The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.

Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.

This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.

Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.

Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.

can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll also learn" section based on this episode's content: You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties Want me to add this to the script, or adjust the tone or number of bullets? give me a dash in front of each bullet You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties can you give me timestamps for this episode. similar to this previous example: Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Timestamps: 00:00 – Intro & The Brain Fog Problem 01:12 – Fixing Brain Energy 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 now i need a one sentence summary of this episode After overcoming his own brain fog, the creator breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance.

Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.

Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity.

Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.

Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.

Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.

Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.

Dave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.

Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back onTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Longevity Switch00:59 – Mitochondria: Power Plants02:14 – What Is Mitophagy04:05 – How Stress Blocks It05:36 – Exercise Extremes07:29 – NAD+ and Silent Damage08:59 – Reversing It: Fasting10:27 – REHIT and Cold Exposure12:02 – The Supplement StackConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.

Dave Asprey breaks down piracetam and the racetam family, the original nootropics that launched the smart drug movement, covering how they work, who benefits, proper dosing, and the safety and regulatory landscape around them.

Dr. Steven Greer, a retired emergency physician and 35-year UFO researcher, joins Dave Asprey to make the case that extraterrestrial intelligence is already interacting with Earth, that suppressed free-energy technology could end global poverty, and that humanity's future depends on a truthful—not weaponized—disclosure before it's too late.

Skin ages faster when oxidative stress overwhelms your defenses, so this episode explains why glutathione — the body's master antioxidant — protects collagen better than collagen itself, and how a new delivery system (RO-GSH) finally makes topical glutathione work, visibly improving wrinkles and skin tone in just one week.

This week's biohacking roundup covers a drug-repurposing screen for longevity, protein restriction's anti-aging effects via FGF21, a new cadaver-derived skin injectable, arts engagement slowing biological aging, and a review of 41 studies testing biohacking interventions (including semaglutide) against epigenetic clocks.

Author Regena "Mama Gina" joins Dave Asprey to reveal how embracing pleasure, embodiment and reverent surrender heals trauma, restores intuition and unlocks the divine feminine in women and men alike.

Dr. Vivek Lal, the physician scientist who discovered the gut-lung axis, joins Host Dave Asprey to reveal how your gut bacteria control lung inflammation through the MMP-9 pathway, and why fixing your lung microbiome may be the next frontier in longevity and respiratory health.

This episode explains how aging is driven by declining antioxidant defenses and mitochondrial damage, and makes the case for glutathione—delivered topically via Glutaryl—as a practical way to support cellular repair.

This episode covers five health research stories: sildenafil's anti-cancer potential, TV watching's effect on brain aging in men, ambient heat's impact on biological aging, superbug risks from industrial chicken farming, and a CO2-based technique to trigger the brain's glymphatic waste-clearance system.

Ashley Grace, executive at Igniton, joins Host Dave Asprey to unpack the science behind subatomic particles called ignitons and how a private $18 million lab charges supplements to boost memory, sleep, and longevity.

A urologist joins the podcast to discuss penis enlargement procedures (fillers, traction, surgery), men's health and confidence, and the growing use of peptides (PT-141, BPC-157, SS-31) and TRT amid ongoing regulatory battles over compounding pharmacy access.

Eating within three hours of bedtime keeps your body's "digestion kitchen" running, blocking the cortisol dip needed for deep overnight repair — so a simple three-hour pre-bed food cutoff ("sleep fasting") can dramatically improve sleep quality, energy, and recovery.

This episode breaks down the latest health research and news — from artificial sweeteners and muscle fat harming cardiovascular health, to a new cholesterol pill, a lettuce-borne outbreak, the gut-brain connection to anxiety, and a banana-blueberry smoothie myth — with practical takeaways and predictions for where the science is heading.

Dave Asprey and microbiologist Kiran Krishnan discuss how spore-based probiotics (like Just Thrive) combat gut endotoxins to improve testosterone, body composition, bone density, and overall longevity.

Dave sits down with Dr. Sean O'Mara to break down the critical difference between visceral and subcutaneous fat, revealing why a six-pack can hide disease, how MRI scans expose what the mirror can't, and the fasting and microbiome strategies that build the fat you actually want.

