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Hope & Histamine: The Paediatric Allergy Podcast

“Helping you understand allergies—one episode at a time”
Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children.
From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical advice—empowering parents, caregivers, and patients with reliable information and hope.
Tune in for expert insights, real stories, and up-to-date recommendations designed to help you breathe a little easier.
- 70 - Newborn Bathing & Baby Skincare: Can They Prevent Eczema? Insights from the EAACI Global Survey
Could a newborn’s first bath and early skincare routine influence their risk of developing eczema? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore an EAACI task force global survey of 319 international specialists, examining clinicians’ recommendations on neonatal bathing, baby skincare and the prevention of atopic dermatitis. We discuss when to give the first bath, how to cleanse delicate newborn skin, and recommendations on moisturisers. We also explore w...
Thu, 29 Oct 2026 - 69 - Nasal Steroids in Children: Allergic Rhinitis, Adenoids & Safety—What Does the Evidence Say?
Are nasal steroid sprays safe for children—and when do they really help? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore intranasal corticosteroids in children, from treating allergic rhinitis and hay fever to their potential role in enlarged adenoids and nasal obstruction. Drawing on a 2026 review in Pediatric Allergy and Immunology, we unpack the evidence behind these widely used treatments and address questions that matter to clinicians and families: • H...
Thu, 22 Oct 2026 - 68 - Paediatric Asthma Update: What’s New in Childhood Asthma Management?
What’s new in childhood asthma care—and what does it mean for everyday practice? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore recent advances in paediatric asthma management, from inhaled treatments and personalised care to the evolving role of biologics in severe asthma. We discuss key questions around asthma diagnosis, inhaler technique, treatment adherence and preventing exacerbations, alongside emerging approaches to help children achieve better asth...
Mon, 12 Oct 2026 - 67 - Omalizumab vs Oral Immunotherapy for Multiple Food Allergies: OUtMATCH Trial Explained
How does omalizumab compare with oral immunotherapy for treating multiple food allergies? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore OUtMATCH Stage 2, comparing omalizumab (Xolair) with omalizumab-facilitated multi-allergen oral immunotherapy (OIT). We unpack the findings on treatment success, allergic reactions, side effects and treatment discontinuation—and explain why tolerability matters when interpreting the results. What do these findings mean fo...
Sat, 03 Oct 2026 - 66 - Eggs and Peanuts in Pregnancy: Why More Didn’t Reduce Infant Allergy Risk
Can eating more eggs and peanuts during pregnancy and breastfeeding reduce a baby’s risk of developing food allergy? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the PrEggNut trial, a large randomised study involving more than 2,100 pregnant women whose babies had a strong family history of allergic disease. Researchers compared a maternal diet rich in eggs and peanuts with a standard-intake diet from pregnancy until four months after birth. Despite grea...
Tue, 22 Sep 2026 - 65 - Kounis Syndrome Explained: When a Severe Allergic Reaction Triggers Acute Coronary Syndrome
What happens when a severe allergic reaction affects not only the skin and airways but also the coronary arteries? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Kounis syndrome—an acute coronary syndrome triggered by an allergic or hypersensitivity reaction. We discuss how mast-cell activation and inflammatory mediators can cause coronary artery spasm, plaque disruption or stent thrombosis, resulting in symptoms that may resemble a heart attack alongside ...
Sun, 13 Sep 2026 - 64 - Rethinking the Blue Inhaler: Budesonide–Formoterol vs Salbutamol in Children with Mild Asthma | The CARE Trial
Is it time to rethink the traditional blue reliever inhaler for children with mild asthma? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the landmark 2025 CARE trial published in The Lancet. This 52-week randomised controlled trial compared budesonide–formoterol with salbutamol as reliever therapy in children with mild asthma. We explore whether an anti-inflammatory reliever inhaler can provide better protection than salbutamol alone, examining the trial’...
Mon, 07 Sep 2026 - 63 - The Peanut Patch Revolution: Is Epicutaneous Immunotherapy the Future of Peanut Allergy Treatment in Children?
Could a simple skin patch transform the treatment of peanut allergy in young children? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence on epicutaneous immunotherapy (EPIT)—also known as the peanut patch—for toddlers and children with peanut allergy. Drawing on findings from the EPITOPE and EPOPEX studies, we examine how peanut patch therapy works, its long-term effectiveness and safety, and whether it can increase the amount of peanut a ...
Fri, 28 Aug 2026 - 62 - Dupilumab in Children: A Game-Changer for Eczema, Asthma and Atopic Disease
Dupilumab has transformed the treatment of several type 2 inflammatory conditions—but how does it work, which children may benefit, and what should clinicians and families know before starting treatment? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the expanding role of dupilumab in paediatrics, including its use in atopic dermatitis (eczema), severe asthma and eosinophilic oesophagitis. We discuss how blocking interleukin-4 and interleukin-13 signalling...
