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In the Decade of Biotech when there will be myriad opportunities to invest in angel-scale biotech startups. After decades of angel investing, I am focusing on the life science side of my portfolio and invite other angels to do the same. Here's why: https://www.labcoatventures.com/why-we-are-focused-on-early-stage-biotech/ I'm Sal Daher, host of the Angel Invest Boston Podcast. After immigrating to Boston as a child and attending Belmont High School, I studied engineering at MIT and Stanford. Decades of work in international finance followed. During that time, I invested in a handful of ventures founded by friends and acquaintances. Now, I'm a member of Walnut Ventures and MIT Angels and spend most of my time as an angel investor. Startups in my portfolio include: SQZ Biotech, Gelesis, Akili Interactive, Vedanta Biosciences, FineTune Learning, Concrete Sensors, Squadle, doDoc, Pixability, Mavrck, Viral Gains, Streamroot, XMOS, Alice's Table and others. Exits include: Exos (Microsoft), Rifiniti (KKR) and PIKA Energy (Generac).
- 497 - Frank Ferguson - Tech Executive, Startup Founder & Angel Investor in "Practical Dreamer" Ep. 7
How does one go from cleaning chicken droppings in Iowa to being a videographer in Iran to heading one of America's iconic technology companies? That question only addresses half of Frank Ferguson's adventurous career; he would eventually co-found and build a remarkably successful business in one of the toughest markets, educational publishing. I spent a bit over an hour in conversation with this idealistic yet intensely practical doer; I could have used another two hours!
In Episode 7 of the Angel Invest Boston Podcast we explored the ideas and traits that made Frank Ferguson a success on so many fronts.
My favorite observation from the conversation with Frank Fergusson neatly encapsulates his homespun recipe for success as an investor:
"You can get sucked in and fall in love with a lot of things, but then you have to ask, "Are these the guys who can actually make it happen?" What are the odds that these guys can keep together, not fight, get over it, be successful, run things correctly, not fall in love with their own things so much that they lose track of the financial realities of the business? Can they sell?"
Below is a listing of some of the topics covered.
Yes, That Bose Corporation! Curriculum Associates, Which Frank Ferguson Built, Continues to Be Hugely Successful Scraping Chicken Droppings in an Iowa Farm From Iowa State University to Teheran Courtesy of Syracuse University & the US State Department Frank Ferguson Thinks about Business School at MIT or Harvard Thanks to a Friendly Psychologist With an MIT Sloan MBA in Hand, Frank Ferguson Goes to Work at Baird Atomic Near Harvard Square Frank Ferguson Meets his Co-founders at Curriculum Associates Just as He Starts Work at the Bose Corporation Frank Ferguson Invests $80,000 in Today's Dollars in Curriculum Associates Circa 1959 - Money Saved through Frugal Living in Iran How Frank Ferguson Connected with Amar Bose, Founder of the Bose Corporation Frank Ferguson Invests in the Bose Corporation Amar Bose Invites Frank Ferguson to Be President of the Bose Corporation in 1969 Frank Ferguson Moonlighted at Curriculum Associates while Running the Bose Corporation Frank Ferguson Left the Bose Corporation When it Was Experiencing Growth of 70% per Year to Get Curriculum Associates off the Ground Amar Bose, Brilliant but Difficult at Times Frank Ferguson Succeeds in Educational Publishing, a Notoriously Tough Business, by Finding a Niche – Differentiated Instruction Curriculum Associates Succeeds but Discord Arises Over the Purchase of a Water Cooler! Competition Gets Rough in the World of Educational Publishing Curriculum Associates' i-Ready Succeeds by Measuring Progress of Individual Student to Help Teachers Better Support Students – Teacher Training a Pivotal Element of i-Ready's Success Before Teacher Training Was Required i-Ready Saw No Gains – With Teacher Training Student Gains Are Dramatic! Ugly Truth – Fifth-grade Teacher Has Three to Five Year Grade Span in Her Classroom Lev Vygotsky, Seneca The Younger & Andrew Bell of Madras College – "By Teaching We Learn" "Talk to Me Baby – How You Can Support Young Children's Language Development" by Betty Bardige Visionary Entrepreneurs Need to Hire Grunts Who Are Really Good at Execution – Frank Ferguson Was the Grunt & Amar Bose Was the Visionary How Amar Bose Hired the Smartest of the Smartest for the Bose Corporation Family with 11 Children Uses the Madras Method Whereby the Elder Learn by Teaching the Younger Sign Up at AngelInvestBoston.com to Hear About Upcoming Free, In-person Events – do Review Us on iTunes Frank Ferguson, Practical & Involved Philanthropist – Lionheart Foundation – Robin Casarjian Frank Ferguson Does Nothing in Half Measures – Elon Musk Would Approve Frank Ferguson - Angel Investor in the Bose Corporation and Curriculum Associates – Participated in the Baird Atomic IPO Hugh Stoddard, Father & Son, Piali De & Senscio Systems Senscio Systems Website Amos Tversky & Daniel Kahneman, "Thinking Fast & Slow", "Nudge" by Cass Sunstein and Richard Thaler Frank Ferguson Connects with Will Graylin, Invests in Loop Pay Now Samsung Pay Will Graylin and ONvocal Frank Ferguson's Approach to Angel Investing – Invests Where He Finds the People and Technologies Compelling – Few Enough Companies So He Can Make a Real Difference People Come up with Great Ideas, Great Markets but Sometimes Forget that there Is Friction in the World Lessons from Iran for Angel InvestorsVisit Angel Invest Boston Sign Up Form and sign up to be informed of upcoming free, in-person events. A text transcript of this interview is available in the Frank Ferguson page on the Angel Invest Boston Home Page.
Wed, 08 Feb 2017 - 1h 08min - 496 - Patrick Rivelli - Startup Founder, Angel Investor - "Love & Biotech Exits" Ep.6
Family considerations drove several of Patrick Rivelli's career choices but did not prevent him from having brilliant triumphs. Success as a consultant was followed by success as an executive. This led him to found his first company and to fund another startup. The most eloquent evidence of his achievements was exiting two biotech startups in eleven years. If you are a seasoned biotech investor, I'm sure that grabbed your attention. Patrick was also instrumental in founding MIT Angels of the Bay Area and now leads the life science track at MIT Angels in Boston.
I learned a lot from this fun chat with Patrick. I hope it will be entertaining and instructive for you as well.
Note: When Sal talked about biotech booming circa 1996 he actually meant to say the internet. Biotech was still a backwater then.
