member at the Santa Fe Institute. Among his honors are the Award for Excellence in Historical Studies from the American Academy of Religion and the PROSE winner for best book in the history of science, technology, and medicine.

Welcome to the October 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with show notes, AMA questions, and transcript: https://preposterousuniverse.com/podcast/2026/10/12/ama-october-2026/

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One reason it's been so hard to directly detect the dark matter is that we're not sure what it is. But for a long time, a leading candidate has been "Weakly Interacting Massive Particles" (WIMPs), so an impressive amount of experimental effort has been put into trying to detect them. Recently, a single provocative event appeared in the LUX-ZEPLIN (LZ) dark matter experiment. Daniel Akerib, a physicist at LZ, joins us to talk about dark matter and the recent data, which has low statistical significance but is intriguing nevertheless.

Blog post with show notes and transcript: https://preposterousuniverse.com/podcast/2026/10/05/370-daniel-akerib-on-a-faint-hint-of-dark-matter/

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Daniel Akerib received a Ph.D. in physics from Princeton University. He is currently Professor of Particle Physics and Astrophysics at the SLAC National Accelerator Laboratory and Professor of Physics, by courtesy, in the physics department at Stanford University. He has been searching for dark matter since the early 1990s, first with the Cryogenic Dark Matter Search and more recently with the LUX and LUX-ZEPLIN projects.

The worry about debates over free will is that they degenerate into semantics -- what do you mean by "free will," really? But there are important substantive issues that shouldn't be ignored. Do people deserve blame for doing wrong things? Can we make choices that create meaning for our lives? Philosopher Gregg Caruso denies the reality of free will, but is in favor of making good choices, as he discusses in his new book How to Live Well Without Free Will.

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Gregg Caruso received a Ph.D. in Philosophy from the City University of New York. He is currently Professor of Applied Ethics and Management and Director of the Patrick J. Waide Center for Applied Ethics at Fairfield University, and Scientific Advisor, Center for Justice and Mental Well-Being, Nova Institute for Health. Among his awards are the Joseph B. Gittler Award from the American Philosophical Association.

In all sorts of ways, the modern world makes it difficult to nurture our individual humanity and connect with the humanity of others. The disciplines that try to do so are, naturally enough, the humanities. Poet Elizabeth Alexander's new book, Signals Across Vast Distances, grapples with the question of how literature and other humanistic studies can help us build empathy and become better people, and why that task is crucial to a flourishing democratic society.

Blog post with transcript: https://preposterousuniverse.com/podcast/2026/09/21/368-elizabeth-alexander-on-why-democracy-needs-imagination/

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Elizabeth Alexander received a Ph.D. in English from the University of Pennsylvania. In addition to her work as a poet and writer, she is currently the President of the Andrew W. Mellon Foundation. She composed and read a poem for Barack Obama's inauguration in 2009. Among her honors are a Guggenheim Fellowship, a National Magazine Award, and several Pushcart Prizes for poetry.

Welcome to the September 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with show notes and transcript: https://preposterousuniverse.com/podcast/2026/09/14/ama-september-2026/

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The course of history is affected by many things, including the political and social situations of large groups of people, their biological and physical abilities, and their geographical and environmental contexts. Sometimes, it would seem, history -- or corporations, or religions, or sports teams -- can be affected by the actions of just a few influential persons. In his new book, Profits, Prophets, Coaches, and Kings, Jared Diamond asks what effect leaders can have, and what it is that makes them successful (or not).

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Blog post with transcript: https://preposterousuniverse.com/podcast/2026/09/07/367-jared-diamond-on-the-course-of-history-and-the-role-of-leaders/

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Jared Diamond received a Ph.D. in physiology from the University of Cambridge. He is currently a professor of geography at the University of California, Los Angeles. Among his awards are the U.S. National Medal of Science, the MacArthur Fellowship, and the Pulitzer Prize. His international bestseller Guns, Germs, and Steel has sold over seven million copies.

Everyone lives through time, but we continue to struggle to fully understand it. We remain unsure whether time is fundamental or emergent, why it has an arrow pointing from past to future, and how that arrow connects to our experience of time's passage. Jim Al-Khalili's new book is On Time: The Physics that Makes the Universe Tick. We discuss what time is at the most basic level, and how it connects to open questions in biology, cosmology, and quantum mechanics.

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Jim Al-Khalili received his Ph.D. in physics from the University of Surrey. He is currently Distinguished Emeritus Professor of Physics at Surrey. He is a Fellow of the Royal Society, and has served as past president of the British Science Association. He has been awarded the Michael Faraday Prize by the Royal Society, and has been appointed an appointed Officer of the Order of the British Empire.

Black holes, as Stephen Hawking discovered, do grow old: they emit radiation, lose mass, and eventually evaporate away. But our fascination with black holes never grows old. This is especially true today, as we are seeing a flood of new data and intriguing theoretical ideas, which both tests the limits of Einstein's general relativity and teach us new things about the astrophysical universe. At the Center of Gravity at the University of Copenhagen, they are currently celebrating Black Hole Week, which provides an excellent opportunity to talk with Center director Vitor Cardoso about what we've been learning about these singular cosmic objects.

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Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/24/365-vitor-cardoso-on-why-black-holes-are-special/

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Vitor Cardoso received his Ph.D. in physics from the Instituto Superior Técnico in Portugal. He is currently a Villum Investigator and Director of the Center of Gravity at the Niels Bohr Institute in Copenhagen, and a Distinguished Professor at Técnico.

One of the paradoxes of science is that it seeks objectively true understanding of the world, but its methodology is driven by ignorance, failure, and uncertainty. Some phenomena we understand pretty well, but interesting research happens at the boundary of what we do and don't know. And there is no foolproof algorithm for moving in the right direction; we need to make conjectures and test them against the world. Biologist Stuart Firestein has been advocating for a better public understanding of the true methods of science, most recently in his new book It Could Be Otherwise: Science In the Age of Uncertainty.

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Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/17/364-stuart-firestein-on-how-science-relies-on-ignorance-and-failure/

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Stuart Firestein received his Ph.D. in neurobiology from the University of California, Berkeley. He is currently Professor of Neuroscience at in the Department of Biological Sciences at Columbia University, and Fractal Faculty at the Santa Fe Institute. He is a fellow of the American Association for the Advancement of Science, the Sloan Foundation, and the Guggenheim Foundation. His research studies cellular mechanisms of signal transduction and olfaction. His previous books include Ignorance: How It Drives Science and Failure: Why Science Is So Successful.

Large Language Models display an uncanny ability to construct human-sounding speech, and can synthesize concepts in novel ways. Is this because they are truly thinking like human beings in some way, or have they found a way to be human-like without reproducing the internal mechanisms of human thought? Chandra Sripada argues that LLM cognition is more human-like than we suppose, and offers evidence from the ways that cognitive scientists study actual humans.

Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/10/363-chandra-sripada-on-how-llms-and-humans-are-cognitive-cousins/

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Chandra Sripada received an M.D. from the University of Texas and a Ph.D. in philosophy from Rutgers University. He is currently a professor of philosophy and psychiatry at the University of Michigan, where he holds the Theophile Raphael Research Professorship and directs the Weinberg Institute for Cognitive Science. He writes Cognition, Decoded, a Substack newsletter about AI, cognitive science, and philosophy.

