The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey shares what he learned testing every controversial and banned focus drug over 25 years, ranking modafinil and racetams as the best performers while crowning pharmaceutical nicotine as the king of focus drugs for its proven cognitive benefits, low cost, and legal accessibility when used safely.

Dave Asprey explores how placebo pills can relieve symptoms even when patients know they're fake, how wall squats can lower blood pressure, why birdwatching may benefit brain health, and what research reveals about THC, rapamycin, pornography, and the brain's reward system.

Dave Asprey sits down with Calocurb CEO Sarah Kennedy to explore how bitter hops compounds stimulate natural GLP-1 and other satiety hormones to reduce appetite, support weight loss, target visceral fat, and preserve muscle without injectable weight-loss drugs.

Dave Asprey and Dr. Tim Cook explore experimental gene therapies, stem cell re-education, and emerging longevity technologies that could reverse biological aging, rejuvenate the immune system, build muscle, and extend human lifespan.

Dave Asprey reveals how to build a science-backed longevity routine for less than $5 a day using affordable supplements, better sleep, sunlight, walking, and simple habits that support healthy aging without expensive biohacks.

Dave Asprey and integrative practitioner Terry Cochran discuss how four metabolic disruptors — amyloids, oxalates, sulfur malabsorption, and histamine — are hijacked by industrial food, glyphosate, and the spike protein, and share practical strategies for clearing these burdens through diet, supplements, and enzymes.

Dave Asprey and Steven Kotler explore the neuroscience of flow states, psychedelics, brain chemistry, trauma, consciousness, and how to train your brain for peak performance without relying on drugs.

Dave Asprey and Hal Elrod explore how morning routines, visualization, affirmations, meditation, and the six SAVERS habits can help reprogram your mindset, overcome procrastination, build resilience, and achieve your goals.

I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me.

John Gray explains how testosterone and estrogen drive male-female relationship dynamics, from emotional communication and conflict resolution to sexual polarity and recovering from public criticism.

Sleep expert Dr. Michael Breus joins Dave Asprey to reveal why fear and anxiety may be driving your sleep problems, how chronotypes and circadian rhythms affect sleep quality, and practical strategies to fall asleep faster, stay asleep longer, and wake up feeling more rested.

Host Dave Asprey sits down with research microbiologist Kiran Krishnan to explore groundbreaking research on cartilage regeneration, joint repair, nitric oxide, vascular health, muscle growth, and how improving blood flow may help the body repair itself and maintain strength as it ages.

Your focus depends on a norepinephrine and dopamine "switch" that chronic stress, bad sleep, and sitting all day drain, and you can turn it back on in about 20 minutes with morning light, movement, and a stack of L-tyrosine, caffeine, and L-theanine.

Dave Asprey breaks down five new health stories on infection-driven cancer risk, finasteride side effects, blueberries and polyphenols, vitamin D and male fertility, and why CoQ10 shows that a strong biological mechanism does not always translate into better outcomes.

Dave Asprey and psychic medical intuitive Julie Ryan explore whether intuitive abilities can be trained, how they may relate to healing and consciousness, and what Julie says happens as people approach death.

Miranda Kerr joins Dave Asprey to explore how simplifying health around clean living, sleep, stress management, meditation, family, and intentional skincare can create a more sustainable approach to wellness.

Dave Asprey shares the five hacks that helped him lose over 100 pounds and feel decades younger, from inventing butter coffee in Tibet to eating more saturated fat, cutting anti-nutrients, intermittent fasting, and prioritizing nutrition over endless gym sessions.

Dave Asprey breaks down new research on vagus nerve stimulation and memory, feline cancer genetics, inherited cognitive ability, mulberries and the microbiome, and how magnesium changes vitamin D metabolism.

The founders of Young Goose explore science-backed, longevity-focused skincare — covering metabolomic skin testing, key ingredients like ergothioneine and ectoin, mitochondrial dysfunction, vampire exosomes, red light therapy stacking, and proteomics — all aimed at targeting the 12 hallmarks of aging rather than just treating surface symptoms.

Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity

Dave Asprey outlines six science-backed methods to melt visceral fat—ranging from high-protein eating and HIIT to cold exposure, weightlifting, quality sleep, and stress reduction—arguing that chronic stress is the root cause that must be addressed for lasting fat loss.

A roundup of five health stories — Novo Nordisk's interest in hair loss, nutritional deficiencies in kids on GLP-1s, stomach-brain synchronization and mental health, food preservatives linked to heart disease, and taurine's stress-protective effects in rats — closing with a reminder to audit the hidden downsides of any health intervention you're already doing.

Dr. Robert Waldinger shares findings from the 85-year Harvard Study of Adult Development revealing that the quality of our relationships—not wealth, fame, or power—is the single greatest predictor of health, happiness, and longevity, and offers practical strategies for building "social fitness" at any life stage.

Dave Asprey and Catharine Arnston explore how spirulina and chlorella may support mitochondrial function, cellular energy, detoxification, brain health, and healthy aging.

A mold illness survivor explains how toxic mold in your home and body causes chronic brain fog, fatigue, and inflammation — and lays out a step-by-step plan to identify the source, remediate your environment, and detox what your body has already absorbed.

Dave Asprey sits down with spiritual teacher Teal Swan to explore narcissism, betrayal, extrasensory perception, the nature of ego, divine masculine and feminine energy, and whether humanity can heal its deepest wounds.

Dave Asprey and neurobiologist Dr. Michael Leon explore how your sense of smell influences memory, sleep, brain aging, and longevity, and why olfactory enrichment may be one of the most overlooked tools for protecting cognitive health.

This episode is a wide-ranging conversation covering testosterone and hormone replacement therapy, peptides, biohacking, psychedelics and spirituality, parenting, and building a health/longevity business, with the hosts sharing personal experiences throughout.

Dave Asprey and Carolina Reis de Oliveira break down how senescent cells, menopause, hydration loss, and peptide science affect skin aging, and what the latest research suggests may help make skin function biologically younger.

This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements.

This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat.

Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.

Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.

This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.

Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.

Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.

can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll also learn" section based on this episode's content: You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties Want me to add this to the script, or adjust the tone or number of bullets? give me a dash in front of each bullet You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties can you give me timestamps for this episode. similar to this previous example: Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Timestamps: 00:00 – Intro & The Brain Fog Problem 01:12 – Fixing Brain Energy 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 now i need a one sentence summary of this episode After overcoming his own brain fog, the creator breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance.

Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.

Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity.

Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.

Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.

Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.

Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.

Dave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.

Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back onTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Longevity Switch00:59 – Mitochondria: Power Plants02:14 – What Is Mitophagy04:05 – How Stress Blocks It05:36 – Exercise Extremes07:29 – NAD+ and Silent Damage08:59 – Reversing It: Fasting10:27 – REHIT and Cold Exposure12:02 – The Supplement StackConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.

Dave Asprey breaks down piracetam and the racetam family, the original nootropics that launched the smart drug movement, covering how they work, who benefits, proper dosing, and the safety and regulatory landscape around them.

Dr. Steven Greer, a retired emergency physician and 35-year UFO researcher, joins Dave Asprey to make the case that extraterrestrial intelligence is already interacting with Earth, that suppressed free-energy technology could end global poverty, and that humanity's future depends on a truthful—not weaponized—disclosure before it's too late.

Skin ages faster when oxidative stress overwhelms your defenses, so this episode explains why glutathione — the body's master antioxidant — protects collagen better than collagen itself, and how a new delivery system (RO-GSH) finally makes topical glutathione work, visibly improving wrinkles and skin tone in just one week.

This week's biohacking roundup covers a drug-repurposing screen for longevity, protein restriction's anti-aging effects via FGF21, a new cadaver-derived skin injectable, arts engagement slowing biological aging, and a review of 41 studies testing biohacking interventions (including semaglutide) against epigenetic clocks.

