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The Dr. Gabrielle Lyon Show

The Dr. Gabrielle Lyon Show

Dr. Gabrielle Lyon

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.

255 - Plant-Based Diets and Muscle: What Two New Trials Found in Older Adults
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  • 255 - Plant-Based Diets and Muscle: What Two New Trials Found in Older Adults

    Eating more plants is not always helpful if it affects muscle health.

    Two recent randomized controlled trials published in the American Journal of Clinical Nutrition investigated the effects of replacing animal protein with plant protein in older adults.

    One study reported that participants adhering to a vegan diet experienced significant muscle loss over a 12-week period. The other study found that older people on a predominantly plant-based vegetarian diet and doing resistance training gained both muscle and strength over the same 12-week period.

    This review looks at the design and results of the studies, considers the importance of both the amount and quality of protein for older adults and provides practical advice on how to put together a plant-based diet to support muscle. Older adults can certainly gain muscle on a predominantly plant-based diet but it's important to be very mindful of certain factors to get the best results.

    Connect with Dr. Gabrielle Lyon:

    Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyonFacebook: https://facebook.com/doctorgabriellelyonYouTube: https://youtube.com/@DrGabrielleLyonX (Twitter): https://x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page

    Chapters:

    00:00 - Eating more plants is not automatically healthy for muscle

    00:44 - Two new trials on plant protein and muscle in older adults

    02:51 - Why protein matters more as we age: anabolic resistance

    04:50 - Trial 1: a self-selected vegan diet in adults over 65

    06:15 - What happened to muscle in the vegan group

    07:18 - Resistance training reduced the losses but did not prevent them

    08:36 - Trial 2: the IMPACT trial, vegetarian vs omnivorous diet with lifting

    09:41 - Results: both groups gained muscle, omnivores gained more

    11:47 - Essential amino acids, protein quality and DIAAS

    13:40 - Why protein quality matters less when total protein is high

    15:05 - The 2023 mycoprotein study

    16:23 - Why a plant-based diet takes more planning

    18:03 - Setting your protein requirement: 1.6 grams per kilogram

    19:03 - Protein quality on a plant-based diet

    20:05 - The takeaway: plant-based eating takes planning

    21:50 - Why plant-based is easier to do well today

    22:57 - Final thoughts

    If you found this episode valuable, share it with someone who would benefit from it.

    Studies mentioned in the podcast:

    https://pubmed.ncbi.nlm.nih.gov/42680254/https://pubmed.ncbi.nlm.nih.gov/42772454/https://pubmed.ncbi.nlm.nih.gov/33599941/https://pubmed.ncbi.nlm.nih.gov/36822394/https://pubmed.ncbi.nlm.nih.gov/28698222/

    The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    Thu, 12 Nov 2026 - 23min
  • 254 - Dismissed as Hemorrhoids, Diagnosed as Stage 3 or 4 Colon Cancer | NBC's Chloe Melas

    NBC News correspondent Chloe Melas joins me to share her experience living with ulcerative colitis for 15 years, a journey she kept private until releasing her new book, The Girl's Guide to Guts, co-written with Judy Batalion. We talk about the differences between IBD and IBS, what blood in the stool might mean, and why one study found that women waited more than twice as long as men to get a diagnosis. Chloe explains her flare plan, how she manages fiber with apples and psyllium, and what it was like to go over ten years without a normal bowel movement. We also discuss colon cancer in adults under 50, celiac disease, diverticulitis, colonoscopy prep, and traveling when your gut is unpredictable. I also explain how essential amino acids help feed the cells that produce the gut's protective mucus. If you’re dealing with bloating, urgency, or bleeding, this conversation can help you recognize when it’s time to call a GI doctor.

