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Fat Science
Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
- 154 - Mailbag: Navigating Menopause and Metabolic Health
Is menopause impacting your weight and health in unexpected ways?
In this episode, the hosts tackle an assortment of listener questions about weight loss, metabolic health, and menopause. They delve into the intricacies of medication tolerance, the ethics of unregulated weight loss drugs, and the physiological changes that can affect women during menopause.
KEY TAKEAWAYS
Understanding metabolic and hormonal impacts during menopause is crucial.Unregulated weight loss drugs pose significant risks and ethical concerns.Medication tolerance and side effects can vary greatly among individuals.NOTABLE QUOTE
"It's not your fault." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 07 Sep 2026 - 47min - 153 - Top Metabolism Killers Revealed
What are the top causes of metabolic disruption?
In this informative episode, Dr. Emily Cooper dives into the factors that quietly sabotage metabolic health. From the intricacies of sleep to the surprising connection between love and metabolism, listeners will learn what enhances or damages their metabolic system.
KEY TAKEAWAYS
Sleep is crucial for metabolic and hormonal balance.
Weight cycling severely impacts metabolic health.
Underlying stress and emotional wellbeing affect metabolism.
NOTABLE QUOTE
"Everyone has strengths and limitations, let's put it that way." — Dr. Emily Cooper
LINKS & RESOURCES
Mechanical Eating Handout: Available on our Patreon page.
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 31 Aug 2026 - 43min - 152 - Mailbag: GLP-1 Injection Reactions
Do you ever wonder how medications like Wegovy and Mounjaro influence your metabolic health?
Dr. Emily Cooper, along with Andrea Taylor and Mark Wright, dives into listener questions about maintaining metabolic health when medication coverage is lost, understanding the role of leptin after weight loss, and the effects of medications like Mounjaro. They also explore the injection site reactions and the complex interplay between thyroid, exercise, and inflammation.
KEY TAKEAWAYS
Loss of medication insurance coverage can significantly impact treatment, but alternative options like pills may be available.
Leptin levels differ by gender; they're naturally lower in men due to different body composition.
Fasting can disrupt hunger signals and glucose regulation, particularly following intermittent fasting.
Injection site reactions are common but switching medications or techniques might alleviate symptoms.
NOTABLE QUOTE
"Obesity is a physical sign of underlying metabolic dysfunction." — Dr. Emily Cooper
LINKS & RESOURCES
To register for course: https://learn.diabesityinstitute.org/products/live_events/live-virtual-update-event
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 24 Aug 2026 - 38min - 151 - How Wildfire Smoke Affects Metabolism
Is wildfire smoke affecting more than just your lungs?
Poor air quality affects not only respiratory health but also metabolic functions. Wildfire smoke can trigger inflammation, oxidative stress, and hormone release, leading to metabolic disturbances.
KEY TAKEAWAYS
Wildfire smoke can impact metabolism, leading to insulin resistance.
Stress hormones released during smoke exposure can raise blood sugar levels.
Air pollution is linked to increased risk of metabolic syndrome components.
NOTABLE QUOTE
"When there were wildfire events, within days, the admissions for diabetes increased." — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 17 Aug 2026 - 38min - 150 - Inside the GLP-1 Secret Shopper Study
Is it really a good idea to get medical care from online pharmacies posing as clinics?
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor dig into a Yale secret shopper study that tested 49 websites selling GLP-1 medications online. The websites look and market like medical clinics, but the study found that most patients never spoke to a clinician at all before getting a prescription. Dr. Cooper, Mark, and Andrea unpack what real medical care requires, why these platforms skip it, and what that means for anyone considering this route.
KEY TAKEAWAY
Two-thirds of the sites in the study issued a prescription with no clinician contact of any kind — despite marketing themselves as medical clinics.
Fewer than 40% asked for any clinical measurement (blood pressure, labs, etc.), and only 18% asked whether the patient even had a primary care doctor.
Many of these sites are financially connected to compounding pharmacies and use leading questions to push add-ons that create untested drug combinations.
Real medical care means a full history, objective labs, and ongoing monitoring — not a five-minute questionnaire and an automatic credit card charge.
NOTABLE QUOTE
"The marketing appears to be a medical clinic or a medical company, when in fact it's really just a sale of a drug." Dr. Emily Cooper
LINKS & RESOURCES
Study published in JAMA on the secret shopper findings
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 10 Aug 2026 - 49min - 149 - The Truth About Exercise and Metabolism
Does exercise really boost metabolism, or is there a hidden truth?
In this episode, Dr. Emily Cooper uncovers the science behind why exercise isn’t just about burning calories. Dive into the fascinating world of myokines, the chemical messengers released by muscles that impact everything from mood to inflammation. Discover why it's not your fault if exercise alone isn't solving your metabolic issues.
KEY TAKEAWAYS
Exercise impacts more than calorie burn; it's a signaling system for the body.
Myokines, released during exercise, affect organs like the brain and liver.
Muscle contractions broadcast vital signals affecting overall health.
NOTABLE QUOTE
"Exercise is more than burning energy; it's communication throughout the body." — Dr. Emily Cooper
LINKS & RESOURCES
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
To register for course: https://learn.diabesityinstitute.org/products/live_events/live-virtual-update-event
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 03 Aug 2026 - 46min - 148 - Mailbag: Understanding Body Dysmorphia
How does biology affect our perception of body size?
Dr. Emily Cooper answers listener questions about body dysmorphia and metabolic dysfunction. Mark and Andrea discuss the challenges with compounded medications and the implications of insurance-driven diet requirements.
KEY TAKEAWAYS
Body dysmorphia can have biological components related to metabolic dysfunction.
Compounded medications may lack the testing and safety guarantees of brand names.
Insurance requirements often lack a medical basis and can hinder proper treatment.
NOTABLE QUOTE
"The altered body image perception may be linked to metabolic signals." — Dr. Emily Cooper
LINKS & RESOURCES
None mentioned.
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 27 Jul 2026 - 40min - 147 - Understanding Metabolism: Latest Scientific Insights
Why is your fat talking to you?
In the latest solo episode, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore groundbreaking research into metabolic health. Learn why the scale doesn't always reflect metabolic risk, and discover the science behind fat's active role in the body.
KEY TAKEAWAYS
Metabolic dysfunction cannot be judged by scale weight alone.
Visceral fat is a stronger predictor of heart failure than BMI.
Hormonal environments profoundly affect fat storage and health risks.
NOTABLE QUOTE
"Your fat is talking to you." — Andrea Taylor
LINKS & RESOURCES
Obesity Reviews Paper
Immunological Reviews Journal Article
European Congress on Obesity Study
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 20 Jul 2026 - 50min - 146 - Why Carbs Are Good For Your Brain
Is your brain starving for glucose?
In this episode, Dr. Emily Cooper explores the critical role of the brain as a metabolic organ and its dependence on glucose and insulin. Listeners will learn why good sleep and a holistic lifestyle are vital for cognitive health.
KEY TAKEAWAYS
The brain uses about 20% of your body's energy at rest.
Insulin plays a non-fuel role in brain function, supporting neural connections and mood.
Sleep is essential for the brain's waste clearance system, the glymphatic system.
Insulin resistance in the brain is linked to cognitive decline and dementia.
Exercise, a balanced diet, and social engagement are key to brain health.
NOTABLE QUOTE
"The brain is the most metabolically active organ in our body." — Dr. Emily Cooper
LINKS & RESOURCES
JAMA: US POINTER Study on Cognitive Decline
Novo Nordisk: EVOKE & EVOKE Plus Trials
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 13 Jul 2026 - 49min - 145 - Mailbag: When Weight Loss Stalls on GLP-1s
Is it normal for GLP-1 medications to become less effective over time?
Dr. Emily Cooper discusses listener questions about the nuances of metabolic health and the real reasons behind weight fluctuations and food cravings. With insights into GLP-1 medications, mechanical eating, and more, the episode aims to debunk myths and provide science-based encouragement.
KEY TAKEAWAYS
Trusting your body's hunger signals can prevent metabolic slowdown.
Mechanical eating can help manage sugar cravings and maintain metabolic health.
Navigating pediatric metabolic issues requires understanding genetic influences and appropriate medical intervention.
NOTABLE QUOTE
"It's not your fault. Trust your body and step up to the higher end of your metabolic flexibility." — Dr. Emily Cooper
LINKS & RESOURCES
American Board of Obesity Medicine: obesitymedicine.org
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 06 Jul 2026 - 45min - 144 - Plastic Chemicals in Your Blood and What Actually Works to Remove Them
Have you ever wondered why your body holds onto weight despite your best efforts?
In this eye-opening episode, Dr. Cooper reveals groundbreaking research showing that 100% of healthy adults carry at least six different plastic-related chemicals in their bodies daily. These endocrine disruptors don't just affect your hormones - they may be stored in your fat tissue and could be a hidden driver of metabolic dysfunction. The good news? New Australian research proves you can dramatically reduce these chemicals in just one week with targeted changes.
KEY TAKEAWAYS
Every single person tested had at least 6 plastic chemicals in their urine, with food packaging being the primary source
Participants cut phthalate levels by 38-54% and BPA by 60% in just 7 days with adjustments in reducing plastic exposure in food and food packaging
Ultra-processed foods introduce plastic chemicals through multiple processing and packaging steps
Certain chemicals like DEHP may be stored in fat tissue and released during weight loss
Heat accelerates plastic migration into food - avoid microwaving in plastic and pouring hot food into plastic containers
Simple swaps like choosing fresh over canned foods and using glass containers make significant impacts
The EPA research office studying these chemicals was recently eliminated, removing key consumer protections
NOTABLE QUOTE
"People who switched to the low plastic food and kitchenware cut the phthalates excretion by 38 to 54% in one week and they cut their BPA excretion by 60% in one week." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 29 Jun 2026 - 50min - 143 - Why Weight Loss Stalls on GLP-1s — Even When You’re Doing Everything “Right
What happens when GLP-1 medications stop working the way you hoped they would? In this mailbag episode, Dr. Emily Cooper answers listener questions about fasting, insulin levels, PCOS, lipedema, plateaus on Zepbound, and the complicated reality behind metabolic dysfunction. From the dangers of under-fueling to why individualized treatment matters so much, this conversation unpacks the science behind weight resistance with clarity and compassion.Key Takeaways
Why fasting and restrictive eating may worsen metabolic adaptation
The real role insulin plays in metabolic health
How PCOS and lipedema complicate weight loss treatment
Why some people plateau on GLP-1 medications over time
The importance of fueling, muscle preservation, and individualized care
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 22 Jun 2026 - 47min - 142 - Normal Weight Abnormal Metabolism: Why Your Scale Doesn't Tell the Whole Story
Could you have metabolic dysfunction even at a normal weight?
This episode challenges everything we've been taught about weight and health. Dr. Cooper reveals that up to 25% of normal-weight people have metabolic syndrome, yet they're rarely screened because doctors assume they're healthy based on appearance alone.
KEY TAKEAWAYS
Weight and metabolic health are not the same thing - you can be metabolically unhealthy at any size
Normal weight people with metabolic dysfunction are often overlooked and undertreated by healthcare providers
Key screening tests include fasting glucose, insulin, HbA1c, triglycerides, HDL cholesterol, blood pressure, and inflammatory markers like HSCRP
Metabolic dysfunction can start in your 20s and take decades to develop into serious disease
Both normal weight and higher weight patients face bias - normal weight people aren't screened enough, while higher weight people have everything blamed on their weight
Early screening and treatment can prevent catastrophic health outcomes later in life
The liver plays a crucial role in metabolism and can become insulin resistant regardless of body weight
NOTABLE QUOTE
"You cannot tell anything about someone's health from their outside, what they look like or what, even what they're doing necessarily, but definitely not their body size. So you can be healthy or unhealthy at any size body, and I think that's what's overlooked quite a bit." — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Appendix: Key References
Primary literature supporting this episode
• Wang et al. Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. Journal of Clinical Endocrinology & Metabolism, 2023.
• Review: Beyond BMI — Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine. Journal of Clinical Medicine, December 2025.
• Korean meta-analyses on metabolic dysfunction phenotypes and cardiometabolic risk, Cardiovascular and Metabolic Sciences Journal review, 2024.
• Frontiers in Nutrition, January 2026. Associations of metabolic heterogeneity with the progression of cardiometabolic multimorbidity.
• International Journal of Obesity, September 2025. Cardiovascular risk factors associated with metabolic health phenotypes.
Mechanism references
• MASLD — metabolic dysfunction-associated steatotic liver disease — nomenclature and clinical framework. AASLD/EASL consensus, 2023.
• Insulin signaling, adipose tissue dysfunction, and ectopic fat deposition — reviews on the upstream-downstream relationship.
• Epicardial adipose tissue and cardiovascular dysfunction — Frontiers in Cardiovascular Medicine, January 2026.
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 15 Jun 2026 - 31min - 141 - Mailbag: Why GLP-1 Medications Sometimes Stop Working
Have you been told your metabolism is broken and there's nothing you can do about it?
This mailbag episode tackles tough questions about medication effectiveness, unexpected side effects, and the complex realities of treating metabolic dysfunction. Dr. Cooper addresses why some people regain weight while still on GLP-1s, explores the connection between hair loss and weight loss medications, and explains why leptin levels can remain stubbornly low even with proper nutrition.
KEY TAKEAWAYS
Weight regain while on GLP-1 medications is more common than most people realize
Hair loss from weight loss medications is usually related to nutrient deficiencies, not the medication itself
Leptin dysfunction involves both hormone levels and signaling pathways throughout the body
Hypoglycemia after meals often indicates complex metabolic issues that require specialized testing
Starting elderly patients on GLP-1s requires careful monitoring of nutrition, blood pressure, and side effects
Mechanical eating differs from intuitive eating and remains important even when medications are working
Annual weight loss rates of 10% or higher indicate medications are still effective
NOTABLE QUOTE
"It is not uncommon to see the weight go up while on these meds, contrary to what people think. They're great, but we always wanna point out some people don't even respond to these." — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 08 Jun 2026 - 51min - 140 - Why Three Major Obesity Organizations Just Changed What Success Means
Ever wonder why you can improve your health but still feel like you're failing because the scale isn't cooperating?
Dr. Cooper breaks down groundbreaking new clinical guidelines from three major obesity organizations that are completely reframing what success in obesity treatment actually means. For the first time, these groups are saying quality of life, energy levels, and overall health matter more than the number on the scale.
KEY TAKEAWAYS
Three major obesity organizations worked collaboratively to issue guidelines prioritizing quality of life over weight loss as primary treatment goals
Guidelines explicitly address medical stigma as a structural barrier to care requiring systemic change
Treatment is positioned as long-term management similar to other chronic conditions like thyroid disorders
Document notably avoids calorie restriction language, focusing instead on healthy lifestyle alongside medication
Setmelanotide receives strong recommendation for rare genetic obesity conditions with available genetic testing
Strong medication recommendations now include GLP-1s like semaglutide and tirzepatide, plus bupropion-naltrexone combination
NOTABLE QUOTE
"Nobody ever asked. Nobody ever looked. Nobody ever said anything. I was like, 'I think there's something wrong with my metabolism or something because I'm not eating a ton.' They're like, 'Well, you must be.' And I'm like, 'N- n- no, I don't think so. I mean, unless it's happening when I'm sleeping. I don't know.'" — Andrea Taylor
Reference Link
Alexander L, Purnell JQ, et al. Pharmacological management of obesity in adults: a clinical guidance statement from The Obesity Society, the Obesity Medicine Association, and the Obesity Action Coalition. Obesity. 2026;34(4):851–870. doi:10.1002/oby.70164https://onlinelibrary.wiley.com/doi/10.1002/oby.70164
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 01 Jun 2026 - 49min - 139 - PCOS is Now PMOS: The Name Change That Changes Everything
Have you been told you have PCOS but nothing seems to help?
In May 2024, after 14 years of global collaboration involving 56 organizations and 22,000 stakeholders, the medical community officially changed PCOS to PMOS - and the reason why reveals everything that's been wrong with how this condition has been understood and treated for decades. Dr. Cooper breaks down why this isn't just a name change, but a complete reframe that puts metabolic dysfunction at the center where it belongs.
KEY TAKEAWAYS
PCOS is now officially called PMOS - Polyendocrine Metabolic Ovarian Syndrome - shifting focus from ovarian problems to metabolic dysfunction70 million women globally are affected during reproductive years, with 70% remaining undiagnosedThe condition can occur at any weight and is driven by insulin resistance and other metabolic signals, not ovarian problemsTreatment should focus on metabolic health rather than weight loss or ovarian interventionsThe name change parallels similar shifts in medicine like MASLD replacing non-alcoholic fatty liver diseaseNOTABLE QUOTE
"Most patients with this label that they've had in the past, the PCOS label, feel a sense of hopelessness, and even join support groups and things like that, and thinking that this will be a condition they have forever. And what I try to do is explain, no, this is just a physical manifestation of the metabolic disruption that we treat all the time" — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 25 May 2026 - 39min - 138 - Mailbag - Why Your Doctor Still Believes Calories In Calories Out
Have you been told it's just calories in calories out while your lived experience says otherwise?
In this mailbag episode, Dr. Cooper addresses complex metabolic questions from listeners worldwide. From eating disorders requiring specialized care to GLP-1 plateau management, each question reveals how individual biology trumps one-size-fits-all solutions.
KEY TAKEAWAYS
Eating disorders like anorexia require comprehensive medical team treatment, not self-management approaches
Side effects from GLP-1 medications often improve with consistent eating patterns and adequate nutrition
The calories in calories out model ignores the biological complexity of how your body actually burns fuel
PCOS responds well to metabolic treatments because it's driven by underlying insulin and hunger hormone imbalances
Sleep deprivation and chronic stress significantly impact GLP-1 effectiveness and overall metabolic function
Bioidentical progesterone may help perimenopause sleep issues without the metabolic side effects of older formulations
Stroke survivors may experience hypothalamic obesity that responds remarkably well to GLP-1 medications
NOTABLE QUOTE
"If that really worked, imagine, you know, would we actually need these sophisticated medications that are so groundbreaking? Would we have had decades and decades, or actually centuries of failed, you know, diet experiences by so many people?" — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 18 May 2026 - 45min - 137 - What Lipedema Really Is and Why Your Doctor Might Be Missing It
Are your legs painful to touch and resistant to weight loss despite your best efforts?
Dr. Ellen Derrick, a vascular surgeon and lipedema specialist, reveals the truth about this misunderstood condition affecting 20% of women worldwide. Lipedema isn't obesity - it's a fat cell disorder where tissue responds abnormally to inflammation, creating painful, swollen areas that don't respond to traditional weight loss methods. She explains the connection between lipedema and venous insufficiency, why patients are often dismissed by doctors, and the emerging treatments offering hope.
KEY TAKEAWAYS
Lipedema affects 20% of the female population but is routinely misdiagnosed as obesityThe condition involves abnormal fat cell response to inflammation, creating painful tissue that resists weight loss86% of lipedema patients also have venous insufficiency, creating a perfect storm of symptomsAnkle cuffs, knee pouches, and saddlebags are classic physical signs that patients often notice from pubertyGLP-1 medications like tirzepatide may help reduce inflammation and tissue tendernessLipedema reduction surgery exists but lacks insurance billing codes, making access challengingA formal medical recognition campaign is underway to establish diagnostic codes by 2026-2027NOTABLE QUOTE
"The medical community really has done an outstanding job, in a way, gaslighting these patients. These patients have been aware that something is different about their body and their legs since puberty." — Dr. Ellen Derrick
GUEST BIO
Dr. Ellen Derrick is a Seattle-based board-certified vascular and general surgeon with over 20 years of clinical experience and a Master of Public Health from the University of Washington. She founded Boxbar Vascular, specializing in lipedema and related metabolic conditions, and serves on the board of the Lipedema Society working toward formal medical recognition of the condition.
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 11 May 2026 - 48min - 136 - Metabolic Breaking News: 3 Developments You Should Know About
Dr. Emily Cooper, Mark Wright, and Andrea Taylor break down three breaking metabolic health stories in this quick bonus episode — from a newly approved oral GLP-1 to a major price drop for Medicare patients.