Wed, 19 Aug 2026 - 61 - Pediatric Hereditary Angioedema: Diagnosis, Treatment & Long-Term Management
Hereditary angioedema (HAE) is a rare but potentially life-threatening genetic disorder that often presents during childhood, yet diagnosis is frequently delayed for many years. Early recognition and timely treatment can dramatically improve quality of life and reduce the risk of serious complications, including airway obstruction. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence and practical approaches to diagnosing and managing paediat...
Sat, 08 Aug 2026 - 60 - Allergy and Eustachian Tube Dysfunction: Causes, Symptoms, Diagnosis & Treatment
Why do your ears feel blocked during allergy season? Can hay fever really affect your hearing? What causes that frustrating sensation of ear fullness, popping, crackling or pressure that just won’t go away? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the important relationship between allergic disease and Eustachian Tube Dysfunction (ETD)—a common but often misunderstood condition affecting both children and adults. Join us as we discuss: What the Eusta...
Sat, 01 Aug 2026 - 59 - Orofacial Granulomatosis (OFG): Symptoms, Diagnosis, Causes & Modern Treatment
Orofacial Granulomatosis (OFG) is a rare but often overlooked inflammatory condition that can present with persistent lip swelling, oral ulcers, gum changes, and facial swelling. Because its symptoms overlap with many other conditions, diagnosis is frequently delayed, leaving patients and families searching for answers. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we take a deep dive into the science and clinical management of Orofacial Granulomatosis. We discuss w...
Fri, 24 Jul 2026 - 58 - Idiopathic Anaphylaxis Explained: Causes, Diagnosis & Treatment
What happens when someone experiences anaphylaxis, but no trigger can be identified? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore idiopathic anaphylaxis—a diagnosis that can be both frightening for patients and challenging for clinicians. Join us as we discuss the latest understanding of idiopathic anaphylaxis, including how it is diagnosed, important conditions that can mimic anaphylaxis, and the investigations needed to exclude identifiable causes such...
Mon, 13 Jul 2026 - 57 - Preventing and Treating Peanut Allergy in Children: From Early Introduction to Immunotherapy
Peanut allergy has become one of the most important and widely discussed topics in paediatric allergy. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the prevention and treatment of peanut allergy in children, from the landmark evidence supporting early peanut introduction to the evolving role of oral immunotherapy. We discuss why peanut allergy develops, which children are at higher risk, and how early dietary exposure may help reduce the chance of allerg...
Sat, 04 Jul 2026 - 56 - Eosinophilic Oesophagitis (EoE) Explained: Pathophysiology, Diagnosis, and Modern Treatment Strategies
In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Eosinophilic Oesophagitis, or EoE— an increasingly recognised allergic inflammatory condition of the oesophagus that can affect feeding, swallowing, growth, and quality of life in children and young people. We break down the pathophysiology of EoE, including the role of food allergens, type 2 inflammation, eosinophils, epithelial barrier dysfunction, and immune signalling pathways. The episode also covers how ...
Wed, 24 Jun 2026 - 55 - Bee and Wasp Sting Allergy in Children: Diagnosis, Risk Assessment and Management of Hymenoptera Venom Allergy
In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the diagnosis and management of Hymenoptera venom allergy in children, including allergic reactions to bee, wasp and other insect stings. We discuss how to distinguish between normal local reactions, large local reactions and systemic allergic reactions, and when a child should be referred for specialist allergy assessment. The episode covers key aspects of diagnosis, including clinical history, venom-specific...
Sun, 14 Jun 2026 - 54 - Food Allergy Anxiety: The Hidden Impact on Children, Parents and Everyday Life
Food allergies are often seen as a medical condition centred around avoidance, emergency plans and adrenaline auto-injectors — but the impact goes far beyond the plate. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore how food allergies affect children’s emotional wellbeing, family life, school experiences, social confidence and overall quality of life. We discuss the anxiety, fear and daily uncertainty that many children and parents live with, from checking...
Sat, 06 Jun 2026 - 53 - Ibuprofen Allergy or NSAID Hypersensitivity in Children? Diagnosis and Management Guide
NSAID hypersensitivity in children can be challenging to recognise, diagnose, and manage safely. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore paediatric NSAID hypersensitivity, including reactions to commonly used medicines such as ibuprofen and other non-steroidal anti-inflammatory drugs. We discuss the different types of NSAID reactions, how to distinguish true hypersensitivity from other adverse effects, and the importance of a careful clinical histor...
