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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=e2_9mHtWwBQ0:00 - Introduction0:36 - Peptides on Cardiovascular Disease1:25 - Ceramides!3:44 - One Ceramide to instill Fear in All!6:16 - Returning to PeptidesReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1022] Lincoff AM, Brown-Frandsen K, Colhoun HM, et al; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563[Study 998] Lundgren JR, Janus C, Jensen SBK, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021;384(18):1719-1730. doi:10.1056/NEJMoa2028198[Study 999] Sandsdal RM, Holt J, Alkhefagie HGA, et al. Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial. Nat Metab. 2026;8:1483-1488. doi:10.1038/s42255-026-01554-4[Study 1000] Mashayekhi M, Beckman JA, Nian H, et al. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis, and inflammation in individuals with obesity and pre-diabetes: a randomized, controlled trial. Diabetes Obes Metab. 2023;25(2):570-580. doi:10.1111/dom.14903.[Study 1001] Akawi N, Checa A, Antonopoulos AS, et al. Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease. J Am Coll Cardiol. 2021;77(20):2494-2513. doi:10.1016/j.jacc.2021.03.314Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4

References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003.

[2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030.

[3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660.

[4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350.

[Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8.

[Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001.

[Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275.

[Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490.

[Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794.

[Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3.

[Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030.

[Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701.

[Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014.

[Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002.

[Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017.

[Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y.

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction2:13 - Blood Cholesterol is not Important13:08 - Something else matters WAY more than Blood Cholesterol16:45 - Main PointsReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2024;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.[2] Dugani SB, Moorthy MV, Li C, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. JAMA Cardiol. 2021;6(4):437–447. doi:10.1001/jamacardio.2020.7073.[3] Magnussen C, Alegre-Diaz J, Al-Nasser LA, et al. Global effect of cardiovascular risk factors on lifetime estimates. N Engl J Med. 2025;393(2):125–138. doi:10.1056/NEJMoa2415879.[4] Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153:e1154–e1276. doi:10.1161/CIR.0000000000001423.[5] Cannon CP, Blazing MA, Giugliano RP, et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372(25):2387–2397. doi:10.1056/NEJMoa1410489.[6] Nordestgaard BG, Langlois MR, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Atherosclerosis. 2020;294:46–61. doi:10.1016/j.atherosclerosis.2019.12.005.[7] Prospective Studies Collaboration, Lewington S, Whitlock G, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829–1839. doi:10.1016/S0140-6736(07)61778-4.[8] Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. BMJ. 2020;371:m4266. doi:10.1136/bmj.m4266.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender750% increased Pancreatic Cancer: https://www.youtube.com/watch?v=_YPIO9CBuw8&t=1s0:00 - Introduction0:25 - CAFs, Vitamin D Receptor, and Cancer3:41 - What happens?5:57 - Why are the results the way they are?8:00 - Vitamin D39:30 - My backlight died and ConclusionsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)]

[Study 1045] Perez KJ, et al. Gemcitabine and nab-paclitaxel ± paricalcitol for metastatic pancreatic cancer. Nat Cancer. 2026;7:928–943.

[Study 1046] Sherman MH, et al. Vitamin D receptor-mediated stromal reprogramming enhances pancreatic cancer therapy. Cell. 2014;159:80–93.

[Study 1047] Grierson PM, et al. Paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer. Clin Cancer Res. 2023;29:4733–4739.

[Study 1048] Chung V, et al. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer. Oncologist. 2025;30.

[Study 1049] Easty D, et al. Paricalcitol with gemcitabine and nab-paclitaxel in advanced pancreatic cancer. BMC Cancer. 2026;26:255.

[Study 1050] Viniotis AF, et al. NABPLAGEM and paricalcitol as neoadjuvant therapy in pancreatic cancer. Oncologist. 2026;31.

[Study 1051] Rasmussen LS, et al. Vitamin D deficiency, inflammation, and survival in pancreatic cancer. Eur J Cancer. 2021;144:72–80.

[Study 1052] Yuan C, et al. Prediagnostic 25-hydroxyvitamin D and pancreatic cancer survival. J Clin Oncol. 2016;34:2899–2905.

[Study 1053] Cho M, et al. Vitamin D deficiency and prognosis in pancreatic adenocarcinoma. J Transl Med. 2013;11:206.

[Study 1054] Van Loon K, et al. 25-Hydroxyvitamin D and survival in advanced pancreatic cancer. J Natl Cancer Inst. 2014;106.