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Thu, 07 May 2026 - 08min - 135 - Mailbag: Mechanical Eating vs Calorie Counting on Ozempic and Wegovy
Have you ever wondered if you should get liposuction when you need skin removal surgery after major weight loss?
In this mailbag episode, Dr. Cooper, Mark, and Andrea tackle questions from listeners around the world, from Germany to Alabama to Chicago. They discuss why restricting calories while on GLP-1 medications can actually work against you, address the reality of finding metabolic-informed doctors internationally, and explain the science behind fat cell removal during skin surgeries. Plus, they share details about the newly approved oral GLP-1 medication orforglipron (Foundayo) and why vegetables, fats and starches matter even when you're protein-focused.
KEY TAKEAWAYS
Restricting calories on GLP-1 medications can lower your metabolic rate and weaken your body's natural GLP-1 production
Liposuction during skin removal surgery may disrupt leptin signaling, though males may be less affected than females due to naturally lower leptin levels
Finding metabolic-informed doctors globally remains challenging, but obesity medicine certification and Canadian and European obesity organizations may offer better resources
The oral GLP-1 medication orforglipron will likely be less expensive but also less effective than dual-agonist medications like tirzepatide
Mechanical eating without calorie counting often produces better long-term results than restrictive approaches
Vegetables provide essential micronutrients and support healthy microbiome function that protein alone cannot replace
Major weight loss surgery like tummy tucks is serious surgery that requires careful consideration and qualified surgeons
NOTE: This episode was recorded before Foundayo (orforglipron) was released on the market. The price is the same as the Wegovy pill. Listen to our episode - “New Obesity Drugs” for more information https://podcasts.apple.com/us/podcast/fat-science/id1715377331?i=1000762362056
NOTABLE QUOTE
"If only they didn't fall into that diet cycle, some of them, their weight would be a hundred pounds less. Yes, it might be still elevated, but a large chunk of that weight was caused by the diet cycle itself." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 04 May 2026 - 44min - 134 - Top 10 GLP-1 Myths Debunked by Science
Ever hear someone say GLP-1 medications cause osteoporosis or make your hair fall out?
This episode tackles the top 10 biggest myths about GLP-1 medications flooding social media and separates the science from the scary headlines. Dr. Cooper breaks down what's actually happening in your body versus what the internet claims, from bone density concerns to the dreaded "Ozempic face."
KEY TAKEAWAYS
· GLP-1 medications don't cause osteoporosis - inadequate nutrition while losing weight can weaken bones
· Hair loss is typically from nutritional deficits, not the medication itself
· These drugs slow gastric emptying but don't cause permanent stomach paralysis
· Weight regain after stopping is expected since you're treating a chronic medical condition
· Muscle loss comes from eating too little, not from the medication directly
· The thyroid cancer warning comes from rodent studies and hasn't been observed in humans
· GLP-1s actually protect the pancreas rather than damage it
NOTABLE QUOTE
"Metabolic dysfunction is biological, it's not something within your means to correct just through lifestyle strategies." — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 27 Apr 2026 - 33min - 133 - New Obesity Drugs: What's FDA Approved and What's Coming
The obesity medication landscape just changed — again. One brand-new pill is already in pharmacies, and five more are in various stages of approval. But the real story isn't the drugs themselves: it's what they're revealing about how your metabolism actually works, and why willpower was never the problem.
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor break down six metabolic medications — two newly FDA-approved and four in the pipeline — covering everything from a flexible new oral GLP-1 pill to drugs that target the brain's central metabolic pathway directly. Dr. Cooper explains the science behind each one, who might benefit, and what the pipeline tells us about the future of metabolic care. This is the most comprehensive drug update the show has done, and it arrives at a moment when the field is moving faster than ever.
Key Takeaways
Foundayo (orforglipron), approved April 1st, is the first small molecule oral GLP-1 — no empty stomach requirement, no cold chain, and potentially lower production costs long-term.
The amylin hormone may uniquely address both "I'm nourished" and "I weigh enough" signals in the brain — making the amylin pathway a powerful and underutilized target.
Retatrutide (Lilly's triple agonist targeting GLP-1, GIP, and glucagon receptors) is showing unprecedented effectiveness plus significant non-scale benefits, including fatty liver reduction — but is still years from approval.
The brain's melanocortin 4 receptor is the CEO of metabolism — regulating energy expenditure, appetite, and insulin — and new drugs targeting it represent the deepest intervention yet.
Many of these medications are showing weight-independent benefits, including improvements in kidney, liver, cardiovascular risk, sleep apnea, and joint health that have nothing to do with how much weight is lost.
Notable Quote
"Everybody focuses on appetite, and you just need to eat less. But now with these medications and how they actually affect our biology, it becomes very clear that there's so much more to this." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 20 Apr 2026 - 47min - 132 - Mailbag: Understanding Insulin Resistance Testing and GLP-1 Medication Side Effects
Have you been told insulin resistance testing doesn't exist or wondered if you're increasing your GLP-1 dose too quickly?
Dr. Cooper, Andrea, and Mark tackle listener questions from around the world, addressing common concerns about insulin resistance testing availability, managing severe GI side effects from higher doses, interpreting DEXA scan results, and developing sustainable maintenance strategies. They discuss the difference between hunger and food noise, explain why winter illness might stall weight loss, and share insights about visceral fat concerns even at normal weight.
KEY TAKEAWAYS
Insulin resistance can be tested through fasting insulin and glucose ratios, even in countries where insulin testing is less common
Rapid weight loss rates above 15% annually may indicate no need for dose increases
Severe GI side effects warrant investigation beyond medication adjustment, including gallbladder evaluation
DEXA scans provide valuable visceral fat measurements, but results should be interpreted alongside overall health markers
Maintenance strategies should focus on nutritional stability before considering medication tapering
NOTABLE QUOTE
"It's not that the medicine causes the rebound weight gain, it's that with the medication in there, the body is getting better signals, and then you go and take the medication away and you're in the same boat." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 13 Apr 2026 - 39min - 131 - Navigating the GLP-1 Wild West: A Conversation With Dr. Vin Gupta
Are you getting a GLP-1 prescription from someone who's never examined you?
Dr. Vin Gupta, pulmonologist and former Chief Medical Officer at Amazon, joins Dr. Cooper to expose the dangerous gap between legitimate obesity medicine and the unregulated direct-to-consumer market. This conversation reveals why proper medical evaluation matters and how profit-driven platforms are exploiting desperate patients.
KEY TAKEAWAYS
GLP-1 medications require individualized medical evaluation, not one-size-fits-all prescribingDirect-to-consumer microdosing platforms lack FDA approval and proper medical oversightThe erosion of trust in healthcare has created opportunities for unregulated treatmentsComprehensive metabolic care includes regular lab work, body composition monitoring, and personalized treatment plansTechnology should enhance medical care, not replace proper physician evaluationNOTABLE QUOTE
"I see so many people that come in, you know, they're obsessed with monitoring their HRV, their heart rate variability, and yet they had no idea they have pre-diabetes and they had no idea that they have triglyceride levels through the roof." — Dr. Emily Cooper
GUEST BIO
Dr. Vin Gupta is a pulmonologist, public health expert, and medical analyst for NBC News. He served as Chief Medical Officer at Amazon and has dedicated his career to translating complex science into actionable health insights at both individual and population levels.
GLOSSARY
GLP-1 medications: Glucagon-like peptide-1 receptor agonists, medications that help regulate blood sugar and appetite, including brand names like Ozempic, Wegovy, and Zepbound
Microdosing: Taking smaller amounts of medication than officially prescribed or approved
Direct-to-consumer (D2C): Healthcare services that bypass traditional medical settings, often delivered through apps or online platforms
HRV: Heart rate variability, a measurement of the variation in time between heartbeats
Pre-diabetes: Blood sugar levels that are higher than normal but not high enough to be diagnosed as type 2 diabetes
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 06 Apr 2026 - 1h 02min - 130 - What Happens to Your Body When You Stop Taking GLP-1s
What really happens when you stop GLP-1 medications — and are the headlines telling you the whole story? The answer is more nuanced than social media wants you to believe.
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor break down four recent studies on GLP-1 treatment outcomes, weight regain, and a groundbreaking new drug that could preserve lean mass during treatment. They walk through the methodology behind each paper, explain why two studies asking the same question got opposite answers, and reveal what a new monoclonal antibody called bimagrumab could mean for the future of metabolic treatment.
Key Takeaways
When you stop treating any chronic metabolic condition, the condition returns — that's not failure, that's biology.
Real-world data showed 56% of people who stopped filling GLP-1 prescriptions maintained or continued losing weight — likely because they continued working with their clinician on alternative treatments.
A new monoclonal antibody called bimagrumab showed 11% body weight reduction on its own, while simultaneously increasing lean mass by 3% — without affecting appetite.
When combined with semaglutide, bimagrumab reduced lean mass loss from 28% to just 11% of total weight lost.
Not eating enough while on GLP-1s drives greater lean mass loss — nutrition is still the best tool for preserving muscle.
Notable Quote
"It wasn't my failure and it was disease underneath everything. Finding that out — that it wasn't my fault — that was the miracle of the whole process to me." — Andrea Taylor
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations
Mon, 30 Mar 2026 - 47min - 129 - Mailbag: Fasting, Food Noise & GLP-1s
Ever wonder why fasting worked at first — then stopped? Or why you lost 80 pounds only to gain back 100?
In this mailbag episode, Dr. Emily Cooper, Mark Wright, and Andrea Taylor tackle the most misunderstood topics in metabolic health. From the harsh reality of fasting culture to the surprising metabolic challenges faced by normal-weight individuals, this conversation validates what you've been experiencing and explains the science behind it. You'll also hear why GLP-1 medications aren't just weight loss drugs, why your body might be fighting you even when you're doing everything right, and what happens when your job — like shift work or firefighting — disrupts your metabolism for years.
KEY TAKEAWAYS
You can have metabolic dysfunction at a normal weight with what appear to be normal labs, for example, when insulin is over suppressed from chronic under-fueling or overexercisingFasting triggers the same biological adaptation as any restrictive diet and typically results in weight regain that's 22 percent higher than starting weightFood noise is biological, not psychological, and stems from an imbalance of hormones and neurotransmitters signaling nutritional insecurityGLP-1 medications may improve immune function because metabolic health and immunity are deeply connectedShift work and chronic sleep disruption can cause real metabolic damage by weakening leptin signals, increasing insulin resistance, and amplifying hunger hormonesNOTABLE QUOTE
"You can't trick your body. You have to have that foundational fueling in there." — Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Join Our Community:patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 23 Mar 2026 - 44min - 128 - Why You Keep Waking Up at Night — What 15,000 Patient Encounters Reveal About Sleep and Metabolism
Are you getting eight hours in bed but still waking up exhausted?
Dr. Emily Cooper shares groundbreaking findings from nearly 15,000 patient encounters at her metabolic clinic. The data reveals surprising connections between stress, eating frequency, sleep quality, and metabolic health — and why the number of hours you spend in bed doesn't tell the whole story.
KEY TAKEAWAYS
Over 60% of patients reported trouble staying asleep, even when they got eight hours in bedHigher stress levels were associated with double the rate of low energy and significantly worse sleep qualityEating frequency matters — patients eating five times per day reported the best sleep and highest energy levelsThe sweet spot between meals is two to four hours — longer gaps were linked to sleep disruption and low energyAny amount of alcohol was associated with fragmented sleep, regardless of stress levelsNearly 65% of patients were not hydrating adequately throughout the dayNOTABLE QUOTE
"If your cortisol goes high, we can get the same effects that happen when we take steroids, which we know promote pre-diabetes, insulin resistance, weight gain." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 16 Mar 2026 - 49min - 127 - Mailbag: Your GLP-1 Questions: Hair Loss, Blood Sugar Spikes & Hormone Therapy
Think squashing your post-meal glucose spike is the healthy thing to do? What if that flat line on your CGM is actually telling your brain you didn't eat — and slowing your metabolism as a result?
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor open the mailbag to tackle listener questions from around the world — Australia, New Zealand, and across the U.S. They dig into hormone replacement therapy and metabolism, why your GLP-1 medication might be causing hair loss, what a normal blood sugar response actually looks like, and how lipedema differs from obesity. Dr. Cooper also revisits metabolic syndrome and why it's not outdated — just underutilized.
Key Takeaways
Hormone replacement therapy isn't a reliable tool for improving metabolism — it's better suited for symptom relief and bone health in specific situations.
Progesterone, which must accompany estrogen if you still have your uterus, can actually disrupt metabolism in some women — acting almost like a steroid.
A flat glucose line after eating isn't the goal — your brain needs to see glucose go up to register that you've been nourished and keep your metabolism running.
Hair loss on GLP-1 medications is more likely tied to nutrient deficiencies (especially iron and protein) than the drugs themselves.
Lipedema is a disease of the fat tissue itself — separate from obesity — and tirzepatide may help reduce the inflammatory symptoms even though it won't eliminate the fat deposits.
Notable Quote
"If your glucose is flat line, your brain's not very convinced that you ate much — and then you're not getting the metabolic benefit." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 09 Mar 2026 - 50min - 126 - Why GLP-1s Alone May Not Be Enough: A Listener's Real Story
What happens when you do everything "right" — the GLP-1, the protein shake, the tracking — and the scale still won't budge? This episode reveals why doing everything “right” might actually be a big part of the problem.
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor welcome Sandy, a listener from Pennsylvania who has been on the metabolic health journey for over a year. Sandy's story is one many listeners will recognize: decades of dieting starting in childhood, a body that kept adapting against her, and a medical system that kept telling her to try harder. But when Dr. Cooper reviews Sandy's actual lab work live on air, what she finds reframes everything — and offers a path forward that has nothing to do with restriction.
Key Takeaways
Suppressed leptin hides a portion of your body fat from your brain, and possibly signals your brain that you're underweight — so your brain fights weight loss even when your body doesn't need protecting.
Low insulin isn't always healthy; it can be a sign of the "selfish brain" redirecting precious glucose to the brain at the expense of your muscles.
Weight cycling — losing and regaining the same weight repeatedly — creates cardiovascular and metabolic risk.
Mechanical eating is the antidote to disordered eating: structured, non-restrictive fueling that rebuilds metabolic trust.
GLP-1 medications can suppress appetite, so under-eating becomes a real risk — especially for people already conditioned to restrict.
The goal isn't the number on the scale. It's metabolic stability and metabolic health, and those things are not the same.
Notable Quote
"It was such a revelation to me to hear you guys talk about it — it's a metabolic disorder. It's not a willpower issue, it's not a personal failing. It's something absolutely beyond my control. Like diabetes would be. Like migraines would be." — Sandy
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 02 Mar 2026 - 56min - 125 - The Science Behind the New Wegovy Pill: One-On-One with Novo Nordisk’s Dr. Jason Brett.
The Science Behind the New Wegovy Pill (with Novo Nordisk’s Dr. Jason Brett)
What actually makes a GLP-1 pill work in the real world—and why does taking it come with such specific rules? And if these meds improve health beyond weight, why does the conversation still get stuck on the scale?
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor are joined by Dr. Jason Brett of Novo Nordisk to break down the science behind the newly approved Wegovy pill. They talk about what it takes to deliver a peptide medication orally, what the dosing and day-to-day routine really look like, and why access and pricing remain such a big part of the story. The conversation also zooms out to the bigger point: treating obesity is about improving health outcomes—like liver and cardiovascular risk—not just weight.
Key Takeaways
Oral semaglutide requires specific formulation technology to survive the stomach and be absorbed at a meaningful level.
The “30-minute rule” isn’t random—it’s part of how the pill has a chance to work as intended.
Treating obesity is about improving health outcomes (like liver and heart risk), not just “moving a number on a scale.”
Pricing and access shape who can actually benefit, even when the science is strong.
Calorie-restriction messaging can backfire for people already dealing with metabolic adaptation and under-nutrition.
Notable Quote
"Fat Science has no financial relationship with Novo Nordisk. No sponsorship. No consulting fees, no affiliate arrangements. Zero." — Mark Wright
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 23 Feb 2026 - 1h 00min - 124 - Mailbag: Your GLP-1 Questions on Pregnancy, Dosing, and Why Diets Cause Fat Gain
Mailbag: Your GLP-1 Questions on Pregnancy, Dosing, and Why Diets Cause Fat Gain
What happens when you stop GLP-1 medications before getting pregnant? Why might your thyroid numbers change on Zepbound? And why do people gain more body fat after dieting — even when they're still eating well? Dr. Cooper tackles your toughest questions.
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener questions covering pregnancy planning on GLP-1s, unmasked thyroid problems, injection site reactions, mechanical eating after bariatric surgery, why diets cause fat regain at a cellular level, and discussing with your doctor whether you should (or shouldn't) increase your medication dose.
Key Takeaways
GLP-1 medications aren't causing gestational diabetes — they may have been masking underlying metabolic dysfunction that becomes visible when the medication is stopped
Thyroid problems can be "unmasked" by GLP-1 treatment because the medications signal to your brain that you're not starving, allowing the pituitary TSH to rise, sometime uncovering a pre-existing thyroid issue
Zepbound may improve iron absorption — if iron levels go too high, testing for hemochromatosis may be warranted
To reduce injection site reactions: warm the medication to room temperature, clean and prep skin but don't over-rub with alcohol, inject at exactly 90 degrees, don't pinch the skin, and stay relaxed
Diets cause fat regain at the cellular level — it's chemistry, not willpower — and the fat often accumulates in the visceral area around organs
There's no need to increase your GLP-1 dose if you're making good progress — an annual weight loss rate of 15% or higher is considered strong
Notable Quote
"You can't think that just because somebody's weight is high, it's because something they're doing is wrong. That is just not founded in science whatsoever." — Dr. Emily Cooper
Links & Resources
Podcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 16 Feb 2026 - 43min - 123 - Wegovy Pill vs. Injection — A Doctor Breaks Down the Newest Form of GLP-1
Wegovy Pill: Who's It For?
The new Wegovy pill is generating massive buzz — but is it actually better than the injection? Before you ask your doctor to switch, there are some surprising requirements that could make or break whether this option works for you.
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor break down the new oral semaglutide approved for obesity treatment. They explain how the Wegovy pill differs from Rybelsus, who's a good candidate to switch (and who isn't), the strict dosing protocol most people don't know about, and what's coming next in the GLP-1 pill landscape — including a less fussy competitor from Eli Lilly.
Key Takeaways
The Wegovy pill uses an upgraded "version two" formulation with enhanced absorption — it's not the same as Rybelsus
Semaglutide targets deep metabolic dysfunction, not just appetite — reducing inflammation, visceral fat, and cardiovascular risk
The pill must be taken first thing in the morning on an empty stomach with minimal water, then nothing else for 30 minutes — breaking this protocol negates effectiveness
The pill is slightly less effective than the highest-dose Wegovy injection, so switching isn't ideal for patients still making progress at maximum dose
Novo Nordisk's cash pay program starts at $149/month for lower doses and $299/month for the highest dose
Eli Lilly's upcoming orforglipron pill uses small molecule technology that won't require the strict dosing ritual
Notable Quote
"When people say it works because it just makes you eat less, that's really missing the point of the sophistication of these meds." — Dr. Emily Cooper
Links & ResourcesPodcast Home: fatsciencepodcast.com
Cooper Center for Metabolism: coopermetabolic.com
Resources from Dr. Cooper: coopermetabolic.com/resources
Join Our Community: patreon.com/cw/FatSciencePodcast
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 09 Feb 2026 - 46min - 122 - Why GLP-1 Medications Work Even When the Scale Doesn't Move
What if the scale isn't moving, but your health is dramatically improving?
If you've ever felt discouraged because the number on the scale won't budge—even on a GLP-1 medication—this episode will change how you think about these drugs. Dr. Cooper breaks down the research showing that the biggest benefits have nothing to do with weight loss. It's all about metabolic health.
This Week on Fat Science
Dr. Emily Cooper, Mark Wright, and Andrea Taylor explore the research proving GLP-1 medications are far more than "weight loss drugs." The team explains how cardiovascular outcome trials revealed unexpected heart protection, why inflammation reduction may be the real mechanism behind these benefits, and what the latest FDA approvals for kidney disease, sleep apnea, and fatty liver mean for patients. Plus: the new oral Wegovy pill, what's coming next in metabolic medicine, and why everyone should be screened for metabolic dysfunction regardless of weight.