Fri, 29 May 2026 - 52 - Penicillin Allergy in Children: Myths, Diagnosis, Delabelling, and Safe Antibiotic Choices
Penicillin allergy is one of the most commonly reported drug allergies in children — but many children labelled as “penicillin allergic” are not truly allergic. In this episode, we explore why penicillin allergy labels matter, how they can affect antibiotic choices, and why accurate assessment is so important for safer, better care. We discuss the difference between true allergic reactions and common childhood rashes, the key features clinicians look for in the history, and when referral or a...
Fri, 22 May 2026 - 51 - Alpha-Gal Syndrome Explained: Tick-Bite Meat Allergy, Symptoms, Diagnosis and Management
In this episode of Hope & Histamine, we explore Alpha-Gal Syndrome (AGS) — a fascinating and increasingly recognised form of tick-bite-related allergy that can cause delayed allergic reactions to red meat and other mammalian-derived products. We break down what Alpha-Gal Syndrome is, how tick bites can trigger sensitisation to the alpha-gal molecule, and why symptoms often appear several hours after eating foods such as beef, lamb, pork or venison. The episode also covers the key clinical...
Mon, 11 May 2026 - 50 - Chronic Urticaria Treatment Explained: Antihistamines, Biologics and New Therapies for Long-Term Hives
Chronic urticaria can be frustrating, unpredictable and deeply disruptive — but modern treatment has moved far beyond “just take an antihistamine.” In this episode of Hope & Histamine, we explore the pharmacological treatment of chronic urticaria, from regular non-sedating antihistamines and dose escalation to specialist therapies such as omalizumab and emerging treatment options. We discuss how chronic spontaneous urticaria is managed using a stepwise approach, when to consider treatment...
Mon, 04 May 2026 - 49 - Chronic Urticaria in Children: Clinical Features, Pathogenesis and Diagnostic Evaluation
In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore chronic urticaria in children, including its key clinical features, underlying pathogenesis, and practical approach to diagnostic evaluation. Chronic urticaria can be distressing for children and families, often causing recurrent itchy wheals, angioedema, sleep disruption and anxiety about possible triggers. This episode breaks down how chronic urticaria presents, why it happens, and how clinicians can disting...
Tue, 28 Apr 2026 - 48 - The Role of Vitamin D in Allergic Disease: Eczema, Asthma, Food Allergy and Beyond
In this episode of Hope & Histamine, we explore the fascinating and often debated role of vitamin D in allergic disease. From eczema, asthma, and allergic rhinitis to food allergy, vitamin D has been linked to immune regulation and allergic inflammation in ways that continue to generate interest among clinicians, researchers, and families alike. We discuss what vitamin D actually does in the body, why it matters for the immune system, and what current evidence suggests about its relations...
Sun, 19 Apr 2026 - 47 - Severe Asthma in Children: Evaluation, Diagnosis and Management
Severe asthma in children can be challenging to recognise, investigate and manage effectively. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the evaluation and management of severe asthma in children, including how to distinguish it from difficult-to-treat asthma, key clinical assessments, common mimics, adherence issues, comorbidities, and the latest treatment approaches. We discuss the importance of a structured paediatric severe asthma assessment, the ...
Thu, 09 Apr 2026 - 46 - Understanding Biomarkers in Asthma and Allergic Diseases
In this episode, we explore the growing role of biomarkers in asthma and allergic diseases and why they are becoming essential in modern diagnosis, phenotyping, monitoring, and personalised treatment. We discuss key asthma biomarkers and allergy biomarkers, including blood eosinophils, FeNO (fractional exhaled nitric oxide), total and specific IgE, and their relevance in identifying type 2 inflammation, allergic asthma, severe asthma, and other allergic conditions. This episode looks at how b...
Sun, 22 Mar 2026 - 45 - How Cigarette Smoke Worsens Asthma: Symptoms, Risks and Prevention
How does cigarette smoke affect asthma? In this episode, we discuss the relationship between asthma and cigarette smoke exposure, including secondhand smoke, passive smoking, and the impact of tobacco smoke on airway inflammation, wheeze, cough, breathlessness, asthma attacks, and long-term asthma control. Learn why smoke exposure is a major asthma trigger, how it affects children and adults, and what families and healthcare professionals can do to minimise exposure and protect lung health. A...
Mon, 16 Mar 2026 - 44 - Treatable Traits in Asthma Care: A Personalised Medicine Approach to Better Asthma Control
Asthma care is changing. In this episode, we explore the concept of treatable traits in asthma and why a personalised, precision-medicine approach is transforming the way we assess and manage patients. Rather than viewing asthma as a single disease, the treatable traits model helps clinicians identify specific biological, clinical, and behavioural factors that drive symptoms, poor control, and exacerbations. We discuss how traits such as eosinophilic inflammation, poor inhaler technique, alle...