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Welcome to the August 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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People who live in large cities produce more patents per person than those who live in small towns. They also walk faster down the street, and use less infrastructure per person. Indeed, the relationships between these quantities and city population obey power laws with apparently universal exponents, reminiscent of scaling laws is biological organisms? Luis Bettencourt argues that they can be explained in similar ways, using ideas from complex systems and network theory.

Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/27/362-luis-bettencourt-on-the-universal-properties-of-self-organizing-cities/

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Luis Bettencourt received a Ph.D. in theoretical physics from Imperial College London. He is currently the Lorna Puttkammer Straus Professor Department of Ecology and Evolution & Data Sciences Institute, as well as Associate Faculty and Special Friend in the Department of Sociology, at the University of Chicago. He is the author of Introduction to Urban Science: Evidence and Theory of Cities as Complex Systems.

One of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alter their behavior accordingly. Most impressively, they are able to sense the presence of similar bacteria by a process called quorum sensing. Today's guest, Bonnie Bassler, is a leader in this field, and explains how quorum sensing allows groups of bacteria to do things (including in our bodies) that wouldn't be possible for individual bacteria.

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Bonnie Bassler received a Ph.D. in biochemistry from Johns Hopkins University. She is currently Andrew K. Golden University Professor of Molecular Biology at Princeton University and a Howard Hughes Medical Institute Investigator. She is a member of the National Academy of Sciences, National Academy of Medicine, and the American Academy of Arts and Sciences. Among her awards are a MacArthur Fellowship, the Gruber Prize in Genetics, and the National Medal of Science.

Welcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Modern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in urban spaces. How does this affect how we think and feel? Psychologist Marc Berman is a pioneer of "environmental neuroscience." In his recent book, Nature and the Mind: The Science of How Nature Improves Cognitive, Physical, and Social Well-Being, he presents evidence that spending time in nature not only puts us in a better mood, it makes us better thinkers.

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Marc Berman received his Ph.D. in psychology from the University of Michigan. He is currently Professor of Psychology and Faculty Co-Director of the Chicago Center for Computational Social Science at the University of Chicago. Among his awards is the American Psychological Association Distinguished Scientific Award for Early Career Contributions.

The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, and demonstrating that would be yet another foundational discovery. In this episode I discuss what is required to invent a plausible theory of dynamical dark energy, This includes considerations from particle physics, possible experimental tests, and the option that we should modify gravity rather than adding a new source of energy to the equations.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/29/359-solo-theories-of-dark-energy/

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The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe, announced in 1998. The most straightforward explanation for these observations is a positive cosmological constant, or vacuum energy. I talk about the origin of the idea with Einstein, how quantum physicists started to think about it and understand the "cosmological constant problem," as well as how its discovery also raised the "coincidence problem." This is the first of two connected solo episodes; the next will be on theories of dark energy that are not the cosmological constant.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/22/358-solo-vacuum-energy-and-the-cosmological-constant/

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Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used to produce proteins. RNA may even have been the first molecule to kick-start the origin of life. Today, scientists are learning how to manipulate mRNA to cure and prevent diseases, whether through vaccination or literally editing one's DNA. Jeff Coller explains how it all works and how mRNA is revolutionizing medicine as we know it.

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Jeff Coller received his Ph.D. in cell and molecular biology from the University of Wisconsin-Madison. He is currently Bloomberg Distinguished Professor of Biomedical Engineering and Director of the RNA Innovation Center at Johns Hopkins University. He is co-founder of Tevard Biosciences and the Alliance for mRNA Medicines, and leads the REPAIRx consortium. He is a fellow of the American Association for the Advancement of Science.

All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books: The Invention of Nature, about Alexander von Humboldt and environmentalism; Magnificent Rebels, about the Jena circle of Romantics including Goethe, Schiller, Schlegel, and others; and most recently The Traveller, about George Forster, an early naturalist, ethnographer, and champion of human equality.

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Andrea Wulf was born in India, raised in Germany, and studied design history at the Royal College of Art, London. She is the author of seven books. She is a Miller Scholar at the Santa Fe Institute and a Fellow of the Royal Society of Literature. The Invention of Nature won multiple prizes, including the Royal Society science book prize and the LA Times book prize.

Welcome to the June 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2026/06/01/ama-june-2026/

New paper I talk about in the beginning of the episode:

One of the major obstacles to understanding quantum mechanics is the difficulty we have in simply accepting what the theory itself is telling us. The problem is that we know what the everyday world looks like -- stuff, arranged in space, evolving through time. So we can't resist the temptation to impose that picture on the quantum description, even if it's not actually there. In this solo episode I talk about what it means to take quantum mechanics at face value, and the difficult work involved in understanding how the everyday world of our experience fits into the picture.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/25/355-solo-looking-quantum-mechanics-in-the-eyeball/

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Here is the survey on physicists' opinions about unsettled big-picture questions:

And here is a short technical overview on the ideas described in this episode:

If you want further papers, look at the papers cited in this one.

Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. Today's guest, Christian List, is a philosopher and political scientist who has arguably done the most to articulate the "compatibilist" perspective on free will, according to which the freedom of rational agents is entirely compatible with underlying mechanistic laws. The reconciliation depends on thinking carefully about emergence and the relationship between levels of reality.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/18/354-christian-list-on-free-will-and-levels-of-reality/

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Christian List received his D.Phil in Politics from Oxford University. He is currently Professor of Philosophy and Decision Theory and Co-Director of the Munich Center for Mathematical Philosophy at LMU Munich. He is a Fellow of the British Academy and a member of Academia Europaea the Bavarian Academy of Sciences and Humanities. Among his honors are the Joseph Gittler Award from the American Philosophical Association. He is the author of Why Free Will Is Real and (with Philip Pettit) Group Agency.

Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people might decide on a fair price to carry out a contract killing, but society generally frowns on the idea. Many examples of morally contestable markets feature less consensus than that one: sex work, drugs, selling organs, adopting children. In his new book Moral Economics, economist Alvin Roth investigates how we should reason through such tricky cases, and what we can learn from them.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/11/353-alvin-roth-on-the-economics-of-morally-contested-markets/

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Alvin Roth received his Ph.D. in operations research from Stanford University. He is currently the Craig and Susan McCaw Professor of Economics at Stanford University and the Gund Professor of Economics and Business Administration Emeritus at Harvard. He was President of the American Economic Association in 2017. He and Lloyd Shapley shared the 2012 Nobel Prize in Economics for "the theory of stable allocations and the practice of market design."

Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and full transcript: https://www.preposterousuniverse.com/podcast/2026/05/04/ama-may-2026/

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The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long way from the final answer. A big next step is understanding how neuronal circuits connect to and guide bodily behavior. Very recent work on mapping the fruit-fly connectome has brought us closer to that goal. I talk with neuroscientist Bing Brunton about the connectome, how we can study it to understand bodily motion in flies and other creatures, and where it's all taking us.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/27/352-bing-brunton-on-connecting-the-connectome-to-the-body/

Bing Wen Brunton received her Ph.D. in neuroscience from Princeton University.. She is currently a Professor of Biology and the Richard & Joan Komen University Chair at the University of Washington, with affiliations at the eScience Institute for Data Science, the Paul G. Allen School of Computer Science & Engineering, and the Department of Applied Mathematics.

Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effective altruism movement. In this podcast episode, we try our best to talk about all of those things -- working from metaethical questions of consequentialism vs. other approaches, to specific flavors of utilitarianism, the practical demands that ethics places on people, the rights of animals, and the decisions we make at the end of our lives.

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Peter Singer received his B.Phil. in philosophy from the University of Oxford. He retired from Princeton University in 2023, and now lives in Melbourne, Australia. He is the author of a number of influential books, including Animal Liberation (1975). He has been named a Companion of the order of Australia, and is a winner of the Berggruen Prize. He is the founder of the charity The Life You Can Save. He and philosopher Kasia de Lazari Radek are co-hosts of the Lives Well Lived podcast (YouTube, Spotify, Apple).

We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are very complicated and we are burdened by all sorts of biases. Today's guest is J. Eric Oliver, who has been teaching a popular course at the University of Chicago called "The Intelligible Self." His academic specialty is political science, but he brings together ideas from psychology, neuroscience, and a broad swath of the humanities. His view is summarized in his recent book, How to Know Yourself: The Art and Science of Discovering Who You Really Are.

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J. Eric Oliver received his Ph.D. in political science from the University of California, Berkeley. He is currently a Professor of Political Science at the University of Chicago. His research interests include contemporary American politics, suburban and racial politics, political psychology, and the politics of science. He is the host of the podcast Knowing: With Eric Oliver.

Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/06/ama-april-2026/

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There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mechanics. But a number of intriguing ideas have arisen along the way, including black hole radiation, the wave function of the universe, the AdS/CFT correspondence, and the role of quantum information theory. Theoretical physicist Daniel Harlow has made significant contributions to our understanding of information loss in black holes; in this conversation we turn those insights onto quantum cosmology, with potentially significant implications for how quantum mechanics itself works.

Daniel Harlow received his Ph.D. in physics from Stanford University. He is currently an associate professor of physics at the Massachusetts Institute of Technology. Among his awards are a Packard Fellowship and the New Horizons in Physics Prize.

"Lamarkism" is a term often attached to a seemingly discredited idea in evolutionary biology: that one organism could acquire characteristics (e.g., becoming stronger through exercise) that would then be inherited by its descendants. This is a different story than the one ultimately told by the modern synthesis of evolutionary biology, according to which inheritance passes through our genome (which doesn't know that we've been working out). In her book The Power of Life: The Invention of Biology and the Revolutionary Science of Jean-Baptiste Lamarck, historian of science Jessica Riskin argues that this picture is too simple, and that Lamarck made contributions we should still pay attention to: most significantly, the idea that organisms have a creative agency of their own, in addition to the influences of the outside world.

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Jessica Riskin received her Ph.D. in history from the University of California, Berkeley. She is currently the Frances and Charles Field Professor of History at Stanford University. Among her awards are the Patrick Suppes Prize in the History of Science and the J. Russell Major Award for French history. Her books include The Restless Clock and Genesis Redux, and she is a frequent contributor to the New York Review of Books.

In the 18th century, philosopher Jeremy Bentham suggested the Panopticon as a model of a prison where inmates could be constantly observed by just a single prison guard. Although his original idea was never built, the word has come to indicate any system of social control through constant surveillance. Nowadays, we are close to creating such a system, not for prisons, but for our everyday lives. The data about our whereabouts and doings is collected by our smart devices, and available for search by the authorities. I talk with law professor Andrew Guthrie Ferguson about the new reality, as discussed in his book Your Data Will Be Used Against You: Policing in the Age of Self-Surveillance.

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Andrew Guthrie Ferguson received his J.D. from the University of Pennsylvania, and an LL.M. from Georgetown University. He is currently a professor of law at George Washington University Law School. He is a member of the American Law Institute (ALI) and was an Advisor to the ALI Principles of the Law, Policing Project. He previously worked as a supervising attorney at the Public Defender Service for the District of Columbia.

Intelligence is a many splendored thing, especially when it comes to comparisons between species. Chimpanzees are better than humans at some numerical tasks, but less good at understanding what numbers actually mean. One window on the ways that species differ is how they play amongst themselves. I talk with anthropologist and cognitive scientist Erica Cartmill about modes of play and other social behaviors among various species, and what they reveal about the ways we all think.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/03/09/346-erica-cartmill-on-how-human-and-animal-minds-think-and-play/

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Erica Cartmill received her Ph.D. in psychology and neuroscience from the University of St. Andrews. She is Professor of Cognitive Science, Anthropology, Animal Behavior, Psychology, and Informatics at Indiana University, Bloomington and an External Professor at the Santa Fe Institute. She is the co-chair of the EVOLANG conferences and the co-director of the Diverse Intelligences Summer Institute. She is co-director of the Possible Minds lab at IU, and also manages the Observing Animals project, which asks for public input on how animals interact with each other.

Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

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Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2026/03/02/ama-march-2026/

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Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be uncertain about our place within the world. This kind of situation arises in cosmology (where the relevant world can extend very far in space or time), and also in quantum mechanics (where new worlds might be created at any measurement), but also when we are simply unsure about the future history of humanity or whether we live in a computer simulation. I talk with philosopher Adam Elga about how to deal with these unique kinds of uncertainties.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/02/23/345-adam-elga-on-being-rational-in-a-very-large-universe/

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Adam Elga received his Ph.D. in philosophy from MIT. He is currently a professor of philosophy at Princeton University. His research involves decision and game theory, epistemology, philosophy of probability, philosophy of mind, and philosophy of science.

It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosophy sense of the term. But such movement isn't inevitable or irreversible, and in very recent times there have been both intellectual arguments explicitly pushing back against the liberal consensus, and political movements that are more openly nativist and authoritarian. I talk with Adam Gurri, the editor-in-chief of Liberal Currents, a web site that "publishes writers of diverse perspectives who share an unflinching commitment to freedom, pluralism, and democracy, in opposition to authoritarianism at home and around the world."

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/02/16/344-adam-gurri-on-liberal-democracy-and-how-to-fight-for-it/

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Adam Gurri received an M.A. in Economics from George Mason University. He is the co-founder and Editor-in-Chief of Liberal Currents.

For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part involves reasoning with probability and uncertainty. And some of it is governed by unavoidable limitations on time and accuracy. Psychologist and computer scientist Tom Griffiths suggests that we have thought about it enough to feel that we have come to understand some general principles, which he explains in his new book The Laws of Thought: The Quest for a Mathematical Theory of Mind.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/02/09/343-tom-griffiths-on-the-laws-of-thought/

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Tom Griffiths received his Ph.D. in psychology from Stanford University. He is currently Professor of Psychology and Computer Science at Princeton University, Director of the Computational Cognitive Science Lab, and Director of the Princeton Laboratory for Artificial Intelligence. He is the co-author of Algorithms to Live By: The Computer Science of Human Decisions, as well as the upcoming The Rational Use of Cognitive Resources.

Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2026/02/02/ama-february-2026/

Note that Mindscape now has a new hosting provider, Libsyn. (Actually a return home, as that was my first host when Mindscape was launched.) Things seem to be going smoothly, but let us know if there are any technical glitches.