Author Regena "Mama Gina" joins Dave Asprey to reveal how embracing pleasure, embodiment and reverent surrender heals trauma, restores intuition and unlocks the divine feminine in women and men alike.

Dr. Vivek Lal, the physician scientist who discovered the gut-lung axis, joins Host Dave Asprey to reveal how your gut bacteria control lung inflammation through the MMP-9 pathway, and why fixing your lung microbiome may be the next frontier in longevity and respiratory health.

This episode explains how aging is driven by declining antioxidant defenses and mitochondrial damage, and makes the case for glutathione—delivered topically via Glutaryl—as a practical way to support cellular repair.

This episode covers five health research stories: sildenafil's anti-cancer potential, TV watching's effect on brain aging in men, ambient heat's impact on biological aging, superbug risks from industrial chicken farming, and a CO2-based technique to trigger the brain's glymphatic waste-clearance system.

Ashley Grace, executive at Igniton, joins Host Dave Asprey to unpack the science behind subatomic particles called ignitons and how a private $18 million lab charges supplements to boost memory, sleep, and longevity.

A urologist joins the podcast to discuss penis enlargement procedures (fillers, traction, surgery), men's health and confidence, and the growing use of peptides (PT-141, BPC-157, SS-31) and TRT amid ongoing regulatory battles over compounding pharmacy access.

Eating within three hours of bedtime keeps your body's "digestion kitchen" running, blocking the cortisol dip needed for deep overnight repair — so a simple three-hour pre-bed food cutoff ("sleep fasting") can dramatically improve sleep quality, energy, and recovery.

This episode breaks down the latest health research and news — from artificial sweeteners and muscle fat harming cardiovascular health, to a new cholesterol pill, a lettuce-borne outbreak, the gut-brain connection to anxiety, and a banana-blueberry smoothie myth — with practical takeaways and predictions for where the science is heading.

Dave Asprey and microbiologist Kiran Krishnan discuss how spore-based probiotics (like Just Thrive) combat gut endotoxins to improve testosterone, body composition, bone density, and overall longevity.

Dave sits down with Dr. Sean O'Mara to break down the critical difference between visceral and subcutaneous fat, revealing why a six-pack can hide disease, how MRI scans expose what the mirror can't, and the fasting and microbiome strategies that build the fat you actually want.

Dave Asprey breaks down a complete $200 biohacking stack—red light bulbs, blackout curtains, light-blocking glasses, creatine, MCT oil, spermidine, and magnesium—that improves sleep, brain energy, and cellular repair without needing expensive protocols.

Shawn Stevenson reveals the minimum number of family meals per week that measurably lowers a child's risk of obesity, and why eating together may be the most overlooked longevity habit in modern life.

Dr. Nayan Patel reveals why oral, liposomal, and even IV glutathione never actually reach your cells, and the transdermal delivery breakthrough that finally does.

Dr. Peter McCullough traces the spike protein's origins to 2015 gain-of-function research, explains why it can persist in the body for years after vaccination, and breaks down the science behind clearing it, the suppression of early COVID treatments, and what he'd change if he ran HHS.

A Japanese village's daily breakfast of natto — rich in spermidine — triggers the Nobel Prize-winning cellular repair process of autophagy, reversing biological aging within 72 hours when combined with proper dosing, exercise, sleep, and diet.

Jordan Harbinger joins Dave Asprey to share how he talked his way out of two kidnappings and breaks down the psychology-driven systems — calendar blocking, pain-point habit hacks, and relationship-building — he uses to stay productive and charming under pressure.

Dave Asprey sits down with Dr. David Perlmutter to explore how brain inflammation and microglial dysfunction drive Alzheimer's, Parkinson's, and other neurodegenerative conditions — debunking the amyloid hypothesis along the way and examining emerging treatments like GLP-1 drugs, 40 hertz light therapy, and lifestyle interventions.

Discover how a suppressed 1910 light therapy can restructure water inside your cells, boost mitochondrial energy, and reverse the damage caused by blue light and EMF exposure.