Tue, 10 Mar 2026 - 43 - Gustatory Sweating After Eating: Frey’s Syndrome Misdiagnosed as Food Allergy
Frey’s syndrome can look exactly like a food allergy: facial flushing, warmth, sweating (sometimes even a “rash-like” redness) that appears within minutes of eating. Parents panic, clinicians worry about IgE-mediated reactions, and children can end up labelled with a food allergy they don’t actually have. In this episode, we unpack Frey’s syndrome (gustatory sweating)—why it happens, who gets it (including infants and children), and the classic pattern: unilateral or patchy facial redness/swe...
Wed, 04 Mar 2026 - 42 - Foetal Origins of Allergy: How Early Nutrition Programs Lifelong Immune Health
In this episode, we unpack The Foetal Origins of Allergy and the idea that the foundations of allergic disease may be laid before birth. Using the lens of early nutritional programming (often discussed within the DOHaD – Developmental Origins of Health and Disease framework), we explore how the in-utero environment can influence immune development, tolerance, and later risk of conditions like eczema, food allergy, allergic rhinitis, and asthma. We’ll break down what the science actually sugge...
Fri, 27 Feb 2026 - 41 - Allergic Reactions to Anisakis in Fish: Symptoms, Diagnosis & Prevention
Ever had a patient (or child) react to fish even when it’s been properly cooked—and the story just doesn’t fit a classic “fish allergy”? This episode dives into Anisakis: the tiny parasitic worm found in marine fish and squid that can trigger allergic reactions ranging from hives and swelling to anaphylaxis—sometimes even without active infection. We break down: What Anisakis is and which fish are most commonly implicatedHow reactions can mimic (or coexist with) true fish/seafood allergyTypic...
Sat, 21 Feb 2026 - 40 - Scombroid (Histamine) Fish Poisoning: Symptoms, Treatment & How to Prevent It
Ever seen someone develop flushing, hives, a pounding headache, or even wheeze soon after eating fish—and everyone assumes it’s a “fish allergy”? In this episode, we unpack Histamine (Scombroid) Fish Poisoning, a common and often mislabelled cause of allergy-like reactions after eating fish such as tuna, mackerel, mahi-mahi, sardines, anchovies, and bonito. You’ll learn why it happens (histamine build-up from improper chilling/handling), how fast symptoms start, and the key clinical clues tha...
Sat, 14 Feb 2026 - 39 - Shellfish Allergy in Children: Symptoms, Diagnosis, Testing & Treatment
Shellfish allergy can feel scary—especially when reactions can be sudden and severe. In this episode, we break down shellfish allergy in a clear, practical way: common symptoms (from hives to breathing problems), when to suspect anaphylaxis, and what to do in the moment. We also cover diagnosis and testing (skin prick tests, blood IgE, and when an oral food challenge might be considered), plus the tricky stuff like cross-contact in restaurants, takeaway risks, and food labels. Whether you’re ...
Sun, 08 Feb 2026 - 38 - Does Colostrum Protect Against Peanut Allergy? Birth Cohort Findings Explained
In this episode, we explore a fascinating question in early-life allergy prevention: could colostrum act as a protective factor against peanut allergy? Using evidence from a birth cohort study, we break down what the research actually found, how strong the association is, and what it might mean for parents and clinicians. We’ll cover: What colostrum is and why it matters for immune developmentHow a birth cohort study is designed (and what it can and can’t prove)Possible biological mechanisms:...
Sat, 31 Jan 2026 - 37 - Extraintestinal Manifestations of Coeliac Disease: Symptoms Beyond the Gut (Skin, Anaemia, Bones & Brain)
Coeliac disease isn’t always a “gut problem.” In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we unpack the extraintestinal manifestations of coeliac disease—the symptoms that show up beyond the digestive tract and can be easy to miss. We explore the most common non-GI presentations, including iron-deficiency anaemia, fatigue, poor growth or delayed puberty, mouth ulcers, dental enamel defects, bone pain/low bone density, headaches, low mood/brain fog, and the classic...
Sun, 25 Jan 2026 - 36 - Coeliac Disease Explained: Symptoms, Testing, and Going Gluten-Free
Coeliac disease can be easy to miss — and the symptoms aren’t always “classic” tummy pain or diarrhoea. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we break down what coeliac disease is, why it happens, and how to recognise it early, especially in children. We cover: The common and hidden symptoms (from abdominal pain and bloating to fatigue, anaemia, mouth ulcers, headaches, and poor growth)Who should be tested — including children with family history, type 1 dia...