Dave Asprey breaks down a complete $200 biohacking stack—red light bulbs, blackout curtains, light-blocking glasses, creatine, MCT oil, spermidine, and magnesium—that improves sleep, brain energy, and cellular repair without needing expensive protocols.

Shawn Stevenson reveals the minimum number of family meals per week that measurably lowers a child's risk of obesity, and why eating together may be the most overlooked longevity habit in modern life.

Dr. Nayan Patel reveals why oral, liposomal, and even IV glutathione never actually reach your cells, and the transdermal delivery breakthrough that finally does.

Dr. Peter McCullough traces the spike protein's origins to 2015 gain-of-function research, explains why it can persist in the body for years after vaccination, and breaks down the science behind clearing it, the suppression of early COVID treatments, and what he'd change if he ran HHS.

A Japanese village's daily breakfast of natto — rich in spermidine — triggers the Nobel Prize-winning cellular repair process of autophagy, reversing biological aging within 72 hours when combined with proper dosing, exercise, sleep, and diet.

Jordan Harbinger joins Dave Asprey to share how he talked his way out of two kidnappings and breaks down the psychology-driven systems — calendar blocking, pain-point habit hacks, and relationship-building — he uses to stay productive and charming under pressure.

Dave Asprey sits down with Dr. David Perlmutter to explore how brain inflammation and microglial dysfunction drive Alzheimer's, Parkinson's, and other neurodegenerative conditions — debunking the amyloid hypothesis along the way and examining emerging treatments like GLP-1 drugs, 40 hertz light therapy, and lifestyle interventions.

Discover how a suppressed 1910 light therapy can restructure water inside your cells, boost mitochondrial energy, and reverse the damage caused by blue light and EMF exposure.

Dave Asprey breaks down which legal focus compounds (caffeine+L-theanine, adaptogens, MCT oil, methylene blue, and especially creatine) actually boost brain energy and performance, and shows how to stack them for sustained, crash-free focus.

This episode covers new research on gut-derived acetate and brain health, GLP-1 side effects on smell and taste, toxoplasmosis prevalence, exercise's outsized mental health benefits, individual variation in processing plant phytonutrients, produce pesticide guidance, and the Unilever-Thorne acquisition — all tied together with a call to actually track your own biomarkers instead of just consuming health news.

Dave Asprey and Ben Azadi discuss metabolic health, covering carnivore diet experiments, cyclical ketosis, electrolytes, sleep optimization, and creatine, while trading practical biohacking tips and reflecting on building health platforms despite online criticism.

3:45 PMClaude responded: Oxytocin researcher and triple board-certified OBGYN Dr.Oxytocin researcher and triple board-certified OBGYN Dr. Anna Cabeca joins Dave to expose what conventional medicine gets wrong about hormones, pleasure, and longevity, and how fixing your oxytocin, estrogen, and FSH levels can transform your health, your brain, and your relationships at any age.

Dave explains how age‑related drops in the mitochondrial cofactor NAD⁺—and overactivity of enzymes that destroy it—drive fatigue, brain fog, and degeneration, then lays out a protocol (diet, polyphenols, fasting, REHIT exercise, and NMN/NR supplementation) to rebuild NAD⁺ and slow aging

Does fish oil actually protect your brain, can your mindset slow aging, and what can butterflies teach us about longevity? Dave Asprey unpacks the week’s biggest biohacking breakthroughs.

5:38 PMClaude responded: Jeff Boyd, founder of MTE, joins Dave Asprey to break down why conventional energy drinks are sabotaging your cortisol, sleep, and gut health, and how a full-s…Jeff Boyd, founder of MTE, joins Dave Asprey to break down why conventional energy drinks are sabotaging your cortisol, sleep, and gut health, and how a full-spectrum stack of adaptogens, nootropics, and prebiotics delivers clean, foundational energy without the crash.

12:24 PMClaude responded: Childhood trauma forged in war becomes the foundation for a biohacking philosophy built around nervous system mastery and intentional living.Childhood trauma forged in war becomes the foundation for a biohacking philosophy built around nervous system mastery and intentional living.