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Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There is tremendous divergence of species over time, but also repeated convergence to forms and mechanisms that are unmistakably useful. We see this clearly in eyes and fins, but the basic pattern also holds for brains and forms of social organization. I talk with philosopher Rachell Powell about what these ideas mean for humans, other terrestrial species, and also for forms of life we have not yet encountered.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/01/26/342-rachell-powell-on-evolutionary-convergence-morality-and-mind/

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Rachell Powell received her Ph.D. in philosophy from Duke University. She is currently a Professor of Philosophy at Boston University. She has held fellowships at the National Humanities Center, the American Council of Learned Societies, the Konrad Lorenz Institute for Evolution and Cognition Research, the National Evolutionary Synthesis Center, the Berlin School of Mind and Brain at Humboldt University, and the Center for Genetic Engineering and Society at North Carolina State University.

"Things fall apart; the centre cannot hold," wrote W.B. Yeats. I don't know about the centre, but the tendency of things to fall apart is pretty universal, ultimately due to the Second Law of Thermodynamics. Anyone living in a society or involved with technology must therefore be interested in the concept of maintenance -- keeping systems working. In his book Maintenance: Of Everything, Part One, Stewart Brand looks at the challenges and rewards of this concept.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/01/19/341-stewart-brand-on-maintenance-as-an-organizing-principle/

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Stewart Brand received an undergraduate degree in biology from Stanford University. He was the founder, editor, and publisher of the Whole Earth Catalog, which won a National Book Award. He founded the journal CoEvolution Quarterly and the WELL electronic community, and was a co-founder of the Long Now Foundation. He has been called "the 20th century's top influencer."

At any given moment, an uncountable number of events are happening, but only some of them matter to us. What does it mean for something to matter, and more importantly, what does it mean for us to matter -- to ourselves as well as to others? The need to matter can be motivation to do great things, but it can also be a reason for people to come into conflict. Philosopher/novelist Rebecca Newberger Goldstein explores this issue in her new book The Mattering Instinct: How Our Deepest Longing Drives Us and Divides Us.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/01/12/340-rebecca-newberger-goldstein-on-what-matters-and-why-it-matters/

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Rebecca Newberger Goldstein received her Ph.D. in philosophy from Princeton University. She is the author of several novels and works of non-fiction. Among her awards are the MacArthur and Guggenheim Fellowships, membership in the American Academy of Arts and Sciences, and the National Humanities Medal.

It's become increasingly clear that the Turing Test -- determining whether human interlocutors can tell whether a conversation is being carried out by a human or a machine -- is not a good way to think about consciousness. Modern LLMs can mimic human conversation with extraordinary verisimilitude, but most people would not judge them to be conscious. What would it take? Is it even possible for a computer program to achieve consciousness, or must consciousness be fundamentally "meat-based"? Philosopher Ned Block has long argued that consciousness involves something more than simply the "functional" aspects of inputs and outputs.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/01/05/339-ned-block-on-whether-consciousness-requires-biology/

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Ned Block received his Ph.D. in philosophy from Harvard University. He is currently Silver Professor in the Department of Philosophy at New York University, with secondary appointments in Psychology and Neural Science. He is also co-director of the Center for Mind, Brain, and Consciousness. He is Past President of the Society for Philosophy and Psychology and was elected a Fellow of the American Academy of Arts & Sciences.

Time for the holiday message! Rounding off the year with a brief and casual reflection on some issue that doesn't quite rise to the level of a full solo podcast. And hopefully something uplifting.

This year, I offer a short apologia for higher education in the liberal arts and sciences, focusing not on the down-to-earth economic/occupational benefits of a college degree, but on the very real ways in which such an education opens up possibilities for personal growth. I think all of us in academia should be loud and unapologetic about the more romantic, idealistic values of the modern university.

Happy holidays all!

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/12/22/holiday-message-2025-the-romance-of-the-university/

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Welcome to the December 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/12/15/ama-december-2025/

In the intro I give a plug for the Pods Fight Poverty effort organized by GiveDirectly. Please consider making a donation to help families in Rwanda!

Enjoy!

The story goes that Wolfgang Pauli, who first proposed the existence of neutrinos, was embarrassed to have done so, as it was considered uncouth to hypothesize new particles that could not be detected. Modern physicists have no such scruples, of course, but more importantly neutrinos turn out to be very detectable, given sufficient resources and experimental technique. I talk with neutrino physicist Ryan Patterson about what current and upcoming experiments teach us about neutrinos themselves, as well as implications for dark matter and why there are more particles than antiparticles in the universe.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/12/08/228-ryan-patterson-on-the-physics-of-neutrinos/

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Ryan Patterson received his Ph.D. in physics from Princeton University. He is currently Professor of Physics at Caltech. His research involves a number of aspects of experimental neutrino physics, including involvement in the NOvA and DUNE experiments.

Game theory is a way of quantitatively describing what happens any time one thing interacts with another thing, when both things have goals and potential rewards. That's a pretty broad class of interesting events, so it is unsurprising that game theory is a useful way of thinking about everything from international relations to the evolution of peacock feathers. I talk with philosopher Kevin Zollman about what game theory is and how it gets used in biology and human interactions. We discuss how thinking in game-theoretic terms can help understand the origin of meaning and intentionality in human language.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/12/01/337-kevin-zollman-on-game-theory-signals-and-meaning/

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Kevin Zollman received his Ph.D. in philosophy from the University of California, Irvine. He is currently the Herbert A. Simon Professor of Philosophy and Social and Decision Sciences in the Department of Philosophy at Carnegie Mellon University. He is also an associate fellow at the Center for Philosophy of Science at the University of Pittsburgh, and a visiting professor at the Munich Center for Mathematical Philosophy. He serves as the Director of the Institute for Complex Social Dynamics at CMU. He is the co-author, with Paul Raeburn, of The Game Theorist's Guide to Parenting.

Machine learning using neural networks has led to a remarkable leap forward in artificial intelligence, and the technological and social ramifications have been discussed at great length. To understand the origin and nature of this progress, it is useful to dig at least a little bit into the mathematical and algorithmic structures underlying these techniques. Anil Ananthaswamy takes up this challenge in his book Why Machines Learn: The Elegant Math Behind Modern AI. In this conversation we give a brief overview of some of the basic ideas, including the curse of dimensionality, backpropagation, transformer architectures, and more.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/11/24/336-anil-ananthaswamy-on-the-mathematics-of-neural-nets-and-ai/

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Anil Ananthaswamy received a Masters degree in electrical engineering from the University of Washington, Seattle. He is currently a freelance science writer and feature editor for PNAS Front Matter.He was formerly the deputy news editor for New Scientist, a Knight Science Journalism Fellow at MIT, and journalist-in-residence at the Simon Institute for the Theory of Computing, University of California, Berkeley. He organizes an annual science journalism workshop at the National Centre for Biological Sciences at Bengaluru, India.

Welcome to the November 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/11/17/ama-november-2025/

In the intro I mentioned a couple of my favorite TV shows of this year. Here is a more thought-out list (no particular order):

Pluribus and Down Cemetery Road also look promising, but too early to tell. (There are a huge number of shows I've never seen, so feel free to add recommendations.)