Topics discussed include:
Patrick Rivelli's Bio Love Drives the Choice of Patrick's First Job Family & Luck Steer One's Career Consulting at Bain Leads to Private Equity Bain Paid for Sloan MBA Work at Bain Was Different After Patrick Graduated from Sloan Patrick Gets Involved in the Life Sciences – Pharma Companies Had Medical Device Businesses Then Biology Was a Backwater in the 1990s – Then Human Genome Was Sequenced by 2003 Consulting Was Taking a Toll on Patrick's Family Life So He Took a Corporate Position Patrick Goes to Work at a Medical Device Company in 1996 – First Internet Wave Just Starting Then Netscape IPO & "The Nudist on the Late Shift" Target Therapeutics Is Sold – Mass Firings Ensue Patrick Has a Tough Period in His Career – Growth & More Self-knowledge Patrick Gets Involved with a Startup for the First Time Patrick Founds Smart Therapeutics "…Nobody Wanted Medical Devices. Everybody Wanted Pets.com and Whatever.com" "You Went from Nerd to Cool Dude" Markets Always Overshoot Boston vs. Bay Area How Boston Has Changed Since the 1960s Patrick Gets Into Angel Investing Chestnut Medical Technologies Is Acquired in 2007 Patrick Gets MIT Angels Moving in the Bay Area Boston Angel Ecosystem Is Highly Collaborative Despite Some Friction Pivots Investing in Biotech vs. Non-biotech Companies – Patrick's Crucial Calculation – Very InstructiveWed, 01 Feb 2017 - 1h 11min - 495 - Fred Bamber "The Perfect Startup Portfolio" Ep. 5 Experienced Venture Capitalist and Wise Angel Investor
As a venture capitalist Fred Bamber helped build such successful companies as Interleaf, Q1 Labs and Volt Server. Now working as an angel investor Fred is invested in such exciting companies as SQZ Biotech, Pixability, Streamroot and ViralGains. In his self-effacing and modest way, Fred reveals deep wisdom gained from 75 investments in his venture capital career. Here are some of the topics covered:
Fred Bamber Finds His Career Path Avoiding the Military Draft Led Him to Work for His First Startup Fred Bamber & Friend Found a Venture Fund – Consulting vs. Venture Capital IPOs Then & Now Investment in Interleaf Makes His First Fund a Success! Two Ways of Connecting in the World of Venture Capital – Via Success & Via Failure Several Losing Investments in Companies Seeking to Exploit the Piezoelectric Effect Themes In Angel Investing – Investing in Brand New Fields i.e. White Spaces '…Oracle has a huge go-to-market cost, and engineering is a tiny bit of it.' Technology Causing Convergence of Consumer & Enterprise Businesses Startups with Jeff Weiss - The Perils of Being Early – Early Augmented Reality (AR) Rich Lane & Reflection Technology – Augmented Reality-like – Projecting Text into the Eye Progress of Technology Is Painful – "Thread Across The Ocean" by John Steele Gordon Michael Lewis & Drama in Business – Paul English & "A Truck Full of Money" Paul English Finds His Inner Entrepreneur after Interleaf Robert P. Smith & "Riches Among the Ruins" – Not Made for Working In Large Companies VCs Should Be Humble Fred Talks About His Investment in Volt Server Uber & Washington, D.C. Cabs Peter Thiel's Critique of Entrepreneurship – "We Were Promised Flying Cars and We Got 140 Characters" SQZ Biotech & Massachusetts Materials Technology What Fred Looks For In a Startup – Technology, Coachability, Tenacity, Openess – VC vs Angel Startups Should Report Frequently – Reports Should Tie In to Previous Reports i.e. Close the Loop Angel Investor Should Be Father Confessor without the Ave Marias Bettina Hein & Pixability – Example of Determination Combined with Openess Beth Marcus' Test For Listening Fred Bamber's Suggestion of the Perfect Number of Angel Investments in a Portfolio Why Sal Daher Is Invested In About 42 Companies The Role of a Board of Directors – Father Confessor Fred's Favorite Pivot – Q1 Labs (IBM) Fred Also Likes Streamroot's Pivots Q1 Labs Pivot Runs Counter the Received Wisdom of Startups Needing a Narrow Focus to Succeed "Crossing the Chasm" by Geoffrey A. Moore "Why Knowledge Matters" by E.D. Hirsch, Jr.Wed, 25 Jan 2017 - 1h 09min - 494 - Beth Marcus "Startupdoc Is In The House" Ep.4 Startup Founder, Inventor, Advisor and Angel Investor
Dr. Marcus has founded several startups including Exos and Zeemote. The technologies on which her companies are based tend to be widely adopted. Very few inventors can say that their invention is in the hands of ten million people. Beth has those bragging rights. She is a recognized expert in the hand-device interface and has provided strategic advice to leading firms in the space. She is also a highly sought-after advisor to startups with particular understanding of product design and fundraising for technology-based enterprises. Her thoughts can be found on Twitter @StartupDoc. Beth, is a graduate of MIT and Imperial College, London, and continues to be involved with both institutions. She is Entrepreneur In Residence at Imperial College London.
In this chatty and candid episode, Beth Marcus imparts some of the hard-earned lessons that can help an entrepreneur turn a defeat into victory. She recounts the story of the remarkable pivot she executed at Exos which led the company from a rout to a very attractive sale to Microsoft. She provides her views on IP strategy, boards of directors, venture capitalists and hiring.
Among the luminaries that play a role in the conversation are Bob Metcalfe, Ed Roberts and Pierluigi Zappacosta.
Wed, 18 Jan 2017 - 1h 02min - 493 - Ben Littauer, Founder, Angel & Advisor - "#1 Fundraising Mistake" - Ep. 3
Ben Littauer travelled an unlikely path from philosophy to communications technology. He brings to life the exciting turns in his careers as founder and angel investor. In his light-hearted style, Ben provides a thoughtful tour of Boston's angel scene in this episode that ranges over many topics including equity crowdfunding. In particular, he explains what leads founders to make the worst fund-raising mistake of all. The philosopher's clarity of thought and the engineer's practicality are in evidence.
Sign up at https://www.AngelInvestBoston.com if you want to be made aware of upcoming in-person events. Obviously, this is of particular interest if you are in Boston or environs.
You can also follow us on Facebook, LinkedIn and on Twitter @AngelInvestBOS
Topics on this podcast:
Fundraising
Equity Crowdfunding
Angel Investing in New England
Cornell University
Harvard Law School
Baranof Software
Walnut Venture Associates, Boston Harbor Angels, Launchpad, Comparison & Contrast
The Capital Network
Mass Challenge
Connection between Coding & Philosophy
COBOL
BBN, Lotus, Lotus 123, Sun Microsystems
ARPANET
MS Excel
VisiCalc, Bob Frankston
Mitch Kapor
Symantec
UNIX
Oracle
Java
MS-DOS, Notework
LAN, Local Area Network, Ethernet, Bob Metcalfe
EMA, Electronic Messaging Association
Paul Graham, Y Combinator
Michael Mark
Babson College
Christopher Mirabile, Ham Lord
Angel Treaty
Boston vs. Silicon Valley
CIC, Cambridge Innovation Center
Kickstarter, Indiegogo
JOBS Act, Reg CF
WeFunder, Mike Norman
NetCapital, Troupe Jewelery, Kitsy Lane
Wed, 11 Jan 2017 - 1h 01min - 492 - Ralph Wagner, Executive, Founder & Angel - "Flunk Calculus, Ace Life" - Ep. 2
Ralph Wagner recalls his journey of self-discovery that led from failure in engineering to incandescent success in marketing and sales. The man who could not do calculus or write code excelled at identifying and exploiting opportunities created by computer technology. In this interview one sees that Ralph's captivating personality is firmly ballasted by good sense and common decency. It is made evident how his interest in people was vital to the success of his many ventures.
If you liked this episode subscribe in iTunes or Google Play so that new episodes will automatically appear in your player. You can find us by searching for Sal Daher or Angel Invest Boston. Do take the time to review us.
Sign up at Angel Invest Boston Signup if you want to be made aware of upcoming in-person events. Obviously, this is of particular interest if you are in Boston or environs.
