BMJ Best Practice Podcast

Acne is a common condition. The Global Burden of Disease estimates the prevalence of acne to be 8%, ranking it the eighth most prevalent disease worldwide. And acne can cause complications - from scarring to dyspigmentation to mental health problems. So what if anything can we do to ensure that it is diagnosed and managed correctly? To answer this and other important questions, please have a listen to this podcast interview with Professor John Barbieri, Assistant Professor of Dermatology at Harvard.  For more on acne, visit BMJ Best Practice. Competing interests: JB has received consulting fees from Dexcel Pharma.

Cervical spine injuries result primarily from motor vehicle accidents, sports activities, and diving into shallow water. These mainly happen with young people. In older people, falls are a common cause. And such injuries can cause a range of complications from pain to radiculopathy to other neurological disability. So what if anything can we do to ensure that cervical spine trauma is diagnosed and managed correctly? To answer this and other important questions, listen to this interview with Michael Fehlings, Professor of Neurosurgery at the University of Toronto, and author of our BMJ Best Practice topic on this condition. Competing interests: MGF served as a consultant for Zimmer, In Vivo Therapeutics, and Pfizer. He receives institutional fellowship grant support from AOSpine, Medtronic, and Depuy-Synthes.

Croup is a frequent cause of acute respiratory distress in young children. Typically, it affects those between six months and three years of age, peaking in the second year of life. And croup can be serious and can cause complications - such as pneumonia. So what if anything can we do to ensure that it is diagnosed and managed correctly? To answer this and other important questions, please do have a listen to this podcast interview with Professor David Johnson who is from the Department of Pediatrics and Physiology and Pharmacology at the University of Calgary, Canada. For more on croup, visit BMJ Best Practice.  Competing interests: none

As the climate changes, we are getting more diseases associated with extremes of temperature - such as frostbite. Frostbite is classically associated with mountaineering and winter activities. But it also occurs in armed conflict and of course in homeless people. Frostbite can result in wound infection, gangrene and amputation. So what if anything can we do to ensure that it is diagnosed and managed correctly? To find the answer to this and other important questions, please have a listen to this podcast interview with Professor Chris Imray, Consultant Vascular and Renal Transplant Surgeon. For more on frostbite, visit BMJ Best Practice. Disclosures: CI has been paid for medicolegal work and receives royalties for the Oxford Handbook of Wilderness and Environmental Medicine.

A US study of high-risk drinking patterns suggests that deaths due to alcohol-associated liver disease are expected to double in the next twenty years. And this condition is associated with a range of complications - including hepatic encephalopathy, GI bleeding, and hepatorenal syndrome. So what if anything can we do to ensure that it is diagnosed and managed correctly? To answer this and other important questions, please have a listen to this podcast interview with Professor Craig McClain, Chief of Research Affairs and Associate Vice President for Health Affairs and Research at the Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine.  For more on alcohol-associated liver disease, visit BMJ Best Practice. CM acts as a consultant for Nestlé, Durect, Allergan, Intercept, and DISCUS. He works for the Veterans Administration on a part-time basis, has received grants from the NIH and VAMC, and is working on the update of the AGC nutritional guideline.

Benign paroxysmal positional vertigo (BPPV) has an incidence of 64 per 100,000 per year, increasing by 40% with each decade of life. This means about 200,000 new patients per year in the USA. And BPPV can cause problems - including falls and accidents and of course injuries. So what if anything can we do to ensure that it is diagnosed and managed correctly? To answer this and other important questions, please do have a listen to this podcast interview with Professor Lorne Parnes of the Departments of ENT, Head and Neck Surgery and Clinical Neurological Sciences, University of Western Ontario. For more on BPPV, visit BMJ Best Practice. Competing interests: none

In 2019, lower respiratory tract infections affected 489 million people worldwide, and were the cause for approximately 2.5 million deaths. Children less than 5 and adults older than 70 were the populations most affected by pneumonia. Mortality was highest in patients aged over 70. So what if anything can we do to ensure that pneumonia is diagnosed and managed correctly? To answer this and other important questions, please do have a listen to this podcast interview with Dr Catia Cillóniz, Associate Professor at the University of Barcelona. For more on community acquired pneumonia, visit BMJ Best Practice. Competing interests: none

Primary hyperparathyroidism is a common disorder affecting 1 in 500 women and 1 in 2000 men aged over 40 years. It can cause a range of complications from osteoporosis to fractures to nephrolithiasis. So what if anything can we do to ensure that it is diagnosed and managed correctly? To answer this and other important questions, please do have a listen to this podcast interview with Dr John Ayuk, Consultant Endocrinologist at University Hospitals Birmingham NHS Foundation Trust.  For more on primary hyperparathyroidism, visit BMJ Best Practice. Disclosures: JA declares that he has no competing interests.

Diabetes mellitus is one of the most common chronic diseases worldwide. Diabetic foot disease is an all too common complication. And it can cause a range of problems - including the ultimate complication - amputation. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Dr. Kieran Walsh talks to Nicole Mottolini about safer management of diabetic foot disease. Nicole is a Podiatrist and Clinical Fellow at NHS Resolution. Competing interests: none For more on diabetic foot disease, visit BMJ Best Practice.