What You'll Learn
Why two-thirds of cardiovascular risk reduction from GLP-1s is completely independent of weight loss
How these medications reduce inflammation, stabilize arterial plaque, and improve vascular function
The difference between MASLD and MASH—and why the name change matters
What the Flow Trial revealed about kidney protection (and why it was stopped early)
How Zepbound earned FDA approval for sleep apnea
Why metabolic screening should happen regardless of what the scale says
Notable Quote
"You can still become incredibly healthier even if the weight is more stubborn. So I think that's the thing, is to discuss with your doctor not 'Oh, I want to lose X amount of pounds' or 'How much weight do you think I should lose?' That is not the conversation. It's more, let's take a look at the health parameters."
— Dr. Emily Cooper
Links & Resources
Podcast Home:fatsciencepodcast.com
Cooper Center for Metabolism:coopermetabolic.com
Resources from Dr. Cooper:coopermetabolic.com/resources
Submit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.
Disclaimer:This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Mon, 02 Feb 2026 - 43min - 121 - Mailbag: Food Tracking, Mechanical Eating Troubleshooting, COVID & Metabolism, and Metformin + GLP-1 Synergy
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener mailbag questions from California, the UK, France, Washington, Wyoming, and beyond.
The team breaks down why Dr. Cooper does not recommend calorie tracking (and when limited tracking can make sense), how to build confidence in eating without data, and why “mechanical eating” sometimes needs medical customization—especially for people with slow gut transit or gastroparesis-like symptoms.
They also dig into bile acid malabsorption after gallbladder removal, when metformin side effects deserve a second look, what we currently know about COVID-19’s potential impact on metabolic health, and why metformin and GLP-1 medications can be complementary—particularly in PCOS.
Key Takeaways
• Long-term calorie tracking can override physiologic cues and reinforce diet mentality.
• Short-term, targeted tracking may be useful when guided by a clinician (e.g., nutrient deficiencies ).
• Obesity and abnormal appetite are both manifestations of metabolic dysfunction—not simple cause and effect.
• Mechanical eating is a framework, not a rigid rule—timing and food choices may need medical tailoring.
• Post-gallbladder diarrhea may reflect bile acid malabsorption and can be treatable.
• Metformin and GLP-1s often complement each other because they target different metabolic states (fasting vs fed).Dr. Cooper’s Actionable Tips
• Stop daily calorie counting—focus on consistent patterns and metabolic nourishment.
• Use mechanical eating basics: eat every few hours, include all food groups, and reduce chemical additives when possible.
• If you’re transitioning away from tracking, consider a dietitian skilled in diet-mentality recovery.
• If frequent eating worsens sleep or bloating, work with a medical dietitian to adjust intervals and food types (especially with slow GI transit).
• If chronic diarrhea appears (especially after gallbladder removal), ask your clinician about bile acid malabsorption and treatment options.
• Use labs to guide therapy: fasting insulin can signal metformin benefit; post-meal patterns can point toward GLP-1 needs.Notable Quote
“Once you start using tracking to stay in a calorie range or a carbohydrate range, you’re putting your brain in front of your physiologic intuition—your body is sending you important cues all the time.”
—Dr. Emily CooperLinks & Resources
The Metabolic Links to PCOS, Release Date 2/24/25
The COVID Connection to Diabetes & Metabolic Health, Release Date 12/16/24
Podcast Home: https://fatsciencepodcast.com/
Episode References: https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdf
Cooper Center: https://coopermetabolic.com/podcast/
Resources from Dr. Cooper: https://coopermetabolic.com/resources/
Submit a Question: questions@fatsciencepodcast.com*Fat Science: No diets, no agendas—just science that makes you feel better. This podcast is for informational purposes only and is not intended to be medical advice.
Mon, 26 Jan 2026 - 41min - 120 - Mailbag: GLP-1 Weight Regain, Meals vs Snacks, and Why Some People Don’t Respond
his week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener mailbag questions that get to the heart of metabolic health. The team explains the real difference between meals and snacks, discusses whether GLP-1 medications can be appropriate for children in complex cases, explores why some people appear to be “non-responders” to Wegovy, and breaks down why alarming headlines about rapid weight regain miss the bigger metabolic picture. They also explain how to set a goal weight using body composition, labs, and overall health—rather than the scale alone.
Key Questions Answered
• What separates a meal from a snack metabolically?
• Why can grazing all day backfire—even with healthy food?
• Are GLP-1s ever appropriate for kids?
• Why do some people feel hungrier as GLP-1 doses increase?
• How are PCOS and insulin dysregulation connected?
• What is a mixed meal tolerance test, and why does it matter?
• Do GLP-1 users really regain weight faster?
• How should goal weight be determined after major weight loss?Key Takeaways
• Meals provide structure; snacks prevent long gaps—both matter.
• GLP-1 “non-response” often signals deeper metabolic issues.
• Weight regain reflects underlying dysfunction, not personal failure.
• Maintenance dosing must be individualized.
• Body composition matters more than BMI or scale weight.Dr. Cooper’s Actionable Tips
• Eat structured meals with carbs, protein, and fats.
• Use snacks strategically to avoid long gaps.
• Ask about deeper glucose/insulin testing when progress stalls.
• Prioritize DEXA body composition over scale-based goals.
• Avoid compounded GLP-1s—especially in children.Notable Quote
“If you stop treating the metabolic dysfunction, the dysfunction is still there—and the body will drive weight back to where it was headed all along.”
—Dr. Emily CooperLinks & Resources
Podcast Home: https://fatsciencepodcast.com/
Episode References: https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdf
Cooper Center: https://coopermetabolic.com/podcast/
Resources from Dr. Cooper: https://coopermetabolic.com/resources/
Submit a Question: questions@fatsciencepodcast.comFat Science: No diets, no agendas—just science that makes you feel better. This podcast is for informational purposes only and is not intended to be medical advice.
Mon, 19 Jan 2026 - 41min - 119 - What the Headlines Get Wrong About GLP-1 Drugs and Metabolism
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor break down two GLP-1 studies that challenge a major media myth: GLP-1 medications don’t drive weight loss just because people eat less. Instead, drugs like tirzepatide and semaglutide create direct metabolic shifts—including increased fat oxidation and improved fuel partitioning—regardless of appetite.
The team also explores mechanical eating, the psychological impact of “diet food,” and Andrea’s 13-year metabolic recovery journey.
Key Questions Answered
If both groups are dieting, why does the tirzepatide group lose more weight?What is metabolic adaptation, and why does dieting slow metabolism so sharply?How do GLP-1s directly increase fat oxidation?What is mechanical eating, and why do GLP-1 users need it?Why does ad-lib eating produce different metabolic responses than calorie restriction?Can mindset alone change hunger hormones? (Yes—the milkshake study.)Why do diet foods and diet sodas fail to improve metabolic health?Why is response to GLP-1s so different from person to person?Key Takeaways
GLP-1s are metabolic drugs—not appetite suppressants.
Their power comes from hormonal effects on fat burning, not reduced food intake.Calorie restriction still slows metabolism.
Even on GLP-1s, dieting triggers significant metabolic slowdown.Ad-lib eating outperforms dieting in the research.
Semaglutide users who ate freely did not show the extra metabolic slowdown seen in dieters.Mechanical eating is the most durable long-term approach.
Regular meals and snacks protect lean mass and prevent famine signaling.Mindset shapes hormones.
Believing a food is “diet” vs. “indulgent” alters ghrelin and satisfaction.Track body composition—not just the scale.
DEXA scans show whether you’re losing fat, muscle, or bone.Dr. Cooper’s Actionable Tips
Don’t diet on GLP-1s. Focus on fueling, not restriction.Use mechanical eating: predictable meals and snacks, no long gaps.Prioritize satisfaction: diet foods often backfire hormonally.Follow your real-world data: long-term changes matter more than short-term scale shifts.Ask about body composition testing if possible.Notable Quote:
“What that study proved is that doing the calorie restriction is causing the metabolic slowing… and that’s why it’s so confusing to me that we keep advising people to restrict calories when they’re trying to improve their metabolic function.” —Dr. Emily Cooper
Links & Resources
Podcast Home: https://fatsciencepodcast.com/
Episode References: https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdf
Cooper Center: https://coopermetabolic.com/podcast/
Resources from Dr. Cooper: https://coopermetabolic.com/resources/
Submit a Question: questions@fatsciencepodcast.com
Dr. Cooper Email: dr.c@fatsciencepodcast.comFat Science: No diets, no agendas—just science that makes you feel better. This podcast is for informational only, and is not intended to be medical advice.
Mon, 12 Jan 2026 - 45min - 118 - GLP-1 Mailbag: Weight Regain, Leptin Resistance, Hypoglycemia & Why Calories Aren’t the Problem
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor tackle a wide-ranging mailbag episode with listener questions from the U.S., UK, and Europe. Topics include unexpected weight regain on GLP-1s, post-meal sleepiness and hypoglycemia, metabolic dysfunction despite normal labs, GLP-1 dosing strategies, and why these medications are about metabolism, not appetite suppression.
Key Questions Answered
Why can weight regain happen on GLP-1s even when habits haven’t changed?How do leptin, ghrelin, injury, stress, and under-fueling affect weight regulation?What does it mean if you get extremely sleepy after meals—is it hypoglycemia?Do GLP-1s increase insulin in a harmful way for non-diabetics?Can you have metabolic dysfunction with normal A1C, cholesterol, and blood pressure?Do GLP-1 medications “wear off,” and how should dosing be adjusted long term?Are GLP-1s just appetite suppressants—or true metabolic treatment?Is it possible to undo decades of calorie counting and restriction-based thinking?What are the risks of the return to extreme thinness in celebrity culture?Key Takeaways
Calories don’t explain metabolism. GLP-1 and GIP work across the brain and body—repairing signaling, not just reducing appetite.Leptin matters after dieting. Years of restriction and weight cycling can weaken leptin signaling, making the brain defend weight gain.Fueling is foundational. Medication can’t replace adequate food, sleep, and recovery.Post-meal fatigue is a clue. Reactive hypoglycemia is common and often misunderstood.Lowest effective dose wins. GLP-1 success is about pacing, not racing to the max dose.Chasing the “last 10 pounds” can backfire. Cosmetic restriction can create new metabolic problems.Dr. Cooper’s Actionable Tips
If weight gain appears after injury or stress, focus first on sleep, regular meals, and full fueling, not restriction.Suspected hypoglycemia? Ask about a mixed meal tolerance test to assess glucose and insulin response.Stay on the lowest GLP-1 dose that’s working and adjust only when progress truly stalls.Push back on “appetite suppressant” language—these meds amplify hormones your body already makes.Notable Quote
“GLP-1s aren’t about eating less—they’re about strengthening metabolic signaling” — Dr. Emily Cooper
Links & Resources
Podcast Home: Fat Science Podcast Website – https://fatsciencepodcast.com/
Podcast Episode References: https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdfCooper Center for Metabolism & Fat Science Episodes: https://coopermetabolic.com/podcast/
Resources from Dr. Cooper: https://coopermetabolic.com/resources/
Submit a Show Question: questions@fatsciencepodcast.com
Dr. Cooper direct show email: dr.c@fatsciencepodcast.comFat Science breaks diet myths and advances the science of real metabolic health. No diets, no agendas—just science that makes you feel better. This show is informational only and does not constitute medical advice.
Mon, 05 Jan 2026 - 39min - 117 - Childhood Obesity, Eating Disorders & GLP-1s: Why It’s Not Your Fault
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor talk with pediatric eating disorder specialist Dr. Julie O’Toole (Kartini Clinic) and pediatric obesity expert Dr. Evan Nadler about what childhood obesity really is: a biologic, metabolic disease—not a willpower problem and not a failure of parenting.
They explore how excess weight, constant hunger, and disordered eating in kids are often signs of underlying metabolic dysfunction and genetics—and why the old “eat less, move more” advice can do real harm, especially when children are shamed or restricted in the name of “health.”
Key Questions Answered
Why is childhood obesity a metabolic disease, not a behavior problem?How are obesity and eating disorders deeply connected instead of opposite extremes?What role do GLP-1 medications play in children—and how do we protect against under-fueling?When should parents suspect genetic drivers like hyperphagia or MC4 mutations?How can medical treatment for obesity actually reduce disordered eating behaviors?When does excess weight become a medical issue requiring metabolic evaluation—not another diet?Key Takeaways
Weight is a symptom. Childhood obesity is often a sign of metabolic dysfunction, not overeating.Obesity & eating disorders overlap. Restriction can trigger disordered eating; disordered eating can worsen obesity.“Eat less, move more” harms. Shame-based approaches delay treatment and increase risk of eating disorders.GLP-1s work metabolically, not just through appetite suppression. Kids still need consistent fueling.Genetics matter. Single-gene differences can drive severe childhood hunger & rapid weight gain.Not treating is harm. Avoiding obesity care violates first, do no harm.Dr. Cooper’s Actionable Tips
If your child is gaining weight or constantly hungry, request metabolic labs (insulin, glucose, lipids, liver, hormones).If the doctor only says “eat less, move more,” ask: “How are we evaluating metabolism and genetics?”On GLP-1s? Monitor for under-fueling (skipped meals, low energy, food anxiety) and intervene promptly.Notable Quote
“Not treating childhood obesity is doing harm. It’s a disease, not a lifestyle choice.” — Dr. Evan Nadler
Links & Resources
Podcast Home: Fat Science WebsiteEpisodes & Show Archive: Cooper Center Podcast PageEducation & Metabolic Resources: coopermetabolic.com/resourcesSubmit a Show Question: questions@fatsciencepodcast.comEmail Dr. Cooper Directly: dr.c@fatsciencepodcast.comConnect with Our Guests
Dr. Evan P. Nadler, MD, MBA – Founder, ProCare Consultants & ProCare TeleHealth
Website: obesityexplained.com
YouTube Channel: Obesity ExplainedDr. Julie K. O’Toole, M.D., M.P.H. – Chief Medical Officer & Founder, Kartini Clinic
Website: kartiniclinic.com
Books: amazon.com/author/julieotoole*Fat Science breaks diet myths and advances the science of real metabolic health. No diets. No agendas. Just science that makes you feel better. This episode is informational only and not medical advice.
Mon, 29 Dec 2025 - 1h 15min - 116 - I’m Working Out—So Why Am I Getting Fatter?
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor talk with exercise physiologist Russell Cunningham and patient Becca Wert about a counterintuitive reality: for some people, exercise can actually slow metabolism, stall weight loss, and trigger weight gain—especially when the brain senses a threat to energy availability.
Dr. Cooper explains how overtraining, under-fueling, and even thinking about workouts can activate famine signals in the brain and shut down key hormone pathways and what it takes to rebuild trust so movement becomes helpful instead of harmful.
Key Questions Answered
How can exercise trigger metabolic slowdown and weight gain instead of weight loss?What lab markers (leptin, ghrelin, thyroid, cortisol, sex hormones) signal that your body is in “conservation mode”?Why did Becca lose more than 120 pounds after stopping intense workouts—and what did her COVID experience reveal about her metabolism?How did Russell’s overtraining syndrome develop, and what did his recovery teach him about fueling, rest, and nervous system regulation?How should fueling before, during, and after activity look different for people who are highly sensitive to energy deficits?When is it time to pull back on exercise, even if every message you’ve heard says “move more”?Key Takeaways
Exercise is stress, not magic. When the brain perceives low energy or famine risk, it can respond to exercise by slowing metabolism, shutting down hormones, and defending body fat.Labs tell the story. Low leptin with high “famine signals,” along with thyroid, cortisol, and reproductive hormone suppression, are red flags that the body is conserving energy—not freely burning fuel.Fueling beats punishment. For sensitive metabolisms, you often “can’t overdo the fueling” around movement—sports drinks and carbs, even for short sessions, can help reassure the brain that it’s safe.Movement ≠ grind. Reframing exercise as enjoyable movement and nervous system regulation (walking, gentle climbing, yard work) helps break from all-or-nothing “training” mindsets that can backfire.Dr. Cooper’s Actionable Tips
If your weight climbs or stalls despite hard workouts and restricted eating, talk with a clinician about metabolic labs instead of just pushing harder.Cushion any exercise with real fuel: eat before, add carbs/electrolytes during, and refuel after—especially if you have a history of dieting, overtraining, or weight cycling.Consider starting with low-intensity, pleasant movement and always “leave gas in the tank” instead of chasing exhaustion as the goal.Notable Quote“Exercise should not be used as a weight loss tool. It should be used as a performance and a health tool.” — Dr. Emily Cooper
Links & ResourcesPodcast Home: Fat Science Podcast Website – https://fatsciencepodcast.com/Cooper Center for Metabolism & Fat Science Episodes: https://coopermetabolic.com/podcast/Resources and education from Dr. Cooper: https://coopermetabolic.com/resources/Submit a Show Question: questions@fatsciencepodcast.comDr. Cooper direct show email: dr.c@fatsciencepodcast.com
Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.
Mon, 22 Dec 2025 - 1h 02min - 115 - The Latest GLP-1 News
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor unpack the biggest GLP-1 headlines from around the world—from the World Health Organization’s first-ever GLP-1 obesity guidelines to access battles, brain research, and the coming wave of generics and new meds.
Dr. Cooper explains what the WHO’s move really means for patients, why long-term treatment matters, and how policy decisions in places like California and India could reshape who actually benefits from these breakthroughs. This isn’t hype—it’s metabolic medicine, health-system reality, and grounded hope.
Key Questions Answered
Why is the WHO’s new guidance on GLP-1s for obesity such a historic turning point?What does it mean to treat obesity as a chronic, relapsing disease—not a willpower problem?Why do GLP-1s usually need to be taken long term, and how is that similar to blood pressure or cholesterol meds?How should GLP-1s be paired with metabolic care—fueling, sleep, movement, and real clinical oversight?What did the “stone cold negative” Alzheimer’s trials show—and why are addiction trials still promising?How could India’s launch of Ozempic and future generics impact global pricing and access?What new GLP-1 and metabolic drugs are on the horizon (like orforglipron, higher-dose oral semaglutide, and GLP-1/amylin combos)?Key Takeaways
WHO is catching up to the science. Obesity is affirmed as a chronic, relapsing disease that deserves pharmacologic treatment—not “eat less, move more” lectures or moral judgment.Long-term meds are the rule, not the exception. Stopping GLP-1s usually leads to weight and risk factors returning, just like stopping blood-pressure meds. That’s physiology, not failure.Behavior ≠ blame. WHO calls for pairing GLP-1s with “behavioral” care—but Dr. Cooper reframes this around fueling, sleep, and supported habits, not deprivation or diet culture.Access is the battleground. Even as WHO elevates GLP-1s, programs like California’s Medi-Cal are cutting coverage for obesity, a move Dr. Cooper calls penny-wise and pound-foolish given the downstream costs of diabetes and cardiovascular disease.Brain outcomes are nuanced. Large oral semaglutide trials failed to slow Alzheimer’s, but GLP-1s (and other obesity meds) still show promise for addiction by modulating reward pathways and the “internal drug factory” (POMC).Global markets are shifting. India’s huge population, looming Ozempic patent expirations, and emerging generics could eventually drive prices down—especially as more manufacturers compete.New meds may expand options. Orforglipron (a small-molecule oral GLP-1), higher-dose oral semaglutide, and a weekly GLP-1/amylin combo could bring more flexible, powerful, and potentially more affordable tools.Dr. Cooper’s Actionable Tips
Think of obesity treatment like any chronic disease: long-term, medical, and individualized—not a short-term “diet.”If you’re using a GLP-1, pair it with real metabolic care: consistent fueling (not under-eating), good sleep, and appropriately fueled exercise.Be cautious with “cheap” or unsanctioned online GLP-1 options—especially if you’re being squeezed out of coverage. Safety and oversight matter.Remember there are other evidence-based obesity meds beyond GLP-1s; if you can’t tolerate or access one class, ask your clinician about alternatives.Notable Quote
“Your metabolism is a lifelong issue. It’s not a headache.”