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Science has an incredibly impressive track record of uncovering nonintuitive ideas about the universe that turn out to be surprisingly accurate. It can be tempting to think of scientific discoveries as being carefully constructed atop a rock-solid foundation. In reality, scientific progress is tentative and fallible. Scientists propose models, assign them probabilities, and run tests to see whether they succeed or fail. In cosmologist Andrew Jaffe's new book, The Random Universe, he illustrates how models and probability help us make sense of the cosmos.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/11/10/335-andrew-jaffe-on-models-probability-and-the-universe/

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Andrew Jaffe received his Ph.D. in physics from the University of Chicago. He is currently a professor of astrophysics and cosmology and Director of the Imperial Centre for Inference and Cosmology at Imperial College, London. His research lies at the intersection of theoretical and observational cosmology, including the Planck Surveyor, Euclid, LISA, and Simons Observatory collaborations.

The universe as revealed by physics is objective: it's out there, existing and behaving in ways that are completely independent of human thought. But the process by which we learn about the universe, and the language with which we talk about it, is extremely human-dependent. Does that mean that aliens would do science differently, and even think differently about physics, even if we all live in the same universe? Physicist Daniel Whiteson has teamed with cartoonist Andy Warner to investigate these questions in their new book Do Aliens Speak Physics?

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/11/03/334-daniel-whiteson-on-the-physics-of-and-by-aliens/

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Daniel Whiteson received his Ph.D. in physics from the University of California at Berkeley. He is currently a professor of physics at the University of California, Irvine. He is a Fellow of the American Physical Society and recipient of an Emmy nomination. He is the author of several books, often with co-author Jorge Cham. He is the co-host (with Kelly Weinersmith) of the podcast Daniel and Kelly's Extraordinary Universe.

Why are people wrong all the time, anyway? Is it because we human beings are too good at being irrational, using our biases and motivated reasoning to convince ourselves of something that isn't quite accurate? Or is it something different -- unmotivated reasoning, or "unthinkingness," an unwillingness to do the cognitive work that most of us are actually up to if we try? Gordon Pennycook wants to argue for the latter, and this simple shift has important consequences, including for strategies for getting people to be less susceptible to misinformation and conspiracies.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/10/27/333-gordon-pennycook-on-unthinkingness-conspiracies-and-what-to-do-about-them/

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Gordon Pennycook received his Ph.D. in psychology from the University of Waterloo. He is currently an associate professor of psychology and Dorothy and Ariz Mehta Faculty Leadership Fellow at Cornell University as well as an Adjunct Professor at University of Regina's Hill/Levene Schools of Business. He is a member of the Royal Society of Canada's College of New Scholars, Artists, and Scientists, and a 2016 winner of the IgNobel Prize for Peace.

Music is math that you can dance to. The fact that certain notes sound good when played together, or in succession, is related to the mathematical properties of the frequencies to which they correspond, an idea that goes back as far as Pythagoras himself. These days we have a much more intricate understanding of these relationships and how to manipulate them. I talk to composer and music theorist Dmitri Tymoczko about how different musical scales are constructed and the math underlying what sounds good.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/10/20/332-dmitri-tymoczko-on-the-mathematics-behind-music/

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Dmitri Tymoczko received a Ph.D. in music composition from the University of California, Berkeley. He is currently a professor of music at Princeton University as well as a composer and performer. He has been the recipient of Rhodes and Guggenheim fellowships. As a composer, his works have been performed by multiple groups, and recorded on several albums.

Welcome to the October 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/10/13/ama-october-2025/

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Certain features of our universe seem unnatural to us. These include "constants of nature" such as the cosmological constant and the mass of the Higgs boson, as well as features of the initial conditions like the curvature of space and the initial entropy. But they can't truly be "unnatural" -- they are literally features of Nature itself. Some have turned to the anthropic principle and the multiverse, while others look to theism for an explanation. I talk here about my views on the various attitudes one might take toward these apparent fine-tunings, and why it is important to think about them.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/10/06/331-solo-fine-tuning-god-and-the-multiverse/

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Some readings of relevance:

A characteristic of complex systems is that individual components combine to exhibit large-scale emergent behavior even when the components were not specifically designed for any particular purpose within the collective. Sometimes those individual components are us -- people interacting within societies or online communities. Studying the dynamics of such interactions is interesting both to better understand what is happening, and hopefully to designing better communities. I talk with Petter Törnberg about flows of information, how polarization develops, and how artificial agents can help steer things in better directions.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/29/330-petter-tornberg-on-the-dynamics-of-misinformation/

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Petter Törnberg received a Ph.D. in complex systems from Chalmers University of Technology. He is now an Assistant Professor at the Institute for Language, Logic and Computation at the University of Amsterdam, Associate Professor in Complex Systems at Chalmers University of Technology, NWO VENI laurate, and senior researcher at the University of Neuchâtel.

Getting along in society requires that we mostly adhere to certainly shared norms and customs. Often it's not enough that we all know what the rules are, but also that everyone else knows the rules, and that they know that we know the rules, and so on. Philosophers and game theorists refer to this as common knowledge. In Steven Pinker's new book, When Everyone Knows That Everyone Knows..., he explores how common knowledge (or its absence) explains money, power, and a wide variety of subtextual human interactions.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/22/329-steven-pinker-on-rationality-and-common-knowledge/

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Steven Pinker received his Ph.D. in psychology from Harvard University. He is currently the Johnstone Family Professor of Psychology at Harvard University. He is the author of several best-selling books and recipient of several honorary doctoral degrees. Among his awards are Humanist of the Year (two different organizations) and the William James Lifetime Achievement Award from the Association for Psychological Science.

Like any machine, bodies occasionally break down, and it's natural to go in search of a replacement part. Ancient societies featured simple prosthetics for teeth, noses, and limbs, while modern medicine pursues more advanced ways of replacing internal organs and microbiomes. But what is striking is not just the impressive ingenuity of our attempts to replicate human anatomy, but the surprising level of difficulty involved in doing it well. I talk with author Mary Roach about the many ways in which humans have chosen to replace bits of themselves, as told in her recent book Replaceable You: Adventures in Human Anatomy.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/15/328-mary-roach-on-replacing-parts-of-our-bodies/

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Mary Roach received a bachelor's degree in psychology from Wesleyan University. Her books include multiple New York Times bestsellers and have appeared on numerous best-of lists. She was a guest editor in the Best American Science and Nature Writing series, and received the Rushdie Award from the Harvard Secular Society.

Welcome to the September 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/09/08/ama-september-2025/

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"Liberalism," divorced from its particular connotations in this or that modern political context, refers broadly to a philosophy of individual rights, liberties, and responsibilities, coupled with respect for institutions and rule of law over personalized power. As Cass Sunstein construes the term, liberalism encompasses a broad tent, from Ronald Reagan and Margaret Thatcher to Martin Luther King and Franklin Roosevelt. But liberalism is being challenged both from the right and from the left, by those who think that individual liberties can go too far. We talk about the philosophical case for liberalism as well as the challenges to it in modern politics, as discussed in his new book On Liberalism: In Defense of Freedom.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/01/327-cass-sunstein-on-liberalism/

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Cass Sunstein received a J.D. from Harvard Law School, and worked as a clerk for Supreme Court Justice Thurgood Marshall. He is currently Robert Walmsley University Professor at Harvard. He served in several government roles during the Obama administration. He is recognized as "by far the most cited legal scholar in the United States and probably the world."