In the UK, the prevalence rate of type 2 diabetes in children is approximately 2.9 per 100,000. This number is rising and another constant has been the increasing rates of obesity. So it is vital that we get prevention and management of this condition right. In this BMJ Best Practice podcast, Dr Christine Bowen talks to Professor May Ng, OBE, Honorary Professor at Edge Hill University, Hon Associate Professor at University of Liverpool, and Consultant Paediatrician and Paediatric Endocrinologist at Mersey and West Lancashire Teaching Hospitals Trust. For more on type 2 diabetes in children, visit BMJ Best Practice. Competing interests: none

Endometriosis is a chronic inflammatory condition defined by endometrial stroma and glands found outside of the uterine cavity. The most common sites affected are the pelvic peritoneum and ovaries. May present incidentally in asymptomatic women, or more commonly in women of reproductive age who complain of chronic pelvic pain and/or sub-fertility. M. Jonathon Solnik, Professor of Obstetrics, Gynaecology and Medical Imaging by Cross-Appointment, Temerty School of Medicine at the University of Toronto, gives us an overview of diagnosis and management of the condition. For more on endometriosis, visit BMJ Best Practice. Competing interests: MJS is an author of a number of references cited in the Best Practice topic. He acts as a consultant for AbbVie (manufacturer of depot leuprolide and elagolix), Medtronic, Felix Health and Olympus.

Fibrocystic breasts are common. The incidence peaks at 400 per 100,000 woman-years at the age of 40 to 44. The condition can cause  pain and tenderness that fluctuate with the menstrual cycle. And there is a higher prevalence of cysts as women approach the menopause. In this BMJ Best Practice podcast, Kieran Walsh talks with Professor Ingrid Lizarraga, Clinical Associate Professor at the Division of Surgical Oncology and Endocrine Surgery, University of Iowa Hospitals and Clinics. Competing interests: None For more on fibrocystic breasts, visit BMJ Best Practice.

The diagnosis of menopause is clinical, based on the absence of menses for 12 months, and does not require further testing for appropriately presenting patients. Oestrogen therapy is an effective treatment for the management of menopausal symptoms including hot flushes, night sweats, and urogenital symptoms. In this podcast, Bradford W. Fenton, Independence Park Medical Services, Anchorage, Alaska, gives us further details of diagnosis and management. For more on menopause, visit BMJ Best Practice. Disclosures: BWF declares that he has no competing interests.

There are concerns that junior healthcare professionals do not use decision support as they don’t see senior staff using it. There are concerns that seniors don't use clinical decision support as they worry about looking things up people in front of people. So a complex issue to discuss. To find out more about this, listen to this interview with Dr Tom Foley, Consultant Child and Adolescent Psychiatrist with expertise in digital health.

Snoring is common. In the 30- to 35-year-old age group, 20% of men and 5% of women snore. By 60, 60% of men and 40% of women will snore habitually. And snoring can affect the quality of life - of both the patient and their partner. In this BMJ Best Practice podcast on snoring, Kieran Walsh talks with Dr Showkat Mirza, Consultant in Otorhinolaryngology and Head & Neck Surgery, Sheffield Teaching Hospitals NHS Trust. For more on snoring, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1035 Competing interests: SM has no competing interests

Adhesive capsulitis affects 2% to 5% of the population. It is slightly more common in women than in men, and is most common in people between the ages of 40 and 70. And it can cause a range of problems - including pain, stiffness, and loss of function. So it is important that we get the diagnosis and management of this condition right. To give us more details about this problem and what we can do about it, Kieran Walsh, Clinical Director at BMJ, speaks with Professor Lance LeClerc, Associate Professor of Orthopedic Surgery at Vanderbilt University Medical Centre in Nashville. For more on adhesive capsulitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1043 Competing interests: None

Gastro-oesophageal reflux disease (GORD) is a common condition that affects between 10% and 30% of people in developed countries. There can be a range of complications from haemorrhage to stricture to Barrett's oesophagus. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on GORD, Kieran Walsh talks with Dr Andres Carrion, Associate Professor of Clinical Medicine at The Division of Digestive Health and Liver Diseases in University of Miami Miller School of Medicine. For more on GORD, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/82 Competing interests: None

Age-related macular degeneration is the third most common cause of visual impairment worldwide. The main risk is advanced disease and resultant visual loss. Prompt diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on macular degeneration, Kieran Walsh talks with Dr. Sajjad Mahmood, Consultant Ophthalmic Surgeon, Medical Retina Specialist, and Honorary Clinical Lecturer at the University of Manchester. For more on age-related macular degeneration, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/554 Competing interests: SM has done consultancy work and received honoraria for lecturing and travel from Bayer Pharmaceuticals and Novartis. He has also been a principal investigator for clinical trials on behalf of Bayer, Novartis, and Roche.

The prevalence of cluster headache is about one in 500. In people coming to a headache clinic, the prevalence is about 10%. Cluster headaches are excruciating and incapacitating, and affect quality of life. Prompt diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on cluster headache, Kieran Walsh talks with Professor Amaal Starling, Associate Professor of Neurology at the Department of Neurology in the Mayo Clinic. Further resources: clusterbusters.org/. Competing interests: AS has received consulting fees from AbbVie, Allergan, Amgen, Axsome Therapeutics, Everyday Health, Lundbeck, Med-IQ, Medscape, Neurolief, Satsuma, and WebMD. We release episodes fortnightly.

Spinal cord compression is an extremely serious disorder that can have devastating consequences. These include weakness of the legs, bladder and bowel dysfunction, and loss of sensation. Rapid diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on spinal cord compression, Kieran Walsh talks with Professor Kenneth Casey, Clinical Associate Professor in Neurosurgery at Michigan State University and Clinical Associate Professor in Physical Medicine and Rehabilitation at Wayne State University School of Medicine. Competing interests: none declared We release episodes fortnightly.