[Study 1055] Mukai Y, et al. Vitamin D supplementation with chemoradiation for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25:1868–1879.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Walnut-Mortality Analysis: https://www.youtube.com/watch?v=3DqCZZgDdF8&t=337s0:00 - Introduction0:45 - It’s a Meee, Cholesterol!3:15 - You heard me, I called you Endothelial5:12 - A New View of Inflammation7:35 - How much to eat?References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1037] Rajaram S, Cofán M, Sala-Vila A, et al. Effects of walnut consumption for 2 years on lipoprotein subclasses among healthy elders: findings from the WAHA randomized controlled trial. Circulation. 2021;144:1083-1085. doi:10.1161/CIRCULATIONAHA.121.054051.[Study 1038] Wu L, Piotrowski K, Rau T, et al. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014;63:382-391. doi:10.1016/j.metabol.2013.11.005.[Study 1039] Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004;109:1609-1614. doi:10.1161/01.CIR.0000124477.91474.FF.[Study 1040] Katz DL, Davidhi A, Ma Y, et al. Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial. J Am Coll Nutr. 2012;31(6):415-423.[Study 1041] Berryman CE, Grieger JA, West SG, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr. 2013;143:788-794. doi:10.3945/jn.112.170993.[Study 1042] Chiang YL, Haddad E, Rajaram S, Shavlik D, Sabaté J. The effect of dietary walnuts compared to fatty fish on eicosanoids, cytokines, soluble endothelial adhesion molecules and lymphocyte subsets: a randomized, controlled crossover trial. Prostaglandins Leukot Essent Fatty Acids. 2012;87:111-117. doi:10.1016/j.plefa.2012.07.007.[Study 1043] Cofán M, Checa A, Serra-Mir M, et al. A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons. J Nutr. 2024;154:395-402. doi:10.1016/j.tjnut.2023.12.007.[Study 1044] Holscher HD, Guetterman HM, Swanson KS, et al. Walnut consumption alters the gastrointestinal microbiota, microbially derived secondary bile acids, and health markers in healthy adults: a randomized controlled trial. J Nutr. 2018;148:861-867. doi:10.1093/jn/nxy004.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:59 - You’re Stressin’ Me, Man, my Glucose is High!5:21 - Not all roads lead to Serine6:10 - A Serine StoryReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1032] He A, Zhu Y, Liang C, et al. Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia. Cell Metab. 2026;38:1385-1403. doi:10.1016/j.cmet.2026.03.006.[Study 1033] Roberts AL, Agnew-Blais JC, Spiegelman D, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry. 2015;72(3):203-210. doi:10.1001/jamapsychiatry.2014.2632.[Study 1034] Vaccarino V, Goldberg J, Magruder KM, et al. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014;56:158-164. doi:10.1016/j.jpsychires.2014.05.019.[Study 1035] Nowotny B, Cavka M, Herder C, et al. Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res. 2010;42:746-753. doi:10.1055/s-0030-1261924.[Study 1036] Heresco-Levy U, Vass A, Bloch B, et al. Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2009;12:1275-1282. doi:10.1017/S1461145709000339.Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:18 - Peptides on Cardiovascular Disease3:09 - Peptides on Reversing Arterial Plaque6:58 - There is hope...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)]

[Study 1018] Marso SP, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016. doi:10.1056/NEJMoa1607141.

[Study 1019] Gerstein HC, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). Lancet. 2019. doi:10.1016/S0140-6736(19)31149-3.

[Study 1020] Gerstein HC, et al. The effect of dulaglutide on stroke: an exploratory analysis of REWIND. Lancet Diabetes Endocrinol. 2020. doi:10.1016/S2213-8587(19)30423-1.

[Study 1021] Hernandez AF, et al. Albiglutide and cardiovascular outcomes in type 2 diabetes and cardiovascular disease. Lancet. 2018. doi:10.1016/S0140-6736(18)32261-X.

[Study 1022] Lincoff AM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023. doi:10.1056/NEJMoa2307563.

[Study 1023] McGuire DK, et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med. 2025. doi:10.1056/NEJMoa2501006.

[Study 1024] Gitto M, et al. GLP-1 receptor agonists and coronary plaque regression after acute coronary syndromes. Acta Diabetol. 2026. doi:10.1007/s00592-025-02606-z.

[Study 1025] Kataoka Y, et al. GLP-1 analogues and delipidation of coronary atheroma. Atheroscler Plus. 2024. doi:10.1016/j.athplu.2024.03.001.

[Study 1026] Heinsen LJ, et al. Liraglutide treatment and progression of coronary artery fibrous plaque. BMC Cardiovasc Disord. 2023. doi:10.1186/s12872-023-03228-5.

[Study 1027] Zhang J, et al. Exenatide versus insulin and carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2020. doi:10.1186/s12933-020-01014-7.

[Study 1028] Rizzo M, et al. Liraglutide decreases carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2014. doi:10.1186/1475-2840-13-49.

[Study 1029] Rizzo M, et al. Liraglutide improves metabolic parameters and carotid intima-media thickness. Cardiovasc Diabetol. 2016. doi:10.1186/s12933-016-0480-8.

[Study 1030] Patti AM, et al. Semaglutide and subclinical atherosclerosis in type 2 diabetes. Biomedicines. 2023. doi:10.3390/biomedicines11051362.

[Study 1031] Sun L, et al. Liraglutide and atherosclerosis in impaired glucose tolerance. Exp Ther Med. 2023. doi:10.3892/etm.2023.11948.