Mon, 19 Jan 2026 - 35 - Wheat Allergy: Symptoms, Causes, Diagnosis & Management
Wheat allergy can be confusing — especially when “gluten-free” gets mixed up with coeliac disease, wheat intolerance, or everyday tummy troubles. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we break down wheat allergy in babies and children in a clear, practical way. You’ll learn the common symptoms (from hives and vomiting to wheeze and anaphylaxis), when to suspect an IgE-mediated reaction vs a delayed reaction, and how clinicians diagnose wheat allergy using a ...
Tue, 13 Jan 2026 - 34 - Pancake Syndrome Explained: Dust Mite–Contaminated Flour and Severe Food Allergy
🥞 Can pancakes really cause anaphylaxis? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Pancake Syndrome — a rare but potentially severe allergic reaction caused by dust mite-contaminated flour rather than the pancake ingredients themselves. You’ll learn how improper storage of flour can lead to mite proliferation, why cooking does not eliminate the allergen risk, and which children are most at risk — particularly those with house dust mite allergy, eczema...
Thu, 08 Jan 2026 - 33 - House Dust Mite Allergy Explained: Symptoms, Triggers, and Practical Solutions
Is house dust mite allergy the hidden cause of year-round sneezing, blocked nose, wheeze, or eczema in children? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore house dust mite allergy—one of the most common triggers of persistent allergic symptoms in children and adults. This episode explains what house dust mites are, why they cause allergy, and how exposure inside the home can drive ongoing symptoms such as allergic rhinitis, asthma, cough, and eczema. W...
Thu, 01 Jan 2026 - 32 - Grass Pollen Allergy (Hay Fever): Causes, Symptoms, and Modern Treatments
Grass pollen allergy, commonly known as hay fever or seasonal allergic rhinitis, affects millions of children and adults—especially during the spring and summer months. In this episode, we break down what a grass pollen allergy is, why it happens, and how it can be effectively diagnosed and managed. You’ll learn how grass pollen triggers allergic inflammation, the common symptoms to watch out for (sneezing, itchy eyes, nasal congestion, cough, and fatigue), and how to distinguish hay fever fr...
Tue, 23 Dec 2025 - 31 - Pollen Food Syndrome (Oral Allergy Syndrome): Symptoms, Triggers & Practical Management
Pollen Food Syndrome (also known as Oral Allergy Syndrome) is one of the most common — yet frequently misunderstood — food-related allergic conditions. In this episode of Hope & Histamine, we unpack why people with hay fever or pollen allergy can experience itching, tingling, or swelling of the lips, mouth, and throat after eating certain fresh fruits, vegetables, and nuts. We explain: What Pollen Food Syndrome is and how it differs from true IgE-mediated food allergyThe role of pollen–fo...
Thu, 18 Dec 2025 - 30 - Blueberries for Babies: Introducing Blueberry as a First Complementary Food
Can babies eat blueberries as one of their first solid foods? When should blueberries be introduced during weaning and complementary feeding? Are blueberries safe, nutritious, and allergy-friendly for infants? In this episode, we explore the role of blueberries as an early complementary food for babies starting solids. Drawing on evidence-based infant nutrition guidance, this episode breaks down when and how to introduce blueberries, their nutritional benefits (including fibre, antioxidants, ...
Sat, 13 Dec 2025 - 29 - Precautionary Allergen Labelling: What ‘May Contain’ Really Means for Families
Precautionary Allergen Labelling (PAL) — those familiar phrases like “may contain nuts” or “made in a factory that handles milk” — is meant to keep people with food allergies safe. But does it always help? Or can it create confusion and unnecessary fear? In this episode, we unpack the world of precautionary allergen labels and what they really mean for families living with food allergies. We explore how PAL is regulated, why companies use it, and the challenges it brings for parents trying to...
Mon, 08 Dec 2025 - 28 - Nasal Adrenaline: A Game-Changer for Anaphylaxis Care?
Severe allergic reactions can happen anywhere, anytime — and every second counts. In this episode, we explore the exciting new development of adrenaline nasal spray (Neffy) as a potential needle-free treatment for anaphylaxis. Could this innovation improve how quickly lifesaving medication is delivered? Could it reduce hesitation, fear of injections, and treatment delays? Join us as we break down: How adrenaline nasal spray works in the bodySafety, ease of use, and real-world benefitsDifferen...
Tue, 02 Dec 2025 - 27 - Ultra-Processed Foods: How They Impact Your Health & Long-Term Disease Risk
Ultra-processed foods (UPFs) are now a major part of children’s diets — colourful packaging, cartoon characters, and convenience make them hard to resist. But what are these foods really doing to young bodies and developing brains? In this episode, we uncover the science behind UPFs and children’s health, including: • How ultra-processed foods affect growth, metabolism, and immune health • Links with obesity, diabetes, fatty liver disease & heart disease risk • The impact on gut bacteria,...