Halitosis is common and can affect people of all ages. Severe halitosis is less common but it can affect confidence and quality of life. It can even result in social isolation. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on halitosis, Kieran Walsh talks with Professor Stephen Porter, Director of the UCL Eastman Dental Institute in London. Competing interests: none declared

We release episodes fortnightly. Osteoarthritis is the most common form of arthritis. It is more common in women than in men, with incidence increasing sharply around the age of 50. And it can cause complications - including the inability to perform activities of daily living and spinal stenosis in cervical and lumbar osteoarthritis. So it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on osteoarthritis, Kieran Walsh talks to Fadi Badlissi, Assistant Professor at Harvard Medical School and Director of the Musculoskeletal Medicine Unit at Beth Israel Deaconess Medical Center in Boston. Competing interests: None

We release episodes fortnightly. Stroke is the fourth and fifth leading cause of death in the UK and US, respectively. There are more than 100,000 strokes in the UK every year. And approximately 10% to 15% of all ischaemic strokes are associated with carotid artery stenosis. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on carotid artery stenosis, Kieran Walsh talks to Brajesh Lal, Professor of Vascular Surgery, University of Maryland School of Medicine and Professor of Neurology, Mayo Clinic. Competing interests: None

We release episodes fortnightly. Bell's palsy is the most common unilateral facial palsy in adults. It is most prevalent in people between 15 and 45 years of age. And it can cause a range of complications - including ongoing facial weakness, keratoconjunctivitis sicca, exposure keratopathy, and ectropion. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks with Professor Matthew Miller about Bell's palsy. Matt is Assistant Professor Otolaryngology and Head and Neck Surgery, University of North Carolina Chapel Hill. Competing interests: none declared

We release episodes fortnightly. Data, AI, oncology, and patients are a wide range of subjects to be addressed in one podcast. Individually they are big topics and when you put them together you really get to high levels of complexity. In this BMJ Best Practice podcast, Kieran Walsh delves into all these topics with Dr Arun Sujenthiran, Senior Medical Director and UK Clinical Lead at Flatiron Health. Flatiron Health is a healthtech company that specialises in data science and oncology. Competing interests: AS is an employee of Flatiron Health Inc, an independent subsidiary of Roche, and holds stock in Roche.

We release episodes fortnightly. Rosacea is a common disorder. Studies suggest a prevalence of 5% for women and 4% for men. And rosacea can cause a range of problems including papules and pustules, telangiectasias, and eye problems. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on rosacea, Kieran Walsh talks to Dr Abel Jarell, Dermatologist and Dermatopathologist, Northeast Dermatology Associates, Portsmouth, New Hampshire. Competing interests: none declared

We release episodes fortnightly. Hypothermia is a serious condition - it can cause rhabdomyolysis, electrolyte disturbances, and cardiac arrhythmias. It can also kill. In the UK, the annual number of hypothermia-related deaths is about 300. And in countries with colder climates, the numbers are far higher. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr Alexander Alexiou, Emergency Medicine Consultant, Barts Health NHS Trust about hypothermia. Competing interests: none declared

We release episodes fortnightly. Parkinson's disease is a common and serious condition. It is the second most common neurodegenerative disorder in the world - only Alzheimer's disease is more common. And Parkinson's disease can cause a range of complications - from dyskinesias to depression to dementia. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks to Delaram Safarpour, Assistant Professor of Neurology at Oregon Health & Science University. Competing interests: DS has received honoraria for participation in advisory boards for Boston Scientific (the manufacturer of Deep Brain Stimulation devices) and Abbvie (the manufacturer of Duopa). She has received consultation fees from Abbott (the manufacturer of Deep Brain Stimulation devices). DS has received an institutional grant and has received an honorarium for lectures from the Parkinson’s Study Group.

Herpes zoster: an update on diagnosis and management The annual incidence of herpes zoster in the UK is between 2 and 4 patients per thousand population. It can cause a range of complications including post-herpetic neuralgia, herpes zoster of the eye, and disseminated zoster. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on herpes zoster, Kieran Walsh talks to Professor Michael Rothberg, Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio. MR declares that he has no competing interests.- The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Data and big data in healthcare are both important and topical. Big data has the potential to transform how we provide healthcare but can also be problematic. There can be problems with how data is captured, cleaned, and corrected or with how we update data. BMJ is playing an increasing role in this field. We have our own BMJ Data Set which provides AI healthcare technologies with current, credible, and AI-ready content. In this BMJ Best Practice podcast on healthcare and data, Kieran Walsh talks to Professor Dipak Kalra, President of The European Institute for Innovation through Health Data.

Status epilepticus is a serious medical emergency. Fortunately, it is relatively rare but when it does occur it can cause a range of serious complications including focal neurological deficits, cognitive dysfunction, and behavioural problems. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on status epilepticus, Kieran Walsh talks to Dr. Rajiv Mohanraj, Consultant Neurologist and Honorary Senior Lecturer at the Manchester Centre for Clinical Neurosciences - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Atrial fibrillation is the most common sustained heart rhythm disorder in adults worldwide. The prevalence is between 2% and 4%. If left untreated, atrial fibrillation is a significant risk factor for stroke, myocardial infarction and congestive cardiac failure. So it is important that we get diagnosis and management of this condition right. In this BMJ Best Practice podcast on new-onset atrial fibrillation, Kieran Walsh talks to Bharat Kantharia, Clinical Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Acute pancreatitis: an update on diagnosis and management Acute pancreatitis is a common and serious condition. The incidence of acute pancreatitis in the UK is about 50 per 100,000 per year. And it can cause a range of complications including acute renal failure, pancreatic abscess and of course chronic pancreatitis. So it is important that we get diagnosis and management of this condition right. In this BMJ Best Practice podcast on acute pancreatitis, Kieran Walsh talks to Professor Scott Tenner, Clinical Professor of Medicine, State University of New York. ST is an author of references cited in the BMJ Best Practice topic on acute pancreatitis. He declares that he has no other competing interests. BMJ Relevant topic link - https://bestpractice.bmj.com/topics/en-gb/3000118 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