You can also follow us on Facebook, LinkedIn and on Twitter @AngelInvestBOS
Topics we touched on:
Success after flunking calculus
IBM
Apple Computers
Kurzweil Learning Systems, Ray Kurzweil
Microsource
KeyFile, Jim Stenzel
Bob Moll, Moll Associates
Arthur D. Little
Meditech, Ed Roberts, Neil Pappalardo
Michael Mark, Interleaf
Steve Watson, Computerland
Visicalc, impact of the first spreadsheet software available on a personal computer
Rent-a-byte
Steve Gaal, TA Associates
Tony Helies
Walnut Venture Associates, Jim Massarelli, Data General
Julian Lange, Visicalc, Software Arts, Babson College
Microsoft Excel, Lotus 123
Eyal Shavit, Software Development Corporation, Underware, Brief, Barry Bycoff, Netegrity
Stefan Mehlhorn, Permessa, Collego, Loop Pay
Jay Singh, Dan Levin, Doron Gan, Tod Loofbourrow, ViralGains
Kendall Tucker, Polis, David Solomont
Wed, 11 Jan 2017 - 1h 02min - 491 - Michael Mark, Super Angel & Founder - "The Best Pivots Ever?" - Ep. 1
In our inaugural episode, angel investing prodigy Michael Mark tells fascinating stories that take us from the precocious founding of his first company to his being a highly-prized investor in hundreds of startups today. The narratives are interwoven with entertaining observations of subjects ranging from comedians to co-founders. Some of the most interesting pivots (radical changes of business plan) are elucidated. Michael's dry wit and unassuming manner make his deep wisdom accessible to all of us.
If you liked this episode subscribe in iTunes or Google Play so that new episodes will automatically appear in your player. You can find us by searching for Sal Daher or Angel Invest Boston.
Sign up at AngelInvestBoston.com Sign Up if you want to be made aware of upcoming in-person events. Obviously, this is of particular interest if you are in Boston or environs.
You can also follow us on Facebook, LinkedIn and on Twitter @AngelInvestBOS
In this conversation we touched on:
The best pivots ever!
Need for focus
When to pivot
How frequently business plans work out
Hiring a CEO
Qualities of the founders
Role of luck in startups
I What a board of directors can do for the startup
How Michael got started in entrepreneurship
Pixability
Exos
Loop Pay
Bettina Hein
Beth Marcus
Will Graylin
Progress Software
Interleaf
Netegrity
Underware
Wed, 11 Jan 2017 - 56min - 490 - Teaser of Episode 3 - Ben Littauer - #1 Fundraising Mistake
This is a teaser of the full, hour-long episode which is still in production. The full episode will be published on January 11th, 2017.
Ben Littauer traveled an unlikely path from philosophy to communications technology. He brings to life the exciting turns in his careers as founder and angel investor. In his light-hearted style, Ben provides a thoughtful tour of Boston's angel scene in this episode that ranges over many topics including equity crowdfunding. In particular, he explains what leads founders to make the worst fund-raising mistake of all. The philosopher's clarity of thought and the engineer's practicality are in evidence.
Sun, 04 Dec 2016 - 02min - 489 - Teaser for Episode 2 - Ralph Wagner - Flunk Calculus, Ace Life
This is a teaser of the full, hour-long episode to be published on January 11, 2017. It contains the full narrative of the events that would propel Ralph to finding his true calling.
Ralph Wagner recalls his journey of self-discovery that led from failure in engineering to incandescent success in marketing and sales. The man who could not do calculus or write code excelled at identifying and exploiting opportunities created by computer technology. In this interview one sees that Ralph's captivating personality is firmly ballasted by good sense and common decency. It is made evident how his interest in people was vital to the success of his many ventures.
Sun, 04 Dec 2016 - 06min - 488 - Teaser for Episode 1 - Michael Mark - Best Pivots Ever? - Full Episode coming 1/11/17
This is a short teaser of the hour-long Epsiode 1 which will be published January 11th, 2017. This teaser contains the entire narrative of what may be the most dramatic and successful pivot ever.
In our inaugural episode, angel investing prodigy Michael Marks tells fascinating stories that take us from the precocious founding of his first company to his being a highly-prized investor in hundreds of startups today. The narratives are interwoven with entertaining observations of subjects ranging from comedians to co-founders. Some of the most interesting pivots (radical changes of business plan) are elucidated. Michael's dry wit and unassuming manner make his deep wisdom accessible to all of us.
Sun, 04 Dec 2016 - 06min - 487 - Angel Invest Boston Episode 0 - Brief Intro to Angel Investing & Boston Startup Scene
In Episode 0 host Sal Daher explains the purpose of the podcast. He makes the point that angel investing is more accessible than most people suspect. He talks about Boston's great ecosystem for startups and angels. In conclusion, he tells a bit about his background and how he got into angel investing.
If you liked this episode subscribe in iTunes or Google Play so that new episodes will automatically appear in your player. You can find us by searching for Sal Daher or Angel Invest Boston.
Sign up a AngelInvestBoston.com if you want to be made aware of upcoming in-person events. Obviously, this is of particular interest if you are in Boston or environs.
You can also follow us on Facebook, LinkedIn and on Twitter (@AngelInvestBOS)
Thu, 01 Dec 2016 - 03min - 486 - Sal Daher - Lessons Learned
In the final episode of the podcast I, Sal Daher, review important lessons I learned in seven years of interviews and decades of investing. In my voice and in the voice of my guests, I recapitulate the discoveries most salient to me and invite listeners to find their own nuggets in the sound archive which will remain available on Apple Podcasts and other platforms. AngelInvestBoston.com will have 250 episode pages with sound, notes, and in most cases, annotated transcripts.
I'll be publishing new content at Substack.com focused on keeping fit as we age. You can find me there under Sal Daher or under Aging Fit. Startups will show up occasionally. Here's a link to the Substack:
Sal Daher's Substack - Aging Fit
Thanks for listening.
Highlights:
· Lesson 1: Company-Specific Risk – The Bad & The Good – Why It Matters in Startup Investing · Lesson 2A: "You know nothing, Jon Snow" – The Need for Tight Risk Control · Lesson 2B: "You Know Nothing, Jon Snow" – Whence a Real 400X Return · Lesson 3A: What to Look for in a Startup? What to Look for in a Founding Team? · Lesson 3B: The Most Significant Results from Ed Roberts' Research · Lesson 4A: It's Important Not to Keep Your Idea Secret but to Talk to Many People About It · Lesson 4B: The Google Problem – Why Founders Should Be Open About their Ideas · Lesson 3B Recapitulated: Robust Finding: Larger Teams Do Better; Startups Tend to Have Teams that Are Too Small · Lesson 5A: Focus, Focus, Focus · Lesson 5B: Focus, Focus, Focus · Lesson 6: Take the Money & Run · Lesson 7: It's a Long Way from the Lab to the Clinic · Why I Am Ending the Podcast – Archive Available – See You at Substack.comGuest: Sal Daher
Topics: angel investing strategies, co-founders, biotech, exits, pivots, partnerships with strategics
Fri, 29 Dec 2023 - 38min - 485 - Sal Daher - Lessons Learned - PODCAST LAUNCH DELAYED UNTIL 12/29/23 at 1:30 AM - Apologies!!
Lessons Learned is a compilation of hard-won lessons in angel investing. They come from my podcast interviews over these seven years as well as from my three decades of angel investing. Hints on how to build your portfolio, how to eliminate sure losers and other practical advice will be offered in the voice of my guests and in my own voice. Sorry that the release of the episode is delayed until Friday 12/29 due to personal matters and this year's Christmas calendar. Thanks for listening.