Sat, 29 Nov 2025 - 26 - Multiplex Allergy Testing with ImmunoCAP ISAC: What Clinicians Need to Know
Discover how ImmunoCAP ISAC multiplex allergen testing is reshaping the future of allergy diagnosis. In this episode, we break down the science behind ISAC technology, how it identifies over 100 molecular allergen components in a single test, and why it’s transforming clinical decision-making for food allergy, respiratory allergy, venom allergy, and complex polysensitisation. We explore: How ImmunoCAP ISAC works and what makes it uniqueWhen clinicians should consider multiplex molecular diagn...
Sun, 23 Nov 2025 - 25 - Basophil Activation Test (BAT): Accuracy, Interpretation & Clinical Use in Allergy Diagnosis
In this episode, we dive deep into the Basophil Activation Test (BAT) — one of the most advanced tools in modern allergy diagnostics. Join us as we break down how BAT works, when to use it, and what the evidence really says about its accuracy in diagnosing IgE-mediated food allergy, drug allergy, and complex sensitisation patterns. You’ll learn: • How BAT compares with skin prick testing and specific IgE • The clinical value of basophil activation markers such as CD63 and CD203c • When BAT im...
Sat, 15 Nov 2025 - 24 - How Accurate Are Allergy Tests? Unpacking IgE-Mediated Food Allergy Diagnostics
How accurate are the tests we rely on to diagnose IgE-mediated food allergy? In this episode, we explore the science behind skin prick testing, serum-specific IgE, and oral food challenges, examining their sensitivity, specificity, predictive values, and real-world limitations. Join us as we separate evidence from assumption, discussing false positives, cross-reactivity, and component-resolved diagnostics—and how to interpret results in the context of clinical history. Whether you’re a clinic...
Mon, 10 Nov 2025 - 23 - Decoding Component-Resolved Diagnostics: A New Era in Allergy Testing
Component-Resolved Diagnostics (CRD) is transforming the way we diagnose and manage food and aeroallergy. In this episode, we break down what CRD really is, how molecular allergy testing works, and how it improves clinical decision-making beyond traditional IgE and skin prick testing. We explore: ✅ What CRD is and when to use it✅ Benefits of molecular allergen testing over extract-based testing✅ Clinical interpretation of key allergen components (Ara h 2, Cor a 9, Fel d 1 and more)✅ Risk stra...
Wed, 29 Oct 2025 - 22 - Peach Allergy Explained: Hidden Risks Behind a Summer Favourite
Peach allergy is more common than most people realise—especially in Europe and among people with seasonal hay fever or birch pollen allergy. In this episode, we unpack everything you need to know about peach allergy, including oral allergy syndrome (OAS) and lipid transfer protein (LTP) allergy, two very different immune responses linked to peach sensitivity. We explore: ✅ Why some people get an itchy mouth from peaches ✅ When a peach allergy can cause anaphylaxis ✅ Practical advice for diagn...
Tue, 21 Oct 2025 - 21 - Lipid Transfer Protein Allergy Explained: From Peaches to Peanuts
In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the complex world of Lipid Transfer Protein (LTP) allergy — a powerful plant food allergen that can cause severe and unexpected allergic reactions. Join us as we unpack how LTP allergy differs from pollen-related food syndromes, why it’s often seen in Mediterranean populations, and what clinicians, families, and patients need to know about cross-reactivity, diagnosis, and management. You’ll learn about: 🌿 What...
Tue, 14 Oct 2025 - 20 - From Birch to Bite: The Hidden Allergy of Pollen Food Allergy Syndrome
Have you ever wondered why some people get an itchy mouth or tingling lips after eating fresh fruit, vegetables, or nuts—especially during pollen season? In this episode of Hope & Histamine, we uncover the fascinating connection between pollen and food allergies, known as Pollen Food Allergy Syndrome (PFAS) or Oral Allergy Syndrome. Join us as we explore how pollen proteins “cross-react” with certain plant foods, why birch and grass pollens are the usual culprits, and what symptoms parent...
Thu, 09 Oct 2025 - 19 - When Beans Bite Back: Everything You Need to Know About Legume Allergies
Did you know that allergies to beans, peas, lentils and chickpeas are becoming more common? In this episode, we explain what a legume allergy really means, why some people with peanut allergy react to other legumes, and how to read food labels safely. We explore the science and clinical nuances of legume allergy, from immunological cross-reactivity and diagnostic challenges to practical dietary management and allergen labelling under UK and EU regulations. We also provide practical tips...