    Thank you to our sponsors:

    Cozy Earth: 20% off home and sleepwear athttps://cozyearth.com with code DRLYONLadder: free 7-day trial, no credit card, plus $10 off your first month athttps://ladder.fit/drlyonBranch Basics: 15% off site-wide athttps://branchbasics.com with code DRLYON

    Connect with Chloe Melas:

    The Girl's Guide to Guts: https://a.co/d/0byBk4InInstagram: https://www.instagram.com/chloemelas/

    Connect with Dr. Gabrielle Lyon:

    Instagram: https://www.instagram.com/drgabriellelyon/TikTok: https://www.tiktok.com/@drgabriellelyonFacebook: https://facebook.com/doctorgabriellelyonYouTube: https://youtube.com/@DrGabrielleLyonX (Twitter): https://x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page

    Chapters:

    00:47 - Meet Chloe Melas and The Girl's Guide to Guts

    03:36 - IBD vs IBS: ulcerative colitis, Crohn's and how they differ

    05:30 - Blood, tenesmus and a decade of laxatives

    07:30 - What a normal stool looks like

    08:31 - Colon cancer in adults under 50

    10:00 - Why Chloe decided to share her story

    13:04 - IBS symptoms, elimination diets and when to see a GI

    16:37 - Colonoscopies, medication and finding the right doctor

    19:18 - Shame, silence and women's health

    20:52 - Why women wait longer for a diagnosis

    22:00 - Chloe's flare plan: sleep, protein and less alcohol

    23:40 - Fiber: how much you need and the apple math

    28:53 - Psyllium, inulin, guar gum and other fibers

    33:13 - What may trigger IBD: antibiotics, environment and genetics

    35:58 - Menstrual cycles and other causes behind IBS-like symptoms

    37:39 - Celiac disease and why you cannot self-diagnose

    41:19 - Celiac in children and early screening

    43:28 - Diverticulitis

    44:22 - Gut habits to start in your 20s

    45:38 - Essential amino acids, threonine and mucin

    46:37 - Sleep, hydration and at-home stool tests

    49:09 - Raising kids with strong guts

    53:17 - Colonoscopy prep that works

    55:09 - The white pants story

    58:33 - Travel strategies for a sensitive gut

    1:00:58 - Judy Batalion and the J pouch

    1:03:00 - How ulcerative colitis was once called psychosomatic

    If you found this episode valuable, share it with someone who would benefit from it.

    Studies mentioned in the podcast:

    https://pubmed.ncbi.nlm.nih.gov/36719111/https://pubmed.ncbi.nlm.nih.gov/41569583/

    Disclaimers:This episode includes paid sponsorships.

    The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    Tue, 10 Nov 2026 - 1h 04min
  • 253 - Does Retatrutide Cause Muscle Loss? The TRIUMPH-1 Phase 3 Results Explained

    Have you heard about retatrutide?

    It's the weight loss drug everybody is talking about. People are buying it online as a research chemical, and patients ask me if I'm prescribing it (I'm not).

    A study in the New England Journal of Medicine shared insights into the drug, which is currently not FDA-approved. At the highest dose, people lost an average of 25% of their body weight over 80 weeks, compared with about 4% body weight for those on placebo. The area I care about most—muscle—doesn’t get much attention.

    In this episode, I go through the TRIUMPH-1 results, how retatrutide compares with semaglutide and tirzepatide, and what protein and resistance training do for muscle during weight loss.

    Find Dr. Gabrielle Lyon at:

    - Instagram: https://www.instagram.com/drgabriellelyon/

    - TikTok: https://www.tiktok.com/@drgabriellelyon

    - Facebook: https://facebook.com/doctorgabriellelyon

    - YouTube: https://youtube.com/@DrGabrielleLyon

    - X (Twitter): https://x.com/drgabriellelyon

    - Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/

    - Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page

    Chapters:

    00:00 Cold open: weight loss we have never seen before with a drug

    00:45 TRIUMPH-1 and phase three: a trial of retatrutide in people without diabetes

    02:49 Approval and mechanism: phase three is not FDA approval, and retatrutide hits GLP-1, GIP and glucagon

    04:53 The headline: 25% of body weight, about 62 pounds, against 15% for semaglutide and 21% for tirzepatide