Wed, 27 Dec 2023 - 02min - 484 - Tom Weldon - A Fountain of Youth
Aging Fit Substack: Learn More
Repeat life science entrepreneur Tom Weldon is now taking on aging. He is commercializing a compound to extend health span developed at a prominent institution. Composed of substances generally considered as safe by the FDA, the formula has shown impressive results in mice and, to date, in one human, Tom himself. Intriguing chat with a dynamic founder.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Tom Weldon What Problem Rejuvant Addresses "... Then the first time the combination is not additive, take it out. That's a process that would probably take a year or two, but it ensures that you'll have an optimal result. Or, you can buy Rejuvant, because we did all that work already..." "... if you decide that you'd like to try Rejuvant and you go on subscription, we give you a free DNA methylation test at time zero and then we give you another one after six months, which is included in the cost ... They're different and they have different algorithms. All of them except two that I'm aware of, one of which is what we provide, requires your current chronologic age as an input..." "... It was actually discovered by Steve Horvath and he developed the first biologic clock ... Your DNA is damaged every second that you're alive. Prior to puberty, your body does an exceptional job of repairing all of that. However, after that, it starts to decline..." "... Is there any evidence that repair is actually at work? How do we know that it's not just removing the methyl molecule from the DNA, and you have damaged the DNA that's just not methylated?..." "... How long have you been on Rejuvant?..." How Tom Became an Entrepreneur "... This company had this trajectory and now it's just gone Chapter 7 recently. That is the tough side of these life science technology companies because the technology moves so fast..." "... very difficult space. What I have seen in the medical device space, these 510k pathway devices where there is an existing predicate device, and then you can design something which is, no worse and perhaps much better than the predicate device..." Advice to the AudienceTopics: biotech, discovering entrepreneurship, founding story
Wed, 20 Dec 2023 - 45min - 483 - Paul Hartung - Fund a Biotech Startup in Hard Times
Aging Fit Substack: Learn More
Life science board member and advisor Paul Hartung is back with wise tips on how to fund your biotech startup in these had times. Listen or read below.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Paul Hartung, Experienced Biotech Board Member & Advisor Paul Hartung Closed a Financing in the Midst of the Last Recession Seek Out the Right Grant Funding, Watch Expenses Pitch Contests Don't Provide Much Money but Can Spotlight Your Startup Peer-Reviewed Publications Can Raise Visibility of Life Science Startups Look Outside Your Area, Consider Syndication Across Angel Groups Watch Out for Funds That Can't Make Good on Term Sheets – It Happens More than You Think Be Upfront About Your Future Funding Plans "The nature of the investors change. For each stage of financing what you want to do is make sure that you identify who the lead investor is. Very important." Lead Investors Summation About Strategic InvestorsTopics: biotech, fundraising, raising money
Wed, 13 Dec 2023 - 09min - 482 - Sal Daher - Startups in the IRA? Pros & Cons from Decades of Investing
Aging Fit Substack: Learn More
In my fourth decade of angel investing, I'm happy with my investments but regret having put them in my IRAs. Here are pros and cons of having illiquid, operationally complex and hard-to-value assets in IRAs.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Investing in Startups via an IRA Can Be Burdensome, Here's Why How I came to Have so Much of my Net Worth in my IRAs Thank You Citibank for Encouraging a Young Banker to Save Thank You Bob Smith for Allowing Me to Fish When the Fish Were Running Why The Fish Are Not Running Any More "Some weeks I spend half my time dealing with IRA-related paperwork. I have many better things to do with my life." The Initial Investment Is a Lot of Work for Everyone Involved Corporate Actions Guarantee Constant Attention to the IRA Is Required Then There Are the Required Annual Valuations It Gets Worse! The Upside of Investing in Startups from the IRAs ConclusionTopics: angel investing strategies
Wed, 13 Dec 2023 - 12min - 481 - Raul Rosa - Art and Craft
Aging Fit Substack: Learn More
Raul Rosa, artist, musician, and sound engineer, discusses his work with the Angel Invest Boston Podcast, some of his favorite interviews, and his own startup, Podspot.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Raul Rosa Raul's Favorite Interviews Fortified Bike Howard Stevenson PodSpot Wistia Piction Health Savran Technologies Advice to the AudienceTopics: discovering entrepreneurship, COVID, robotics/AI
Wed, 13 Dec 2023 - 35min - 480 - Katharine Woodman-Maynard - Talent and Wisdom
Aging Fit Substack: Learn More
Katharine Woodman-Maynard has for seven years created a gorgeous and enduring graphic manifestation of this podcast on the web. I am fortunate to have this gifted artist enhancing my work with her talent and wisdom. She returns to talk about her favorite interviews, to share her journey as a professional artist and to offer valuable advice for those starting out.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Katharine Woodman-Maynard Katharine's Perspective of Startups "... I'm very grateful to you for having connected me with Drew Madson, who founded Readlee. Tell a little bit of the story. How did you connect with Drew?..." EndeavorOTC "... I found it fascinating in the interview that Eddie talked about how it was actually shown in trials to be more effective for adults than it was for children..." "... Human interaction resets us, brings us back to normalcy because if we're off on our own, we go batty..." Katharine's Professional Artistic Journey Sticking to a Schedule "... Once you can learn self-compassion for yourself and realize you're human and you make mistakes and not waste so much energy on being negative and hard, I think you're a lot freer to, advance in your career because you're not so hard on yourself..." Advice to the AudienceTopics: discovering entrepreneurship, ed tech, platform
Wed, 06 Dec 2023 - 46min - 479 - Ethan Pierce - AI Helps Kids Read
Aging Fit Substack: Learn More
Ethan Pierce's startup Adaptive Reader makes great literature accessible to kids not reading at grade level. Harnessing generative AI with sophisticated prompts and quality control by humans creates compelling texts based on the classics. Ethan and his co-founder even have a promising business model. Great chat!