— Andrea TaylorLinks & Resources
Podcast Home: Fat Science Podcast Website – https://fatsciencepodcast.com/ Cooper Center for Metabolism & Fat Science Episodes: https://coopermetabolic.com/podcast/ Resources and education from Dr. Cooper: https://coopermetabolic.com/resources/ Submit a Show Question: questions@fatsciencepodcast.comDr. Cooper direct show email: dr.c@fatsciencepodcast.com*Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better.
Mon, 15 Dec 2025 - 39min - 114 - Listener Mailbag: Set Point Theory, Trauma & Metabolism, and Why 1200 Calories Can Still Lead to Weight Gain
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor answer listener questions about BMI cutoffs, weight cycling, metabolic adaptation, trauma, GLP-1 differences, and why some people gain weight on ultra-low calories. Dr. Cooper explains what’s really happening inside the metabolic system and why individualized treatment—not dieting—creates sustainable change.
Key Questions Answered
If my BMI doesn’t “qualify” for GLP-1s, is Naltrexone + Bupropion helpful—and what labs matter first?Does being overweight always indicate metabolic dysfunction, and why are U.S. rates so high?If diets damage metabolism, what do you do when you’re already 80 pounds overweight?How long does it take for leptin and ghrelin to stabilize with mechanical eating?How can someone gain weight on 1,200 calories/day?After sleeve gastrectomy, how do you eat enough while on a GLP-1?Is set point theory real—and how does the melanocortin pathway influence it?If obesity runs in my family, will I need meds like Zepbound for life?How do trauma and stress alter long-term metabolic health?Can GLP-1s offset weight gain from steroids, mood meds, or hormones?Why might Ozempic work well while Mounjaro causes weight gain?Key Takeaways
1. BMI rules don’t reflect metabolic truth.
A mid-20s BMI can still mask significant dysfunction, especially with weight cycling.2. Weight cycling is metabolically stressful.
Repeated losses/regains increase visceral fat, insulin abnormalities, and cardiovascular risk.3. Obesity is a multi-hormonal disease.
Most people need pharmacology plus sleep, fueling, and movement—not restrictive dieting.4. Metabolic adaptation is powerful.
Under-fueling lowers thyroid output, suppresses fat-burning, and slows metabolism dramatically.5. After bariatric surgery or on GLP-1s, frequency matters.
Frequent, nutrient-dense snacks protect muscle, metabolism, and energy.6. Set point changes with better signaling.
GLP-1s and related therapies help the brain accurately detect weight and lower the defended level.7. Genetics often mean lifelong support.
Family patterns of obesity usually indicate long-term need for metabolic medication.8. Trauma amplifies metabolic risk.
Childhood trauma disrupts IGF-1, sleep, stress hormones, insulin, leptin, and ghrelin.9. Medications can cause weight gain—GLP-1s can help counteract it.
Steroids, mood meds, hormonal agents, and more can be metabolically unfriendly.10. “Newer” isn’t always better.
Some people respond poorly to the GIP component in Mounjaro/Zepbound. Individual physiology rules.Dr. Cooper’s Actionable Tips
Request deeper evaluation: DEXA, visceral fat, fasting insulin/glucose, leptin, reproductive hormones.Stop restrictive dieting permanently—mechanical eating protects metabolic stability.Work with a fueling-focused dietitian (often ED-trained).Review your medication list for drugs known to cause weight gain.Don’t switch GLP-1s or chase higher doses if your current regimen works.Notable Quote
“Obesity isn’t a willpower problem. It’s a metabolic disease, and when the underlying system is supported, the body finally has permission to change.” — Dr. Emily Cooper
Links & Resources
Podcast Home: Fat Science Podcast WebsiteSubmit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comDr. Emily Cooper on LinkedInMark Wright on LinkedInAndrea Taylor on InstagramFat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.
Mon, 08 Dec 2025 - 47min - 113 - A Patient’s Guide to Taking Back Your Health
Dr. Emily Cooper, Mark Wright, and Andrea Taylor talk with Maria from Buffalo, a longtime listener who shares her lifelong journey with obesity, psoriatic arthritis, and binge eating—and how finally understanding the science of metabolism gave her hope. Maria describes early childhood weight gain, joint damage, and years of restrictive dieting and food shame, then explains how GLP‑1 therapy (Zepbound) plus mechanical eating helped her lose about 50 pounds while eating more food, more often, and with more joy.
Dr. Cooper breaks down the underlying biology—leptin, weight set point, the melanocortin pathway, and the impact of pain, sleep, and chronic inflammation on hunger hormones—and reframes obesity as a symptom of deeper metabolic problems, not a character flaw. This episode doubles as a practical, emotionally honest guide for patients trying to navigate a traditional health‑care system without a dedicated metabolic specialist.
Key Questions Answered
How can rapid childhood weight gain, autoimmune disease, and early joint damage signal serious metabolic dysfunction rather than “too much food” or “not enough exercise”?
What is leptin, what does “too low for your size” mean, and how does that affect hunger, weight set point, and weight loss?
What is monogenic obesity testing, who might qualify for free genetic screening, and how can results inform (but not necessarily change) treatment?
How do GLP‑1 medications like Zepbound work with mechanical eating so someone can lose weight while eating more regularly and with more variety?
Which labs (fasting glucose, insulin, leptin, etc.) help uncover hidden metabolic issues, and when is a mixed‑meal test more useful than a simple fasting snapshot?
When should brain‑active medications (such as bupropion/naltrexone combinations) be considered, and what trade‑offs and side effects matter?
How can patients respectfully push for tests, challenge old “eat less, move more” advice, and set boundaries around weigh‑ins and stigmatizing language?
Key Takeaways
It’s not your fault: Rapid childhood weight gain and early‑onset obesity often reflect serious metabolic biology, including rare gene variants, growth phases, and hormone signaling—not gluttony or laziness.
Obesity is a symptom: Excess weight is better understood as a side effect of underlying metabolic fires (leptin issues, insulin resistance, brain signaling problems) that need proper diagnosis and treatment.
Leptin really matters: Low leptin for your size can act as a biological brake on weight loss, and chronic dieting, under‑fueling, over‑exercise, and some high‑dose supplements can suppress it further.
GLP‑1s plus mechanical eating: Medications like Zepbound can quiet food noise and support weight loss, but scheduled, balanced eating is essential to avoid under‑fueling, protect muscle, and support hormones.
Pain and sleep are metabolic: Chronic pain and poor sleep increase hunger hormones like ghrelin and disrupt repair processes, worsening metabolic dysfunction unless directly addressed.
Script your visits: Bring a printed list of diagnoses, medications, and questions; use patient portals to request specific tests; and practice simple boundary phrases around weighing and diet talk.
Notable Quote
“This isn’t all just caused by diets and things like that. There was an original metabolic problem. It was amplified because of the food restriction and the psychology around it, but you are a product of cumulative insults to your system—not a moral failure.” — Dr. Emily CooperLinks & Resources
Podcast Home: https://fatsciencepodcast.com/
Cooper Center for Metabolism & Fat Science Episodes: https://coopermetabolic.com/podcast/
Resources and education from Dr. Cooper: https://coopermetabolic.com/resources/
Submit a Show Question: questions@fatsciencepodcast.com
Dr. Cooper direct show email: dr.c@fatsciencepodcast.com
Fat Science is informational only and does not constitute medical advice.
Mon, 01 Dec 2025 - 59min - 112 - Listener Mailbag – Practical Metabolic Care, GLP‑1 Myths, and the Dangers of Microdosing
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor field your most urgent metabolic health questions—exploring care advocacy, novel drug use, lab results, and how to filter fact from fiction in the TikTok age.
Dr. Cooper offers clinical clarity, real-world perspective, and actionable hope—with an emphasis on what truly matters for your long-term health and energy.
Hear from listeners experiencing real breakthroughs (and challenges) with GLP-1s, get tips for navigating confusing cholesterol results, and learn why self-advocacy and good science matter more than credentials or hype. This is not a quick-fix episode; it’s real metabolic medicine, mythbusting, and grounded encouragement for your health journey.
Key Questions Answered
What labs and scores best assess your true metabolic risk—and how do you make sense of fasting glucose, glucose-insulin ratio (GIR), and FIB-4?How can you find a medical provider who’ll actually give you the time and attention metabolic care requires?Why do GLP-1s benefit more than weight loss alone? Listeners report help with sleep apnea, inflammation, and food noise—what does the science say?How should you reintroduce carbs after restriction, and what’s the safest way to monitor (beyond A1C)?What’s up with rising cholesterol on Zepbound, and when do you worry?Does serotonin syndrome relate to GLP-1s? (Short answer: No—Dr. Cooper explains why.)What are the dangers of “GLP-1 microdosing” as pushed by social media, and what happens when influencers overstep good science?Key Takeaways
Care that cares: The best doctor isn’t always the most credentialed—find someone, MD, NP, or PA, who takes your questions seriously and goes deeper than the surface. Labs that matter: Fasting glucose, insulin, GIR, HbA1c, plus advanced lipid testing (CardioIQ, NMR) are critical for uncovering hidden risk—not just chasing numbers. GLP-1s act broadly: Listeners see gains in sleep, inflammation, and appetite regulation. These benefits are real, not just anecdotal, and Dr. Cooper shares the clinical rationale. Smart fueling, even on GLP-1s: If you lack hunger cues, “mechanical eating” prevents under-fueling and cellular stress—especially important for maintaining muscle and metabolism. Rethinking “microdosing”: TikTok trends are not medical advice—microdosing with black-market GLP-1s is unproven, poorly regulated, and potentially unsafe. Rely on trusted, legal medication sources only.Dr. Cooper’s Actionable Tips
Request a full panel for metabolic health: ask your provider about fasting insulin, GIR, HbA1c, lipids, and FIB-4—even if you haven’t been flagged as “at risk”. For those on GLP-1s: Don’t skip meals; create a schedule with protein and fiber to avoid muscle loss and ensure micronutrient intake. Experiencing cholesterol shifts on medication? Ask for a breakdown (HDL, LDL, particle size) and consider advanced panels (CardioIQ, NMR) to better understand your risk. If reintroducing carbs after restriction, pair them with protein or fat and test glucose/insulin at intervals post-meal to personalize your plan. Avoid unregulated “microdosing” and buy only from reputable, FDA-approved outlets—protect your long-term health over quick fixes.Notable Quote
“The most important thing is somebody who cares, not necessarily their degrees.”— Dr. Emily Cooper
Links & Resources
Podcast Home: Fat Science Podcast WebsiteSubmit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on Instagram
Advanced cholesterol testing: CardioIQ at Quest, NMR at LabCorpFat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.Mon, 24 Nov 2025 - 46min - 111 - Listener Mailbag – Metabolic Mysteries, Medication Strategies, and Dr. Cooper’s Science-Based Answers
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor dive into your burning questions from around the world—exploring misunderstood metabolic problems, hard-won solutions for real people, and the science behind the headlines. From “selfish brain” physiology to the rollercoaster of insurance and medication access, Dr. Cooper brings clinical clarity and practical hope.
Hear real-world listener stories, get advice on tuning your metabolic health, and learn why personalization—not “calories in, calories out”—leads to better outcomes. This is no silver bullet show: it’s metabolic medicine, mythbusting, and science-backed encouragement for your journey.
Key Questions Answered
What is the “selfish brain” and how does it really impact blood sugar and diabetes risk?Why do GLP-1 medications affect stamina and hunger, and how should you fuel your body if you’re using them?If insurance pulls coverage for medications like Ozempic or Zepbound, what are your practical, safe, and affordable options?How do metabolic markers, medication “cocktails,” and genetic testing shape Dr. Cooper’s individualized care—and can you taper off meds and maintain results?What does “normal” blood sugar look like after meals, and how do you distinguish trends from outliers?Key Takeaways
Metabolism is complex—individualized care is essential. Diabetes, hypoglycemia, and insulin resistance all have personal causes and require testing like the Mixed Meal Tolerance Test to solve—not one-size-fits-all advice. GLP-1s require smart fueling. Many experience reduced stamina on these medications. Dr. Cooper recommends upping both complex and simple carbs pre-exercise and consulting with a registered dietitian if fatigue persists. Insurance coverage is a challenge—but not the end. Generic options (like liraglutide/Victoza via Mark Cuban Cost Plus Drugs), manufacturer programs, and “cocktail” regimens can support continued progress, even if you lose access to top-brand GLP-1s. Feedback loops & genetics drive lasting outcomes. While some patients can successfully—slowly—taper medications, most with metabolic dysfunction will need long-term support. “Clean eating” alone rarely reverses underlying feedback loop glitches. Monitoring is powerful. Using blood sugar monitors (especially for diabetics) can demystify meal spikes and help fine-tune nutrition and medication timing. Personal stories reflect broader truths. Listeners share struggles and solutions, reinforcing that metabolic health spans medication, motivation, and mindset.Dr. Cooper’s Actionable Tips
Always dig deeper with testing—not just A1C but also post-meal spikes via the Mixed Meal Tolerance Test.If you’re prescribed a GLP-1 and struggle with energy, increase carb intake safely and talk to a doctor about medication adjustment. For lost coverage, stick to FDA-approved sources: Lilly Direct for Zepbound, Novocare for Wegovy, and Mark Cuban for generics. Don’t risk unregulated online compounds. Recognize the difference between generalized “healthy” habits and targeted strategies that actually move your biomarkers.Stay consistent and compassionate—focus on small improvements over extremes and absolutes.Notable Quote
“The metabolism is regulated by a feedback loop…when you introduce outside hormone forms, you strengthen signals to favor fuel utilization over energy conservation.”— Dr. Emily Cooper
Links & Resources
Podcast Home: Fat Science Podcast WebsiteSubmit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comDr. Emily Cooper on LinkedInMark Wright on LinkedInAndrea Taylor on InstagramGeneric medication access: Mark Cuban Cost Plus DrugsZepbound direct: Lilly DirectAdditional info: Novocare for WegovyFat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice.
Mon, 17 Nov 2025 - 55min - 110 - From Voodoo to Mainstream: Debunking Diet Culture in the Age of GLP-1s
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor take a trip to the past when Dr. Cooper didn’t have many supporters in medicine. She shares what it was like to be ridiculed by her peers, why she refused to give up on her patients, and how her science-based approach to metabolism was finally validated by mainstream medicine.
Hear the raw, unfiltered story of resilience, patient advocacy, and scientific discovery that led Dr. Cooper from being dismissed as “voodoo” to blazing a trail for real metabolic health.
Key Questions Answered:
Why did so many in the medical community reject Dr. Cooper’s methods—like challenging “calories in, calories out”—when she started treating metabolic issues?What does the rise of GLP-1 medications reveal about the true science behind appetite, metabolism, and weight?How did Dr. Cooper hold onto her integrity and keep practicing effective, patient-centered medicine despite overwhelming opposition?When does medical “common sense” get replaced by real science, and what does that mean for anyone struggling with diets that fail?Key Takeaways:
Progress means facing skepticism. Dr. Cooper was once called a "voodoo doctor" and even yelled at by other physicians for her scientific methods, but results spoke louder than her critics. Metabolism is personal and complex—restrictive diets and “eat less, move more” advice often backfire. Hormonal science and careful patient tracking revealed why old rules failed. Persistent curiosity and data-driven practice, not popularity, eventually shift the culture. Dr. Cooper leaned on a “matrix” of metabolic markers long before these tests were commonplace. GLP-1 medications (like Byetta and Victoza) have moved from obscure tools to mainstream, validating Dr. Cooper’s approach to treating the whole metabolic system. True healing means fueling, not restricting. “Eating more,” not less, was key to metabolic recovery for many patients—a radical, often ridiculed idea that’s now supported by science and real-world clinical data from thousands of patients.Patient stories mirror the medical journey—today, both patients and providers can look back and realize that “voodoo” was simply science ahead of its time.Dr. Cooper’s Actionable Tips:
Question easy answers—when in doubt, follow the data, not tradition.Find a provider who listens, tests, and adapts treatment to you—not just your weight or a number on a scale.Remember that real science can be lonely before it’s mainstream. Trust progress, even when it feels slow.Celebrate freedom from food guilt; focus on nourishment, steady energy, and self-compassion, not dieting extremes.Notable Quote:
“It does make you feel lonely because you feel like there’s no one to talk to, but it was always about doing right by the science and by my patients.” — Dr. Emily Cooper
Fat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only, not medical advice.
Check out our website to submit a question, explore resources, or reach our hosts.
Have questions for Dr. Cooper, a show idea, or feedback?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on InstagramMon, 10 Nov 2025 - 54min - 109 - Mailbag: Low Blood Sugar Explained, Relief From Food Noise, Calorie Restriction Warning, Metabolic Health care on a Budget, and More.
his week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor tackle the biggest listener questions about sustainable weight loss, metabolic health, and why restrictive diets so often backfire. From medications like GLP-1s to common myths about exercise and nutrition, this episode delivers practical science and down-to-earth advice for anyone struggling with their weight and/or health.
Dr. Cooper breaks down why obesity is a physical sign of underlying metabolic dysfunction and sets the record straight about what really works for long-term health—spoiler: it’s not endless calorie counting or exercise alone. Listeners from around the world share their struggles and triumphs, and Dr. Cooper explains the roles of genetics, “food noise,” dealing with hypoglycemia, and the best ways to fuel your body.
Key Questions Answered:
Can someone with obesity achieve lasting weight loss without medication? Why don’t diets and exercise alone work long-term?What is reactive hypoglycemia after gastric bypass, and how should it be managed?How can people with limited access to healthcare still improve metabolic health?What is “food noise,” and how do new medications target the brain’s hunger and satiety signals?Should people use calorie restriction or focus on fueling their bodies for better metabolic health?Key Takeaways:
Obesity is best understood as a physical sign of metabolic disease, not a personal failure.There is no diet or exercise program shown to sustain long-term weight loss for those with obesity—medical therapies are usually necessary. Caloric restriction and exercise without medical intervention can slow metabolism and drive weight regain (the “diet backlash” effect). Good metabolic health is possible at any body size. Nutrition, physical activity, sleep, and stress management are essential but cannot, by themselves, reverse obesity.Medications like GLP-1s can help “quiet” food noise by restoring healthy communication between the gut and brain.Lifestyle strategies support metabolic function but aren’t strong enough to reverse metabolic disease alone. Focus on eating regular meals, balanced nutrients, and fueling your activity—not on perfection or restriction.Dr. Cooper’s Actionable Tips:
Find a clinician who listens and is curious about your health, not just weight or calorie intake.Don’t be pressured to take medication if you feel healthy and have good lab results, regardless of your weight.Fuel your body consistently with a mix of protein, healthy fats, and complex carbs—perfection isn’t necessary.Prioritize sleep and stress management, as both are critical for metabolism.Notable Quote:"There is no diet or exercise program that leads to long-term weight loss in someone with obesity. There isn't. Any time you're introducing that restriction you're opening the door to what's called metabolic adaptation, a slowing of the metabolic system. Why would you want to do that? If your whole goal is to strengthen the metabolic system, why would we want to introduce something that's been proven scientifically to slow the metabolic system down?" — Dr. Emily Cooper
Resources from the episode:Fat Science is your source for understanding why metabolic health—not weight alone—matters more than ever. No diets, no agendas, just science that makes you feel better. This show is informational only, not medical advice.
Check out our website to submit a question to the listener mailbag.
Have questions for Dr. Cooper, a show idea, feedback, or just want to connect?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on InstagramMon, 03 Nov 2025 - 52min - 108 - New Blood Pressure Guidelines: What You Need to Know
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor dive into the latest U.S. blood pressure guidelines—and reveal why nearly half of all Americans face risks that can no longer be ignored. Early intervention and smart lifestyle changes are at the heart of these new recommendations.
Why is high blood pressure such a hidden danger? What do the new “elevated” and “stage one” categories mean for real people? How do doctors decide when it’s time for medication versus lifestyle changes? And how does blood pressure connect to kidneys, strokes, and even dementia? Dr. Cooper unpacks the science, gives practical advice, and shares why home monitoring is now a crucial part of medical care.
In this conversation-dense episode, the team breaks old myths and empowers listeners to take charge—so that “keeping an eye” on blood pressure becomes active prevention, not passive worry.