[Study 997] Lundgren JR, et al. Healthy weight loss maintenance with exercise, liraglutide, or both. N Engl J Med. 2021. doi:10.1056/NEJMoa2028198.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:09 - No Good Research on Health Effects of Fiber5:21 - This is what we Need!8:08 - Whoops.. Hypocrisy? 12:50 - Main PointsReferences [1] Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171(12):1061-1068. doi:10.1001/archinternmed.2011.18[2] Chuang SC, Norat T, Murphy N, et al. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2012;96(1):164-174. doi:10.3945/ajcn.111.028415[3] Buil-Cosiales P, Zazpe I, Toledo E, et al. Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2014;100(6):1498-1507. doi:10.3945/ajcn.114.093757[4] Li S, Flint A, Pai JK, et al. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study. BMJ. 2014;348. doi:10.1136/bmj.g2659[5] Katagiri R, Goto A, Sawada N, et al. Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study. Am J Clin Nutr. 2020;111(5):1027-1035. doi:10.1093/ajcn/nqaa002[6] Burn J, Bishop DT, Mecklin JP, et al. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008;359(24):2567-2578. doi:10.1056/NEJMoa0801297[7] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr. 2005;82(3):559-567. doi:10.1093/ajcn.82.3.559[8] Ziai SA, Larijani B, Akhoondzadeh S, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol. 2005;102(2):202-207. doi:10.1016/j.jep.2005.06.042[9] Abutair AS, Naser IA, Hamed AT. Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial). Nutr J. 2016;15(1):86. doi:10.1186/s12937-016-0207-4[10] Solà R, Bruckert E, Valls RM, et al. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. Atherosclerosis. 2010;211(2):630-637. doi:10.1016/j.atherosclerosis.2010.03.010[11] Burke V, Hodgson JM, Beilin LJ, Giangiulioi N, Rogers P, Puddey IB. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension. 2001;38(4):821-826. doi:10.1161/hy1001.092614[12] Wolever TM, Jenkins DJ, Mueller S, et al. Psyllium reduces blood lipids in men and women with hyperlipidemia. Am J Med Sci. 1994;307(4):269-273. doi:10.1097/00000441-199404000-00005Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:48 - Freezing Aging through Exercise4:18 - The Exercise Methylome7:02 - A Bit Gene CrazyReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1006] Janssens GE, Trętowicz MM, Grevendonk L, et al. Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle. Nat Aging. 2026;6:1482-1500. doi:10.1038/s43587-026-01150-x.[Study 1007] Voisin S, Seale K, Jacques M, et al. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Aging Cell. 2024;23:e13859. doi:10.1111/acel.13859.[Study 1008] Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007;2(5):e465. doi:10.1371/journal.pone.0000465.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What’s the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D’Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). *Lancet*. 2021;398(10312):1713-1725. doi:10.1016/S0140-6736(21)01122-3[6] Clarke R, Emberson JR, Parish S, et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. *Arch Intern Med.* 2007;167(13):1373-1378.[7] Ding M, Wennberg A, Ek S, et al. The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age. *Sci Rep.* 2021;11(1):24440. doi:10.1038/s41598-021-03959-5.[8] Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. *Lancet*. 2020;396(10263):1644-1652. doi:10.1016/S0140-6736(20)32233-9Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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0:00 - Introduction4:43 - Berberine on Colorectal Cancer21:36 - 5 Free Health Tests1:03:15 - Glycine Restriction and Cancer1:39:12 - Favorite Anti-Aging Hack2:06:00 - Lithium on Alzheimer's Disease2:29:20 - Vitamin K on Cardiovascular Disease3:14:00 - Housekeeping/Hanging Out

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0:00 - Introduction

4:02 - Collagen for Skin 'Debunked'

36:30 - Ketones track with Liver Disease

52:15 - Butyrate and Cancer

1:25:50 - Seed Oils - Harmful?

1:59:55 - Ineffective Creatine

2:17:17 - Non-Nutritive Sweeteners and Cognitive Decline

2:42:39 - Housekeeping, Updates, Hangout

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Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman

1:15:20 - Lipid Heart Model of Heart Disease

1:27:28 - Lean Mass Hyper-Responders

1:35:10 - Mechanisms of Action Discussion

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Timestamps

0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield’s Motivations for Clinical Education 53:12 – Ending Remarks

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping

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Table of Content

0:00 - Introduction

05:18 - Carnivore Diet

34:39 - LDL Cholesterol & Heart Disease

1:00:11 - Taurine on Longevity & Health

1:13:04 - One Meal a Day - Context Matters

1:22:27 - Fiber - Good or Bad? Mixed Reviews...

1:38:10 - Cancer is a Metabolic Disease?

2:07:10 - Fasting raises Inflammation!?

2:16:52 - Q&A

2:37:23 - Stories of Health Success

2:44:22 - My PhD Progress, Life outside of University

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0:00 – Introduction.
5:30 – Toxic Acrylamides in Coffee.
18:46 – The Physionic Dream.
50:05 – Sucralose and Insulin Sensitivity.
57:00 – Insulin & Body Fat.
1:23:25 – Carbohydrate-Insulin Model of Obesity.
2:17:35 – GlyNAC for Anti-Aging.
2:29:50 – Hyaluronic Acid on Skin Aging.
2:40:45 – The Future Content.

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0:00 - Introduction.
3:00 - Dr. John Campbell, High Intensity Health.
39:40 - Nutrition Gurus.
53:00 - My Investigation on Non-Nutritive Sweeteners.
1:03:05 - Improving the 'Detailed Study Analyses'.
1:09:53 - Sweeteners break your Fast?
1:14:23 - Alternate Day Fasting.