Dave Asprey breaks down which legal focus compounds (caffeine+L-theanine, adaptogens, MCT oil, methylene blue, and especially creatine) actually boost brain energy and performance, and shows how to stack them for sustained, crash-free focus.

This episode covers new research on gut-derived acetate and brain health, GLP-1 side effects on smell and taste, toxoplasmosis prevalence, exercise's outsized mental health benefits, individual variation in processing plant phytonutrients, produce pesticide guidance, and the Unilever-Thorne acquisition — all tied together with a call to actually track your own biomarkers instead of just consuming health news.

Dave Asprey and Ben Azadi discuss metabolic health, covering carnivore diet experiments, cyclical ketosis, electrolytes, sleep optimization, and creatine, while trading practical biohacking tips and reflecting on building health platforms despite online criticism.

3:45 PMClaude responded: Oxytocin researcher and triple board-certified OBGYN Dr.Oxytocin researcher and triple board-certified OBGYN Dr. Anna Cabeca joins Dave to expose what conventional medicine gets wrong about hormones, pleasure, and longevity, and how fixing your oxytocin, estrogen, and FSH levels can transform your health, your brain, and your relationships at any age.

Dave explains how age‑related drops in the mitochondrial cofactor NAD⁺—and overactivity of enzymes that destroy it—drive fatigue, brain fog, and degeneration, then lays out a protocol (diet, polyphenols, fasting, REHIT exercise, and NMN/NR supplementation) to rebuild NAD⁺ and slow aging

Does fish oil actually protect your brain, can your mindset slow aging, and what can butterflies teach us about longevity? Dave Asprey unpacks the week’s biggest biohacking breakthroughs.

5:38 PMClaude responded: Jeff Boyd, founder of MTE, joins Dave Asprey to break down why conventional energy drinks are sabotaging your cortisol, sleep, and gut health, and how a full-s…Jeff Boyd, founder of MTE, joins Dave Asprey to break down why conventional energy drinks are sabotaging your cortisol, sleep, and gut health, and how a full-spectrum stack of adaptogens, nootropics, and prebiotics delivers clean, foundational energy without the crash.

12:24 PMClaude responded: Childhood trauma forged in war becomes the foundation for a biohacking philosophy built around nervous system mastery and intentional living.Childhood trauma forged in war becomes the foundation for a biohacking philosophy built around nervous system mastery and intentional living.

Your body's built-in mitochondrial cleanup process (mitophagy) is being silently suppressed by modern stress, eating habits, and aging, but you can reactivate it through fasting, high-intensity exercise, cold exposure, NAD+ supplementation, and compounds like urolithin A and spermidine.

This week Dave breaks down five studies that challenge what you think you know about copper and Alzheimer's, sugar-free diets, strength training, childhood brain development, and taurine, and why the label is almost never the whole story.

11:13 AMClaude responded: A board-certified psychiatrist and neuroscientist breaks down why ketamine and MDMA therapy repair trauma at the epigenetic level, why most antidepressants are…A board-certified psychiatrist and neuroscientist breaks down why ketamine and MDMA therapy repair trauma at the epigenetic level, why most antidepressants are keeping people sick, and why psychedelic medicine is the biggest breakthrough in the history of psychiatry.

2:30 PMClaude responded: Dermatologist Dr.Dermatologist Dr. Michael Christopher exposes the melanoma detection gap most doctors don't know exists and shares the tools, habits, and skin science that can save your life.

Vitamin C — not willpower — is the missing key to effortless focus, because your brain can't produce the neurotransmitters it needs without it, and learning to supplement and absorb it correctly can eliminate mental fatigue at its biological root.

GLP-1 drugs are moving aging clocks, the FDA finally caught up to Europe on sunscreen, and a DNA sugar may regrow hair — Dave Asprey breaks down six stories that all come back to the same question: what is this molecule actually doing inside your body?