Your body's built-in mitochondrial cleanup process (mitophagy) is being silently suppressed by modern stress, eating habits, and aging, but you can reactivate it through fasting, high-intensity exercise, cold exposure, NAD+ supplementation, and compounds like urolithin A and spermidine.

This week Dave breaks down five studies that challenge what you think you know about copper and Alzheimer's, sugar-free diets, strength training, childhood brain development, and taurine, and why the label is almost never the whole story.

11:13 AMClaude responded: A board-certified psychiatrist and neuroscientist breaks down why ketamine and MDMA therapy repair trauma at the epigenetic level, why most antidepressants are…A board-certified psychiatrist and neuroscientist breaks down why ketamine and MDMA therapy repair trauma at the epigenetic level, why most antidepressants are keeping people sick, and why psychedelic medicine is the biggest breakthrough in the history of psychiatry.

2:30 PMClaude responded: Dermatologist Dr.Dermatologist Dr. Michael Christopher exposes the melanoma detection gap most doctors don't know exists and shares the tools, habits, and skin science that can save your life.

Vitamin C — not willpower — is the missing key to effortless focus, because your brain can't produce the neurotransmitters it needs without it, and learning to supplement and absorb it correctly can eliminate mental fatigue at its biological root.

GLP-1 drugs are moving aging clocks, the FDA finally caught up to Europe on sunscreen, and a DNA sugar may regrow hair — Dave Asprey breaks down six stories that all come back to the same question: what is this molecule actually doing inside your body?

A Johns Hopkins and Harvard-trained neurologist with 37 years of experience reveals why your brain is physically shrinking right now, why brain fog and cognitive decline are always treatable, and exactly what to do about it.

2:29 PMClaude responded: Food is your most powerful medicine, and Dr.Food is your most powerful medicine, and Dr. William Li proves it with the science of how everyday foods starve cancer, what 720,000 living centenarians reveal about longevity, and why your vascular health determines how long and how well you live.

After struggling with weight for years, Dave Asprey discovered that adding fat (butter and MCT oil) to his coffee instead of sugar transformed his metabolism, helped him lose 100 pounds, and sparked a global movement now known as Bulletproof Coffee.

The edges of medicine are moving faster than the mainstream — from an engineered virus stopping pancreatic cancer to a diabetes drug cutting breast cancer risk to 21 years of Finnish data finally settling the sauna debate — and your job is to catch the signal before it becomes a headline.

In this episode, Dave Asprey and the founders of Mara Labs discuss how sulforaphane (in their BroccoLite supplement) activates all three detox pathways to help the body excrete microplastics, heavy metals, BPA, and other environmental toxins, while also covering its benefits for brain health, hormone balance, autism, and longevity.

Host Dave Asprey interviews Justin Kirkland of Amino Innovations and Precision Peptide Company, a chemist with 30 years of experience, about how peptides are synthesized, sourced safely in the US, and delivered through injections, microneedle patches, and nasal sprays, while discussing quality control issues in the gray market, which peptides are most promising or overhyped, and how genetics and gut bacteria influence individual responses.

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5:29 PMClaude responded: This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control…This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control the pace of aging, new evidence linking depression to immune biology, and a genetics paper that says half your lifespan was loaded before you were born.

Dr. Andrew Salzman joins Dave Asprey to explain how gut barrier breakdown drives systemic aging through NAD depletion and inflammation, and why creatine and targeted NAD support are key to reversing it.

Dave Asprey and Dr. Jessica Peatross expose the root causes of chronic illness — parasites, toxic mold, histamine dysfunction, and cortisol imbalance — while challenging mainstream medicine's failures on everything from Lyme disease to the California Medical Board.

Drawing from Okinawa's blue zone lifestyle, this episode breaks down the five science-backed habits (mindful eating, purpose, staying active, strong social bonds, and stress resilience) that help people live past 100.

9:03 PMClaude responded: Dr.Dr. Patrick Porter, PhD, founder of BrainTap, joins Host Dave Asprey to reveal how flickering light, 40 hertz gamma frequency, and brainwave entrainment technology backed by 72 peer-reviewed studies can break up amyloid plaque, reset your sleep, and rewire your brain for peak performance in as little as 10 minutes a day.