Sat, 04 Oct 2025 - 18 - Living With Soya Allergy: Hidden Ingredients, Soya Lecithin & Label Dilemmas
Soya is one of the 14 major allergens, but it often hides in unexpected places. In this episode, we explore the world of soya allergy, uncovering the role of soya lecithin in foods, and what allergen labelling laws really mean for patients, families, and healthcare professionals. We’ll discuss the difference between soya protein and soya derivatives, why some people react to trace amounts, and how manufacturers handle precautionary allergen labelling. Whether you’re living with a soya allergy...
Wed, 01 Oct 2025 - 17 - Beyond Typical: Understanding Atypical FPIES and Its Unique Challenges
Beyond the Usual: Exploring Atypical FPIES takes you inside the complex world of Food Protein-Induced Enterocolitis Syndrome (FPIES)—a rare but increasingly recognised form of food allergy. This podcast unpacks the science, clinical challenges, and lived experiences surrounding atypical FPIES, where allergic mechanisms blur the line between classic FPIES and IgE-mediated food allergy. Whether you’re a healthcare professional, researcher, or parent navigating FPIES, this podcast offers clear, ...
Sat, 27 Sep 2025 - 16 - FPIES Uncovered: Demystifying Food Protein-Induced Enterocolitis Syndrome for Parents & Clinicians
Food Protein-Induced Enterocolitis Syndrome (FPIES) can be overwhelming for parents and healthcare professionals alike. In this episode, we break down everything you need to know about FPIES — from understanding the symptoms and triggers to exploring the latest research, diagnosis strategies, and treatment options. Featuring expert insights and practical tips, this podcast is your go-to resource for navigating FPIES with confidence. Whether you’re a parent, paediatrician, allergist, or ...
Mon, 15 Sep 2025 - 15 - Beyond the EpiPen: Debunking Anaphylaxis Myths and Misconceptions
Anaphylaxis remains one of the most critical emergencies in allergy care, yet myths, misconceptions, and inconsistent guidelines often leave both clinicians and patients confused. In this episode, we cut through the noise to explore the truth behind anaphylaxis management, debunk common myths about epinephrine use, and highlight key differences across major guidelines from organisations like BSACI, EAACI, AAAAI, and NICE. Join us as we bring in expert insights, real-world case studies, and ev...
Wed, 03 Sep 2025 - 14 - Anaphylaxis Unpacked: Recognition & Response
Anaphylaxis is a life-threatening medical emergency that can strike suddenly and escalate within minutes. In this episode, we unpack the essentials of recognising, treating, and preventing anaphylaxis. From the first warning signs and the crucial role of adrenaline to long-term care and patient education, we explore practical strategies that every healthcare professional, parent, and patient should know. Drawing on current guidelines and real-world clinical insights, this episode aims t...
Mon, 25 Aug 2025 - 13 - From Risk to Resilience: The IMPACT Peanut Study
Peanut allergy can make everyday life stressful — from birthday parties to school snacks. But what if there was a way to help children build protection instead of just avoiding peanuts altogether? In this episode, we dive into the Immune Tolerance Network IMPACT trial, a groundbreaking study testing whether tiny, carefully measured doses of peanut protein could help young children live with less fear and more freedom. We’ll break down what the research found, what it means for families ...
Wed, 13 Aug 2025 - 12 - Double Trouble: Unpacking Nut and Sesame Seed Co-Allergy in Europe
In this episode, we dive into a groundbreaking European multicenter study that sheds light on the often-overlooked overlap between nut and sesame seed allergies. Why do so many children allergic to tree nuts also react to sesame? How can we accurately diagnose and define coexistent allergies through challenge-proven testing? Join us as we unpack the methodology, clinical significance, and real-world implications of this important research. Whether you’re a clinician, researcher, or allergy-aw...
Wed, 06 Aug 2025 - 11 - Peanuts, Pills, and Progress: The AR101 Breakthrough
In this episode, we dive into the fascinating world of oral immunotherapy (OIT) and explore the efficacy and safety of AR101 (now known as PTAH)—a groundbreaking treatment designed to reduce the risk of severe allergic reactions in children and adolescents with peanut allergy. We unpack the science behind this novel therapy, discuss key clinical trial findings (including the pivotal PALISADE study), and explore what AR101 means for families living with the daily anxiety of accidental peanut e...
Sat, 02 Aug 2025 - 10 - Nutty About Allergies: The Peanut Problem
Peanuts – love them or fear them, they sure know how to cause a stir. In this episode, we’re diving into the nutty world of peanut allergy—why it happens, how to spot it, and what you can do if you or your child has it. We’ll bust some common myths, chat about how early peanut introduction might actually help prevent allergies (yep, really!), and hear real-life stories from families living with peanut allergy every day. Plus, we’ll talk about what to do in an emergency and what new treatments...