Key Takeaways:
New guidelines lower the bar for concern—120 over 80 is now “caution,” and 130 over 80 is “hypertension.” Early action matters.Untreated high blood pressure can lead to irreversible organ damage, strokes, kidney disease, and cognitive decline.Doctors now have a better toolkit: updated cutoffs, risk “calculators” that include zip code, and clearer protocols for who needs medication right away.Lifestyle changes (fruit, vegetables, less sodium, more movement, quality sleep, stress management, and alcohol moderation) are the first line for many—especially in the “elevated” category.Metabolic syndrome often includes high blood pressure; medicines like GLP-1s and metformin may help regulate pressure as well as metabolism.Accurate home blood pressure monitoring is strongly recommended, with validated cuff meters (not wrist models).Dr. Cooper shares actionable tips:
Eat five servings of fruits and vegetables daily for potassium—bananas, spinach, potatoes, kiwis all help.Get a “validated” cuff monitor and check morning/evening, resting, following best practices.Ask your doctor about the new guidelines and risk calculators (found at the American Heart Association website).Notable Quote:
“Home readings are very valuable. I really encourage people to look at the Validate BP site, find a good meter, and keep a log. Catching high blood pressure early and treating it aggressively can have profound impacts on your future health.”— Dr. Emily Cooper
Resources from the episode:
Fat Science is your source for understanding why blood pressure—and metabolic health—matter more than ever. No diets, no agendas, just science that makes you feel better.This show is informational only, not medical advice.
Check out our website to submit a question to the listener mailbag.Have questions for Dr. Cooper, a show idea, feedback, or just want to connect?Email questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on InstagramMon, 27 Oct 2025 - 42min - 107 - The Mailbag: GLP‑1s, Leptin, Hormones & Insurance Advice
Fat Science Ep 106The Mailbag: GLP 1s, Leptin, Hormones & Insurance AdviceThis week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor open the listener mailbag to answer real questions from around the world about metabolism, hormones, and GLP-1 therapy. From the UK to Seattle, listeners share personal stories of confusion and discovery — and Dr. Cooper brings metabolic science back into focus.What really happens when you stop GLP-1 medications? Why can someone eat less yet gain weight? What does leptin resistance actually mean? And how can hopeful moms safely navigate treatment before pregnancy?In this conversation-rich episode, the team moves beyond myths, helping listeners understand how hormones — not willpower — drive metabolism, appetite, and long-term health.Key Takeaways:• GLP-1 medications don’t “work by starving you” — they help the body use energy better by resetting fuel use hormones.• Restrictive eating and “calories in, calories out” oversimplify metabolism and often worsen hormonal imbalance.• Leptin isn’t just about levels — signaling quality determines how well your brain recognizes stored body fat.• Pregnancy and metabolic health require careful timing; GLP-1s aren't used during pregnancy, but improved metabolic strength before conception matters most.• Rapid weight loss from GLP-1 meds can risk muscle depletion; maintaining steady nutrition and proper dosing is key.• Insurance coverage for GLP 1s remains unpredictable, but persistence and documentation can open doors.Personal Stories & Practical Advice:Andrea and Mark share their own experiences reconciling appetite changes on GLP-1 therapy — from remembering to eat when hunger signals quiet down to finding fueling strategies that work.Dr. Cooper offers practical guidance rooted in clinical data: why ordered eating keeps metabolism stable, how dietitians with eating disorder expertise support GLP-1 patients, and when to adjust medication doses to protect muscle mass.Notable Quote:“It’s not technically the weight that’s messing up fertility — it’s the metabolic dysfunction that causes weight as a symptom.” — Emily Cooper, MD.In this listener mailbag edition of Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor unpack the science behind GLP-1 medications, leptin resistance, and hormone balance. From fertility to appetite changes and insurance frustrations, this episode explains how metabolism—not willpower—drives lasting health. Hear real-world advice on fueling, mechanical eating, and safe GLP-1 use.
Resources from the episode:
Fat Science is a podcast on a mission to explain where our fat really comes from — and why it won’t go (and stay) away. We’re committed to a world where people understand that fat isn’t a failure and metabolism is not a math problem.This show is for informational purposes only and not a substitute for medical advice.
Check out our website where you can ask a mailbag question.
Have a question for Dr. Cooper, a show idea, feedback, or just want to connect?Email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with:
Dr. Emily Cooper on LinkedIn
Mark Wright on LinkedIn
Andrea Taylor on InstagramMon, 20 Oct 2025 - 34min - 106 - The Fallacy of GLP-1 “Diets” & the Microdosing Ad Frenzy
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright take on one of the biggest misinformation waves in popular health media: the rise of “microdosed” GLP‑1s and so‑called “GLP‑1 diets.”
As GLP‑1 medications dominate headlines and social media feeds, the hosts cut through the noise to explain what’s actually safe, what’s marketing hype, and why restrictive diets go against metabolic science.
Dr. Cooper reveals how calorie‑cutting research became misinterpreted, how compounded microdoses are being promoted like supplements, and why “just eat less” remains one of the most harmful messages for people trying to improve their metabolic health.
From the hormonal backlash of dieting to potentially-dangerous online telehealth shortcuts, this episode exposes how the new era of “skinny shots” and influencer‑driven microdosing campaigns echo decades of failed diet culture.
Key Takeaways:
GLP‑1 medications were never meant to be microdosed — these are serious prescription treatments, not vitamin‑like supplements.“GLP‑1 diets” persist because clinical trials paired the drugs with low‑calorie plans — but science hasn’t yet proven those restrictions help long‑term.Chronic calorie restriction weakens metabolism, disrupts hormones, and sets up “defensive weight gain.”Compounded or telehealth‑prescribed GLP‑1 versions are often untested and can be risky; many forms haven’t even been through FDA approval.Real progress comes from fueling your metabolism — eating enough, exercising with support, and stabilizing your brain’s hunger signals.Personal Stories & Practical Advice:Andrea opens up about the challenge of “mechanical eating” on GLP‑1 therapy — remembering to eat even when not hungry — while Mark shares how his own food relationship transformed once he focused on fueling, not restriction. Dr. Cooper emphasizes her 25‑year‑old shift away from calorie‑cutting, showing how patients thrive when metabolism is strengthened, not starved.
Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay) away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question.Have a question for Dr. Cooper, a show idea, feedback, or just want to connect? Email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.
Mon, 13 Oct 2025 - 36min - 105 - Childhood Obesity: Science, Shame & New Hope
This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor are joined by renowned childhood obesity expert Dr. Evan Nadler for a deep, honest conversation about what really is making our kids fat—and what’s finally changing about how kids, parents, and doctors can fight it.
The panel unpacks why the word “fat” is still so emotionally charged, how culture and even healthcare still get it wrong about weight, and why obesity must be recognized as a medical disease—not a moral failure. Dr. Nadler shares stories from two decades on the front lines, Dr. Cooper highlights transformative new science, and Andrea brings personal experience that challenges stereotypes and reveals the harm of shame-based approaches.
From the latest treatments—including medication and surgery for kids under 12—to the power of genetics, hormones, and family history, this episode breaks the silence, busts the myths, and lays out hope for families everywhere.
Key Takeaways:
The global prevalence of childhood obesity keeps rising, with 15 million kids in the US now affected, and most will progress to adult obesity without intervention.Obesity in kids is driven by a complex web of biology—genes, prenatal health, and hormones—not “overeating” or lack of willpower.Parental health before and during pregnancy strongly affects a child’s risk of obesity, and interventions work best when started early—even before birth.Shame, strict dieting, and constant focus on weight do lifelong damage. Kids need support, not blame, and a focus on total health—sleep, nutrition, stress, and fun movement.New medications (like GLP-1 agonists) and bariatric surgery are safe, evidence-based options for select children, and can be life-changing when used correctly.Advances in science and patient care show that individualized treatment (not “one-size-fits-all” fixes) leads to the best long-term health and lower risk of serious complications in adulthood.There are always choices—kids and families should know they are not alone, and there are always next steps in medical care, whatever age or size a child may be.Resources from the episode:Fat Science is dedicated to empowering families and changing the conversation about metabolism—reminding us all that fat isn’t a failure. For more resources, stories, and to submit a listener question, visit our website. If you are a healthcare professional and are interested in Dr Cooper’s upcoming training course, click on provider course at the Fat Science Podcast website!
If you have questions, a show idea, feedback, or want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.
Connect with Dr. Evan Nadler on his website.
*This podcast is for informational purposes only and is not intended to replace professional medical advice.
Mon, 06 Oct 2025 - 1h 10min - 104 - How Microdosing Can Backfire
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take a hard look at the buzz around microdosing metabolic medications—from what “microdosing” actually means to the risks of following trends without clinical supervision. The team unpacks widespread misunderstandings about dosing for drugs like Ozempic, Zepbound, and low-dose naltrexone (LDN), explains why social media advice can be dangerous, and highlights just how unique every person’s metabolic needs are.
Dr. Cooper shares patient examples and lays out the science behind hormone regulation, medication resistance, and why skipping a full evaluation could backfire. We cover why glandular extracts and testosterone supplements can disrupt your body’s natural balance and why trying to “trick” your metabolism with tiny doses can sometimes do more harm than good.
Key Takeaways:
Microdosing means doses far below anything supplied by drug companies—it’s not the same as prescribing a lower dose within the normal range.Popular trends in LA and beyond push people toward self-experimentation, often with compounded drugs or unsupervised regimens.Taking metabolic drugs without a clinical need can weaken natural hormone production and create dependency—even with “natural” supplements.GLP-1s, GIPs, naltrexone, and testosterone all show very different outcomes depending on your genetics, history of dieting, childhood athletics, or use of other medications.More is not always better. Too high a dose can create medication resistance, while too low might “numb out” your hormone response.Professional evaluation, sleep, nutrition, and self-kindness remain the first line of defense for metabolic health, rather than skipping over those and heading straight to medication.Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question. If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
If you are a healthcare professional interested in Dr. Cooper's training course, go to FatSciencePodcast.com and click on the top right button for Provider Course.Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram
Mon, 29 Sep 2025 - 42min - 103 - 5 Surprising Metabolic Studies From 2025
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down five eye-opening research studies from 2025 that challenge everything you thought you knew about obesity, dieting, and metabolism.
The hosts explore surprising new evidence on fitness trackers, the metabolic power of joy (and dessert!), the risks of intermittent fasting, how yo-yo dieting can damage kidney health, and the permanent impact of dieting on your brain-gut connection.
Dr. Cooper shares clinical insights and explains why simple fixes—strict diets, calorie counting, and food restriction—can actually backfire, causing more harm than good. From the science of hormone signaling to the pitfalls of diet culture, the conversation reveals powerful new reasons to embrace flexibility, balance, and self-kindness on the journey to metabolic health.
Key Takeaways:
Fitness trackers can dramatically underestimate calorie burn—errors can reach 93%, especially for people with higher body weight. Companies rarely test enough real-world diversity and may fudge numbers for marketing.Including dessert and “forbidden foods” in your diet leads to better metabolic outcomes, greater mental stability, and less risk of binge eating or weight regain. Joyful eating helps regulate critical hormones like leptin and ghrelin.Intermittent fasting is linked to hair loss. Energy deficits force the body to use fatty acids as fuel, which can damage hair follicle stem cells. Long-term fasting negatively disrupts glucose/insulin balance and destabilizes metabolism.Yo-yo dieting (weight cycling) now shows a direct connection with kidney damage—even in those at normal weight. Rapid weight shifts restrict kidney blood flow, raise cortisol, and cause irreversible damage.Dieting creates lasting changes in the microbiome and brain-gut signaling that promote weight regain and appetite dysregulation. Even a single round of weight cycling can create stubborn metabolic obstacles.Personal Stories & Practical Advice:Andrea shares why dessert is a staple of her happiness—and how mental restriction backfires. Dr. Cooper gives real-world examples from patients: eating favorite foods can unlock better weight results, while “diet damage” often lingers until medical treatment repairs it.
Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question. If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.
REFERENCES FOR THIS EPISODEAlshurafa, N., et al. (2025). “More accurate fitness tracking for people with obesity.” *Scientific Reports*, Northwestern University Feinberg School of Medicine.Alfouzan, N.W., & Nakamura, M.T. (2025). “Reduced food cravings correlated with a 24-month period of weight loss and weight maintenance.” *Physiology & Behavior*, Vol. 291.Chen, H., Liu, C., Cui, S., et al. (2025). “Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.” *Cell*, Vol. 188.The Endocrine Society (2025). “Yo-yo dieting may significantly increase kidney disease risk in people with type 1 diabetes.” *Journal of Clinical Endocrinology & Metabolism*, February 2025.Fouesnard, M., et al. (2025). “Weight cycling deregulates eating behavior via the induction of durable gut dysbiosis.” *Advanced Science*, 2025
Mon, 22 Sep 2025 - 47min - 102 - Centuries of Evidence: Why Diets Don’t Work
This week on Fat Science, Mark Wright, Andrea Taylor, and Dr. Emily Cooper dig deep into the science and history behind why diets don’t work for lasting weight management. From early fad diets, through to modern metabolic research, the episode explains why calorie restriction often backfires—and why fueling the body is key to long-term health.
Dr. Cooper unpacks the latest evidence about metabolic adaptation, the hormonal drivers of weight regain, and the persistent harms caused by repeated dieting. Listeners will leave with a renewed understanding of metabolism’s complexity, the importance of medical advocacy, and the critical need to challenge diet culture and weight bias.
Key Takeaways
Short-term weight loss from dieting is common, but centuries of evidence show most weight is regained—sometimes with additional harm.Metabolic adaptation and hormonal changes (like drops in leptin and rises in ghrelin) make weight regain almost inevitable for most people after calorie restriction.Repeated dieting (weight cycling) increases the risk of cardiovascular disease and visceral fat, not just regaining lost weight.The biggest breakthroughs in metabolism came in the 20th century, but weight bias and diet industry profits keep the focus on ineffective short-term strategies.True long-term progress rests on regular fueling, metabolic evaluation, and avoiding the trap of repeated restrictive diets.Expert Insights & Practical Advice
Dr. Cooper highlights landmark studies (Minnesota Starvation Experiment, Dutch famine, the "Biggest Loser" follow-up) illustrating how diets slow metabolism and can even cause lasting damage.The science behind metabolic hormones—leptin, ghrelin, adiponectin, GLP-1—shows why the body fights back against weight loss and why medications must be paired with metabolic support, not additional restriction.Reflections on weight bias in medicine, the need for informed consent around diets, and how current research is still catching up to clinical reality.Personal Stories & Culture Critique
Andrea shares how social circles demonstrate the futility of diets and the cycle of weight loss and regain.Mark recounts professional experiences highlighting systemic bias and cultural attitudes toward weight and health, advocating for preventive medicine as the path forward.The hosts challenge listeners to rethink their relationship with food, prioritize health, and push back against societal shame and stigma.Resources from the Episode
Fat Science is committed to debunking the myths about metabolism, diabetes, and fat. We empower listeners with evidence-based information, challenging the culture of blame and restriction. This podcast is for informational purposes and not medical advice.
Explore our website to join our live audience for the milestone 100th episode recording on Thursday, September 4th at 9 a.m. PST—ask Dr. Cooper a question and celebrate with us!Send questions, show ideas, or feedback: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.If you are a provider and interested in DI's training course or training manual for providers:Connect with Dr. Emily Cooper on [LinkedIn]Connect with Mark Wright on [LinkedIn]Connect with Andrea Taylor on [Instagram]Fat Science: No diet, no agenda—just science that makes you feel better.
Mon, 15 Sep 2025 - 51min - 101 - Fat Science Live: Celebrating Our 100th Episode!
The 100th episode of Fat Science brings together Dr. Emily Cooper, Andrea Taylor, and Mark Wright for a live mailbag celebration with listeners worldwide. Hear how the show began, reflect on lessons learned, and get answers to the questions people wish their doctors would address—especially about metabolism, obesity, diabetes, GLP-1 medications, and more.
Dr. Cooper shares the big-picture science behind “why we get fat,” the true drivers of metabolic dysfunction, and the evolution of her pioneering clinical practice. Andrea and Mark reveal the patient’s perspective—an honest look at what happens when the latest science meets real lives. Plus, practitioners and patients weigh in on the shifting cultural tide: it’s not a diet problem, it’s a metabolic problem.
Key Takeaways:
GLP-1 medications do not appear to harm future fertility or cause birth defect risks; improved metabolism may even help down the road.Leptin resistance/suppression: what labs really mean, why mechanical eating matters, and how ghrelin and other signals clarify the picture.“Diet Drug” stigma is outdated; GLP-1 medications target dysfunction, not willpower.Compounded GLP-1 solutions can be risky. Dr. Cooper explains supply chain, testing, and safer cost-saving alternatives like Lilly Direct, NovoCare, and Canadian Kwik pens.Autoimmune diseases (like celiac) may interfere with signals, but GLP-1s—especially bioidentical ones—are still options with careful monitoring.“Selfish Brain” explained: labs to request, what cerebral insulin suppression looks like, and why fueling and sleep are core solutions.Hashimoto’s: often distinct from metabolic dysfunction; both need tailored management and mechanical fueling.Heavy lifting & nutrition: protein needs often overstated—1.0–1.3g/kg ideal; pre-bed protein useful; DEXA scans help track muscle mass.Menopause & metabolism: estrogen/leptin loss, why patch plus micronized progesterone is often safest, and how each choice impacts metabolic health.Navigating insurance complexities, tariffs, and lifetime maxes—when and how to explore creative access.Metabolic changes tied to cycles, pregnancy, birth control: which progestins are weight-neutral, what to ask, and which labs to run if hitting plateaus.GLP-1s often improve blood pressure; dizziness may mean time to reduce meds, not the GLP-1.Personal Stories & Practical Advice:Andrea and Mark share a decade-plus of metabolic journeys—their dramatic health wins and the ongoing battle for self-compassion and body image. Listeners celebrate victories: reversing fatty liver, thriving after cancer, and breaking free from diet cycles.
“No diets. No agendas. Just science that makes you feel better.” The audience and hosts repeat this Fat Science tagline to mark the milestone.
Resources:Fat Science explains where fat really comes from and why it won’t just go away. We’re committed to empowering people with accurate information about metabolism and busting the myth that fat is failure. This podcast is informational only and not medical advice.
Check out our new website to ask a mailbag question. Contact us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram
Mon, 08 Sep 2025 - 1h 25min - 100 - Eating Your Way to Normal
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the dangers of under-fueling and challenge dieting myths with guest Gina Davito. This episode dives into Gina’s journey from extreme restriction and over-exercising to finally achieving metabolic balance and freedom from food obsession.
Dr. Cooper sheds light on the science behind metabolic adaptation, appetite regulation, and why fueling your body—rather than restricting—is essential for long-term health. Listeners will come away with a new perspective on weight management, the power of metabolic healing, and a celebration of food as a source of nourishment and joy.
Key Takeaways:
Chronic dieting and excessive exercise can trigger severe metabolic adaptation and worsen weight gain, creating a cycle that is hard to break without proper medical support.Abnormal hunger and weight gain are symptoms of underlying metabolic dysfunction, not lack of willpower—often exacerbated by early and repeated dieting.True progress involves nourishing the body and trusting medical guidance, sometimes including tailored medications to reset metabolic balance.Mental freedom from food-related anxiety arrives with metabolic healing—allowing for joy in eating and exercise for health rather than punishment.Early interventions for kids showing unusual hunger or weight patterns should focus on metabolic evaluation, not restriction.Personal Stories & Practical Advice:
Gina describes her transformation from compulsive restriction to vibrant health and athleticism—no longer trapped by thoughts of food or weight.Andrea and Mark share their relief at experiencing food freedom and highlight the importance of enjoying both food and movement.Resources from the episode:
Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Mon, 01 Sep 2025 - 51min - 99 - Mailbag: GLP-1s, Liver Health, Mechanical Eating & Metabolic Truths
This week on Fat Science we answer your questions in another, always-popular mailbag episode. Join Mark Wright, Andrea Taylor, and Dr. Emily Cooper and learn why some people don’t respond to GLP-1 medications, get the latest on new, oral weight-loss drugs, and explore the science behind elevated liver enzymes.