Chris Rinsch, co-founder and President of Timeline Longevity, joins Host Dave Asprey to reveal the 18-year science behind urolithin A, the postbiotic compound that outperforms rapamycin, triggers mitophagy, and is quietly becoming the most clinically validated longevity supplement on earth.

Claude responded: Dr.Dr. Molly Maloof, physician and former Stanford educator, joins Host Dave Asprey to reveal how human connection reshapes your biology at the cellular level, why longevity escape velocity is already here, and which peptides, psychedelics, and regenerative medicine breakthroughs are rewriting the rules of healthspan.

L-theanine, a 4,000-year-old amino acid found in tea, stacks with caffeine at a 2:1 ratio to create calm, focused alertness, and when combined with quality sleep, stress management, and clean coffee, it can deliver monk-like focus over the long term.

A single creatine dose sharpens your sleep-deprived brain, your gum is loading you with microplastics, irregular bedtimes may double your heart attack risk, scientists just decoded a plant molecule that kills cancer cells in the lab, and researchers built a reversible on/off switch for sperm production with no hormones required.

A UK physiotherapist (Will Harlow) joins Dave Asprey on the Human Upgrade podcast to debunk common fitness myths for people over 50, arguing that resistance training rather than cardio or walking alone is the key to building muscle, bone density, and long-term independence.

Your relational environment is a hormonal input, and John Gray breaks down the biology of attraction, testosterone, estrogen, and desire to show you exactly how to hack it.

If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD).I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm.Thank you to our sponsors!-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air-The One Device | Use code DAVE for $10 off at theonedevice.com/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:40 – Gut Ecosystem01:00 – Constant Snacking02:57 – Gut-Brain Connection03:40 – Why Standard Fasting Can Backfire07:22 – The Fasting Sweet Spot09:21 – Introducing the FMD10:43 – Pre-Reset: Prep Days13:24 – The 5-Day FMD Protocol16:47 – Meal Timing & Circadian Rhythm17:46 – Sleep, Stress & Recovery18:22 – How Often to Do FMD19:23 – WrapupConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your hormones, your immune system, and your ability to act fast are the only things standing between you and a week that just proved institutions can't save you.

A former T-Mobile VP turned quantum tech founder explains how a remote energy field delivered over any distance produced measurable improvements in brain waves, HRV, and ATP production across 25 published studies — and why no sticker or passive device can protect you from what 5G, Starlink, and everyday EMF are actually doing to your mitochondria.

Dr. Kara Fitzgerald reveals how a targeted diet and supplement protocol reversed biological age by over three years in eight weeks, then goes deep on the Yamanaka factor science that could make that just the beginning.

Brain fog isn't a willpower problem — it's a stressed nervous system, and ancient heat rituals like infrared sauna and contrast therapy are the most effective ways to reset it.

Dave Asprey breaks down five new research stories — from Finnish dirt playgrounds and exercise variety data to facial aging AI, bone-building wearables, and the raw milk H5N1 situation — and tells you exactly what to do with each one.

Dave Asprey and Brad Pizzoli discuss how combining Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges mitochondrial function, fights inflammation, and improves circulation to address chronic illness and slow aging.

Nurse practitioner and women's health expert Cynthia Thurlow joins Dave Asprey to expose the hormonal, gut, and environmental root causes of perimenopause that mainstream medicine ignores, and the real solutions that give women their bodies, brains, and relationships back.

Urolithin A researcher breaks down the science of immune aging, mitochondrial decline, and how a compound derived from pomegranates may restore the cellular cleanup process your body loses after 40.

Kambo researcher and practitioner Caitlin Thompson breaks down the peptide science, risks, and remarkable healing potential behind frog venom ceremonies and why intentional suffering might be one of the most powerful biohacking tools you have never tried.

Neuroscientist Dr. Tommy Wood breaks down the science of brain aging, cognitive decline, and the biohacking strategies you can use to build a sharper, more resilient mind at any age.