COPD or chronic obstructive pulmonary disease is common. The pooled global prevalence is 15% in men and 9% in women. The expanding epidemic of smoking and the ageing of the population means that its prevalence is increasing. And COPD is a serious disease. It is associated with recurrent pneumonia, cor pulmonale, and respiratory failure. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr. Hanna Sandelowsky, GP, Head of Unit at the Academic Primary Healthcare Centre, and Senior Researcher at Karolinska Institutet in Sweden. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Transient ischemic attacks are common - in the UK, the US and around the world. And they are important – mainly because of the high risk of stroke following a TIA. The risk of stroke is high in the first 7 days. So it is important to get on with diagnosis, investigations, and management as soon as possible. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr Jennifer Simpson, Vascular Neurologist and Associate Professor in the Department of Neurology at the University of Colorado. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Axial spondyloarthritis is a chronic progressive inflammatory arthropathy, which ultimately may lead to radiographical changes in the spine and sacroiliac joints. This radiographical stage is known as ankylosing spondylitis. Inflammatory back pain is the hallmark clinical feature. This is defined as back pain that is of insidious onset, is worse in the morning, and improves with exercise. In this podcast, Markku Kauppi, Professor of Rheumatology, Helsinki University, gives a clinical overview of the condition. For more on ankylosing spondylitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/366 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Ischaemic stroke is a leading cause of morbidity and mortality. The World Health Organization defines stroke as “a clinical syndrome consisting of rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin”. David Wang, Professor of Neurology, Barrow Neurological Institute, Phoenix, Arizona, gives us a clinical overview of the condition. For more on ischaemic stroke, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/3000114 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Essential tremor is characterised by a progressive tremor of the upper extremities, present in posture and action, without other neurological signs or symptoms. The prevalence and incidence increases with age, but the condition can appear in early adulthood in those who have a family history. Sheng-Han Kuo, Assistant Professor of Neurology, Columbia University, New York, gives us an overview of the condition. For more on essential tremor, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1089 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Patients with asthma present with recurrent episodes of shortness of breath, chest tightness, wheezing, or coughing. Examination typically demonstrates an expiratory wheeze; however, in severe asthma there is poor air entry and the chest is silent. Lauren Eggert, Clinical Assistant Professor, Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, gives us a clinical overview of the condition. For more on asthma, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/44 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Bacterial meningitis represents a life-threatening inflammation of the meninges. Elisabeth Adderson, Associate Member, St. Jude Faculty, Director, Pediatric Infectious Diseases Fellowship Program, St. Jude Children's Research Hospital, Memphis, gives an overview of the condition. For more on bacterial meningitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/3000104 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Type 1 diabetes mellitus is a metabolic disorder characterised by hyperglycaemia due to absolute insulin deficiency. The condition develops due to destruction of pancreatic beta cells, mostly by immune-mediated mechanisms. In this podcast, Rajesh Garg, Professor of Medicine, University of Miami Miller School of Medicine, gives us an overview of the condition. For more on type 1 diabetes, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/25 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Generalised anxiety disorder (GAD) is a common condition defined as chronic, excessive worry for at least six months that causes distress or impairment. Christopher Gale, Research Director and Consultant Psychiatrist, Southern District Health Board, New Zealand gives a clinical overview of the condition. For more on GAD, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/120 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Lyme disease is an infectious disease transmitted to humans through the bite of infected ticks. Erythema migrans develops at the site of tick bite usually within 1 to 2 weeks and is a pathognomic feature. Constitutional symptoms such as fever, headache, myalgias, fatigue, and arthralgias may occur. In this podcast, Janak Koirala, Professor of Medicine and Infectious Diseases, Division of Infectious Diseases, Southern Illinois University School of Medicine, gives us an overview of the condition. For more on lyme disease, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/224 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Chronic congestive heart failure is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. It is a major and growing public health problem. In this podcast, Syed Wamique Yusuf, FACC, FRCPI Syed Wamique Yusuf, Professor of Medicine, Department of Cardiology, University of Texas MD Anderson Cancer Center, gives a clinical overview of the condition. For more on chronic congestive heart failure, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/61 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Jet lag and sleep phase disorders affect millions of travellers worldwide. Rapid change in time zone produces a constellation of symptoms called jet lag disorder. Symptoms include difficulty initiating and maintaining sleep, reduced daytime alertness, general malaise, and gastrointestinal symptoms. In this podcast, Ashish Adlakha, Assistant Clinical Professor, Neurology and Sleep Medicine, Connecticut Healthcare, gives us a clinical overview. For more on jet lag, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1017 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Fadi Badlissi, Assistant Professor, Harvard Medical School, and Director of the Musculoskeletal Medicine Unit, Beth Israel Deaconess Medical Center, Boston, gives us a clinical overview of gout. For more on gout, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/13 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Venezuelan equine encephalitis is a mosquito-borne virus, endemic to Central and South America. It usually causes mild and self-limiting disease in humans, however CNS infection can lead to long-term neurological sequelae and death, particularly in children. In this podcast we get a clinical overview of the disease, from Stalin Vilcarromero, Assistant Professor and Clinical Research Scientist, Department of Medicine, Stony Brook University, New York, USA. For more on Venezuelan equine encephalitis virus, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1614 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Nigel Cowley is a GP from the Denmark Road Medical Centre in Bournemouth, UK, with a special interest in mental health, and in this podcast he shares his advice on, and experiences of, assessing, managing and treating patients with anxiety and depression. For more on anxiety and depression, visit BMJ Learning: learning.bmj.com - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Pregnancy in women living with HIV is complicated not only by HIV infection itself but also by the medical and psychosocial comorbidities associated with HIV. Prof Rachel Scott, Scientific Director of Women’s Health Research for MedStar Health Research Institute, and Assistant Professor in Obstetrics and Gynaecology, Georgetown University, gives us a clinical overview of caring for pregnant women with HIV. For more on HIV in pregnancy, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/556 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Henipavirus is a rare, but emerging, infection in the Asia-Pacific region. An outbreak of Nipah virus infection was reported in India in May 2018, but was quickly contained. Catherine Houlihan, Clinical Lecturer at University College London London, gives us a clinical overview of the disease. For more on henipavirus, see BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/1607 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Global trends in the estimated number of drug users (2009 to 2014) indicate that the use of opioids, including the use of heroin and opium, and the non-medical use of pharmaceutical opioids, has stabilised at high levels. Worldwide, around 35.1 million people are estimated to have used opioids in 2016. How can clinicians recognise and manage those misusing opioids? Here to offer advice is Prof Jonathan Lee, Medical Director at The Farley Center at Williamsburg Place, Williamsburg, US. For more on opioid use disorder, visit Best Practice: bestpractice.bmj.com/topics/en-gb/200 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