Hi, in this episode, I cover a bunch of topics from my experience at the doctor, my own hypocrisy, some things I learned from you, and finally - the main topic of discussion: Insulin resistance and how plastics (phthalates) affect it. Oh, and if you're on Spotify or YouTube, it's now a video podcast, as well!

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Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine.

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Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs

In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers.

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Related Videos:
Mechanisms: https://youtu.be/Ijt1lqxn2AQ
Therapies: https://youtu.be/iLdcoIIiByo

Scientific Review:
Reprogramming of Fatty Acid Metabolism in Cancer
British Journal of Cancer

I think you'd be better served if we change how we do things on the Physionic Podcast.

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In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria.

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration
Video: https://www.youtube.com/watch?v=7uBHNUSI6hI
Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s

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Study:
A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Benjamin Bikman

In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat.

Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans
Video: https://youtu.be/ldUBG4-EJDo

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Study:
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
A Brianne Thrush

Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy.

Video Version: https://youtu.be/x6EOhTzVKsE
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure

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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence).

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
Video: https://www.youtube.com/watch?v=KQBmtzT4VTU

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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa

In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption.

Video: https://youtu.be/QfII7CANt14
Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle

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Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see..

Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress-

Video: https://youtu.be/TiO16KoH0Fs

Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications?


Video: https://youtu.be/zMkV91E2Bic
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/

In this episode, I attempt to make sense of calories in vs out and reconcile that with the hormone argument for fat loss.

Video Podcast: https://youtu.be/x1ZjjDzCdc0

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Mitochondria have a dark side, find out how.

Video Podcast: https://www.youtube.com/watch?v=HPx7cv1I7eU

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In this podcast, we look at a study that investigates how weight loss affects hormones and long term weight regain - is the deck stacked against you?

Study: https://www.nejm.org/doi/full/10.1056/nejmoa1105816
Video Podcast: https://youtu.be/-t5d0S5MRwE

0:00 - Introduction
2:47 - Study Design
6:58 - Weight Loss & Weight Regain Results
9:45 - Long Term Hormonal Changes from Weight Loss
34:12 - Conclusions/Take Aways

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How does intermittent fasting affect your health, even when you do not lose weight with it? Let's find out.

Study: https://pubmed.ncbi.nlm.nih.gov/29754952/#:~:text=Men%20with%20Prediabetes-,Early%20Time%2DRestricted%20Feeding%20Improves%20Insulin%20Sensitivity%2C%20Blood%20Pressure%2C,Cell%20Metab.
Video Podcast: https://youtu.be/1t0HUSlFNiQ

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0:00 - Introduction
3:23 - Study Design
9:03 - Intermittent Fasting on Health Results
18:24 - "Fasting Increases Inflammation"
20:08 - Intermittent Fasting on Health Continued
23:00 - Conclusions/Take Aways

Title says it all...

Video Podcast: https://youtu.be/u4XirePJKfg

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In this episode, we'll be discussing how sirtuins play their role in mitochondrial health and insulin resistance.

Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/
Video Podcast: https://youtu.be/M9INrzrfsu4  

0:00 - Introduction
3:10 - Diabetes Background
8:30 - Mitochondria Background
13:33 - Mitochondria & Insulin Resistance
20:33 - Sirtuins
43:40 - Conclusions/Take Aways

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In this episode, I summarize the content from a brand new scientific review that discusses the difference between creatine supplementation for the brain vs the rest of the body, as well as a possible alternative.

Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/
Video Podcast: https://youtu.be/gltKZA6JQr0

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In this episode, I cover a study sent to me by a subscriber wherein the researchers discuss a new model for understanding metabolism through their self titled 'Compensation Hypothesis'.

Study: https://www.sciencedirect.com/science/article/pii/S0960982221011209
Video Podcast: https://youtu.be/O7TY-HMZkKA

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In this podcast, I'll be detailing a brand new study deeply investigating the decline in metabolism with age.

Study: https://science.sciencemag.org/content/373/6556/808
Video Podcast: https://youtu.be/cXHxl8dPqG0

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0:00 - Introduction
6:02 - Metabolism over the Lifespan
13:35 - 2 Factors that lead to Metabolism Decline?
23:58 - Conclusion/Take Aways

In this episode, we'll dive into two very similar studies trying to distinguish the effect of the ketogenic diet on cholesterol, blood sugar, insulin, and blood fats (triglycerides).

Video Podcast: https://youtu.be/yx2OuoMZBFg
Study A: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001988/pdf/nutrients-13-00814.pdf
Study B: https://pubmed.ncbi.nlm.nih.gov/12949361/

0:00 - Introduction
3:40 - Study Design
12:18 - Keto on Cholesterol
20:07 - Keto on Blood Sugar & Insulin
22:25 - Keto on Triglycerides
24:05 - Discussing the Results
37:48 - Conclusions/Take Aways

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In this episode, we'll dissect a study wherein the researchers attempt to find out how an unrestricted intermittent fasting protocol works for overweight individuals in aspects of weight, muscle, metabolism, and cardiovascular outcomes like cholesterol, blood sugar, insulin, and so on.