You are not overeating because you lack willpower, you are overeating because you have been biologically and behaviorally programmed to, and this episode explains exactly how to stop.

Everything you've been told about diet and exercise is wrong — here's how eating more fat, skipping breakfast, and ditching the gym helped one biohacker lose 100 pounds and turn back his biological clock by 20 years.

5:17 PMA virologist who cured her own terminal cancer, the molecule that makes fasting actually work, a hair loss treatment that makes minoxidil obsolete, the sardine stack that beats your supplement shelf, and a 70-year study that should embarrass half the country's health policy — this week, the gap between what's known and what you're doing about it has never been more expensive to ignore.

1:44 PM Your white blood cells already make the most powerful wound-healing molecule on the planet, and this episode tells you exactly how to use it.

A sitting government health official and lifelong longevity insider joins Host Dave Asprey to reveal how the U.S. is finally overhauling its approach to diet, aging, AI, and chronic disease from the inside out.

1:25 PMCreatine is not just a bodybuilding supplement anymore, and Host Dave Asprey breaks down the full science of why this cheap, safe, and massively underrated compound may be the single most versatile biohack available for boosting brain power, protecting mitochondria, building muscle, and extending longevity in both men and women.

A stealth bacterial infection hiding in cat scratches, a common amino acid quietly cutting men's lifespans, contact lenses that upgrade your vision beyond normal, a supplement stack that actually moves motivation, and a 30-second nervous system reset you can do for free — Dave breaks down five under-the-radar findings that are changing how serious biohackers think about daily health.

Women's hormone therapy hasn't meaningfully evolved since the 1960s, and Dr. Sarah Daccarett is here to fix that, walking Host Dave Asprey through the real science of bioidentical hormones, vaginal delivery, and why optimizing estrogen, progesterone, and testosterone is the most powerful longevity move a woman can make at any age.

Dave Asprey breaks down why aging is driven by oxidative stress at the cellular level, and reveals how NASA-researched algae, specifically spirulina and chlorella, can activate your body's built-in antioxidant defenses to slow the process from the inside out.

Toxic mold is silently destroying your health, relationships, and home — and Dave Asprey and Superstratum founder Seth Jones break down exactly what it costs you and how to finally fix it for good.

A warrior mom shares how she reversed her son's autism through biomedical intervention — and why gut health, toxic load, and early action are the keys most doctors won't tell you about.

4:47 PMYour "clean" supplements may be quietly poisoning you, and Host Dave Asprey and PUORI founder Oliver Amdrup-Chamby break down exactly why, covering fish oil oxidation, heavy metals in protein powder, glyphosate in collagen, and the foundational supplements that actually move the needle on longevity.

A step-by-step breakdown of the exact brain states, amino acids, and light environment changes that separate people who fall asleep easily from people who lie awake staring at the ceiling.

The most advanced stem cell clinic on the planet just figured out how to upgrade your brain like hardware, and Dave went to Costa Rica to be one of the first to try it.

The neuroscience of why optimizing your body means nothing if you're starving the half of your brain responsible for meaning, consciousness, and everything that makes life worth living.

Your gut microbiome controls far more than digestion, and in this episode Host Dave Asprey and Omni-Biotic's Hannah Kleinfeld break down exactly how it drives your brain function, sleep, metabolism, heart rate variability, hormones, and long-term health outcomes.

Your eyes have a built-in nightly repair cycle that most people unknowingly disrupt, and by adopting seven simple daily habits — including red light therapy, blueberries, cold exposure, grounding, distance viewing, deliberate blinking, and aligning with natural light cycles — you can reactivate that self-healing switch and restore or preserve your vision naturally.

SNL, pistachios, AI doctors, your microbiome's architecture, colon cancer under 50, and a measles comeback — this week's news is a masterclass in why the assumptions you haven't questioned yet are the most dangerous ones.

Dave Asprey and McCall McPherson expose why standard thyroid testing and treatment is failing millions of patients, breaking down the full T4 to T3 hormone pathway, the hidden environmental triggers destroying thyroid function, and the overlooked connections between low thyroid, testosterone, Hashimoto's, and misdiagnosed ADHD in kids.