Dr. Cooper offers practical insights backed by metabolic research. She also addresses gluten-free diets, flavored seltzers, craving pathways in the brain, chronic pain management, and the importance of consistent eating patterns for metabolic health.
Key Takeaways:
About 20% of people may not respond to GLP-1s due to genetic and metabolic differences; deeper lab and genetic testing may be needed to uncover root causes.New oral GLP-1 options like Orforglipron are on the horizon, promising greater convenience and accessibility.Transient increases in liver enzymes can occur with rapid weight changes; regular monitoring and medical guidance are important.The POMC pathway in the brain plays a crucial role in cravings and metabolism—medications like Contrave can help by targeting this pathway.Flavored seltzers are generally fine, but watch for BPA-lined cans; gluten-free isn’t always healthier unless medically necessary.Chronic pain medications often impact metabolism—exploring underlying metabolic causes and non-GABA, non-opioid alternatives with providers is key.Consistent, “patterned” eating supports metabolic stability and brain function.Personal Stories & Practical Advice:
Andrea shares how tweaking her medication “cocktail” and eating patterns improved her results.Dr. Cooper and Mark discuss real-life snack strategies for fueling brain power and avoiding metabolic pitfalls.Resources from the episode:
Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Mon, 25 Aug 2025 - 43min - 98 - Muscle, Metabolism, and Mentality: Lessons from an 82-Year-Old Powerlifter
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they dive into the power of strength training—not just for elite athletes, but for everyday health and longevity.
This week’s guests bring unique perspectives: Faith Ireland, retired Washington State Supreme Court Justice and 82-year-old world-record-holding powerlifter, and Russell Cunningham, MA, CRC, exercise physiologist who specializes in rehabilitation, human performance, and the science of aging strong.
Faith shares her inspirational journey from recovering after a car accident to competing internationally with 15 world records. Russell explains the hard science behind why muscle strength and power are linked to bone density, fall prevention, metabolism, and even brain health. Dr. Cooper adds the medical lens, showing why strength training is essential for long-term vitality.
Key Takeaways:
Strength training preserves lean mass, protects bone health, and improves functionality at any age.Research shows if you can’t leg press at least 50% of your body weight, your fall risk skyrockets; strength training dramatically reduces that risk—even into your 90s.Power, not just strength, is key: the ability to move quickly and explosively helps prevent falls and injuries.Strength training improves more than muscles—it benefits insulin resistance, metabolic health, and brain function, with emerging links to dementia prevention.Starting safely matters: Small steps, proper form, and gradual adaptation are essential to build a foundation and avoid injuries.Even 10 minutes of lifting or bodyweight movement can build health when done consistently.Personal Stories & Practical Advice:
Faith explains how returning to lifting after back injury and hip replacements gave her confidence and resilience, even through cancer treatments.Andrea admits she’s been putting off strength training and asks Faith for advice on how best to get started.Russell shares insights from research showing why explosive strength matters for both older adults and younger people alike.Dr. Cooper explains the risks of “too much too soon,” highlights foundational training phases, and describes how nutrition and hormonal health affect results.Mark gets candid about how yoga and even golfing without a cart reminded him how fitness translates into everyday life.Resources from the episode:
Faith Ireland’s memoir: Getting to Justice: From Unwed Mother to State Supreme CourtDr. Emily Cooper’s book: The Metabolic Storm (2nd edition; new edition forthcoming)Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.
Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on Instagram
Check out our new website where you can submit a mailbag question and sign up for our upcoming 100th Episode live audience taping on Thursday, September 4th at 9 a.m. PST! Be part of the milestone and bring your questions for Dr. Cooper.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us atquestions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute, working to expand access to effective, science-based metabolic care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 18 Aug 2025 - 1h 00min - 97 - The Stress Hormone Cortisol: Friend or Enemy?
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unravel the complex role of cortisol, the body’s primary stress hormone.
Dr. Cooper explains how cortisol isn’t always bad—it helps us adapt to stress, mobilize energy, and even save our lives in emergencies, but chronic elevation can cause serious health problems like insomnia, weight gain, and increased risk for diabetes and heart disease.
The team explores the science behind how stress impacts metabolism, why recovery and adaptation are essential, and practical, science-backed strategies for managing stress in everyday life.
Key Takeaways:
Cortisol helps the body adapt to acute stress but becomes harmful when chronically elevated, increasing risk for major health issues including metabolic dysfunction.Chronic stress can impair sleep, disrupt blood sugar regulation, and suppress immune function.Managing stress involves more than just eliminating stressors—recovery, lifestyle shifts, and purposeful micro-breaks are vital for a healthy stress response.Meditation, certain types of yoga, gentle exercise, fueling workouts with carbs, and improving sleep all have proven benefits for regulating cortisol.Balancing lifestyle choices, nourishing the body with complex carbs, antioxidants, and gut-friendly foods, and setting boundaries are crucial for long-term metabolic health.Personal Stories & Practical Advice:
Andrea opens up about stress shopping and learning healthier coping habits.Mark shares how his career-induced sleep deprivation affected his health, and the positive changes he’s made.Dr. Cooper offers actionable advice on finding realistic ways to “take the load off,” from better sleep to more intentional rest.Resources from the episode:
Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
Check out our new website where you can ask a mailbag question and sign up to be in the audience for our 100th episode we’re recording on Thursday, September 4th at 9 a.m.PST. Be part of the live audience and ask Dr. Cooper a question. We’d love to celebrate this milestone with you!
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 11 Aug 2025 - 49min - 96 - How Parental Perception Shapes Kids’ Bodies
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the surprising influence of parental perception on children’s weight and metabolic health. Dr. Cooper breaks down the science connecting how parents think and talk about body size to the way their kids develop physically and emotionally. The episode tackles the real-world consequences of parental concerns, dieting mindsets, and body image on children’s metabolism, offering insights into creating supportive environments for healthy growth.
Key Takeaways:
Parental focus on weight—even with good intentions—can inadvertently lead to increased weight and metabolic dysfunction in children, regardless of their starting size.Kids’ brains are attuned to perceptions of scarcity or restriction, which may trigger a slowed metabolism and greater long-term weight gain.Positive, open communication and listening to children’s cues around hunger and satisfaction are crucial for healthy development.Early restrictive interventions, like dieting or food policing, can increase risk for disordered eating, poor self-esteem, and metabolic issues.Healthcare providers and parents should prioritize metabolic health over weight-centric approaches, leaving space for normal growth patterns and individual differences.Personal Stories & Practical Advice:
Andrea shares her childhood experiences with parental dieting, restriction, and its lasting emotional effects.Dr. Cooper outlines practical steps for parents: trust your child’s hunger cues, ensure regular nutritious meals, avoid body shaming language, and seek medical advice privately if concerned about weight.Mark emphasizes how society’s focus on body size can harm both kids and adults, reinforcing the need for compassion and science-driven solutions.Resources from the episode:
Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, you can now reach us at Fat Science’s new website: https://fatsciencepodcast.com, or email us at questions@fatsciencepodcast.com, or dr.C@fatsciencepodcast.com.
For scientific reference sample listings related to topics in this episode, see https://fatsciencepodcast.com/wp-content/uploads/2025/06/Scientific-References-Fat-Science-Episodes.pdf
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 04 Aug 2025 - 41min - 95 - Fat Science Mailbag: The Dangers of Restricting Calories, Bariatric Plateaus, GLP-1 Dose Adjustments, Weight Expectations & More
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright open the Fat Science mailbag to answer listener questions from around the globe.
This episode covers real-world metabolic challenges—from navigating calorie restriction and GLP-1 medications to the complexities of bariatric surgery, prednisone’s impact on weight, and menopause.
Dr. Cooper offers clear explanations and practical advice for healthcare professionals and patients alike on understanding metabolic dysfunction, interpreting lab results, and setting realistic weight loss expectations.
Key Takeaways:
Calorie restriction and intermittent fasting can destabilize metabolism, making recovery complex for some patients—gradual changes and medical monitoring are essential.Bariatric surgery can be an effective intervention for those with significant insulin resistance or high hunger signals. Pre-surgery metabolic testing (like insulin, glucose, and ghrelin levels) is valuable in assessing the likely benefit.Plateaus after surgery, persistent weight struggles, and the role of genetics highlight the need for root-cause investigation, not just symptom management.Prednisone and hormone therapies (including MHT for menopause) can affect metabolic health; small dietary adjustments, body composition testing, and tailored exercise are crucial for optimizing outcomes.Guidance on GLP-1 medication maintenance: Most patients benefit from staying on weight loss meds long-term, but dose adjustment is possible when side effects arise. Stability over many months is critical before considering any taper.Personal Stories & Practical Advice:
Andrea shares her experience with bariatric surgery and ongoing metabolic management, emphasizing realistic expectations and the benefit of medication-surgery synergy.Listeners ask: how to evaluate readiness to stop weight loss meds, address side effects, and balance hormone needs during menopause.Resources from the episode:
Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.
Updates on Dr. Cooper’s upcoming virtual metabolic health training—ideal for practitioners in the UK and beyond.Information about Melanocortin pathway testing programs for severe, persistent obesity.https://uncoveringrareobesity.com/Link to previous show. “GLP-1s: Will I Have to Take Them Forever?” (5/19/25)https://open.spotify.com/episode/1GZA71gTMSz0idbnEYblVO?si=gJXxNkbYTHykhNDw0Ebltg Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 28 Jul 2025 - 41min - 94 - Metabolic Drugs: Why One Size Doesn’t Fit All
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright unpack the latest breakthroughs in metabolic medications and why individual biology requires personalized treatment.
Dr. Cooper explains how modern therapies for metabolic dysfunction go far beyond the old “one pill fixes all” approach. Discover how hormone-based medications like GLP-1 agonists are changing obesity and diabetes care, why medication response can differ drastically between individuals, and what the future holds for tailored metabolic treatments.
You’ll come away with a clearer understanding of why effective weight management isn’t just about diet or willpower—it’s about precision medicine.
Key Takeaways:
Metabolic dysfunction is a complex, multi-hormonal disease; no single medication will work for everyone.New therapies, including dual and triple hormone agonists (like GLP-1, GIP, and amylin analogs), offer synergistic and individualized effects.Clinical observation shows that increasing doses or the “latest” medication doesn’t guarantee better results—some people may even find that their progress disappears after increasing to maximal doses.Lab markers (like ghrelin and leptin) could help personalize treatment, but cost and availability limit widespread testing.Concerns about muscle loss with GLP-1 drugs are common, but clinically, the risk mostly depends on nutrition, strength routines and muscle mass at baseline.Accessibility and cost remain barriers; new small-molecule drugs may improve affordability in the near future.Personal Stories & Practical Advice:
Andrea relates how understanding her true metabolic issues, rather than just dieting, led to sustainable health changes.Dr. Cooper describes her clinic’s approach to measuring body composition and tracking lean mass to avoid unwanted muscle loss.Listeners are encouraged to work with knowledgeable providers, beware of “one size fits all” narratives, and stay hopeful as newer, more effective treatments emerge.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 21 Jul 2025 - 49min - 93 - Endocrine Disruptors: Hidden Chemicals and Metabolic Health
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright revisit the critical topic of endocrine disruptors—chemicals in our environment that interfere with hormones and impact metabolism, weight, and overall health.
Dr. Cooper breaks down how everyday exposures to substances like phthalates, BPA, and others can have generational effects on metabolic pathways and disease risk. The episode highlights the link between these chemicals and the rising rates of obesity, diabetes, and even cancer, while offering practical steps for minimizing exposure in daily life.
Key Takeaways:
Endocrine disruptors are chemicals found not only in food but in everyday items such as furniture, makeup, plastics, and baby products, making exposure widespread and difficult to avoid.These chemicals can mimic or block hormones, disrupting critical metabolic and developmental processes, with effects that may pass to future generations.Regulatory oversight in the U.S. is decreasing, with significant EPA budget cuts threatening existing screening and cleanup programs targeting endocrine-disrupting chemicals.Air quality improvements, especially through HEPA filtration, and making informed choices during preconception, pregnancy, and early childhood, can help reduce exposure.Consumer awareness, advocacy, and using resources like the Environmental Working Group (EWG) app are key strategies for individuals seeking to lower risk.Personal Stories & Practical Advice:
Andrea shares the everyday struggle to find safe, affordable alternatives and the surprise of seeing improvements in metabolic hormone levels after changing air filters and reducing workplace exposures.Dr. Cooper discusses strategies to minimize risk during critical windows such as preconception and pregnancy, and emphasizes the power of informed consumer choices in driving safer product development.Resources from the episode:
Environmental Working Group (EWG) resources and app for product safety ratingsU.S. EPA Endocrine Disruptor Screening Program (EDSP)PubMed for scientific research on specific chemicals (BPA, phthalates, PFAS)Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute, which aims to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 14 Jul 2025 - 40min - 92 - Profits vs. Prevention: How Do We Fix Healthcare?
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright tackle the frustrations of navigating the American healthcare system—especially when it comes to treating metabolic dysfunction, diabetes, and obesity. Mark vents about insurance obstacles, while Dr. Cooper breaks down how short-term thinking, excessive profit layers and lack of preventive care put patient health at risk.
Andrea and Dr. Cooper share personal stories and expertise about the high cost and complexity of accessing vital medications. Together, they explore how incentives, policies, and profit motives harm patient outcomes and propose ideas for a system that truly values health over profits.
Key Takeaways:
The U.S. healthcare system appears to prioritize short-term profits over long-term health, making it hard for patients to access necessary preventive treatments.Insurance companies create barriers to care by denying medications until a patient’s condition worsens, favoring “sick care” over prevention.The cost of medications in the U.S. is often exponentially higher than in other countries due to lack of price negotiation and excessive middlemen.Access to essential drugs often depends on your employer, state, or industry, creating inequities for those outside favored sectors.Real cost savings—and better outcomes—come from investing in prevention and allowing providers and patients to make informed decisions without interference.Personal Stories & Practical Advice:
Mark and Andrea describe fights with insurance for medication access, including resorting to Canadian pharmacies and out-of-pocket payments.Dr. Cooper explains how prevention in her clinic has reduced heart attacks, strokes, and new cases of diabetes among her high-risk patients.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 07 Jul 2025 - 47min - 91 - Metabolic Workup 101: What Tests Reveal About Your Health
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down the essentials of a true metabolic workup. This episode moves beyond social media diet trends and digs into the science behind comprehensive lab panels, what they measure, and why they matter for your whole-body health.
Dr. Cooper explains how to interpret common and advanced metabolic markers—like blood sugar, insulin, cholesterol, hormone levels, and more—while Andrea and Mark share personal insights into the power of understanding your metabolic baseline. If you’re concerned about weight, diabetes, or just want to know your numbers, this episode gives you the knowledge to talk confidently with your healthcare provider.
Key Takeaways:
A whole-body metabolic approach goes beyond just weight or blood pressure—comprehensive lab work (plus family history) is essential to uncover risks or dysfunction early.Standard blood panels provide useful clues (glucose, cholesterol, liver, kidney, blood pressure), but advanced tests (A1C, lipid particles, hormone levels, inflammation markers) round out the picture.Metabolic dysfunction is driven by factors far deeper than calories in/out—dieting and under-fueling can actually weaken metabolism over time.Medication for metabolic health is not a failure; it’s a science-backed intervention. Early and accurate testing allows for better, evidence-based treatment.Don’t ignore “borderline” results—addressing issues early is easier and more effective than trying to reverse advanced dysfunction later.Personal Stories & Practical Advice:
Andrea recounts her life-changing journey from endless dieting to real answers through complete metabolic testing and individualized treatment.Mark highlights the need for patients to advocate for themselves and ask for more than just the standard panel at annual exams.References:
Diet Failure Rate
• Mann, T., et al. (2007). "Medicare's search for effective obesity treatments: diets are not the answer." American Psychologist, 62(3), 220-233
• Anderson, J. W., et al. (2001). "Long-term weight-loss maintenance: a meta-analysis of US studies." American Journal of Clinical Nutrition, 74(5), 579-584
Persistent Metabolic Adaptation
• Fothergill, E., et al. (2016). "Persistent metabolic adaptation 6 years after 'The Biggest Loser' competition." Obesity, 24(8), 1612-1619
• Rosenbaum, M., & Leibel, R. L. (2010). "Adaptive thermogenesis in humans." International Journal of Obesity, 34(S1), S47-S55
Long-Term Hormonal Disruption
• Sumithran, P., et al. (2011). "Long-term persistence of hormonal adaptations to weight loss." New England Journal of Medicine, 365(17), 1597-1604
• Rosenbaum, M., et al. (2005). "Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight." Journal of Clinical Investigation, 115, 3579-3586
Weight Cycling Cardiovascular Risks
• Montani, J. P., et al. (2006). "Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory." International Journal of Obesity, 30(S4), S58-S66
Resources:
Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on InstagramFat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org
Mon, 30 Jun 2025 - 45min - 90 - Fatty Liver Disease: What You Need to Know
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright uncover the truth about fatty liver disease and its rapid rise in both adults and children. It’s estimated 125 million Americans have the disease.
Dr. Cooper explains the critical role the liver plays in metabolism—covering hundreds of essential functions—and why fatty infiltration poses serious risks. The episode demystifies diagnosis, risk factors, and treatment options, empowering listeners to take a proactive approach to liver health and metabolic wellness.
Key Takeaways:
Fatty liver disease, now known as MASLD—Metabolic Dysfunction-Associated Steatotic Liver Disease, affects about 30% of adults, and is rising in youth, especially those with obesity or type-2 diabetes.Risk is not limited to higher body weights; up to 15% of normal-weight people are also affected, with genetics playing a significant role.Diagnosis can be tricky: blood enzymes (ALT, AST) and platelet counts factor into the highly predictive FIB-4 score, while imaging (like fibroscan) provides clarity on severity.Untreated, fatty liver can progress to inflammation, fibrosis, and even require a liver transplant, though early-stage disease is often reversible with proper intervention.Treatment focuses on improving metabolic function—through medication, diabetes management, and sometimes lifestyle changes—as solely relying on diet and exercise may not be enough, particularly for advanced cases.Personal Stories & Practical Advice:
Andrea shares her own experience discovering fatty liver disease and seeing rapid improvement after metabolic treatment.The hosts discuss common misconceptions, and why liver health should be checked in both children and adults, regardless of body size or outward health.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 23 Jun 2025 - 37min - 89 - Is Male Menopause Real?
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the concept of “male menopause” and whether it’s backed by science. Dr. Cooper breaks down hormonal changes in men, including testosterone decline, metabolic dysfunction, and the myths surrounding andropause.
The episode dives into why men and women experience aging differently, how metabolism ties into hormone shifts, and what really happens to male fertility and energy over time. After listening, you’ll understand why “male menopause” isn’t the full story and what really matters for men’s health as they age.
Key Takeaways:
There’s no sudden “male menopause”—testosterone declines gradually in men, unlike the rapid hormonal changes seen in female menopause.Metabolic dysfunction can suppress testosterone in men, leading to fatigue, muscle loss, and changes in body fat distribution.Converting testosterone to estrogen in belly fat can further suppress testosterone, creating a cycle that impacts energy and mood.Testosterone therapy might be beneficial for some men with low levels, but should always be guided by a healthcare provider after thorough evaluation.Most supplements marketed to “boost testosterone” are unproven and potentially unsafe—focus on medical advice and proper testing.Personal Stories & Practical Advice:
Mark shares his journey with testosterone treatment and how restoring balance improved his mood and energy.Andrea and Dr. Cooper discuss the importance of understanding individual lab results, getting the full metabolic picture, and consulting with primary care providers before considering hormone therapy.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 16 Jun 2025 - 34min - 88 - The Rise of Metabolic Telehealth
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the expanding world of telehealth in treating metabolic issues. Dr. Cooper sheds light on both the promise and pitfalls of accessing medications like GLP-1s through online platforms. The episode dives into the effectiveness of patient-provider relationships, the importance of comprehensive and personalized care, and the potential red flags in impersonal telehealth services. After listening, you’ll understand the benefits of telehealth and why thoughtful, thorough medical guidance is crucial for metabolic health.