Tue, 29 Jul 2025 - 9 - Peanut Allergy Prevention: Does Early Exposure Stick? Insights from LEAP-ON & LEAP-TRIO
In this episode, we explore the groundbreaking LEAP-ON and LEAP-TRIO studies — follow-ups to the landmark LEAP trial that showed early peanut introduction in infants at high risk for allergy can dramatically reduce the development of peanut allergy. But does the benefit last if peanuts are later avoided? Join us as we unpack the latest research on the durability of early allergen exposure, why it matters for families and clinicians, and what it means for allergy prevention strategies wo...
Mon, 28 Jul 2025 - 8 - LEAP of Faith: How Early Peanuts Changed Allergy Prevention
In this episode, we dive into the groundbreaking LEAP (Learning Early About Peanut Allergy) study, which transformed how we understand — and prevent — peanut allergy in children. We explore the science behind early peanut introduction, the study’s design and results, and what it means for parents, clinicians, and public health. Join us as we unpack the evidence, bust common myths, and discuss the future of allergy prevention. Sources: Du Toit, G., Roberts, G., Sayre, P.H., Bahnson, H.T., Radu...
Sat, 19 Jul 2025 - 7 - Skin, Food, Lungs: Unpacking the Atopic March
Unpacking the Atopic March is your go-to podcast for exploring how allergies unfold across childhood. From babyhood eczema and food allergies to school-age asthma and hay fever, we break down the science behind why allergic conditions seem to follow one another — a phenomenon known as the atopic march. Join us as we unpack the latest research, hear from leading allergy experts, and share real-life stories from families navigating these conditions. We’ll explore key questions like: Why do some...
Sat, 12 Jul 2025 - 6 - Tasting Tolerance: The EAT Study Uncovered
What if the key to preventing food allergies lies in what – and when – we feed our babies? In this episode, we dive into the groundbreaking Enquiring About Tolerance (EAT) study, a landmark trial that challenged long-held beliefs about infant feeding and allergy prevention. Join us as we explore how introducing allergenic foods early – including peanut, egg, and dairy – may influence the development of food tolerance in infants. We’ll unpack the science, discuss what the findings mean for fam...
Mon, 30 Jun 2025 - 5 - Egg Allergy Unhatched
Egg allergy is one of the most common food allergies in children — but what does it really mean for day-to-day life? In this episode, we explore the science behind egg allergy, from early signs and diagnosis to safe food choices and long-term outlook. We also discuss how egg allergy differs from egg intolerance, the role of baked egg in desensitisation, and what parents need to know about vaccinations containing egg proteins. Whether you’re managing a new diagnosis or seeking evidence-based g...
Thu, 26 Jun 2025 - 4 - Say Cheese—Or Don’t: Tackling Lactose Intolerance
Do milk and dairy products cause tummy troubles or allergic reactions in your child? In this episode, we break down the key differences between lactose intolerance and cow’s milk protein allergy (CMPA) — two often-confused conditions with very different causes, symptoms, and treatments. Learn how to spot the signs, get the right diagnosis, and make informed dietary choices. Whether you’re navigating food labels, planning school lunches, or managing symptoms at home, this episode offers ...
Mon, 16 Jun 2025 - 3 - Milk Matters: Understanding Cow’s Milk Allergy
Milk Matters is your trusted guide to understanding, diagnosing, and managing cow’s milk allergy in infants and children. Whether you’re a concerned parent, caregiver, or simply seeking clarity, this podcast offers evidence-based insights delivered in an easy-to-understand format. Hosted by a healthcare professional, each episode explores the signs and symptoms of CMA, how it’s diagnosed, practical tips for managing a milk-free diet, and how to support your child’s growth, nutrition, and emot...
Tue, 10 Jun 2025 - 2 - Histories and Hives: Navigating Allergy Clues
What does a rash, a wheeze, or a swelling really mean? In this episode, we dive into the essential skill of allergy-focused history taking — the cornerstone of accurate diagnosis and effective management. Whether it’s food, drugs, or environmental triggers, asking the right questions can unlock crucial clues. Join us as we explore practical tips, key red flags to watch out for, and common pitfalls to avoid, all grounded in evidence-based practice. Perfect for clinicians, parents, and anyone n...
Sat, 07 Jun 2025 - 1 - Navigating Food Allergies in Children
Food allergies in children can be overwhelming—but you’re not alone. This podcast is a valuable resource for evidence-based insights, practical guidance, and compassionate support in managing childhood food allergies. Hosted by a healthcare professional, each episode explores the signs, symptoms, diagnosis, and treatment options for common food allergies, from milk and eggs to nuts and beyond. Learn how to read labels, prevent reactions, handle emergencies, and advocate for your child at scho...
Sat, 07 Jun 2025
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