This week, we're joined by Sian Griffiths, Emeritus Professor at the Chinese University of Hong Kong, Visiting Professor at Imperial College London, and Chair of the Public Health England Global Health Committee. Professor Griffiths discusses the 2002-2003 SARS outbreak in Hong Kong, and what healthcare professionals should know about the virus. For more on SARS, visit BMJ Best Practice: newbp.bmj.com/topics/en-gb/904 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Alissa Willis, Staff Neurologist in the Neurological Institute's Mellen Center for Multiple Sclerosis, Cleveland Clinic, gives us a clinical overview of multiple sclerosis. For more on multiple sclerosis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/140 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Sudhakar Selvaraj, assistant professor of psychiatry at the University of Texas Health Science Centre, gives us a clinical overview of bipolar disorder. For more on bipolar disorder, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/488 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

We know that infectious disease outbreaks are caused by pathogens, but some would argue that they are also a biological manifestation of social inequality. Here to discuss the politics of disease outbreak, and how this informs how the global community should respond to them, is Simukai Chigudu, Associate Professor of African Politics and Fellow of St Antony's College, Oxford University. To find out more about BMJ's Global Health initiatives, visit: bmj.com/company/global-health-ii

What is glanders, and how do you recognise, refer and report it? Dr Robert Norton, Director of Microbiology, Townsville Hospital, Australia, gives us the answers. For more information on Glanders, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1601 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Prof Tim Collins, Associate Professor of Neurology, Duke University Medical Center, USA, gives us a clinical overview of migraine. For more on migraine, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/10 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Prof Mike Morgan, National Clinical Director Respiratory NHS England, gives us a clinical guide to COPD. To learn more about COPD, visit BMJ Learning: Managing acute exacerbations of COPD in primary care - bit.ly/2sQPK1R Chronic obstructive pulmonary disease: diagnosis and assessment of severity - bit.ly/2TdNgpU Chronic obstructive pulmonary disease: long term management - bit.ly/2FSYAoj Spirometry in practice - bit.ly/2RQ6ntD _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Dr Jacob A Lebin, Emergency Medicine Resident, University of Washington, Harborview Medical Center, gives a clinical guide to marine toxins poisoning. To learn more about marine toxins poisoning, visit BMJ Best Practice. https://bestpractice.bmj.com/topics/en-gb/1605 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

South American haemorrhagic fevers are a group of five highly dangerous and highly infectious diseases. Professor Thomas Ksiazek, Professor of Pathology, University of Texas Medical Branch, Galveston, US, talks us through how to recognise, refer and report these fevers. For more information on South American haemorrhagic fevers, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/1612 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Prof David Dance, senior clinical research fellow and consultant microbiologist, Lao-Oxford-Mahosot Hospital, Vientiane, Laos, gives us a clinical overview of melioidosis. For more information on melioidosis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1601 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Dr Jonathan Quick, author of 'The End of Epidemics: The Looming Threat to Humanity and How to Stop It', discusses the threat of epidemics and pandemics, and how they can be prevented. To learn more about epidemics and pandemics, visit BMJ Best Practice. bestpractice.bmj.com _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Learn how to recognise, refer and report Poxvirus infection, with Dr Thomas Blanchard, Consultant in Infectious Diseases, Department of Infectious Diseases and Tropical Medicine, Royal Liverpool Hospital. During a poxvirus outbreak there may be many potential contacts most of whom can be managed by passive surveillance by public health authorities. A symptomatic contact needs to be a risk assessed as most do not need to be seen in full personal protective equipment in a regional infectious diseases unit. For example, a close household contact who develops fever and rash is at high risk, whereas someone who happens to live in the same city and has a fever but no rash is at very low risk. To learn more about Poxvirus, visit BMJ Best Practice. bestpractice.bmj.com/topics/en-gb/1611 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Lisa Bebell, Instructor in Medicine, Massachusetts General Hospital, and who conducts research in to infectious diseases and critical care medicine, gives us a clinical guide to Marburg Virus. To learn more about Marburg Virus, visit BMJ Best Practice. bestpractice.bmj.com/topics/en-gb/1615 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

In this podcast, Rakesh Patel, Clinical Associate Professor in Medical Education and Honorary Consultant Nephrologist at the University of Nottingham, talks us through making a diagnosis in the context of infectious diseases. For more information, visit BMJ Best Practice: bestpractice.bmj.com _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

This podcast is a clinical guide to abrin poisoning, with Scott Phillips, Associate Clinical Professor of Medicine, Clinical Pharm & Toxicology, University of Colorado - Denver. To learn more about abrin poisoning, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1051 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Clayton Willey, Professor of Pathology, UPMC Presbyterian Hospital Division of Neuropathology, Pittsburgh, USA, talks us through the recognition, referral and reporting of Rift Valley Fever. To learn more about Rift Valley Fever, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/1602 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

A clinical guide to viral haemorrhagic fevers in children, with Nathalie MacDermott, Wellcome Clinical Research Training Fellow, Imperial College London. To learn more about viral haemorrhagic fevers, visit BMJ Best Practice. bestpractice.bmj.com/topics/en-gb/1210 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