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Ethan Pierce Adaptive Reader and What it is Solving "... It's much better if they have this contact with the author, albeit in a structure that's simplified. After all, we're always reading Dante in the translation. We're reading Homer in the translation. It doesn't make it any less compelling..." Teachers' Opinions of Adaptive Reader "... That controversy, the conversation, the passion around helping these students read is really important and that's why we've been really grounded in research here and these conversations with these experts. I think talking to these teachers, the biggest challenge that they face is just getting kids to read at all..." Ethan's Entrepreneurial Journey Palette How Adaptive Reader Came About How Can Listener's Participate in Adaptive ReaderTopics: discovering entrepreneurship, product, robotics/AI
Wed, 29 Nov 2023 - 35min - 478 - Brian Denenberg - Helping Startups Grow
Angel Scale Biotech: Learn More
Brian Denenberg is an angel investor, company advisor, and co-founder. Here, he discusses some of the companies he has been involved with, including Fairmarkit, Tive, and his work at Venture Lane Studio helping startups grow sales.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Brian Denenberg Fairmarkit How Fairmarkit Was Started Tive Inbound vs Outbound Marketing "... What Tive did, he innovated a tracker that goes on shipments, and it could go anywhere in the world, and it could not just tell you where the shipment was. It could tell you the condition of the shipment..." "... Scientists don't know the huge difference that exists between the lab and the clinic and industry. There's a massive gap and they think that something that works in the lab will work in a clinic or an industry very easily, but it mostly does not..." Venture Lane Studio "... We call it a studio. It gives us the flexibility to work in different ways. The best way to think of it is like an accelerator. It's really bespoke. We take three to four companies at a time. We're not looking to doing big cohorts..." Cedience CIRT Qase Brian's Background How Brian Got into Startups Advice to the AudienceTopics: angel investing strategies, biotech, discovering entrepreneurship
Wed, 22 Nov 2023 - 41min - 477 - Brian Freeman, MD - Burn More Calories
Angel Scale Biotech: Learn More
Brian Freeman, MD, co-founded Energesis to help overweight people lose weight by growing their energy-burning brown fat. Experiments in mice have shown this approach works with GLP-1 drugs such as Wegovy in accentuating weight loss. Great chat with a compelling repeat founder.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Brian Freeman Energesis: The Problem it's Solving "... What we're doing is we're acting on those cells and basically nudging them to make more mature brown fat cells, so that the mass of the brown fat cells increases..." "... That's pretty much it. We're trying to recapitulate cold exposure in a pill. That's right..." "... one of the issues with weight loss due to, let's call it caloric restriction ... The body doesn't take it lightly because we've evolved not to starve, right? ... The normal physiologic response to that is to reduce metabolic rate. That makes it harder and harder to lose weight as your weight goes down, and it makes it very difficult to keep that weight off..." Further Thoughts on Energesis Brian's Entrepreneurial Journey "... What if you could magically make everybody in America lean overnight, think of what that would do to healthcare costs. It would be reduced by at least two-thirds..."Topics: biotech, discovering entrepreneurship, product, founding story
Wed, 15 Nov 2023 - 44min - 476 - Andy Bartlett, PhD - The Fun in Angel Investing
Angel Scale Biotech: Learn More
My Walnut buddy Andy Bartlett, PhD brings great energy to the group and an expert's perspective on computing. We talked about our favorite startups including Savran Technologies, evTS, and BioFeyn. He has interesting things to say about ChatGPT. We also had a great chat about his angel journey.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Andy Bartlett Savran Technologies "... three of the things I really love to see in startups is a founder like Çağrı that will go through walls, that's so important. Defensibility that they have a moat, so the strong patent portfolio..." evTS BioFeyn "... We're talking about the University of Illinois Gies School of Business. I'm so impressed with the way the faculty is running that business school. They're running it like a disruptive business..." "... They've gone ahead and they've kept this very affordable. The full program, it's 18 classes plus three capstones costs about $23,000 total..." Andy's Entrepreneurial Background "... My mother's family had entrepreneurship. My great-grandfather, Alonzo Dodge, started a Dodge Moving and storage company. I always thought my grandfather had founded it, but actually, it was his father. They always ran that. That was the family business..." "... Eventually, I got my way into the electrical engineering department and I've embraced that for years and years..." "... At Chrysler, I could draw a block diagram to model some algorithm I wanted to use for onboard diagnostic testing of the Chrysler vehicles. I could model it. I could simulate it. I could pull down a menu and immediately generate code that would run on a computer in the backseat of a test car. I would drive around and I could do my experiments and collect my data..." Andy's Opinion on ChatGPTTopics: angel investing strategies, biotech, discovering entrepreneurship
Wed, 08 Nov 2023 - 58min - 475 - Kevin Majeres, MD - Joy at Work
Angel Scale Biotech: Learn More
Kevin Majeres, MD, teaches cognitive behavioral therapy (CBT) at Harvard Medical School. CBT is the gold standard to treat mental health conditions without drugs. CBT can also help with workplace issues such as burnout or anxiety. Dr. Majeres (pronounced Majors) has built a digital platform, OptimalWork.com, to improve the quality of work life. I learned really useful things from this interview.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Dr. Kevin Majeres What OptimalWork is Solving "... what we are doing is bringing the insights of cognitive behavioral therapy out of the normal context, which is working with the cognitive behavioral therapist. We're bringing that to people in the setting of their work..." "... In fact, everything with regard to eating behaviors, there's abundant evidence that cognitive behavioral therapy works. At one level, you could see that the more someone was afraid of hunger, the more likely they would be to act on it..." "... This is why I think anxiety is the most central emotion to understand because anxiety is the urge to avoid challenge as challenge..." "... Cognitive behavioral therapy, I should say, it also tends to focus on what's happening right now. What are the emotions showing up right now? Where's the avoidance right now? Where does the reframing have to take place right now?" "... I think that we need more and more things like Endeavor OTC that are helping to identify what are the particular mental muscles that can be worked out, and whether these things are going to be universally applicable, or maybe there are certain subpopulations that that's exactly the workout that they need..." "... How would you compliment this Cybex machine for the mind with cognitive behavioral therapy?" "... That in a sense is like what we teach people at The Golden Hour, is how to just briefly strategize what you're about to do, lay out the steps in advance, think of how you want to be stretching yourself in these steps, calm your mind down for a moment, and then launch into it. Then you're going to have full traction, and then you get momentum. Flow is really just momentum in work..." Dr. Majeres' Psychiatry Journey "... anxiety is adrenaline waiting to be reframed..." Advice to the AudienceTopics: discovering entrepreneurship, scholar
Wed, 01 Nov 2023 - 50min - 474 - Jason Burke - Angel Investing Made Better
Jason Burke wants a better way for angels to invest in startups. He founded All Stage, the platform for angel investing that powers TBD Angels which he also co-founded. In this illuminating interview Jason discusses how All Stage helps the angel ecosystem. We also chatted about Moolah Kicks, and Folia Health.
Here's how All Stage's deal looks like in the All Stage platform:
All Stage deal within the All Stage product
Highlights:
● Sal Daher Introduces Jason Burke
● All Stage and the Problem it's Solving
● "... Because unless you've done sales a lot, it's really hard to deal with rejection, especially for scientific founders..."
● "... It's an example of some of the connective tissue between Showcase, the founder tool, and Community, the investor tool, to allow for that collaboration to happen..."
● Moolah Kicks
● Folia Health
● Jason's Entrepreneurial Journey
● "... I built the Tufts cross-country site, which today in 2023 doesn't seem groundbreaking, but at the time having a password on a site and detecting the IP address of who's using it and greeting them, that sort of stuff was absolute magic to do..."
● "... which came first? Angel investing or starting a company?"
● "... Was it a personal relationship, the first investment that you made as an angel?"
● Advice to the Audience
Wed, 25 Oct 2023 - 41min - 473 - Milena Peregrino, PhD - Reversing Muscle Loss
Angel Scale Biotech: Learn More
Brazilian startup MirScience Therapeutics is working on reversing muscle loss. I had an illuminating chat with co-founder Milena Peregrino, PhD about the technology and the company's progress.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Milena Peregrino MicroRNAs and What They Do MirScience Therapeutics "... Keeping in mind that we're talking about mouse models, it has not gone into human trials yet, but this is very promising..." "... We are going to need the non-rodent species. For now, we are planning to go with non-human primates, so monkeys..." How MirScience Was Founded Milena's Background "... Most people die from the results from falls. It's not necessarily immediately, it's within six months. If they have a severe fall, old people decline very fast and so this has huge implication for people to age better. The ability to have muscular old people going around instead of frail people who fall over easily..." Why Milena Chose Biology Advice to the AudienceTopics: biotech, discovering entrepreneurship, founding story
Wed, 18 Oct 2023 - 35min - 472 - Agustin Lopez Marquez - AI for Discovery Dining
Repeat founder Agustin Lopez Marquez, ex-nference, brings his AI savvy to food delivery with his new startup. Built on CloudKitchens' infrastructure, Mowgli addresses pain points for diners, sous-chefs and drivers. Loved my chat with this brilliant and practical founder. Sample Mowgli's homey meals from exotic places at https://khipi.com/. (delivers only to Boston & Cambridge for now)
Highlights:
● Sal Daher Introduces Agustin Lopez Marquez
● "... my co-founder, who happens to be my wife, Brinda, she was the one that started the company and the first product about a couple of years back..."
● "... The idea here is that these are meals for explorers, for people who like to venture out, travel. This is not pizza or your usual weekend fare for the kids, and so forth..."
● "... it's an infrastructure play that has happened in the last three to five years. It's modular kitchens that are just the kitchens that are meant for delivery-only companies..."
● "... You're going to become like the McDonald's of adventurous eating..."
● "... we already have more than 10 drivers that consistently, every Tuesday, they choose to work for Khipi as opposed to working for any other food delivery company..."