In a relatively short period of time, exoplanets (planets around stars other than our Sun) have gone from an intriguing conjecture to an active field of scientific study, with over 5,000 confirmed discoveries. The task now is to move beyond merely accumulating new examples, and embarking on systematic studies of their properties. What fraction of stars have planets, how are they distributed in size and distance, what kinds of atmospheres do they have, are any promising homes for life? I talk with Natalie Batalha about what we've learned so far, and prospects for future discoveries.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/08/25/326-natalie-batalha-on-what-we-know-and-will-learn-about-exoplanets/

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Natalie Batalha received a Ph.D. in astrophysics from the University of California, Santa Cruz. She is currently a professor of astronomy and astrophysics at UCSC. She has served as Science Team Leader, Mission Scientist, and Project Scientist for NASA's Kepler satellite observatory. She is a member of the American Academy of Arts and Sciences, and was listed as one of Time Magazine's 100 Most Influential People in the World in 2017.

The world is becoming pixelated. As computers and other digital devices become ubiquitous, human knowledge and communication and information is gradually being converted into, and manipulated as, strings of bits. What does that really mean, and what are the ramifications going forward? Alvy Ray Smith is a computer scientist, co-founder of Pixar, and author of A Biography of the Pixel. We go through the journey of how he helped make computer animation a reality, and the implications of what he calls the "Great Digital Convergence."

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/08/18/325-alvy-ray-smith-on-pixar-pixels-and-the-great-digital-convergence/

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Alvy Ray Smith received a Ph.D. in computer science from Stanford University. He has been a professor of electrical engineering and computer science at New York University, a member of the Computer Graphics Lab at the NY Institute of Technology, director of computer graphics at Lucasfilm, and cofounder of Pixar and Altamira. He is a member of the National Academy of Engineering and a Fellow of the America Association for the Advancement of Science as well as the American Society of Genealogists. He is the winner of two technical Academy Awards.

It is not manifestly obvious that universities should be where most scholarly research is performed. One could imagine systems that separated out the tasks of "teaching students" and "generating new knowledge." But it turns out that combining them yields spectacular synergies, both from letting students experience cutting-edge research and from keeping researchers inspired by interacting with bright young minds. Today we talk to Elizabeth Mynatt, Dean of Computer Sciences at Northeastern, both about her own research in "human-centered computing," and about the bigger-picture issues of why basic research is important, and why universities are such good places to do it.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/08/11/324-elizabeth-mynatt-on-universities-and-the-importance-of-basic-research/

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Elizabeth Mynatt received a Ph.D. in computer science from the Georgia Institute of Technology. She is currently Dean of the Khoury College of Computer Sciences at Northeastern University. She is a senior investigator with Emory's Cognitive Empowerment Program and co-PI for the NSF AI-CARING Institute. She is a fellow of the Association for Computing Machinery and the American Association for the Advancement of Science, and a member of the American Academy of Arts and Sciences. She was lead author on the National Academies report, "Information Technology Innovation: Resurgence, Confluence, and Continuing Impact."

Welcome to the August 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/08/04/ama-august-2025/

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The search for a foundational theory of quantum mechanics that all physicists can agree on remains active. Over the last century a number of contenders have emerged, including Many-Worlds, pilot-wave theories, and others, but all of them have aspects that many people object to. Jacob Barandes has taken up the challenge, proposing a new formulation of quantum theory in which there is no wave function, only real degrees of freedom with fundamentally stochastic dynamics. We talk about this new theory and the challenges facing it.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/07/28/323-jacob-barandes-on-indivisible-stochastic-quantum-mechanics/

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Jacob Barandes received his Ph.D. in physics from Harvard University. He is currently Senior Preceptor in Physics and Associated Faculty in Philosophy at Harvard. He teaches both physics and philosophy courses at Harvard, where he has been the recipient of several teaching awards.

When we think of the capacities that distinguish humans from other species, we generally turn to intelligence and its byproducts, including our technological prowess. But our intelligence is highly connected to our ability to use language, which is in turn closely related to our capacities as social creatures. Philosopher Philip Pettit would encourage us to think of those social capacities, as enabled by language, as the primary locus of what makes humans different, as discussed in his new book When Minds Converse: A Social Genealogy of the Human Soul. And that linguistic aptitude helps us understand the nature of agency, responsibility, and freedom.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/07/21/322-philip-pettit-on-language-agency-politics-and-freedom/

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Philip Pettit received his Ph.D. in philosophy from University College Belfast. He is currently Laurance S. Rockefeller University Professor of Human Values at Princeton University and Distinguished University Professor of Philosophy at Australian National University. He is a Fellow of the Academy of Social Sciences in Australia, the Australian Academy of the Humanities, the American Academy of Arts and Sciences, and the Guggenheim Foundation, among other honors.

Quantum field theory is the basis for our most successful theories of fundamental physics. And yet, there are things we don't understand about it. Some of these puzzles are relatively well-known, while others are less celebrated. David Tong joins us to talk about some of the more interesting and perplexing aspects of quantum field theory. He also discusses his new project to write a series of textbooks covering (all?) important topics in theoretical physics. To date, these include Classical Mechanics, Quantum Mechanics, Fluid Mechanics, and Electromagnetism.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/07/14/321-david-tong-on-open-questions-in-quantum-field-theory/

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David Tong received his Ph.D. in theoretical physics from Swansea University. He is currently a professor of Theoretical Physics in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge. He is a winner of the Adams Prize and a Simons Investigator. In addition to his books, he has written many freely-available sets of lecture notes on topics in physics.

Welcome to the July 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/07/07/ama-july-2025/

Our universe started out looking very simple: hot, dense, smooth, rapidly expanding. According to our best current model, it will end up looking simple once again: cold, dark, empty. It's in between -- now, roughly speaking -- that things look complex. I have been working to understand the stages by which complexity comes into existence, thrives, and eventually disappears. Without going into technical details, in this solo episode I give an overview of the general picture and the clues we are looking at to better understand the process of complexogenesis.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/30/320-solo-complexity-and-the-universe/

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The Santa Fe Institute has recently published a four-volume set of classic papers on complexity. David Krakauer provided a comprehensive introduction that has been published as a standalone book.

It is common to refer to philosophy as "a series of footnotes to Plato." But in the original quote, Alfred North Whitehead was more careful: he limited his characterization to "the European philosophical tradition." There are other traditions, both ancient and ongoing: Chinese philosophy, Indian philosophy, Africana philosophy, and various indigenous philosophies. For the most part, these do not get nearly as much attention in European and American schools as the European tradition does. Bryan Van Norden argues for expanding philosophy's geographical scope, to the benefit of philosophy in general.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/23/319-bryan-van-norden-on-philosophy-from-the-rest-of-the-world/

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Bryan Van Norden received his Ph.D. in philosophy from Stanford University. He is currently James Monroe Taylor Chair in Philosophy at Vassar College and Chair Professor in the School of Philosophy at Wuhan University. Among his books are Introduction to Classical Chinese Philosophy and Taking Back Philosophy: A Multicultural Manifesto. He is a recipient of Fulbright, National Endowment for the Humanities, and Mellon fellowships.