How to recognise, refer and report Lassa fever, with John Schieffelin, Assistant Professor of Medicine & Pediatrics, Tulane University School of Medicine, New Orleans. To learn more about Lassa Fever, visit BMJ Best Practice. https://bestpractice.bmj.com/topics/en-gb/1609 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Susan Smolinske, Director of the New Mexico Drug and Poison Information Centre, and Professor of Pharmacy Practice and Administrative Sciences, University of New Mexico, gives us a clinical guide to ricin poisoning. To learn more about ricin poisoning, visit BMJ Best Practice. bestpractice.bmj.com/topics/en-gb/1051 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

A clinical guide to Brucellosis, with Drs Nick Beeching, Senior Lecturer Clinical Infectious Diseases, and Alessandro Gerada, Medical Microbiology Trainee, both at the Liverpool School of Tropical Medicine. To learn more about Brucellosis, visit BMJ Best Practice. https://bestpractice.bmj.com/topics/en-gb/911 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

International travel is increasingly common. Between 10% and 42% of travellers to any destination, and 15%-70% of travellers to tropical settings experience ill health, either while abroad or on returning home, Malaria is the commonest specific diagnosis, accounting for 5%-29% of all individuals presenting to specialist clinic, followed by dengue, enteric fever, and rickettsial infections . In this podcast Doug Fink specialist registrar, and Victoria Johnston consultant, in infectious diseases at The Hospital for Tropical Diseases join us to discuss diagnosis, and treatment - and why the clinically most interesting diagnosis is rarely the right one. Read the full practice article: www.bmj.com/content/360/bmj.j5773 This podcast was produced by The BMJ. _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Dr Mary-Margaret Fill currently works as a Medical Epidemiologist in Communicable and Environmental Diseases and Emergency Preparedness at the Tennessee Department of Health. To learn more about Avian Influenza, visit BMJ Best Practice. http://bestpractice.bmj.com/topics/en-gb/455 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Christopher Paddock, Medical Officer and pathologist in the Rickettsial Zoonoses Branch in CDC’s Division of Vector-Borne Diseases, gives a clinical guide to recognising and managing typhus group rickettsiae. For more on typhus group rickettsiae, take a look at Best Practice: http://bestpractice.bmj.com/topics/en-gb/1604 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

A clinical guide to recognising and managing Tularaemia. Dr Isaac Bogoch is a clinical researcher, Toronto General Hospital Research Institute, Canada. To learn more about Tularaemia Infection, visit BMJ Learning https://goo.gl/7kRgeu And BMJ Best Practice bestpractice.bmj.com/topics/en-gb/916 _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Dr. Matthieu Million is a Senior Lecturer and Hospital Practitioner at the Infectious Diseases Unit, Centre Expert du Microbiote Humain, in Marseille, France. To learn more about Coxiella Burnetii Infection, visit BMJ Best Practice (http://bestpractice.bmj.com/topics/en-gb/1139) and BMJ Learning (http://learning.bmj.com) _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Hypertension: everything you need to know about the new 2017 AHA/ACC guidelines This podcast covers the implications of the new 2017 ACC/AHA guidelines for clinicians and their patients, including changes to the definition of hypertension, self monitoring, management and new recommendations in relation to existing guidelines. Dr Jeffrey Brettler is a general internist who practices at the Kaiser Permanente West Los Angeles Medical Center and is the author of the BMJ Best Practice topic, Essential Hypertension. Dr Brettler is interviewed by Dr Alison Walker, a Clinical Editor for BMJ Best Practice and BMJ Learning. To learn more about Hypertension, visit BMJ Best Practice (bestpractice.bmj.com/topics/en-gb/26). 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults (acc.org/guidelines#doctype=Guidelines) _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Plague - a guide to diagnosing and managing Yersinia Dr. Amesh Adalja is a Senior Scholar at the Johns Hopkins University Center for Health Security. He also serves on the City of Pittsburgh’s HIV Commission. He is board certified in internal medicine, emergency medicine, infectious diseases, and critical care medicine. To learn more about Yersinia Infection, visit BMJ Best Practice (http://bestpractice.bmj.com/topics/en-gb/1156). _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Botulism: a guide to recognition, reporting and referral - with Dr Claudia Kraft Dr Claudia Kraft, MD, CCFP (EM), MSc, is an emergency physician, formerly a full-service family physician. She has practiced in the Canadian Arctic/subarctic for her entire medical career, first in Iqaluit, Nunavut and now in Yellowknife, Northwest Territories (where she lives with her partner Steve, their son Henry, and their husky). To learn more about Botulism, visit BMJ Best Practice (https://bestpractice.bmj.com/topics/en-gb/810). _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