● "... I understand you have 400 customers ordering right now. 90 of those are super dedicated and they order every week. They give you 80% of your business..."
Topics: co-founders, culture, discovering entrepreneurship, robotics/AI
Title: AI for Discovery Dining
Wed, 11 Oct 2023 - 38min - 471 - Todd Zion, PhD - More Magical Proteins
Angel Scale Biotech: Learn More
Repeat founder Todd Zion, PhD is back to update us on exciting developments at his second biotech startup, Akston Bio. We also geeked out a bit on how these magical proteins are concocted in the company's bioreactors. Fun and instructive chat with a stellar founder.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Todd Zion Akston Bio's Founding Story "... The antigen in this case is the person's own insulin..." "... you're still taking advantage of that antibody portion, but you've neutered it so that it no longer alerts the immune system, but it retains one property that antibodies all have, which is the ability to recycle and last for very long periods of time in circulation..." "... We took the veterinary candidates and we partnered those with a company called Dechra Pharmaceuticals, PLC. They're one of the leaders in veterinary pharma development and this is all in the public domain..." "... We made a pivot at that point saying, 'Well, what if we just go back to the portion of the antibody that interacts with the immune system and make ourselves a vaccine against COVID-19 using the same exact technology?'..." "... you're going to continue involved in manufacturing, or are you just going to buckle down in the veterinary space and spin off these other technologies to other players?..." "... if you're not pivoting at least once in your development, you're probably doing something wrong..." Todd's Funding History "... what goes on in a bioreactor, which is the heart of what you're doing? Geek out a little bit of bioreactors..." "... there are these companies that do nothing but transfect CHO cells to produce particular types of protein..." EnergesisTopics: biotech, COVID, discovering entrepreneurship
Wed, 04 Oct 2023 - 45min - 470 - Eddie Martucci, PhD - Digital Therapy for ADHD
Angel Scale Biotech: Learn More
Rather than purloin my kids' Ritalin, I play EndeavorOTC daily to improve my attention and be sharper. Eddie Martucci, PhD is the founder of Akili that developed the app which is backed by real science. In fact, the kid's version is FDA-cleared to treat ADHD in 8-12 year olds. Don't miss this great chat.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Eddie Martucci
The Science Behind EndeavorOTC
"... This is not IQ. This is attention. You can have extremely high IQ or low IQ and have a high attention score and low IQ or vice versa..."
"... people with ADHD, it is not that they don't want to pay attention ... It's that that system of the brain that allows you to filter out what's irrelevant to your goal and focus in on what's relevant, that part of the brain, that interference filter is weakened..."
"... You cannot become addicted to it because can't do it for more than 25 minutes period..."
Eddie's Entrepreneurial Journey
Advice to the Audience
Topics: discovering entrepreneurship, founding story, product
Wed, 27 Sep 2023 - 38min - 469 - Susan Conover - Piction Health Takes Off
Angel Scale Biotech: Learn More
The third time is the charm for Piction Health. Super founder Susan Conover is back to talk about the third iteration of their business model which is showing promise of scaling profitably. Her AI has ingested a million diagnosed images of hair and skin conditions and is now making dermatologists 15X more productive. See for yourself at PictionHealth.com.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Susan Conover What Piction Health is Solving "... We solve the full problem for patients, end-to-end. If they have a rash or a mole they're worried about, or a case like that, they submit a case, we review that case within 24 hours with our board-certified dermatologist, we call in prescriptions..." A Typical Consultation at Piction Health "... How did you discover this? How is it that it dawned on you that this is the direction to go in?..." "... Dermatologists loving working with us is one of our really important metrics that we want to make it really easy for them..." "... How can our listeners be helpful to Piction Health?" Thoughts to the AudienceTopics: biotech, discovering entrepreneurship, robotics/AI
Wed, 20 Sep 2023 - 28min - 468 - Rabeeh Majidi, PhD - AI for Shoulder Injuries
Angel Scale Biotech: Learn More
Rotator cuff tears are debilitating. What if you could take action to avoid them? Rabeeh Majidi, PhD founded OrthoKinetic Track to do just that through a wearable device and a predictive algorithm. Listen to our chat to learn more.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Rabeeh Majidi What OrthoKinetic Track is Solving "... What I would say is that orthopedic telemedicine lacks comprehensive physical exams..." "... How is it that your system solves a problem that is of real interest to the providers?..." "... it's not just about what you know, but also who you know..." How Rabeeh Became an Entrepreneur Parting Thoughts to the AudienceTopics: biotech, discovering entrepreneurship, founding story
Wed, 13 Sep 2023 - 37min - 467 - Richard Vlasimsky - Finding Lung Cancer Early
Angel Scale Biotech: Learn More
Richard Vlasimsky is using AI to create a low-cost way of vastly expanding our ability to detect lung cancer early. His algorithm for detecting lung nodules in chest x-rays just got FDA clearance. Listen to this remarkable founder who's done a lot with modest funding.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Richard Vlasimsky What IMIDEX is Solving "... how much your studies cost to get your 510k.." "... We had multiple radiologists looking at the image, and then we had a final truther that adjudicated these independent reads that the radiologist did..." "... Payers care about catching it early so that they have better outcomes and the costs are much lower ... The providers, being the medical systems or the physicians, typically hospitals, they care about it because of liability issues and also because they could have the opportunity to treat something and they would get the revenue stream..." "... It's like a very fine-tooth comb picks up all the nits. The specificity relates to how many of those things that you pick up are actually what you're looking for and not false positives..." Exit Possibilities "... his definition of a startup is an enterprise that uses resources that it does not yet command..." Richard's Entrepreneurial Journey "... You had this experience of joining a startup, then creating your own startup which was using machine learning..." Advice to the AudienceTopics: biotech, discovering entrepreneurship, robotics/AI, founding story
Wed, 06 Sep 2023 - 41min - 466 - Ben Holmes - Growing New Cartilage
Angel Scale Biotech: Learn More
Growing new cartilage in your knees is a dream about to become reality. Listen to Ben Holmes, PhD, co-founder of Nanochon, to learn about his promising technology. Shoutout to Richard Meiklejohn of M2D2 for the introduction.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Ben Holmes What Problem Nanochon is Solving "... That's really what we're looking to do, is offer a solution that can be a much easier, much more cost-effective solution for providers, but also something that can really provide much better short and long-term outcomes for patients, and, ultimately, make the knee replacement obsolete..." The Solution: What it is, and How it Works "... We're seeing much better repair, and we're doing it with something that's an easy-to-use, off-the-shelf product..." What is I-Corps? Future Funding Plans Names and Numbers Ben's Entrepreneurial Journey Advice to the AudienceTopics: biotech, discovering entrepreneurship, founding story
Wed, 30 Aug 2023 - 41min - 465 - Drew Madson - Young Readers Win Big
Angel Scale Biotech: Learn More
During COVID, Readlee, Drew Madson's startup, offered teachers a highly effective way to measure and remedy reading deficits among online learners. This led to the company being acquired by Paper, the tutoring platform. An inspiring interview.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Drew Madson What Readlee is Solving Behind the Scenes of Readlee How Readlee Came to Be "... COVID just highlighted this need that already existed..." "...I highly recommend checking out The Opportunity Atlas. If listeners haven't looked at this, it's an amazing analysis of how certain interventions can actually improve people's ability to make more money over the course of their lives and have more opportunity and flourishing..." "... What are large language models going to do to this space?..." How Drew Developed an Interest in Education Parting ThoughtsTopics: discovering entrepreneurship, founding story, product
Wed, 23 Aug 2023 - 40min - 464 - David Kessler - #1 Peeve with Founders
Angel Scale Biotech: Learn More
Tech founder David Kessler discusses his journey as an angel investor in companies such as CleanFiber, Wasabi, and Hilltop Bio.