Key Takeaways:
Telehealth has improved accessibility and convenience for metabolic care, but not all platforms offer the same quality of support.The lack of personalized interaction and lab-based assessments in many telehealth services can pose risks to patient health.Quick, transactional telehealth models often prioritize medication sales over holistic care and ongoing patient monitoring.Comprehensive care requires detailed history-taking, follow-up, and lab work—elements often missing in mass-market telehealth.Listeners should watch for red flags such as no direct provider interaction, absence of lab testing, and subscription models tied to product sales.Personal Stories & Practical Advice:
Andrea reflects on her own journey and the difference a dedicated, whole-person approach made to her health.Dr. Cooper shares her experience testing a mass-market telehealth site, exposing the superficial nature of some programs.The panel urges listeners to seek out board-certified providers and reputable telehealth organizations for genuine care.Link to US National telehealth clinics with Board Certified Obesity Medicine providers: Knownwell (non-affiliated)
Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 09 Jun 2025 - 39min - 87 - Mailbag: Metabolism Myths, Plateaus, and More
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright answer listener questions from around the world about metabolic health. This mailbag episode explores widely-debated topics like “starvation mode,” weight loss plateaus, the relationship between metabolism and cognitive health, cannabis and metabolism, metabolic effects of liposuction, and the latest on GLP-1 medications.
Key Takeaways:
Dr. Cooper dispels myths around “starvation mode,” citing research on the long-term metabolic impact of dieting and caloric restriction.Weight loss plateaus are often misunderstood—Dr. Cooper explains the natural adaptations behind them and how to assess true progress.Metabolic health plays a major role in brain function, cognitive decline, depression, and dementia prevention.Cannabis affects metabolic pathways in complex ways, with regular use potentially causing negative metabolic effects.Liposuction can trigger metabolic rebound and rapid fat regain for some patients, especially when leptin levels are low.Updates on GLP-1 meds: Liraglutide is available in generic form, but costs fluctuate. New oral and combination therapies are on the horizon.Personal Stories & Practical Advice:
Andrea and Mark reflect on their own journeys with dieting, weight plateaus, and medication.Dr. Cooper shares clinical experiences with metabolic rebound after liposuction and ways to navigate pharmacologic treatments.Correction: Lilly has a lower cash pay for Medicare and Medicaid, but Novo Nordisk is not yet.
References related to diet-induced metabolic adaptation, also called biological adaptation and defense of body weight.
1. Keys, A., Brozek, J., Henschel, A., Mickelsen, O., & Taylor, H. L. (1950). The Biology of Human Starvation. University of Minnesota Press.
2. Dulloo, A. G. (2021). Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation. Obesity Reviews, 22, e13189.
3. Müller, M. J., & Bosy-Westphal, A. (2013). Adaptive thermogenesis with weight loss in humans. Obesity, 21(2), 218-228.
4. Rosenbaum, M., & Leibel, R. L. (2010). Adaptive thermogenesis in humans. International Journal of Obesity, 34(S1), S47-S55.
5. Fothergill, E., Guo, J., Howard, L., Kerns, J. C., Knuth, N. D., Brychta, R., ... & Hall, K. D. (2016). Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity, 24(8), 1612-1619.
6. Johanssen, D. L., Knuth, N. D., Huizenga, R., Rood, J., Ravussin, E., & Hall, K. D. (2012). Metabolic slowing with massive weight loss despite preservation of fat-free mass. Journal of Clinical Endocrinology & Metabolism, 97(7), 2489-2496.
7. Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011). Long-term persistence of hormonal adaptations to weight loss. New England Journal of Medicine, 365(17), 1597-1604.
8. MacLean, P. S., Bergouignan, A., Cornier, M. A., & Jackman, M. R. (2011). Biology's response to dieting: the impetus for weight regain. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 301(3), R581-R600
Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 02 Jun 2025 - 33min - 86 - Why Sometimes It Takes a Little Patience
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore why metabolic health transformations require time, persistence, and a holistic approach. Andrea shares her 14-year journey with Dr. Cooper, highlighting the slow, individualized nature of healing a dysfunctional metabolism and why quick fixes rarely work.
Dr. Cooper explains how complex feedback loops, hormonal adaptations, and life events can slow progress—and why health markers, not just the number on the scale, are crucial measures of success. The conversation encourages patience, self-compassion, and a focus on sustainable health, not just rapid weight loss.
Key Takeaways:
Healing metabolic dysfunction is a complex, highly individualized process that often takes years—not weeks or months.Dieting, stress, disrupted sleep, and misguided exercise can send the body into "famine mode," making weight loss even harder.Metrics like blood pressure, cholesterol, and glucose often improve before significant weight loss occurs—these health gains matter.Medications and bariatric surgery can help in stubborn cases, but long-term success depends on a combination of medical, lifestyle, and psychological support.As many as 20% of patients may be "non-responders" to current treatments, highlighting the need for ongoing metabolic research and new therapies.Personal Stories & Practical Advice:
Andrea details her long road—from early GLP-1 medications and plateaus to bariatric surgery and ongoing adjustments—with the emphasis that patience paid off.Dr. Cooper and Mark reinforce the importance of redefining food as fuel and joy, not the enemy, and letting go of blame or unrealistic expectations tied to the scale.The episode highlights small wins, the value of routine lab work, and celebrating all forms of progress—especially the non-scale victories.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 26 May 2025 - 40min - 85 - GLP-1s: Will I Have to Take Them Forever?
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down the latest science behind GLP-1 medications like Ozempic, Wegovy, and Mounjaro. Dr. Cooper shares her decades of expertise on how these drugs work, their evolution, and whether you really have to take them for life.
The episode dives deep into the individual factors that impact tapering off, the importance of metabolic signals (like famine and security signals), and why medication is just one piece of the metabolic puzzle.
Key Takeaways:
GLP-1 medications have advanced significantly, with more convenient dosing and greater effectiveness for many—but responses vary widely from patient to patient.Weight on the scale isn’t the only measure; body composition, nutrient levels, and metabolic markers are critical in determining treatment and possible tapering.Not everyone needs to take GLP-1s forever—tapering is possible, but it depends on individual health markers, genetics, and whether metabolic signals are balanced.The future of metabolic health lies in combination therapies that target multiple pathways, not just GLP-1s.Dieting alone disrupts metabolic signals, making professional metabolic medicine and nutrition guidance essential for long-term health.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 19 May 2025 - 39min - 84 - Dosing Download: How much? When? Is It Working?
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes.
The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.
Key Takeaways:
Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.Personal Stories & Practical Advice:
Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper’s guidance.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 12 May 2025 - 44min - 83 - Mailbag: Your Questions Answered
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science for a special mailbag episode answering listener questions about metabolic health. Dr. Cooper explains the difference between mindful and mechanical (timed) eating, especially for those using medications like Zepbound.
The team also addresses emotional challenges tied to frequent eating, societal fat shaming, and the complexities of medication side effects for those on GLP-1 agonists and antipsychotics. Real experiences and practical advice help shed light on fueling your body, breaking free from diet culture guilt, and navigating complex emotions on the journey to better health.
Key Takeaways:
GLP-1 medications like Zepbound affect appetite and metabolism but can also suppress hunger cues; mechanical eating—timing meals and including all food groups—prevents nutritional deficits and supports long-term metabolic health.Eating too few calories, even when appetite is low, can be detrimental; mechanical eating helps maintain muscle mass and prevent stalled metabolism.Emotional barriers, guilt, and anxiety around food are common due to fat shaming and past dieting experiences. Meal planning and support from dietitians can help ease this transition.GLP-1s may alter medication absorption or trigger anxiety episodes due to blood sugar fluctuations; monitoring and professional advice are recommended when combining with psych meds.Personal Stories & Practical Advice:
Andrea shares strategies for getting enough nutrition when appetite is low, her experiences with fat shaming, and her approach to enjoying food without guilt.Mark and Dr. Cooper discuss breaking free from restrictive food mindsets and building a positive, fuel-focused relationship with eating.Key Takeaways:
Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.
Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 05 May 2025 - 36min - 82 - Starved For Answers: The Fallout of Federal Science Cuts
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the urgent issue of deep funding cuts to scientific research in the United States. Dr. Cooper shares firsthand insight on how these changes are affecting patient care and scientific integrity, highlighting the pressures researchers face—including censorship and loss of resources at institutions like the NIH.
The conversation sheds light on how misinformation, government interference, and reduced diversity in studies threaten the future of metabolic, cancer and public health research. Listeners will better understand why research matters for everyday health, and what’s at stake when critical projects lose funding.
Key Takeaways:
Sweeping research cuts at major institutions like NIH jeopardize progress in areas like metabolic health, cancer, ALS, heart disease, and Alzheimer’s.Researchers are facing censorship and pressure to alter or suppress scientific findings in nutrition, autism, and vaccine research.Reducing diversity in research undermines scientific accuracy and inclusivity, risking treatments that don’t address the needs of all populations.Slashed funding will stall new medical discoveries, limit future treatment options, and may have consequences for decades to come.Misinformation around vaccines and public health is rising as government agencies are pressured to alter or hide true scientific data.Resources:
Links:
Current Medical Reporting
Nutrition Information
Nutrition for Mortals Podcast with Dietitians: Matt and Jen
Infectious Diseases, Immunizations
Kevin Hall Research
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us atinfo@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 28 Apr 2025 - 37min - 81 - Blood Fats: The Good, the Bad & the Ugly
This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright dive into the world of blood fats—unpacking what cholesterol numbers really mean for your health. They break down HDL (the “good” cholesterol), LDL (the “bad” cholesterol), triglycerides, and spotlight the often-overlooked lipoprotein(a), a genetic risk marker with significant consequences for heart health. The team dispels myths about fats in our diet, covers the impact of lifestyle and genetics, and explores how advanced testing can reveal hidden risks. You’ll come away understanding which fats matter most, why particle size counts, and what actions can help manage your numbers and protect your heart.
Key Takeaways:
Blood fats, specifically HDL, LDL, and triglycerides, are critical indicators of cardiovascular risk. Advanced testing can identify dangerous subtypes and genetic markers like lipoprotein(a) that standard panels miss.HDL has benefits, but high numbers don’t cancel out high LDL; LDL particle size and count are crucial—small, dense particles are more harmful.Lipoprotein(a) is a major genetic risk factor for heart disease and stroke that isn’t modifiable by diet or exercise; new treatments are in development.Plant-based monounsaturated fats (like olive oil and avocados), resistant starches, and soluble fiber offer metabolic and heart-health benefits, but even perfect diets may not lower genetic cholesterol risks.Lifestyle factors—exercise, avoiding smoking, quality sleep, and managing conditions like diabetes—are critical for reducing cardiovascular risk, especially if you have inherited risk markers.Heart health isn’t just about body size—“looking healthy” doesn’t guarantee healthy arteries; everyone should know their numbers and consider advanced heart scans as needed.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 21 Apr 2025 - 37min - 80 - Diabetes Wake-Up Call: The Silent Epidemic
Diabetes Wake-Up Call: The Silent Epidemic
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take on a troubling statistic—half of American adults are either diabetic or prediabetic, and for those with prediabetes, 8 in 10 don’t know it. Think about your own family. The odds are one in two of your loved ones are at risk.
The good news is diagnosing diabetes is easy, and in many cases it’s reversible. Dr. Cooper breaks down the tests you should get, the numbers to look for and the top treatments. Taking control of your diabetes risk just could save your life.
Key Takeaways:
Diabetes affects nearly half of the U.S. population, with approximately 80% of prediabetes cases undiagnosed.Type 1 diabetes requires lifelong insulin therapy, while type 2 is often linked to genetic predisposition and lifestyle, with potential for reversal.Regular screening for glucose (blood sugar) and HbA1c levels (your long-term blood sugar average) is crucial for early detection of prediabetes and diabetes, applicable to both adults and children from age 10.Managing diabetes involves a comprehensive approach, including diet, exercise, lifestyle modifications, and medications like metformin and GLP1’s.Medications are not a failure but a crucial tool in preventing severe complications and maintaining a high quality of life.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Mon, 14 Apr 2025 - 38min - 79 - Understanding Metabolic Health: Top Ten Strategies (Part 2)
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright continue exploring the top ten positive things you can do for your metabolism, focusing on steps five through one. With an honest and approachable discussion, this episode sheds light on essential topics like endocrine disruptors, nutrition, sleep, body image, and why the focus should be on health, not weight. Get practical advice for positive changes you can implement in your daily life.
Key Takeaways:
Endocrine Disruptors – Learn about EDCs and MDCs, their widespread presence, and steps to minimize exposure for better metabolic health.
Nutrition for Health, Not Weight Loss – Shift your focus to fueling your body and maintaining a positive relationship with food, emphasizing nutrition over diet restrictions.
Sleep and Sleep Apnea – Understand the critical role of sleep in metabolism, and consider sleep apnea testing to improve metabolic function and overall well-being.
Body Image – Address the influence of societal pressures and focus on positive self-image to support metabolic health, being mindful of language around children.
Focus on Health, Not Weight – Highlight the importance of prioritizing health metrics over weight, and recognize the limitations of using BMI as a sole indicator of health.
Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 07 Apr 2025 - 37min - 78 - Understanding Metabolic Health: Top Ten Strategies (Part 1)
n this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright break down their top ten lifestyle strategies to enhance your metabolic health. They critically discuss powerful yet straightforward approaches that can significantly improve metabolism. The focus is on easy-to-implement, applicable tips, from knowing key health numbers to managing stress effectively.
Key Takeaways:
Know Your Numbers: Understanding baseline health metrics like blood pressure, glucose, and cholesterol is crucial for assessing risk and taking proactive steps toward better health. Dr. Cooper breaks down the key metrics you should ask your doctor about.Physical Activity: Integrate enjoyable and consistent physical activities into your daily routine to strengthen bones, muscles, and cardiovascular health.Stress Management: Be aware of the impact stress can have on metabolism and explore ways to address stress in life, including therapy, meditation, and lifestyle changes.Gut Health: Maintain a varied diet rich in probiotics and prebiotic foods to support a healthy microbiome and overall well-being.Substances: Avoid substance overuse including alcohol and nicotine, which can negatively impact metabolic health.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 31 Mar 2025 - 48min - 77 - The People Side of Metabolic Medicine
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the human connections in metabolic medicine. With special guest Alisha, a nurse practitioner at the Cooper Center for Metabolism, the episode delves into how patient-provider relationships have a profound impact on metabolic health outcomes.
If you're interested in how the world of metabolic medicine is evolving and want a human-centered perspective, this episode is a must-listen. You’ll walk away with a better understanding of how interconnected our body’s health systems are and why personalized care matters.
Key Takeaways:
Alisha’s Journey: Discover how Alisha transitioned from the ICU to preventive care in metabolic medicine, driven by her desire to prevent end-stage diseases she witnessed firsthand.Breaking Myths: The episode sheds light on why counting calories isn't the answer and how metabolic dysfunction is not just a collection of isolated symptoms but a comprehensive system affecting overall health.Preventive Mindset: Learn from Dr. Cooper and Alisha as they discuss the importance of early intervention, preventive care, and how understanding your body’s metabolic signals today can avert future health issues.Finding the Right Help: Looking for an expert in obesity medicine? Click the following link to find a board-certified specialist in your area: https://abom.learningbuilder.com/public/membersearchResources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 24 Mar 2025 - 35min - 76 - Listener Spotlight
On this episode of Fat Science, it’s time to hear from some of you, our listeners. Dr. Emily Cooper, Andrea Taylor and Mark Wright are joined by two loyal listeners, Scott and Heidi. The episode explores personal anecdotes and transformative moments thanks to a deeper understanding of metabolic health and its broader implications. It also shows you don’t have to have Metabolic Syndrome to benefit from understanding the science connected to it.
Key Takeaways:
Weight control and diets have long been struggles, but a scientific understanding of metabolism can demystify these challenges.Addressing familial and individual metabolic issues requires comprehensive evaluation beyond lifestyle adjustments.Sleep quality profoundly affects metabolic rates, highlighting the interplay between hormones like ghrelin and leptin.Personal Stories & Practical Advice:
Scott finds resonance with the podcast through its unpacking of metabolism beyond diet culture, while Heidi recognizes the alleviation of stress and restriction, changing family health dynamics.Dr. Cooper pushes for awareness of underlying medical issues over lifestyle blame, advocating for thorough evaluations.Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, send an email to emily@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 17 Mar 2025 - 37min - 75 - Compounded Drugs Part 2
On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright delve deeper into the topic of compounded metabolic drugs.
Dr. Cooper addresses criticisms from listeners about the previous discussion and provides insights into the economic reasons driving people towards compounded drugs. She also dissects the ethics and economics of the diet industry transforming into a subscription medicine model and the role of insurance in accessibility to metabolic treatments.
Key Takeaways:
Compounded drugs often act as a misleading alternative to brand medications, lacking FDA approval and potentially jeopardizing health outcomes.Employers significantly influence weight-related treatment coverage, and advocacy for coverage changes can be a crucial step towards accessible medications.Insurance restrictions and economic barriers force many to explore compounded drugs despite potential risks.The rise of online subscription models parallels the diet industry’s modus operandi of exploiting vulnerable demographics for profit.Greater transparency and regulation within the pharmaceutical and insurance sectors are needed to ensure safe and equitable access to treatments.Personal Stories & Practical Advice:
Andrea reflects on her decision to prioritize health despite the significant cost by sourcing medications through Canada rather than risking compounded drugs.Discussions emphasize the importance of a comprehensive and guided medical approach, advocating for patient education and active engagement with healthcare providers.Important Update: Changes in GLP-1 Medication Availability and Compounding Regulations
This episode was recorded before recent regulatory developments regarding GLP-1 medications. As of our current information:
The FDA has determined that shortages have been resolved for all formulations of tirzepatide (marketed as Mounjaro and Zepbound) and semaglutide (marketed as Rybelsus, Ozempic, and Wegovy). Consequently, compounding these medications is no longer legally permitted under FDA regulations.
Additionally, Novo Nordisk has expanded its patient assistance program by implementing enhanced coupon discounts across all Wegovy dosage strengths to improve affordability and access to match Lilly's efforts for Mounjaro and Zepbound access.
Please note that regulatory policies and manufacturer programs regarding these medications continue to evolve. For the most up-to-date information, we recommend consulting current FDA announcements and manufacturer websites.
Resources:
Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 10 Mar 2025 - 33min - 74 - More Mailbag
On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright open the mailbag and answer questions from listeners all over the world.
Dr. Cooper provides expert insights into complex questions about metabolic health, covering topics including metabolic dysfunction, the effects of chemotherapy on metabolism, a discussion of GLP-1s and those trying to get pregnant and the role of iodine in the diet.
Engaging and informative, this episode also arms you with the vocabulary and understanding needed to discuss metabolism with your healthcare provider.
Key Takeaways:
Metabolic medications like GLP-1s are not just for weight loss; they target the metabolic system, improving fertility and metabolic health. The jury is still out as to whether taking GLP-1s are safe for those trying to become pregnant, but management is possible knowing the half-life of the various GLP-1 drugs. Chemotherapy can impact metabolism; a comprehensive metabolic assessment post-treatment is essential for recovery. Iodine is crucial for thyroid function, and deficiencies may arise from using non-iodized salts; checking iodine levels can guide supplementation. Managing mindset and mechanical eating is essential when using metabolic medications to avoid calorie-counting traps.Personal Stories & Practical Advice:
Andrea shares her journey of freeing herself from calorie counting and embracing a healthier mindset. Listeners' questions reflect global engagement and common challenges faced in managing metabolic health.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 03 Mar 2025 - 42min - 73 - The Metabolic Links to PCOS
On this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the intricate metabolic ties to Polycystic Ovarian Syndrome (PCOS). Dr. Cooper provides expert insight into how understanding these links can transform what seems like a permanent condition into a reversible one.
“ I feel like there's so much despair around PCOS when it actually doesn't have to be a long-term condition,” says Dr. Cooper. “I know some of that desperation comes from the infertility piece of it… so it's really important to calm down the (metabolic) dysfunction to be successful in fertility.”