    06:52 Trial design: 2,339 adults, 80 weeks and no prescribed diet

    08:45 Results by dose: 17 to 28% on retatrutide, about 4% on placebo and the bariatric surgery comparison

    10:29 The top dose: more than half dropped below a BMI of 30, plus the 104-week extension

    13:10 Beyond the scale: waist, blood pressure, triglycerides, insulin, CRP, knee pain and sleep apnea

    15:37 The muscle question: TRIUMPH-1 does not report body composition

    16:32 Phase 2 DEXA data: about 30 to 40% of weight lost was lean tissue

    18:22 Protein and training: the 1.2 versus 2.4 g/kg deficit study

    20:24 The goal: lose fat and keep muscle

    21:29 Pharmacology: SURMOUNT-5 put tirzepatide at 20% against 14% for semaglutide

    22:30 What glucagon adds, and why there is no head-to-head trial yet

    25:23 Side effects, and why more drug is not better medicine

    27:23 What TRIUMPH-1 changes, and the study still missing

    28:48 Not FDA approved, and where obesity pharmacology goes next

    29:51 Close: the goal was never weight loss

    Study and References:

    Jastreboff AM, Kaplan LM, Davies MJ et al. 2026. Retatrutide, a triple hormone receptor agonist, for treatment of obesity. N Engl J Med. DOI: https://doi.org/10.1056/NEJMoa2604169

    Coskun T et al. 2025. Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial. PMID: 40609566 https://pubmed.ncbi.nlm.nih.gov/40609566/

    Longland TM et al. 2016. Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial. PMID: 26817506 https://pubmed.ncbi.nlm.nih.gov/26817506/

    Aronne LJ et al. 2025. Tirzepatide as compared with semaglutide for the treatment of obesity. PMID: 40353578 https://pubmed.ncbi.nlm.nih.gov/40353578/

    Wilding JPH et al. 2021. Once-weekly semaglutide in adults with overweight or obesity. PMID: 33567185 https://pubmed.ncbi.nlm.nih.gov/33567185/

    Jastreboff AM et al. 2022. Tirzepatide once weekly for the treatment of obesity. PMID: 35658024 https://pubmed.ncbi.nlm.nih.gov/35658024/

    Disclaimer:The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    Thu, 05 Nov 2026 - 30min
  • 252 - Muscle Physiologist: It Took Two Soy Burgers to Approach the Muscle Response of One Beef Patty | Dr. David Church

    How do the amino acids in a soy patty and a beef patty compare once they reach your blood?

    In a trial he helped design, Dr. David Church matched a 4-ounce beef patty against a soy-based burger. He had to double the soy to roughly match the single beef patty in essential amino acids. The blood amino acid levels shocked him.

    David joins me at Protein Summit 3.0 to explain what happened.

    He also tells me why muscle protein breakdown is so much harder to measure than synthesis, and shares insights from his 21-day testosterone study, where the men on testosterone lost all of their weight as fat while the placebo group lost about half of theirs as fat-free mass.

    Thank you to our sponsors:

    - Cozy Earth: 20% off home and sleepwear at cozyearth.com with code DRLYON

    - Timeline: an additional 20% off at timeline.com/lyon

    - Bon Charge: 30% off sitewide in their Black Friday sale with code DRLYON30

    Find Dr. David Church at:

    - UAMS profile: https://uams-triprofiles.uams.edu/profiles/profile/5838748

    - Instagram: https://www.instagram.com/dr.myohead

    - LinkedIn: https://www.linkedin.com/in/david-church-6b0662280

    - X (Twitter): https://x.com/DrMyohead

    Find Dr. Gabrielle Lyon at:

    - Instagram: https://www.instagram.com/drgabriellelyon/

    - TikTok: https://www.tiktok.com/@drgabriellelyon

    - Facebook: https://facebook.com/doctorgabriellelyon

    - YouTube: https://youtube.com/@DrGabrielleLyon

    - X (Twitter): https://x.com/drgabriellelyon

    - Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/

    - Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page

    Chapters:

    0:00 – Dr. David Church on the Nandrolone Aging Study in Mice

    3:17 – What Testosterone Changed in Men During a 21-Day Energy Deficit

    6:14 – Androgens, Hormones and What We Still Do Not Know in Women

    9:43 – Stable Isotope Tracers Explained With Legos

    10:56 – Why Muscle Protein Breakdown Is So Hard to Measure

    13:23 – How Testosterone May Recycle Amino Acids Inside the Muscle Cell

    16:01 – Net Protein Balance, Burns and Whole-Body Protein

    18:38 – Obesity, Anabolic Resistance and the 1.2 g/kg Protein Target

    24:38 – Testosterone and Protein as Complementary Levers

    26:15 – Nandrolone, Satellite Cells and Muscle Memory

    32:50 – The Soy Burger vs. Beef Patty Trial

    40:18 – Plant Protein, Low Appetite and Essential Amino Acid Supplements

    41:16 – GLP-1 Responders and Why Dr. Lyon Uses Essential Amino Acids

    47:49 – Are Essential Amino Acids Requirements Higher Than We Thought?

    Disclaimers: This episode includes paid sponsorships.

    The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    Tue, 03 Nov 2026 - 58min
  • 251 - Essential Amino Acids Explained: Protein Quality, Leucine, BCAAs and How Much You Need

    Protein has become a numbers game, and the numbers leave out the essential amino acids your muscle, brain and metabolism depend on. Protein is how you get them, and its quality may change how well you age.

    In this episode, Dr. Gabrielle Lyon brings together some of her favorite moments with Dr. Don Layman, Dr. Heather Leidy and Dr. Jess Gwin to break down the essential amino acid requirement, cut through the confusion on protein quality (what a protein label leaves out, plant vs. animal sources, branched-chain amino acids, and leucine), and explain what the research says about essential amino acids in brain function, mood, sleep, energy deficit, and anabolic resistance as we age.

    If you have ever wondered what your protein label isn't telling you, or why half an ounce of nuts and an ounce of lean beef count as the same serving, this conversation offers a clear, practical look at what the science says.

    Thank you to our sponsors:

    - BodyHealth: 20% off your first order at bodyhealth.com with code LYON20

    - Tushy: 10% off your first bidet order at hellotushy.com with code DRLYON

    Find Dr. Don Layman, Dr. Heather Leidy and Dr. Jess Gwin at:

    - Dr. Heather Leidy: https://nutrition.utexas.edu/directory/heather-leidy/

    - Dr. Don Layman: https://x.com/donlayman

    - Dr. Jess Gwin: https://www.researchgate.net/profile/Jess-Gwin

    Find Dr. Gabrielle Lyon at:

    - Instagram: https://www.instagram.com/drgabriellelyon/

    - TikTok: @drgabriellelyon

    - Facebook: facebook.com/doctorgabriellelyon

    - YouTube: youtube.com/@DrGabrielleLyon

    - X (Twitter): x.com/drgabriellelyon

    - Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/

    - Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page

    Chapters:

    0:00 – Why the Requirement Is Essential Amino Acids, From Muscle to Mood and Sleep

    3:24 – Dr. Jess Gwin on Protein Quality and Why the Dietary Guidelines Miss It

    5:36 – What a Protein Label Does and Doesn't Tell You

    6:50 – Nuts vs. Lean Beef and the Cost of Going Plant-Based

    9:35 – Dr. Don Layman on Branched-Chain Amino Acids, Leucine and mTOR

    11:19 – How Much Protein Reaches the Leucine Threshold

    14:00 – Dr. Jess Gwin on Essential Amino Acids Under Energy Deficit and Stress

    16:36 – Dosing, Aging and Anabolic Resistance

    19:26 – Whole Foods vs. Amino Acid Powders as Tools

    21:29 – Dr. Lyon's First-Meal Routine

    Disclaimers:This episode includes paid sponsorships.

    The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

    Thu, 29 Oct 2026 - 22min
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