Video Podcast: https://youtu.be/TjEKr7ysbfI
Study: https://pubmed.ncbi.nlm.nih.gov/32986097/

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0:00 - Introduction
5:33 - Study Design
7:26 - Could they Stick to IF?
9:22 - Individual Weight Loss
11:16 - Total Weight Loss
14:40 - Body Composition (Muscle, Fat, etc.)
21:19 - Metabolism
23:25 - Blood Sugar, Insulin, Cholesterol, etc.
26:31 - Conclusions/Take Aways

This week, I return by simply answering questions you guys sent me on Instagram and YouTube.

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0:00 - Introduction
2:35 - Thank you
5:25 - Limited Protein Absorption
8:04 - Protein on Lifespan
12:09 - Ideal Body Fat for Testosterone
14:25 - Threshold that Muscle Stops Protein Synthesis
17:40 - Creatine Bloat
20:48 - Origin of the Virus

In this episode, I cover a scientific review on the literature of protein for muscle growth. We'll be covering protein total amount, timing, type, differences in men and women, aging, and more. Enjoy.

Video Podcast: https://youtu.be/7h-kLKmknEo
Scientific Review: https://link.springer.com/article/10.1007/s40279-019-01053-5

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In this episode, we investigate how elevated blood fats change how our mitochondria "behave" and its affect on autophagy.

Video Podcast: https://youtu.be/g6JJzVkYM7I
Study: https://www.sciencedirect.com/science/article/abs/pii/S0026049521001037

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In this podcast, I dive deeper into yet another study comparing the ketogenic diet for blood cholesterol, with the added bonus of briefly touching on insulin sensitivity. In this episode, we start to recognize the key difference between a healthy ketogenic diet and an unhealthy ketogenic diet.

Study: https://pubmed.ncbi.nlm.nih.gov/15070924/
Video Podcast: https://youtu.be/KEcyW496KGA

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In this episode, we'll be going again into the ketogenic diet, but the context hath changed as the people being tested are healthy and young, non-overweight, unlike previous studies. There are some other caveats, as well, that we'll go into, so buckle up and let's dive in.

Study: https://pubmed.ncbi.nlm.nih.gov/30408717/
Video Podcast: https://youtu.be/bX1cax3zvfQ

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In this episode, we dive into a study looking at how 16 hour intermittent fasting affects a variety of health outcomes when paired with resistance training in non-beginner lifters.

Study: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0
Video Podcast: https://youtu.be/2B99DJwPMCk

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In this episode, the 'keto hater' takes on a study that simply investigates the effects from the ketogenic diet in bodyweight, cholesterol, and blood sugar in people who are overweight.

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/pdf/ecc09200.pdf
Video Podcast: https://youtu.be/bsH1qubGSB8

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In this episode, we'll be beginning our look at senescent cells, how and why they occur, as well as the main drivers of senescence in aging and disease.

Video Podcast: https://youtu.be/NcBpJv5WIhY
Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/pdf/JCB_201708092.pdf

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In this episode, we'll be discussing how different types of saturated and unsaturated fats impact mitochondria in our muscle cells.

Video Podcast: https://youtu.be/2T9I1FmlFyE
Study: https://link.springer.com/content/pdf/10.1007/s00125-005-1895-z.pdf

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In this episode, I discuss some of the valid and non-valid (by my estimation) critiques of the recent ketogenic diet study I covered on the YouTube channel. I also discuss the nutrition style that I follow, specifically.

Video Podcast: https://youtu.be/eE2QpdRSeFY
Keto Damages the Heart Video: https://youtu.be/CAkjoT28yZw
Keto Damages the Heart Podcast: https://youtu.be/lpns8gfR3H8

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In this episode, I discuss a study looking at how a protein (Emilin) and a molecule (TGF-beta) create a scenario in which high blood pressure occurs in animals *and* in the same effect is seen in humans with high blood pressure.

Study: https://pubmed.ncbi.nlm.nih.gov/30354220/
Video Podcast: https://youtu.be/88GqvZ2XjrM

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In this episode, I discuss how, and potential reasons why, cancer cells feed off sugar/glucose.

Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783224/
Video Podcast: https://youtu.be/vszypCVgpaE

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In this episode, we go into a study that investigates if alcohol affects our muscle growth potential by specifically looking at muscle protein synthesis, as well as some proxy markers of protein breakdown.

Study: https://pubmed.ncbi.nlm.nih.gov/24533082/
Video Podcast: https://youtu.be/CaRPAx9gL4U

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This is an involved one, but if you care to join me as I explain my recent publication with my lab wherein we discover and describe a new pathway by which autophagy is mediated in cells, then you'll learn some cutting edge science.

My Study: https://www.researchgate.net/publication/350870898_Parkin-independent_mitophagy_via_Drp1-mediated_outer_membrane_severing_and_inner_membrane_ubiquitination

Video Podcast: https://youtu.be/QmX5xN3H7aU

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This podcast gets really nitty gritty in that it discusses the intracellular signaling pathways and the association between smooth muscle cells and a protein rich foundation known as the extracellular matrix - what causes this weakness in the aorta of the vascular system leading to aneurysm formation? Find out.

Study: https://youtu.be/YlQtTdj2eLo
Video Podcast: https://youtu.be/YlQtTdj2eLo

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In this episode, we finish up from last week by discussing how mitochondrial "behavior" is affected by excessive exercise, as well as its impact on mitochondrial reactive oxygen generation, which can cause damage to our cells.

Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub

MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING
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In this episode, I cover a brand spankin' new study wherein the researchers attempt to answer the question of overdoing exercise and its impact on muscle mitochondria, as well as blood sugar regulation.

Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub

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In this episode, we take a look at a study that investigates the impact weight loss/calorie restriction has on metabolic adaptation; we also briefly discuss the idea of metabolic "damage". This is one of a few episodes that I'll be using to cover the topic of metabolic adaptation.

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328781/?fbclid=IwAR3WSvSpNLzgnwfGh_xyAEx4Txh9z91LnjbW2CFrbbzSS0cM-47MGL4eUxU

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In this episode, I take us on a brief breakdown of a study looking at the ketogenic diet and its impact on heart cell death, heart size, and mitochondrial content. Some intriguing, potentially alarming, results here, but we'll see what interpretations we can really make on this data - dive in with me!

Study: https://www.nature.com/articles/s41392-020-00411-4

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In this episode, I attempt to make it as clear as possible, by comparison of high fat/keto to high carbohydrate diets and how they differ in their ability produce body fat loss, although one promotes greater fat burning/oxidation.

Video Podcast (available at 10am ET): https://youtu.be/Ns0tXvLI-OI

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In this episode, I give a bit of a higher level view on metabolic flexibility - what is it? Why is it important? Instances of it? How to improve it? That's all covered in this podcast - enjoy!

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In this episode, I briefly cover certain aspects of a study that looks into how effective fasting, specifically multi day water fasting, affects our mitochondrial content in our cells (muscle).

Video Podcast: https://youtu.be/KMU1OcGjjLw

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In this episode, I cover more detail on an experiment I decided to try on myself over the last 10 months wherein I try to maintain my muscle with minimal effort. I answer questions from 10 people who wrote questions out on how I pulled it off, as well as other questions related to fat loss and muscle perseveration.

Video being Discussed [I Ran an Experiment on Myself]: https://youtu.be/qtim_tXkVoQ

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In this podcast, we'll be going over a presentation I gave in one of my courses on Muscle Biology - specifically, how certain mutations in a gene can impede muscle cells' ability to fuse, and on top of that, why some people survive it and why others do not.

Study: https://www.nature.com/articles/ncomms16077

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There is no human condition wherein you will be at peak form in multiple areas. Much like the idea of the generalist vs the specialist - your body can't be a specialist in all ways, and in the same vein, there is no diet that will be the "ultimate" diet that will help you achieve peak-ness in all areas. The discussion of lifespan vs health span is a great example of that, as well as the idea of growth and uncontrolled growth (cancer).

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In this content, I dive into a study looking into three hunger related hormones and the effect water fasting and calorie counting have, in obese and lean individuals, on three hunger hormones - leptin, melanocyte stimulating hormone (MSH), and Aguiti Related Protein (AgRP). Does fasting stimulate these hormones or does calorie counting? Does obesity play a factor? Find out!

Study: https://pubmed.ncbi.nlm.nih.gov/15212642/

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In this episode, I discuss a molecule I ran across when listening to the Joe Rogan Experience. This molecule, known as fractalkine, has some unique characteristics and potential implications in a series of different diseases and brain related health outcomes - mostly related to inflammation in the brain.

Review: https://pubmed.ncbi.nlm.nih.gov/26084002/

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In this episode, we briefly discuss three ways that creatine positively affects us in muscle, the brain, and inflammation. I also introduce my first paid content that I spent most of 2020 working on, as well as a new website for your viewing pleasure - it was a busy 2020 for me!

Creatine Book and Course: https://www.physionic.org/booksandcourses

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In this episode, I go into a bit more detail on a topic I've just started releasing content on (in video form). This subject is on a hormone that also leads to fat storage, much like insulin, yet many keto espousing gurus either ignore or are not aware of it; this is convenient, since this hormone is stimulated by fat consumption, not carbohydrate consumption (the exact anti-thesis to insulin).

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In this episode, we'll be diving head long into a study investigating the first slice of "chrono nutrition" on Physionic. I love this study, because they do several things really well and give us some clear answers regarding intermittent fasting and its impact on insulin sensitivity *independent* of calorie intake (finally!).

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528549/pdf/nqaa192.pdf

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In this podcast, I decided to jump into an area I've created a decent amount of isolated content and put it into one place. I go into a bit of depth, but not complete depth into three mechanisms of muscle growth - from the classic "muscle damage" to metabolic stress. Knowing this information can easily help us understand how to create training programs that aren't centered around old fashioned thinking - something I'll certainly touch on more, in the future.

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In this episode, we'll be diving into our third and final part of our "Nutrition on Depression" podcast wherein we'll be touching on depression's link in obesity, epigenetics, and the amino acid tryptophan (the same stuff found in turkey, and many other foods). Hopefully you find some, if not all, the information useful and informative. If you'd like to see the visuals, check out the video version of the podcast, as well.