A Johns Hopkins and Harvard-trained neurologist with 37 years of experience reveals why your brain is physically shrinking right now, why brain fog and cognitive decline are always treatable, and exactly what to do about it.

2:29 PMClaude responded: Food is your most powerful medicine, and Dr.Food is your most powerful medicine, and Dr. William Li proves it with the science of how everyday foods starve cancer, what 720,000 living centenarians reveal about longevity, and why your vascular health determines how long and how well you live.

After struggling with weight for years, Dave Asprey discovered that adding fat (butter and MCT oil) to his coffee instead of sugar transformed his metabolism, helped him lose 100 pounds, and sparked a global movement now known as Bulletproof Coffee.

The edges of medicine are moving faster than the mainstream — from an engineered virus stopping pancreatic cancer to a diabetes drug cutting breast cancer risk to 21 years of Finnish data finally settling the sauna debate — and your job is to catch the signal before it becomes a headline.

In this episode, Dave Asprey and the founders of Mara Labs discuss how sulforaphane (in their BroccoLite supplement) activates all three detox pathways to help the body excrete microplastics, heavy metals, BPA, and other environmental toxins, while also covering its benefits for brain health, hormone balance, autism, and longevity.

Host Dave Asprey interviews Justin Kirkland of Amino Innovations and Precision Peptide Company, a chemist with 30 years of experience, about how peptides are synthesized, sourced safely in the US, and delivered through injections, microneedle patches, and nasal sprays, while discussing quality control issues in the gray market, which peptides are most promising or overhyped, and how genetics and gut bacteria influence individual responses.

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5:29 PMClaude responded: This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control…This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control the pace of aging, new evidence linking depression to immune biology, and a genetics paper that says half your lifespan was loaded before you were born.

Dr. Andrew Salzman joins Dave Asprey to explain how gut barrier breakdown drives systemic aging through NAD depletion and inflammation, and why creatine and targeted NAD support are key to reversing it.

Dave Asprey and Dr. Jessica Peatross expose the root causes of chronic illness — parasites, toxic mold, histamine dysfunction, and cortisol imbalance — while challenging mainstream medicine's failures on everything from Lyme disease to the California Medical Board.

Drawing from Okinawa's blue zone lifestyle, this episode breaks down the five science-backed habits (mindful eating, purpose, staying active, strong social bonds, and stress resilience) that help people live past 100.

9:03 PMClaude responded: Dr.Dr. Patrick Porter, PhD, founder of BrainTap, joins Host Dave Asprey to reveal how flickering light, 40 hertz gamma frequency, and brainwave entrainment technology backed by 72 peer-reviewed studies can break up amyloid plaque, reset your sleep, and rewire your brain for peak performance in as little as 10 minutes a day.

Chris Rinsch, co-founder and President of Timeline Longevity, joins Host Dave Asprey to reveal the 18-year science behind urolithin A, the postbiotic compound that outperforms rapamycin, triggers mitophagy, and is quietly becoming the most clinically validated longevity supplement on earth.

Claude responded: Dr.Dr. Molly Maloof, physician and former Stanford educator, joins Host Dave Asprey to reveal how human connection reshapes your biology at the cellular level, why longevity escape velocity is already here, and which peptides, psychedelics, and regenerative medicine breakthroughs are rewriting the rules of healthspan.

L-theanine, a 4,000-year-old amino acid found in tea, stacks with caffeine at a 2:1 ratio to create calm, focused alertness, and when combined with quality sleep, stress management, and clean coffee, it can deliver monk-like focus over the long term.

A single creatine dose sharpens your sleep-deprived brain, your gum is loading you with microplastics, irregular bedtimes may double your heart attack risk, scientists just decoded a plant molecule that kills cancer cells in the lab, and researchers built a reversible on/off switch for sperm production with no hormones required.

A UK physiotherapist (Will Harlow) joins Dave Asprey on the Human Upgrade podcast to debunk common fitness myths for people over 50, arguing that resistance training rather than cardio or walking alone is the key to building muscle, bone density, and long-term independence.