BMJ Clinical Director Dr Kieran Walsh speaks with Dr Tom Fletcher (http://www.lstmed.ac.uk/about/people/dr-tom-fletcher) about Ebola infection. Dr Tom Fletcher is a Wellcome Trust/Ministry of Defence Research Training Fellow and an Infectious Diseases Speciality Registrar in Liverpool. He is a physician in the Defence Medical Services and his research is on investigating the pathogenesis of Crimean-Congo Haemorrhagic Fever. He is specifically interested in viral haemorrhagic fevers and, during a recent secondment with the World Health Organisation, was deployed to West Africa to help with the Ebola outbreak. Here are links to studies and guidelines that were referred to. Ebola: Technical guidance documents for medical staff from the World Health Organisation (WHO)- http://www.who.int/csr/disease/ebola/protective-measures-staff/en/. Implementing an Ebola Vaccine Study — Sierra Leone - https://www.cdc.gov/mmwr/volumes/65/su/pdfs/su6503a14.pdf. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - http://www.nejm.org/doi/full/10.1056/NEJMoa1502924. To learn more about Ebola Virus Infection, visit BMJ Best Practice (http://bestpractice.bmj.com/best-practice/monograph/1210.html). _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Following acute exposure to the hepatitis C virus, most people develop chronic infection that increases the risk for long-term hepatic complications. Current treatment with oral direct-acting agents aims to eradicate the virus. Jawad Ahmad, Professor of Medicine in the Division of Liver Diseases at The Mount Sinai Hospital in New York, discusses hepatitis C infection with BMJ Knowledge Centre's U.S. Clinical Lead Sheila Feit, including future directions for a rapidly evolving field. More information available at the BMJ Best Practice website: http://bestpractice.bmj.com. About BMJ Best Practice BMJ Best Practice takes you quickly and accurately to the latest evidence based information, whenever and wherever you need it. Our step by step guidance on diagnosis, prognosis, treatment and prevention is updated daily using robust evidence based methodology and expert opinion. We support you in implementing good practice. Sign up to a free 7 day trial here*: bestpractice.bmj.com/info/subscribe/free-trial/ The below topics will be made freely available for 2 weeks from World Hepatitis Day (28th July 2017): Hepatitis C Step-by-step management: http://bestpractice.bmj.com/best-practice/monograph/128/treatment/details.html Treatment guidelines including American Association for the Study of Liver Diseases (AASLD) and European Association for Study of the Liver (EASL) http://bestpractice.bmj.com/best-practice/monograph/128/treatment/guidelines.html Hepatitis C Clinical Update in The BMJ (free access until 10th August 2017) http://www.bmj.com/content/358/bmj.j2861 *Please note that free personal trials and personal subscriptions are not available in North America. _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Most people with chronic hepatitis B infection are asymptomatic, but long-term complications may include cirrhosis, hepatocellular carcinoma, or liver failure. Jawad Ahmad, Professor of Medicine in the Division of Liver Diseases at The Mount Sinai Hospital in New York, discusses hepatitis B virus infection with BMJ Knowledge Centre's U.S. Clinical Lead Sheila Feit, including how to approach diagnostic serologies and treatment to help reduce the risk of advanced liver disease. More information available at the BMJ Best Practice website: http://bestpractice.bmj.com. About BMJ Best Practice BMJ Best Practice takes you quickly and accurately to the latest evidence based information, whenever and wherever you need it. Our step by step guidance on diagnosis, prognosis, treatment and prevention is updated daily using robust evidence based methodology and expert opinion. We support you in implementing good practice. Sign up to a free 7 day trial here*: bestpractice.bmj.com/info/subscribe/free-trial/ The below topics will be made freely available for 2 weeks from World Hepatitis Day (28th July 2017): Hepatitis B Diagnostic investigations: http://bestpractice.bmj.com/best-practice/monograph/127/diagnosis/tests.html Hepatitis B Step-by-step management: http://bestpractice.bmj.com/best-practice/monograph/127/treatment/details.html Treatment guidelines including American Association for the Study of Liver Diseases (AASLD) and European Association for Study of the Liver (EASL) http://bestpractice.bmj.com/best-practice/monograph/127/treatment/guidelines.html *Please note that free personal trials and personal subscriptions are not available in North America. _ The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

A BMJ Clinical Evidence systematic overview looks at the evidence for medical and surgical treatments of trigeminal neuralgia, and the uncertainties that exist due to gaps in the evidence. This has been summarised in The BMJ. The authors of the overview and bmj.comsummary, Prof. Joanna Zakrzewska from the Facial Pain Unit at the Eastman Dental Hospital, London, and Mark Linskey, Professor of Neurological Surgery at the University of California Irvine, discuss the evidence, the issues around it, and put this all into a clinical context. Read the full systematic overview: http://clinicalevidence.bmj.com/x/systematic-review/1207/overview.html Disclaimer: The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. BMJ does not warrant the accuracy of the information contained in the podcast and to the fullest extent permitted by law, BMJ Publishing Group Limited is not responsible for any loss whatsoever resulting from the application of, or reliance upon, the information contained in this podcast.

Post-traumatic stress disorder may develop (either immediately or delayed) following exposure to a stressful event or situation of an exceptionally threatening or catastrophic nature. According to DSM-5, it is characterised by 4 groups of symptoms: intrusion symptoms, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. These symptoms must impair function for a diagnosis to be made. In this podcast, Mathew Hoskins, Consultant Psychiatrist and Clinical Teaching Fellow, Cardiff University, gives us a clinical overview of the disorder. For more on PTSD, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/430 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Persistent depressive disorder is a category that includes various forms of chronic depression in which depressive symptoms are present 'more days than not' over at least a 2-year period (1 year in children and adolescents). David J. Hellerstein, Professor of Clinical Psychiatry, Columbia University Medical Center, gives us a clinical overview of the condition. For more on persistent depressive disorder, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/805 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Chronic sinusitis is inflammation of the paranasal sinuses lasting more than 12 weeks. Symptoms include facial pressure, rhinorrhoea, postnasal drainage, congestion, and general malaise. Raj Sindwani, Section Head of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic Foundation, gives us a clinical overview of the condition. For more on chronic sinusitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/15 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to Covid-19. Abigail Davis, GP and section editor, covers the latest evidence around vaccine immunogenicity in different immunosuppressed populations, as well as the use of interleukin-6 inhibitors in COVID-19 patients. And Emma Scott, section editor, updates us on mucormycosis, or black fungus infection in COVID-19 patients. For more, see: BMJ Best Practice's topic on COVID-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning COVID-19 in primary care module: new-learning.bmj.com/course/10065230 Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00676-0/fulltext Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19: https://www.nejm.org/doi/full/10.1056/NEJMoa2100433 WHO Therapeutics and COVID-19: living guideline: https://app.magicapp.org/#/guideline/nBkO1E/section/LrV7OL Indian Council of Medical Research advice on mucormycosis: https://www.icmr.gov.in/pdf/covid/techdoc/Mucormycosis_ADVISORY_FROM_ICMR_In_COVID19_time.pdf