Study: https://www.nature.com/articles/s41380-020-00925-x
Video (after 10am ET): https://youtu.be/Nxe9AeVlblM

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In this episode, we continue our dive into these different nutrients and nutritionally linked reasons why people have worsening depression and what to do against it, nutritionally. This is part 2 of a 3 part podcast series discussing nutrition and its relationship to depression. I'll go into the microbiome, cortisol release from the HPA axis, and BDNF on brain cell growth.

Study: https://www.nature.com/articles/s41380-020-00925-x

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In this episode, I begin with part 1, wherein we'll be discussing how depression is linked to inflammation, mitochondrial dysfunction, and oxidative stress, as well as several nutrients that can help reduce these effects negatively affecting mental health.

Study: https://www.nature.com/articles/s41380-020-00925-x

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In this episode, I'll be trying my best to make sense of a pretty "all over the place" scientific review that attempts to make sense of how fasting (and calorie deficits) affect skin health, as well as aging.

Video Version: https://youtu.be/ihV7hOhAk58

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In this episode, we dive into a study that investigates the effect caffeine has on insulin sensitivity, but also on a few other parameters, like blood pressure, catecholamines, and free fat.

Study: https://care.diabetesjournals.org/content/25/2/364.full-text.pdf

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In this episode, I have the absolute pleasure of welcoming a good friend of mine back to the podcast to discuss a paper he picked out looking at a unique way that creatine affects our fat cells - specifically, the mitochondria within fat cells.

Creatine Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656041/

Alec's Podcast (Physiology Forum):
Apple: https://podcasts.apple.com/us/podcast/the-physiology-forum/id1524358256?id=1524358256&ign-mpt=uo%3D4
iHeartRadio: https://www.iheart.com/podcast/269-the-physiology-forum-63366437/
Podbean: https://thephysforum.podbean.com/

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In this episode, we dive into an extremely simple study that investigates how quickly men and women, compared against one another, gain muscle strength from a resistance training program. Not only that, it touches on some interesting perspectives related to hormones and how the lack of testosterone in women may not be as detrimental as one might imagine - tune in and find out!

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756754/

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In this podcast, we'll be going over a study that touched on an interesting discovery between fat cells and our immune system when a person undergoes an extended (10 day) water fast.

Study: https://reader.elsevier.com/reader/sd/pii/S2212877820301563?token=8C7127DDF72DF25D84C3810C2A6673547BFB183F9FA75E6692EA9472DCC7CC12A193097F7212AC3D993955B07CAA1405

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In this episode, I do a deep dive into a study that finally tries to answer if saturated fat increases our cholesterol levels, independent of weight gain. Not only that, it also investigates the impact it has on the liver in terms of fatness - does it cause fatty liver disease?

Study: https://academic.oup.com/jcem/article/104/12/6207/5540968

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In this episode, I'll be taking you through a study on alternate day fasting and its affects on cholesterol, fat, muscle, and three unique hormones - all in people without cardiovascular issues, which makes this study that much more unique.

Study: https://onlinelibrary.wiley.com/doi/10.1038/oby.2010.54

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In this podcast, I brush across a variety of concepts and information related to the hypothesis of "body weight set point" that espouses the idea that the body sticks to roughly the same set point in body weight when we attempt to change our weight, the body fights against that imposed change - why? What mechanisms and reasons might there be? Is there a better theory?

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990627/#bib-010

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In this episode, I'll be walking us through a case study that recently released on a natural bodybuilder that was followed and measured by researchers for 12 months. They wanted to know how extreme dieting to low single digit body fat would affect testosterone, thyroid hormone, muscle mass, metabolism, and more, and if there were any negative effects, how long would it take to recover?

Study: https://pubmed.ncbi.nlm.nih.gov/32898035/

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In this episode, we'll be getting into a study looking at the ketogenic (high fat) diet and its comparison to a calorie restricted low fat diet on various markers of health.

Study: https://academic.oup.com/jcem/article/88/4/1617/2845298

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In this episode, I'll be explaining, based on a brand new case study, why the risk for re-infection is present, and what this means for the future of vaccines and herd immunity.

Study: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1275/5897019

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In this episode, we cover a study investigating if 4 different artificial sweeteners (Sucralose, RebA, Saccharin, and Aspartame) cause weight gain, insulin issues, spikes in blood sugar, cravings, and more.

Study: https://academic.oup.com/ajcn/article/109/5/1288/5475055

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In this episode, we'll be looking at a brief clinical trial looking at coenzyme Q10 (CoQ10, ubiquinone) and its affect on migraines in clinically evaluated migraine sufferers. If CoQ10 works, how much was used? How beneficial is it? Are there caveats? All that and more is covered here.

Study: https://www.semanticscholar.org/paper/Efficacy-of-coenzyme-Q10-in-migraine-prophylaxis%3A-A-S%C3%A1ndor-Clemente/a3d4701fc58f7747a1cff3ddcd978a0794a50dc2

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In this episode, we'll be diving into a study investigating the role intermittent fasting has on a series of health markers, but specifically on cholesterol and blood pressure - it's not all good news, or is it?

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645638/

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In this episode, I discuss a meta-analysis looking into the associations between animal and plant based proteins, as well as total protein, and their relationships to cancer, cardiovascular disease (heart disease, stroke, etc.), and overall mortality. Is plant protein superior?