Economics is seeing an upsurge in the importance of controlled, reproducible empirical studies. One area where this has had a great impact is on development economics, which studies the economies of low- and middle-income societies. Edward Miguel has been at the forefront of both the revolution in empirical methods, and in applying those techniques to alleviating poverty in sub-Saharan Africa and elsewhere.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/16/318-edward-miguel-on-the-developing-practice-of-development-economics/

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Edward Miguel received his Ph.D. in economics from Harvard university. He is currently Distinguished Professor of Economics and Oxfam Professor in Environmental and Resource Economics at the University of California, Berkeley. He is also Faculty co-Director of the Center for Effective Global Action and a Faculty Research Associate of the National Bureau of Economic Research. Among his awards are the Frisch Medal of the Econometric Society, the Kenneth Arrow Prize of the International Health Economics Association, and multiple teaching awards.

The human brain is extremely complicated, but decades of careful neuroscientific research have revealed quite a bit about how it works, including how certain genes affect particular brain behaviors. Nevertheless, this progress has not led to quite as much improvement in the treatment of brain disorders as we might expect. I talk with neuroscientist Nicole Rust about why this is and how to improve the situation, as discussed in her new book Elusive Cures.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/09/317-nicole-rust-on-why-neuroscience-hasnt-solved-brain-disorders/

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Nicole C. Rust received her Ph.D. in neuroscience from New York University. She is currently a professor of psychology at the University of Pennsylvania. She is also a contributing editor at The Transmitter and an editor at BrainFacts.org. Among her awards are the Troland Research Award from the National Academy of Sciences.

Welcome to the June 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/06/02/ama-june-2025/

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Einstein's general theory of relativity, plus some reasonable assumptions about the universe and what it's made of, has a remarkable implication: that as we trace cosmic evolution into the far past, we ultimately hit a singularity of infinite density and curvature, the Big Bang. Did that really happen? Einstein's theory is classical, after all, and the world is quantum. And whose to say what assumptions are reasonable? Niayesh Afshordi and Phil Halper have written a new book, Battle of the Big Bang: The New Tales of Our Cosmic Origins, that surveys all of the mind-bending possibilities.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/26/316-niayesh-afshordi-and-phil-halper-on-the-big-bang-and-before/

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Niayesh Afshordi received a Ph.D. in astrophysics from Princeton University. He is currently a professor of physics and astronomy at the University of Waterloo, and associate faculty in the cosmology and gravitation group at the Perimeter Institute for Theoretical Physics.

Phil Halper is a science communicator and a fellow of the Royal Astronomical Society. His astronomy images have been featured in major media outlets including The Washington Post, the BBC, and The Guardian, and he has published several papers in peer-reviewed journals.

Every time you see an apple spontaneously break away from a tree, it falls downward. You therefore claim that there is a law of physics: apples fall downward from trees. But how can you really know? After all, tomorrow you might see an apple that falls upward. How is science possible at all? Philosophers, as you might expect, have thought hard about this. Branden Fitelson explains how a better understanding of probability can help us decide when new evidence is actually confirming our beliefs.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/19/315-branden-fitelson-on-the-logic-and-use-of-probability/

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Branden Fitelson received a Ph.D. in philosophy from the University of Wisconsin-Madison. He is currently Distinguished Professor of Philosophy at Northeastern University. He is a co-founder of the Formal Epistemology Workshop, and winner of the 2020 Wolfram Innovator Award.

There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, but the operate and survive in ways that are quite different from what we're familiar with. They live off of nutrients that have penetrated from the surface, or sometimes off of pure electrons. Karen Lloyd is a scientist who has traveled around the world studying these organisms, as she explains in her new book Intraterrestrials: Discovering the Strangest Life on Earth.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/12/314-karen-lloyd-on-the-deep-underground-biosphere/

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Karen Lloyd received a Ph.D. in marine sciences from the University of North Carolina. She is currently the Wrigley Chair in Environmental Studies and Professor of Earth Sciences at the University of Southern California. Among her awards are a Sloan Fellowship, a Simons Early Career Investigator, and a NASA Early Career Fellowship.

Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in diagnostics. This is an area that is a perfect match between an important question and the capabilities of machine learning, to the point where AI can out-perform human doctors. And second, our understanding of aging and what to do about it. Eric even gives some actionable advice on how to live more healthily into our golden years.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/05/episode-313-eric-topol-on-the-changing-face-of-medicine-and-aging/

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Eric Topol received and M.D. from the University of Rochester. He is currently the Gary and Mary West Chair of Innovative Medicine in the Department of Translational Medicine at Scripps Research. He is also the Founder, Scripps Research Translational Institute, and Senior Consultant, Scripps Clinic, Division of Cardiovascular Diseases. Among his awards are the Hutchinson Medal from the University of Rochester and membership in the National Academy of Sciences. His books include Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again, and Super Agers: An Evidence-Based Approach to Longevity.

Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/04/28/ama-may-2025/

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The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) But the road to widespread acceptance isn't always an easy one. Why did it take so long between Anton van Leeuwenhoek seeing "animalcules" in a microscope (1670s) to Louis Pasteur's work on pasteurization and vaccination (1860's)? Thomas Levenson is the author of a new book exploring this fascinating history: So Very Small: How Humans Discovered the Microcosmos, Defeated Germs--and May Still Lose the War Against Infectious Disease.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/04/21/episode-312-thomas-levenson-on-the-mutual-history-of-humans-and-germs/

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Thomas Levenson received a B.A. in East Asian Studies from Harvard University. He is currently Professor of Science Writing and director of the graduate program in science writing at the Massachusetts Institute of Technology. He is the author of numerous books and has written and produced a number of science documentaries for television.

Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or does matter emerge from consciousness? While it might be straightforward to think that consciousness arises from the collective behavior of atoms in the brain, Annaka Harris and others argue that consciousness could be the fundamental stuff from which matter arises. She talks with a variety of experts in her new audio series, Lights On: How Understanding Consciousness Helps Us Understand the Universe.

Blog post with show notes and transcript: https://www.preposterousuniverse.com/podcast/2025/04/14/311-annaka-harris-on-whether-consciousness-is-fundamental/

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Annaka Harris received a BFA from New York University. She is the author of Consciousness: A Brief Guide to the Fundamental Mystery of the Mind. She is a co-founder of Project Reason.

Welcome to the April 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/04/07/ama-april-2025/

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A couple of links relevant to the intro:

Cosmologists were, let us be honest, pretty stunned in 1998 when observations revealed that the universe is accelerating. There was an obvious plausible explanation, the cosmological constant proposed by Einstein, which is equivalent to a constant vacuum energy pervading space. But the cosmological constant was known to be enormously smaller than its "natural" value, and it seems fine-tuned for it to be so small but not yet zero. Once burned, twice shy, and since then we have been looking for evidence that the dark energy might not be strictly constant, even though that's even more fine-tuned. We talk to cosmologist Marc Kamionkowski about recent evidence that dark energy might be changing with time, and what this might have to do with the Hubble tension and other cosmic anomalies.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/31/310-marc-kamionkowski-on-dark-energy-and-cosmic-anomalies/

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Marc Kamionkowski received his Ph.D. in physics from the University of Chicago. He is currently the William R. Kenan Jr. Professor in the Department of Physics and Astronomy at Johns Hopkins University. Among his prizes are the Gruber Cosmology Prize, the Dannie Heineman Prize for Astrophysics, membership in the National Academy of Science, and a Guggenheim Fellowship.