Bulimia nervosa is an eating disorder, characterised by severe preoccupation about weight and body shape. Includes recurrent episodes of binge eating with compensatory mechanisms, such as self-induced vomiting, to prevent weight gain. Debra Safer, Associate Professor, Co-Director of Stanford Eating and Weight Disorders Program, Stanford University School of Medicine, gives us an overview of the condition. For more on bulimia nervosa, see BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/441 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Giant cell arteritis is a common form of vasculitis in people aged 50 years or older. The extracranial branches of the carotid artery are usually affected. Kenneth J. Warrington, Professor of Medicine, Mayo Clinic College of Medicine, gives us an overview of the condition. For more on giant cell arteritis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/177 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Emma Scott, section editor, updates us on vaccination for pregnant and breastfeeding women. And Abigail Davis, GP and section editor, covers myocardial infarction and pre-existing respiratory conditions. For more, see: BMJ Best Practice's topic on covid-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning covid-19 in primary care module: new-learning.bmj.com/course/10065230

Childhood constipation is typically characterised by infrequent bowel evacuations, large stools, and difficult or painful defecation. Symptoms may result from low fibre, poor nutrient, and/or insufficient water intake, which leads to excessive hardening of the stool. This often starts as an acute problem but can progress to faecal impaction and chronic constipation. Claire Zar-Kessler, Instructor in Pediatric Gastroenterology, Massachusetts General Hospital for Children, Boston gives us a clinical overview of the condition. Please always check the licensed indications for medications in your own country. For more on constipation in children, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/784 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Depression can describe both a mood and an illness. Major depressive disorder is a clinical syndrome involving mood, neurovegetative functions, cognition, and behaviour. It affects 5% to 10% of patients in the primary care setting. Dean F. MacKinnon, Associate Professor, Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital, Baltimore, gives us an overview of how to diagnose and manage depression in adults. For more on depression in adults, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/55 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Emma Scott, section editor, updates us on vaccination and the risk of blood clots. And Abigail Davis, GP and section editor, covers acute kidney injury, venous thromboembolism prevention, and secondary bacterial pneumonia. For more, see: BMJ Best Practice's topic on covid-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning covid-19 in primary care module: new-learning.bmj.com/course/10065230 EMA: ema.europa.eu/en/news/astrazenecas-covid-19-vaccine-ema-finds-possible-link-very-rare-cases-unusual-blood-clots-low-blood MHRA: gov.uk/government/news/mhra-issues-new-advice-concluding-a-possible-link-between-covid-19-vaccine-astrazeneca-and-extremely-rare-unlikely-to-occur-blood-clots JCVI: gov.uk/government/publications/use-of-the-astrazeneca-covid-19-vaccine-jcvi-statement/jcvi-statement-on-use-of-the-astrazeneca-covid-19-vaccine-7-april-2021 WHO: who.int/news/item/07-04-2021-interim-statement-of-the-covid-19-subcommittee-of-the-who-global-advisory-committee-on-vaccine-safety COVID-19 rapid guideline: managing COVID-19: nice.org.uk/guidance/NG191 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Chronic kidney disease (CKD) is a common condition that is often unrecognised until the most advanced stages. The most common causes are diabetes mellitus and hypertension. Manisha Singh, Assistant Professor, Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, gives us an overview of the condition. For more, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/84 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Depression in children is characterised by sad or irritable mood, anhedonia, decreased capacity to have fun, decreased self-esteem, sleep disturbance, social withdrawal or impaired social relationships, and impaired school performance. It is one of the most common paediatric psychiatric disorders, especially among girls during adolescence. David A. Brent, Endowed Chair in Suicide Studies, Professor of Psychiatry, Pediatrics, Epidemiology, and Clinical and Translational Science, University of Pittsburgh, gives us an overview of the condition. For more on depression in children, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/785 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Deep vein thrombosis (DVT) is the development of a blood clot in a major deep vein in the leg, thigh, pelvis, or abdomen, which may result in impaired venous blood flow and consequent leg swelling and pain. Scott C. Woller, Director, Thrombosis Clinic, Intermountain Medical Center, Murray and Professor of Medicine, University of Utah, gives us an overview of the condition. For more on DVT, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/70 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Raynaud's phenomenon (RP) is characterised by vasospasm that causes digits to change colour to white (pallor) from lack of blood flow, usually brought on by cold temperatures. Affected areas subsequently turn blue due to de-oxygenation and/or red due to reperfusion. It can be a painful condition and can lead to complications. Janet Pope, Professor of Medicine, Division of Rheumatology, Department of Medicine, University of Western Ontario, gives a clinical overview of the condition. For more on Raynaud's phenomenon, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/193 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Matt Castleden, GP and section editor, updates us on pulse oximetry, prognostic scoring, and management in hospital. And Abigail Davis, GP and section editor, covers Covid-19 vaccination and chronic conditions, including advice for patients with thrombocytopenia, and those taking immunosuppressive drugs, ACE inhibitors or ARBs. For more, see: BMJ Best Practice's topic on management of coexisting conditions in the context of COVID-19: bestpractice.bmj.com/topics/en-gb/3000190 BMJ Best Practice's topic on covid-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning's quick tips module: proning in critical care: learning.bmj.com/learning/modules/elucidat/10065419 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning covid-19 in primary care module: new-learning.bmj.com/course/10065230

Asthma exacerbations present with acute or sub-acute onset of wheeze and respiratory distress, the symptoms and signs of which vary depending on the developmental and maturational age of the child. Triggers include viral or bacterial infection, inhaled allergens, environmental irritants, emotion, medications, and poor adherence with preventive therapy. Paul D. Robinson, Respiratory and Sleep Physician, The Children's Hospital at Westmead and Associate Professor, Discipline of Paediatrics and Child Health, University of Sydney, gives a clinical overview of acute asthma exacerbations in children. For more on acute asthma exacerbations in children, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1098 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.