Study: https://www.bmj.com/content/370/bmj.m2412

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In this episode, I had the pleasure of having a friend and microbiome researcher Bern Monari on to educate us on the microbiome and the research therein. I hope this podcast ends up interesting, because I certainly found it to be, and Bern adds quite a bit to my knowledge of the matter. Enjoy!

Bern's LinkedIn (to ask questions): https://www.linkedin.com/in/bernadinemonari/

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Bern's References:

1. Marchesi JR, Ravel J. The vocabulary of microbiome research: a proposal. Microbiome.2015;3:31.

2. NIH Human Microbiome Project defines normal bacterial makeup of the body [press release]. nih.gov: NIH, 2015-08-31 2015.

3. Ochman AHM, Steffen F, Michael LW, Anne EP, Beatrice HH, Howard. Social behavior shapes the chimpanzee pan-microbiome. Science Advances.2016;2(1).

4. Engel P, Kwong WK, McFrederick Q, et al. The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions. mBio.2016;7(2):e02164-02115.

5. Rudman SM, Greenblum S, Hughes RC, et al. Microbiome composition shapes rapid genomic adaptation of Drosophila melanogaster. Proceedings of the National Academy of Sciences.2019;116(40):20025-20032.

6. Edwards VL, Smith SB, McComb EJ, et al. The Cervicovaginal Microbiota-Host Interaction Modulates <span class="named-content genus-species" id="named-content-1">Chlamydia trachomatis</span> Infection. mBio.2019;10(4):e01548-01519.

7. Jobira B, Frank DN, Pyle L, et al. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. The Journal of Clinical Endocrinology & Metabolism.2020;105(6).

8. Luu M, Monning H, Visekruna A. Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy. Frontiers in Immunology.2020;11(1225).

9. Allegretti J. Stool transplants are now standard of care for recurrent C. difficile infections - Harvard Health Blog. health.harvard.edu. https://www.health.harvard.edu/blog/stool-transplants-are-now-standard-of-care-for-recurrent-c-difficile-infections-2019050916576. Published 2019. Updated 2019-05-09. Accessed2020.

10. Types of Infections After Stem Cell or Organ Transplants. https://nyulangone.org/conditions/infections-after-stem-cell-or-organ-transplants/types. Published 2020. Accessed 07/16/2020, 2020.

11. Cdc. Reports of Selected E. coli Outbreak Investigations | E. coli | CDC. 2020. https://www.cdc.gov/ecoli/outbreaks.html. Accessed 2020-02-26T02:39:54Z.

12. van de Wijgert JHHM, Verwijs MC, Agaba SK, et al. Intermittent Lactobacilli-containing Vaginal Probiotic or Metronidazole Use to Prevent Bacterial Vaginosis Recurrence: A Pilot Study Incorporating Microscopy and Sequencing. Scientific Reports.2020;10(1):1-15.

13. Yong E. You're Probably Not Mostly Microbes. The Atlantic. 2016-01-08, 2016.

In this episode, I had the pleasure of having a fellow researcher and class mate David Rach on the podcast to discuss his experience as a participant in a CoVID-19 vaccine trial. However, not only that, he is getting his PhD in Microbiology and Immunology, so he was able to discuss some of the science behind vaccine development, as well as the preliminary results of the trial he was in.

David's Info
Twitter: @DavidRach2
Facebook Post on the Topic: https://tinyurl.com/yazocyla
Vaccine Trial Data: https://www.medrxiv.org/content/10.1101/2020.06.30.20142570v1.full.pdf?fbclid=IwAR3guvvo_TdhDAh1tDZwTUH5rRH-p-I7sanyfoM9Dp3-8wK-cydchyNrmEU
More info: coronaviruspreventionnetwork.org

In this episode, we'll be taking a look at some information on fiber, but more poignantly focused on stomach bloating and how it relates to fiber, as well as some things to consider to lower bloating from the lack or incorrect fiber intake.

Fiber & Gas Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774297/

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In this episode, I go on a monologue wherein I discuss the various ways skin can be damaged and become unhealthy before diving into a few habits and ingredients that have been known to aid in replenishing the health and youth of our skin.

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In this episode, I decided to dedicate some time to discussing the brand new reports that a woman suffering from sickle cell anemia has been effectively cured of the disease that would have continued to ruin her life moving forward. The cure wasn't a drug, but the first time use of genetic engineering to cure the disease. Pretty brilliant work on all involved.

Article: https://www.npr.org/sections/health-shots/2020/06/23/877543610/a-year-in-1st-patient-to-get-gene-editing-for-sickle-cell-disease-is-thriving

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In this episode, I discuss two topics. First, we go into how to change the intensity variable when building an effective at home workout program for muscle growth, muscle maintenance, and muscle tone. Secondly, we dive into a bit of cancer and how cancer can "hide" or protect itself against chemotherapies - how does it return?

2:48: Workout at Home
21:35: Cancer & Chemotherapy

Hey everyone, in this episode, I'll be going into a bit of history on how the United States handled their medical practices in the 1800s by comparison to Europe. I talk about the impact Johns Hopkins University had on the entire medical field in the United States, and then I discuss a bit on zoonotic viruses (viruses that jump from animals to humans).

Medical History: 1:36
Zoonotic Virus: 23:04

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