Consciousness is easier to possess than to define. One thing we can do is to look into the brain and see what lights up when conscious awareness is taking place. A complete understanding of this would be known as the "neural correlates of consciousness." Once we have that, we could hopefully make progress on developing a theoretical picture of what consciousness is and why it happens. Today's guest, Christof Koch, is a leader in the search for neural correlates and an advocate of a particular approach to consciousness, Integrated Information Theory.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/24/309-christof-koch-on-consciousness-and-integrated-information/

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Christof Koch was awarded a Ph.D. from the Max Planck Institute for Biological Cybernetics. He is currently a Meritorious Investigator at the Allen Institute for Brain Science, where he was formerly president and chief scientist, and Chief Scientist at the Tiny Blue Dot Foundation. He is the author of several books, most recently Then I Am Myself the World - What Consciousness Is and How to Expand It.

We often study cognition in other species, in part to learn about modes of thinking that are different from our own. Today's guest, psychologist/philosopher Alison Gopnik, argues that we needn't look that far: human children aren't simply undeveloped adults, they have a way of thinking that is importantly distinct from that of grownups. Children are explorers with ever-expanding neural connections; adults are exploiters who (they think) know how the world works. These studies have important implications for the training and use of artificial intelligence.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/17/308-alison-gopnik-on-children-ai-and-modes-of-thinking/

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Alison Gopnik received her D.Phil in experimental psychology from Oxford University. She is currently a professor of psychology and affiliate professor of philosophy at the University of California, Berkeley. Among her awards are the Association for Psychological Science Lifetime Achievement Award, the Rumelhart Prize for Theoretical Foundations of Cognitive Science, and a Guggenheim Fellowship. She is a past President of the Association for Psychological Science. She is the author of The Scientist in the Crib, The Philosophical Baby, and The Gardener and the Carpenter, among other works.

Welcome to the March 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Link to the 2012 Moving Naturalism Forward workshop, mentioned in the episode.

Blog post with questions and full transcript: https://www.preposterousuniverse.com/podcast/2025/03/10/ama-march-2025/

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A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it that way. And even if you have no interest in cocktails as such, the general principles extend to other activities in art and in life. I talk to scientist-turned-mixologist Kevin Peterson about how to think about the simple magic of a perfect drink.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/03/307-kevin-peterson-on-the-theory-of-cocktails/

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Kevin Peterson received a Ph.D. in Mechanical Engineering from the University of Michigan. He is currently co-owner of both Castalia (an experimental craft cocktail bar) and Sfumato Fragrances in Detroit, Michigan. He is the author of Cocktail Theory: A Sensory Approach to Transcendent Cocktails.

Mindscape Petrichor Negroni (from the episode)

Stir over an ice cube, express with orange peel (not shown).

It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and success of life on this planet. The oceans are a paradigmatic complex system: there are many components, distinct but mutually interacting, that add up to a nuanced whole. We talk with ocean physicist Helen Czerski about what the ocean is and how it's changing.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/24/306-helen-czerski-on-our-energetic-oceans/

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Helen Czerski received her Ph.D. in physics from the University of Cambridge. She is currently an Associate Professor at the Department of Mechanical Engineering at University College London. She is the author of several books, most recently The Blue Machine: How the Ocean Works. She is a frequent television presenter for the BBC and elsewhere.

Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotional, imperfect creatures, so a successful theory of politics has to account for these features. One phenomenon that has grown in recent years is an alignment of cultural differences with political ones, so that polarization becomes more entrenched and even violent. I talk with political scientist Lilliana Mason about how this has come to pass, and how democracy can deal with it.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/17/305-lilliana-mason-on-polarization-and-political-psychology/

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Lilliana Hall Mason received her Ph.D. in political psychology from Stony Brook University. She is currently an SNF Agora Institute Associate Professor of Political Science at Johns Hopkins University. She is the author of Uncivil Agreement: How Politics Became Our Identity and co-author (with Nathan Kalmoe) of Radical American Partisanship: Mapping Violent Hostility, Its Causes, and the Consequences for Democracy.

The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institutes of Health and the National Science Foundation. I explain a little about what is being cut and why these funds are important to scientific progress. I try, for what it's worth, to provide these explanations in a way that would be informative to those who generally favor cutting government waste in dramatic fashion.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/12/bonus-cuts-to-science-funding-and-why-they-matter/

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It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. Science is no different. Many successful scientists are not very good at explaining what goes into successful scientific practice. To understand that, it's necessary to study science in a scientific fashion. What kinds of scientists, in what kinds of collaborations, using what kinds of techniques, do well? I talk with James Evans, an expert on collective intelligence and the construction of knowledge, about how science really works.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/10/304-james-evans-on-innovation-consolidation-and-the-science-of-science/

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James Evans received his Ph.D. in Sociology from Stanford University. He is currently the Max Palevsky Professor of History and Civilizations, Director of Knowledge Lab, and Faculty Director of Computational Social Science at the University of Chicago; External Professor at the Santa Fe Institute; External Faculty at the Complexity Science Hub, Vienna; and Visiting Faculty Researcher at Google.

Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/02/03/ama-february-2025/

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A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/

James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.

Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk with physical biologist Chris Kempes about how physics can help us understand the size of organisms, their metabolisms, and features of major transitions in evolution.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/20/302-chris-kempes-on-the-biophysics-of-evolution/

Chris Kempes received his Ph.D. in physical biology from the Massachusetts Institute of Technology. He is currently Professor and a member of the Science Steering Committee at the Santa Fe Institute. His research involves the origin of life and the constraints placed by physics on biological function and evolution.

Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, make sure it is deployed in ways that align with our values, and how to deal with the political and social dangers associated with systems that are not always guided by the truth.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/13/301-tina-eliassi-rad-on-al-networks-and-epistemic-instability/

Tina Eliassi-Rad received her Ph.D. in computer science from the University of Wisconsin-Madison. She is currently Joseph E. Aoun Chair of Computer Sciences and Core Faculty of the Network Science Institute at Northeastern University, External Faculty at the Santa Fe Institute, and External Faculty at the Vermont Complex Systems Center. She is a fellow of the Network Science Society, recipient of the Lagrange Prize, and was named one of the 100 Brilliant Women in AI Ethics.

A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to say that most philosophers haven't yet caught up to. I will talk about ideas from quantum mechanics and quantum gravity that bear on the question of whether time is emergent or fundamental, and the implications of each possibility.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/06/300-solo-does-time-exist/

Some of the papers discussed herein:

It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial informal idea to sitting down and doing the work.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/23/holiday-message-hits-and-misses/

Here are links to the papers I discuss in the episode.

Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist and astrobiologist Michael Wong about how we can define what "functions" are and the role they play in the evolution of the universe.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/16/299-michael-wong-on-information-function-and-the-origin-of-life/

Michael Wong received his Ph.D. in planetary science from Caltech. He is currently a Sagan Postdoctoral Fellow at the Carnegie Institution for Scienceʼs Earth & Planets Laboratory. He is in the process of co-authoring two books: A Missing Law: Evolution, Information, and the Inevitability of Cosmic Complexity with Robert M. Hazen, and a revised edition of Astrobiology: A Multidisciplinary Approach with Jonathan Lunine.

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!

Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/12/02/ama-december-2024/

Support Mindscape onPatreon.