Key Takeaways:
PCOS is often misunderstood as solely an ovarian issue, but it is deeply rooted in neuroendocrine and metabolic imbalances. Diagnosing PCOS involves analyzing menstrual irregularities, androgen levels, and related physical symptoms like hirsutism and acne. Traditional treatments include metformin and spironolactone, but focusing on overall metabolic health can lead to reversal of PCOS symptoms. The importance of comprehensive metabolic health, including regular fueling, sleep quality, and potentially targeting specific metabolic pathways, is emphasized. Misguided advice to lose weight often exacerbates PCOS; instead, enhancing metabolic signals offers a sustainable solution.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 24 Feb 2025 - 36min - 72 - Letting Go of Calories-In, Calories-Out
On this episode of Fat Science, it’s time to let go of the old paradigm “calories in, calories out.” Join hosts Dr. Emily Cooper, Andrea Taylor and Mark Wright as they kick CICO to the curb.
The idea that a person’s weight is determined only by the ratio of calories consumed and calories burned is an over-simplification and often not true, especially for people with metabolic dysfunction.
Dr. Cooper reveals the real key to weight management is not calorie counting but understanding metabolic function influenced by the neuroendocrine system. Through personal stories and insights, they explore why diets don’t work and how acknowledging the complexity of metabolism can lead to better health.
Key Takeaways:
Caloric intake does not have a static burn rate; it's controlled by dynamic neuroendocrine signals. Metabolic adaptations occur with calorie restriction, reducing metabolic rate, making weight loss unsustainable over the long term. The science holds answers to metabolic dysfunction, revealed by metabolic testing and hormone imbalance recognition. Education and communication can challenge and change the stigma and bias around weight, leading to a more informed society.Personal Stories & Practical Advice:
Andrea shares her journey about ignoring diets and focusing on metabolic health for long-term benefits. Dr. Cooper recounts her challenges in communicating her findings in a positive way, leading to greater acceptance and understanding among patients, healthcare providers and the general public.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 17 Feb 2025 - 37min - 71 - Straight Talk on Compounded Drugs
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore the world of compounded drugs. These are medications prepared by pharmacists to meet specific needs of patients when commercially-available products are not an option. Changes in dose, accommodating patients with allergies or sensitivities and drug shortages are some of the reasons the FDA allows compounded drugs to be made and sold.
Key Takeaways:
Compounded drugs are manufactured by pharmacies to offer alternatives to brand medications but lack FDA approval for safety and efficacy. Loopholes in drug shortage laws have allowed a surge in compounded GLP1s, though these shortages are now being resolved. Concerns arise over the quality, dosing, and potential immune reactions that compounded drugs might provoke, especially when not FDA-tested. Choosing FDA-approved drugs ensures strict regulation, accountability and proper testing to safeguard health. Consumers face aggressive marketing tactics aiming to sell compounded drugs at lower prices without guarantees of safety or effectiveness.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 10 Feb 2025 - 36min - 70 - Cravings: Culprit or Symptom.
n this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore cravings and the role they play in metabolic dysfunction.
If you watch some drug company commercials these days, you’d think cravings are the culprit for obesity. In reality, they are just a symptom of a deeper metabolic problem.
This episode of Fat Science uncovers why this oversimplification is not just misleading but harmful to those struggling with metabolic dysfunction.
Join us as we explore the science behind cravings, debunk common myths and highlight the importance of understanding your metabolic health.
Key Takeaways:
Not Just an Overeating Problem: Learn why targeting cravings alone is not the answer to managing weight and metabolic health.
Metabolic Dysfunction Explained: Discover how metabolic dysfunction manifests in various forms, such as irregular appetite signals, and why addressing the root cause is crucial for effective treatment.
The Role of Medications: Dr. Cooper breaks down commonly-prescribed medications like Contrave, Qsymia, and Saxenda—explaining their true function in strengthening metabolic pathways rather than merely suppressing cravings.
Misleading Advertising: Understand the detrimental effects of current advertising campaigns that focus on willpower and cravings and how they perpetuate weight stigma and misinformation.
Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 03 Feb 2025 - 39min - 69 - Who Are We Calling Fat?
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore one of the most contentious topics in the world of health and fitness: the definition and measurement of fat.
BMI (Body Mass Index) has long been the standard, but recent studies have called its efficacy into question.
Dr. Cooper reveals why BMI can be a flawed indicator of health, exploring alternate measurements like waist circumference and body composition while discussing their limitations and potential misuses.
This episode highlights the real issue: identifying and treating metabolic dysfunction and achieving true health beyond just numbers on a scale or tape measure.
Key Takeaways:
BMI: A Flawed Metric? Dr. Cooper reveals the limitations of BMI. She shares intriguing insights into how factors like muscle mass and gender-specific body composition can skew BMI readings and recounts fascinating stories from her career, including a case where an Olympic athlete was classified as obese purely based on BMI.
The Lancet's Insight. The team discusses a recent paper by the esteemed Lancet Commission, which argues for de-emphasizing BMI in favor of other health indicators. They dive into the importance of looking at the complete clinical picture, including blood sugar swings, energy levels, and more.
Anecdotes and Real-life Experiences. Andrea Taylor shares her journey of struggling with various diets until discovering metabolic dysfunction as the root problem.
Insurance and Medical Ethics. Discover the ethical dilemmas of using BMI for decisions on insurance coverage and medical treatments. Mark brings attention to startling cases where statistically healthy individuals were denied life insurance based on high BMI.
Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 27 Jan 2025 - 40min - 68 - Get Healthy in 2025 With These 5 Resolutions
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright explore five New Year’s resolutions you can make (and not break) for a healthier 2025.
The conversation shifts away from unattainable goals and toward practical steps for enhancing overall well-being in the new year.
Key Takeaways:
- Address Metabolic Syndrome
If you suspect you have metabolic syndrome, 2025 is the year to take action. Dr. Cooper explains how to identify and address it with testing and medical guidance. Health Over Beach Body
Shift the focus from attaining a "beach body" to improving your overall health. Andrea discusses the importance of self-acceptance and the harm of societal pressures. Don't Diet
Commit to not dieting. Dr. Cooper emphasizes the metabolic dangers of calorie restriction and the benefits of balanced nutrition. Get Enough Sleep
Quality sleep is crucial for metabolic health. Learn why 7-9 hours of sleep and timing your sleep cycles matter. Be Kind to Yourself
Embrace self-love and physiologic intuition. Andrea shares how this has transformed her relationship with food and body image.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 20 Jan 2025 - 37min - 67 - Mailbag: Questions From You!
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright field questions from listeners. Throughout the show, our hosts highlight the importance of compassionate, science-based medical care and underscore the significance of finding healthcare providers who address metabolic issues as medical, not lifestyle, concerns.
Among the topics addressed:
Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 13 Jan 2025 - 34min - 66 - Metabolic Meds: What’s Now & What’s Next!
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright take a comprehensive look at the current FDA-approved medications designed to treat metabolic dysfunction and what may be approved next.
Dr. Cooper discusses the range of factors that determine whether these essential drugs are available for those who need them. Government approval, drug company strategies and insurance company policies all play a role.
Key Takeaways:
Pharmaceutical Approval Process: Pharmaceutical companies typically seek FDA approval for one drug indication at a time due to the high costs and extensive trial requirements. Approval for obesity drugs is more stringent than for diabetes, involving costly and rigorous trials. Rebranding Drugs for Accessibility: Drugs like Liraglutide (originally Victoza for diabetes) are rebranded as Saxenda for obesity to bypass insurance coverage issues. However, rebranding can create coverage gaps for weight-loss purposes, leaving some patients without access. Insurance Coverage Challenges: Insurance companies often limit coverage for these medications unless a patient has a diagnosed condition like type 2 diabetes. Preventative benefits of metabolic medications are frequently overlooked by insurers, limiting broader access. Risks with Compounded Medications: Compounding pharmacies are creating untested versions of GLP-1 drugs to address affordability and shortages, raising safety concerns. Future Developments in Metabolic Meds: New potential drugs, such as a dual hormone agonist and high-dose semaglutide as a daily pill, show promise in improving metabolic health and accessibility.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 06 Jan 2025 - 37min - 65 - Metabolic Markers: The Power of Your Blood Lab Results
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright reveal how metabolic lab tests are crucial in diagnosing, understanding and treating metabolic dysfunction.
Key Takeaways:
Metabolic Functions:
Understanding blood markers like glucose, insulin, and cholesterol offers in-depth knowledge about overall health. Metabolic Syndrome:
Defined by issues like pre-diabetes, high blood pressure, and cholesterol problems, increasing the risk of severe health events. Lab Testing:
Routine testing every 3-4 months for monitoring and adjusting treatments. Dr. Cooper also reveals which labs are key to diagnosing metabolic dysfunction. Comprehensive Assessment:
Insights into advanced tests for detailed metabolic evaluation. Genetic Awareness:
Highlighting the role of genetics in health risks and the importance of preventive measures.Personal Stories & Practical Advice:
Andrea shares her journey and health improvements through dedicated metabolic management. Mark discusses the transformative impact of metabolic treatment, how it sometimes takes years to improve metabolic markers and the importance of consistency when taking metabolic meds.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 30 Dec 2024 - 36min - 64 - Surviving the Holidays
In this episode of Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the challenges of maintaining metabolic health during the holiday season. Dr. Cooper emphasizes the importance of keeping a regular routine to manage stress and avoid metabolic disruptions. The team shares practical advice for navigating family gatherings and enjoying the holidays without compromising your health.
Key Takeaways:
Society's excessive focus on weight and appearance can be harmful; value shouldn't be based on physical changes. GLP1 medications need to be introduced gradually; skipping meals while on them can disrupt metabolism. Avoid contentious family discussions about weight, diet, and metabolism to prevent stress. Tryptophan in turkey is not the cause of post-meal drowsiness; overeating likely is. Stick to regular sleep and eating patterns to manage stress and maintain metabolic health. Extreme exercise during holidays can raise cortisol levels; maintaining a consistent routine is better. Family traditions and memories are important; a balanced approach to holiday eating can improve your overall experience.Personal Stories & Practical Advice:
Andrea discusses her family's tradition of holiday baking and her evolving relationship with food. Mark shares memories of Scandinavian holiday foods and the comfort he finds in holiday eating traditions. Dr. Cooper advises on balancing food intake and avoiding overemphasis on weight loss during holidays.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
Mon, 23 Dec 2024 - 35min - 63 - The COVID Connection to Diabetes & Metabolic Health
In this episode of Fat Science, hosts Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the compelling and urgent topic of COVID-19's impact on metabolic health.
COVID-19 has introduced a serious new layer of complexity because it can exacerbate existing conditions like diabetes, obesity, cardiovascular and thyroid disease.
The latest data reveal a shocking statistic—the risk of developing diabetes can increase by up to 40 percent after a COVID infection.
So what should we know about these risks, and how can scientific insight help us navigate this new terrain?
Key Discussion Points:
Early Data and Predictions: Insights from Dr. Cooper's clinic, supported by the Diabesity Institute, which identified early links between COVID-19 and metabolic disease risk. Real-World Impacts: The clinic’s database comprising around 2,500 patients with more than 10 years of data, which showcases the regression of metabolic health progress post-pandemic. Public Health: The importance of vaccinations, continuous COVID monitoring, and preventive practices to mitigate these risks. Metabolic Meds: The role of medications like Metformin and Ozempic in managing complications from pre-diabetes and diabetes, particularly during COVID.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope.
Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Mon, 16 Dec 2024 - 31min - 62 - Understanding Disordered Eating (You’re Probably Doing It) & Eating Disorders
In this episode of Fat Science, hosts Dr. Emily Cooper, Andrea Taylor and Mark Wright explore eating disorders, disordered eating and their profound impact on metabolic health.
Eating disorders and disordered eating are much more common than people realize, affect a significant portion of the population and contribute to serious metabolic issues. So what are eating disorders and disordered eating? How do they differ, and what are the health implications?
Listeners will gain a deep understanding of the spectrum of eating behaviors, from normal eating to clinically dangerous eating disorders.
Disordered Eating:Behaviors such as repeated dieting, calorie restriction, carb restriction, intermittent fasting, and keto diets, often accompanied by an excessive focus on body image, body shape and body size. This is prevalent in the majority of the population.
Eating Disorders: Clinically dangerous conditions like anorexia nervosa, bulimia nervosa, and ARFID, which are life-threatening and require aggressive medical intervention.
Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope.
Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org.
Mon, 09 Dec 2024 - 33min - 61 - The Hidden Epidemic: Understanding and Reversing Insulin Resistance
In this episode of Fat Science, hosts Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the topic of insulin resistance and its impact on metabolic health.
It’s estimated one in three Americans has the condition, which often leads to prediabetes and even full-blown diabetes.
So what is insulin resistance? How can we tell if we have it? And what can we do to reverse it?
Listeners will gain a comprehensive understanding of how lifestyle, nutrition and medication can influence metabolic function and insulin sensitivity.
Key Takeaways:
Insulin’s Role:
Insulin is an anabolic hormone essential for transporting energy throughout the body and for muscle mass retention, with high levels leading to increased muscle and body fat. Insulin Resistance:
Often a precursor to metabolic syndrome, it can lead to prediabetes, diabetes, and hypertension by altering liver fat production and impacting heart health. Environmental Factors:
Awareness of endocrine disruptors and their influence on metabolic health. Treatment:
Exploring medications like Metformin and emerging treatments such as GLP1 GIP dual agonists for reducing insulin resistance. Hormonal Influence:
Highlighting the roles of adiponectin and leptin in metabolic health and their improvement through lifestyle changes and medications.Resources:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope.
Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 02 Dec 2024 - 30min - 60 - The Connection Between Mood & Metabolism
In this episode of Fat Science, hosts Mark Wright, Andrea Taylor, and Dr. Emily Cooper delve into the intricate relationship between mood and metabolism. They explore how our body chemistry influences our emotional states and the significant impact that factors like sleep and blood sugar levels have on mood regulation.
Key topics discussed include:
Mood and Metabolism:Dr. Cooper explains how fluctuations in blood sugar can lead to emotional disturbances, including feelings of anxiety and low motivation. The hosts share personal anecdotes about how hunger and lack of sleep can affect their moods. The Role of Sleep:The conversation highlights the importance of sleep for overall health, emphasizing its critical role in metabolic function and mood stability. Dr. Cooper notes that poor sleep can exacerbate metabolic issues, leading to a cycle of mood disorders. Impact of Mood Disorder Medications:The episode addresses various medications used to treat mood disorders, discussing their effects on metabolism. Listeners learn about the potential side effects, including weight gain and insulin resistance, associated with common antidepressants and ADHD medications. Understanding Appetite Suppressants: The hosts discuss misconceptions around appetite suppressants and stimulants, revealing that while they may reduce hunger, they do not necessarily boost metabolic rates. This segment cautions against relying on such medications for weight management.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Mark Wright on LinkedIn. Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 25 Nov 2024 - 36min - 59 - Fake News About Fat
On this episode of Fat Science, your body might be lying to your brain about your fat! Dr. Emily Cooper, Andrea Taylor, and Mark Wright take a deep dive on the metabolic signaling mechanisms that influence weight management and appetite. Delve into the complexities of the metabolic loop and why conventional advice often falls short. Andrea shares her personal transformation and newfound understanding of food and body image.
Key Takeaways:
Nutritional Security Signals:
Positive signals can decrease famine signals, promoting weight stability and a balanced appetite. Metabolic Pathway:
Healthy metabolic signaling is essential for optimal regulation of satiety, energy, and insulin levels. Feedback Loops:
Maintaining a strong feedback loop is critical; glitches caused by genetics, deprivation diets, and under fueled exercise can make recovery challenging without medication. Misleading Dietary Advice:
Common popular recommendations often worsen metabolic conditions instead of fixing them. Insulin Resistance:
Addressing the root cause of high insulin levels is crucial for effective treatment. Emotional and Genetic Factors:
Food phobia, body image dissatisfaction and genetic predispositions impact metabolic health significantly.Personal Stories & Practical Advice:
Andrea recounts her journey to viewing food positively, vastly improving her well-being. Dr. Cooper emphasizes understanding beyond surface-level metrics like clothing sizes.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 18 Nov 2024 - 33min - 58 - The Pitfalls of Digestive Aids on Your Metabolism
This week on Fat Science, we explore how popular digestive aids can interfere with your metabolism. Dr. Emily Cooper is back with co-hosts Andrea Taylor and Mark Wright. Dr. Cooper demystifies the roles of digestive enzymes and probiotics, offering a science-based approach to managing gut health. This episode sheds light on how diet impacts the microbiome plus the benefits and potential drawbacks of supplementation.
Key Takeaways:
Digestive enzymes help break down food, which may aid digestion, but they can backfire. Probiotics potentially improve gut microbiome health, but not all pro probiotics are alike. A varied diet rich in whole and fermented foods can naturally support gut health, often reducing the need for supplements. Caution against unnecessary food group elimination, particularly gluten, unless medically advised. Medical evaluation is crucial for identifying the root causes of gastrointestinal issues before resorting to supplements or restrictive diets. Long-term use of medications like PPIs for acid reflux has potential side effects, including disruption of the microbiome. Probiotics might help mitigate PPI-induced microbiome issues, but choosing the right one is key.Personal Stories & Practical Advice:
Andrea discusses her journey with acid reflux and surgical intervention, which resolved her need for medication. Mark shares his long-term experience with acid reducers, highlighting the importance of regular health checks and exploring alternative solutions.
Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope.
Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 11 Nov 2024 - 32min - 57 - Can the Wrong Kind of Exercise Make You Fat?
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they explore how exercise can harm your metabolism and can even lead to weight gain. Dr. Cooper explains how pushing too hard can disrupt hormones like cortisol and leptin, leading to slowed metabolism and long recovery times. The importance of a balanced approach to exercise, nutrition and rest is emphasized, along with the potential pitfalls of overtraining and exercising without proper fueling.
Key Takeaways:
Overtraining can disrupt multiple hormones and slow metabolism. Proper fueling is crucial for effective exercise and recovery. Balance in exercise, rest, and nutrition is essential for long-term health. More exercise isn't always better; "training smarter, not harder" is key.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 04 Nov 2024 - 33min - 56 - What Your Blood Knows About Your Metabolism.
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they delve into the importance of understanding blood tests for metabolic health. Dr. Cooper provides valuable insights into how these tests can reveal essential details about your metabolism. The episode also highlights the significance of blood markers like A1C, insulin, and hormone levels in maintaining metabolic health.
Key Takeaways:
Blood tests offer a detailed view into overall health and metabolism, focusing on blood sugar levels, hormones, and cholesterol among other markers. A1C or HbA1C measures average blood sugar over three months, identifying normal range, pre-diabetes, or diabetes. However, it's essential to recognize potential inaccuracies and the necessity of additional markers. Regular testing and using multiple markers are crucial due to the possibility of variations in single tests. The importance of understanding the relationship between glucose and insulin levels is emphasized. Hormone levels like testosterone, estrogen, cortisol, and insulin play a key role in metabolic health and are interconnected with metabolic functions and well-being. Early detection through advanced blood tests, such as fasting insulin and LDL particle analysis, is vital for managing metabolic dysfunction effectively.Personal Stories & Practical Advice:
Andrea shares her positive outcomes from discussing expanded test panels with her doctors, resulting in a better understanding of her health. Mark discusses his experience with testosterone therapy and the resulting improvements in energy and mood.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 28 Oct 2024 - 39min - 55 - What is the Best GLP-1 Drug for Me?
Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they explore the best GLP-1 drugs for treating Metabolic Syndrome and weight management. Dr. Cooper sheds light on the differences between popular options like Victoza, Ozempic, and Mounjaro. Andrea shares her personal journey with these medications, emphasizing their life-changing potential. Mark underscores the importance of consulting knowledgeable doctors and staying informed through science-based education.
Key Takeaways:
GLP-1 drugs mimic naturally occurring hormones to regulate appetite and metabolism. Victoza and Ozempic are similar in function, while Manjaro targets both GLP-1 and GIP hormones. Medication choice is highly individual and should be tailored to personal health needs and circumstances. Consistent eating patterns and regular check-ups are essential to maintaining balance and a healthy metabolism. Personal stories from Andrea highlight the profound impact these drugs can have on well-being.Resources from the episode:
Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
If you have a show idea, feedback, or just want to connect, email info@diabesityinstitute.org.
Mon, 21 Oct 2024 - 37min
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