Sponsored by Purdue University enrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces David Kessler "... This is like a very counterintuitive investment for angel investors, but it was angel-funded..." The Importance of Updates What Hilltop Bio Does "... This is why I want to create infrastructure to help the angels support these academic founders with connections..." Wasabi "... helping founders hone their messaging, hone their presentation..." "... Basically, the question is, what other ways of looking at the world are there and are you flexible enough to say that there are other ideas out there, and you may wind up pivoting into one of those..." How David Kessler Got into Angel Investing "... Start slow, start small, and don't invest alone..." Advice to the AudienceTopics: angel investing strategies, building wealth, product
Wed, 16 Aug 2023 - 41min - 463 - Salvatore Viscomi - The Hospital at Home
Angel Scale Biotech: Learn More
Salvatore Viscomi, M.D. is CEO of Carna Health, a digital platform that is making it easier for patients with chronic conditions to do tests at home that would normally have to be done in the hospital.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Salvatore Viscomi What Carna Health is Solving "... We connect the device to our platform, we collect the data, we stage the disease, and then we share that information with the patient-provider..." "... The solution is really to bring the testing to the community, identify the 90% of people that don't know they have it, let them know they have it..." "... The devices on their own without connectivity and without a platform are really not a scalable solution for the type of programs that are needed to make an impact on these diseases ... The doctors are connected through a physician portal, and we identify all the people that are being screened..." Carna Health's Business Model "... We don't want our patients, necessarily, who are not feeling well, have medical conditions, to be exposed to other patients and potentially get infected..." "... One of the ways that Carna Health enables hospital home, is that it provides some of that testing in real-time, so patients don't need to go into a laboratory or phlebotomist..." Digital Twins: What Are They? Salvatore's Entrepreneurial Journey Advice to the Audience "... I think our system has been based on being very reactive to disease as opposed to prevention. The truth is that about 80% of longevity is determined by you and your environment and 20% by your genetics..."Topics: biotech, discovering entrepreneurship, product, robotics/AI
Wed, 09 Aug 2023 - 43min - 462 - Nick LaRovere and Matt Hawkins - Pryzm.ioWed, 02 Aug 2023 - 40min
- 461 - Jina Klapisch - Sal's Weight Coach
Coach Jina Klapisch who helps Sal Daher keep off 100 pounds is our guest in this episode. Sal and Jina discuss how HMR clients are able to take off and keep off significant weight with no hunger or feeling of deprivation. Check out HMR Weight Loss and Lifestyle Coaching at:
https://www.hmrnatick.com/about_us
Highlights:
● Sal Daher Introduces Jina Klapisch
● What Sets HMR Apart From the Rest
● How HMR Works
● "... What you're doing here is helping people discover the things that are easy for them to do repeatedly and make them into habits, and not try to do stuff that's hard, impossible for them..."
● Decision-Free
● Sal's Diet Journey at the Age of Thirteen
● Oprah and HMR
● "... when you're trying to make a very big change in your life, whether it's quitting smoking or quitting drinking, or with food, you need to take a break from that substance ... so that you can see clearly as you lose this weight and start to really figure out who I am as an eater..."
● How Your Environment Can Affect Your Weight
● Outlive by Peter Attia MD
● "... The first half mile that you walk every single day is the golden half mile. The first mile you walk is the golden mile. That is going to add years to your life..."
● Advice to the Audience
● Jina's Background
● "... 80% of weight loss is keeping it off, the hard part..."
● Jina's Parting Thoughts
Wed, 26 Jul 2023 - 53min - 460 - Staircase Wit: Shake Tech - Left out tech I use for making shakes - here it is
After recording the full episode titled "Tech & Weight Control" I realized I left out some important technologies I use in making the shakes that support my keeping off 100 pounds. So, here's a mini-episode with that staircase wit, as the French call it.
Highlights:
· Ninja Creami Ice Cream Maker · Ninja Bullet & Cuisinart Mini-Prep Plus Are Smaller & Cheaper Alternatives · Shaker Bottles Are Real Calorie-Savers · Acaia Digital ScaleTopic: Healthy Aging
Guest: Sal Daher
Title: Staircase Wit: Shake Tech
Wed, 19 Jul 2023 - 03min - 459 - Tech & Weight Control - Sal Daher reviews the tech that helps him keep off 100 pounds
Technology has long conspired against our health by making us fatter, more sedentary and sleepless. However, we can recruit tech as our ally in building healthy habits. Here is a review of the tech that is helping me keep off 100 pounds.
Highlights:
· Tech Can Make Us Less Healthy but It Can Be Good for Us Too · Getting Help in Weight Loss Is Really Powerful, You Can't Do It Alone · MyFitnessPal App · Noom App · Fitbit Charge 4 Tracker + Fitbit App · WHOOP Band and App · Shoutout to the Great Products from Hoplark · Plenity, FDA-Cleared Weight Control Device (Does Not Act Systemically) · "I used it [Plenity] as an on-ramp for my HMR diet..." · Fitbod · Life Fitness Elliptical Cross-Trainer · NordicTrack Cross Country Exerciser · Tonal · Bowflex SelectTech · $19.99 Chin-up Bar from Amazon · Marathon Sports · PowerStep Arch Support · The Drive: Podcast with Peter Attia, M.D. · Huberman Lab Podcast · HMR: for When You Are Really Serious About Losing WeightTopic: Healthy Aging
Guest: Sal Daher
Title: Tech & Weight Control
Wed, 19 Jul 2023 - 26min - 458 - Sal Daher - Sleep and Weight
Angel Scale Biotech: Learn More
Getting enough sleep is important to Sal Daher's effort to keep off 100 pounds. This short episode discusses how sleep connects with weight and how to improve sleep in support of weight control.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Why We Don't Sleep Enough Markets & Technological Innovation Are to Blame but the Solutions Need to Come from Individuals and Voluntary Associations, not from Leviathan We Know We Need to Sleep More but the Cards Are Stacked Against It Why Is Sleep So Important to Weight Control? As We Age Our Need for Sleep Does Not Decline but Our Ability to Sleep Does Why I do Early Morning Exercises Outdoors – GoodLux Technologies Huberman Lab Podcast Offers Valuable TipsTopic: Healthy Aging
Wed, 12 Jul 2023 - 14min - 457 - Sal Daher - Exercise and Weight
Angel Scale Biotech: Learn More
Sal Daher, CFA discusses the role of exercise in his keeping off 100 pounds of body weight with no drugs and no surgery, just good habits for eating, exercising and sleeping. Listen for tips and for encouragement on building your exercise plan.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Why Exercise? How Much Exercise Do I need? Don't Get Overly Ambitious – Start Slowly but Build Steadily Within Safe Limits Do Try to Get Out of Your Comfort Zone – Here's Why Think You Can't Exercise? Listen to These Stories Then, Tell Me You Can't Exercise No Financial Stake in HMR, Just Immense Gratitude for How Much They Have Helped Me It Matters When You Exercise Short Bouts Build Up Do a Variety of Exercises Zone 2 / Zone 5 Training Exercise Has an Unexpected Side Effect for Me I've Never Regretted ExercisingTopic: Healthy Aging
Wed, 05 Jul 2023 - 20min - 456 - Sal's Travel Diet - How Sal Daher works on keeping off 100 pounds on the road
Nearly two years after starting the effort to take off and keep off 100 pounds, I took a series of trips. Here's how I coped with the challenges of being on the road and maintaining my weight.
Highlights:
· Trips to Napa Valley, Hamburg and San Sebastián Took Me Away from my Usual Supports · Travelling Heavy to Napa Valley · "…there may be people who can travel and not gain weight. But I'm not one of them. Therefore, I have to do unreasonable things to keep off those 100 pounds." · Traveled Ultra-light to Hamburg – Just Carry-on · A Thought about the Effects of Alcohol on Sleep · Traveled Medium-heavy to San Sebastián – 23 Days Away Is a Long TimeWed, 28 Jun 2023 - 06min - 455 - Sal's Diet - Keeping off 100 pounds is mostly about diet. Here's how Sal eats to stay at ideal body weight in his 60s.
I'm Sal Daher and I'm keeping off 100 pounds of body weight with no drugs and no surgery. I'm doing it by building and reinforcing healthy habits. I eat a lot but do not put on weight. It was not easy to build the healthy habits I practice but it can be done.
Highlights:
· Introduction · Food Intake Is the Main Driver of Weight Management, Not Exercise · Repeatable Changes You Can Live With · What I Eat for Lunch Regularly Now · My Fat but Fit Delusion · Your Longevity Is Up to You, Nature Does Not Care About It · I Could Not Change My Habits Alone, Not Even in Singapore · I Needed Help to Build and Maintain My New Habits · A Cool Mind Trick · There's a Reason They Are Called "Support Groups" · Getting Back to Diet – Here's What I Eat Throughout the Day · Breakfast – This One Is for You Ralph Wagner · Hydration Is Really Crucial – Always Trying Cool New Drinks · Mid-morning Snack – Efficiency Is the Keyword · Lunch – See Above – But There's More · Vegetables and Fruits Are My Best Friends · Mid-afternoon Snack – My Vitamix Blender Comes in Handy · Supper – It's a Lot of Food So I Try Not to Eat Too Close to Bed Time · Evening Snack – The Treat I Look Forward to All Day Long · After My Evening Snack, My Probiotic · The Biggest Aha! Moment of My Dieting Career · ConclusionWed, 28 Jun 2023 - 26min - 454 - Layne Sadler - KeyBio
Angel Scale Biotech: Learn More
Layne Sadler founded KeyBio to help pharmaceutical companies better identify genetic traits in patients that may explain differing responses to cancer treatments. KeyBio's computational approach promises to add a new dimension to precision medicine, which now looks at the genetics of the tumor, by also incorporating the genetics of the patient to improve outcomes in clinical trials.
Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Layne Sadler What KeyBio is Solving "... The revenue is solely focused on cancer drug discovery and the reason for that is because that's where all the money is in the pharmaceutical industry..." "... 90% of clinical trials fail and the cost averages around 792 million, spending about a billion dollars to run a trial..." "... I developed this AI platform and I wanted to start collaborating with other principal investigators or heads of labs in the Boston area..." "... The DNA of tumors, over time, it mutates and it becomes very different from the DNA of the host..." Why Layne Chose EntrepreneurshipTopics: biotech, founding story, discovering entrepreneurship
Wed, 21 Jun 2023 - 32min - 453 - Jason Syversen - Cyberwarrior
Angel Scale Biotech: Learn More
After a career at DARPA, defending America from cyber threats, Jason Syversen founded Siege Technologies which had a great exit. He now focuses on angel investing and philanthropy. Inspiring chat.
Sponsored by Purdue University entrepreneurship, and Peter Fasse, patent attorney at Fish and Richardson.
Highlights:
Sal Daher Introduces Jason Syversen What Problem Siege Technologies is Solving "... How do you measure and predict probability of success and collateral damage for a cyberattack? That is actually the technology we end up being acquired for when we sold..." "... I took over 10X Venture Partners, which is an angel group..." SportsVisio and What it is Solving "... That was a really interesting example of you think that this is all figured out even in pro leagues, and yet it really isn't..." Jason's Background "... if you had a choice between being born in a family with trust funds where your parents really don't care about you or being born in a hardscrabble family where the parents do care about you, choose the latter..." "... Human infants need nurturing and then beyond that, and when we're grown, we need a society around us that supports us ... This lack of connection is the biggest problem in America today..." Advice to the AudienceTopics: discovering entrepreneurship, founding story, product
Wed, 14 Jun 2023 - 39min - 452 - Saleh Daher - Losing 100 Pounds - No Drugs, No Surgery
Losing and keeping off 100 pounds is hard. Having done it, Sal wants to convince you that you too can gain control of your weight. No drugs, no surgery, just new habits patiently created and reinforced. Sal's daughter Grace Daher conducted this frank interview.
Highlights:
Here's the Story of How Sal Daher Lost 100 Pounds with No Drugs and No Surgery – You Can Do It Too Sal Introduces His Daughter Grace Daher Who Is Asking the Questions When Sal Was First Told He Needed to Lose Weight A Big 13-Year-Old on a 1,300 Calorie Diet – Misery! Early On It Was Evident that Sal Was Triggered by Food but His Brother William Was Not Sal Became More Active in College but Bad Diet Caused Weight Gain Lost Weight During Summer Break in Brazil – Less Eating More Moving Sal Was Fit in College, But Still Overweight – Did Not Realize the Burden He Was Carrying Around Sal Got Down to His Ideal Body Weight in His Mid 30s Out of Concern for His Blood Pressure Lost the Weight on the HMR Program – No Hunger – More Is Better How the Weight Came Back On – Grace Remembers Sal's Struggles HMR Program Turns Down Chance to Coach Oprah Winfrey Individually Because They Did Not Have Data to Support that Approach Attending Weekly Support Group Is Essential for Success Long Term – Alcoholics Anonymous Example Grace Was Shocked to See Sal's Weight Loss After the Isolation from COVID Sal Was Proud to Be Fat but Fit – His Doctor's Warnings Were Not for Fit People Like Him Being Overweight Has a Lot to Do with Genetics – We Have to Fight Our Genes A Painful Health Event Motivated Sal to Take the Weight Off for Good How the HMR Program Works The First Three Weeks Were Hard – Plenity Helped Maintaining Your Weight Loss Means Acquiring a Whole New Set of Habits The Multiple and Marvelous Benefits of Exercise There are No Magic Pills – Except Exercise The Importance of Human Connectedness in Weight Control Sal's Regrets for Not Having Taken Off the Weight Earlier Sal Is a Big Supporter of Statins "How are you managing to keep off those 100 pounds?" Committed to a Baseline of 10,000 Steps Per Day Highly Structured Eating Cool Facts About Coffee "Why Is getting sleep so important?" "…you need the support of a coach to help you work out those particulars…"Wed, 07 Jun 2023 - 49min - 451 - Gloria Kolb, Co-Founder of Elidah - Device to treat urinary incontinence in women
With minimal funding, Gloria Kolb and her husband Eric Kolb have created a device to treat urinary incontinence that has received a coveted clearance from the FDA. Elidah, their startup, expects to exceed $3 million in DTC sales this year. I really enjoyed this story of a couple bootstrapping a promising business together.
Highlight:
· Sal Daher, CFA Introduces Gloria Kolb, Co-Founder of Elidah · Elidah Is Solving Urinary Incontinence in Women – Device Induces Kegel Exercises · Just Got FDA Clearance for Overactive Bladder · "She only needs to wear it for 20 minutes a day, and then it turns off automatically." · Differentiation from Other Devices: FDA Cleared for Incontinence · Randomized Control Trial Result: 75% of Women Experienced Statistically Significant Improvement · "It drives me crazy that women do wait so long and they don't tell anyone and they just deal with it for a long, long time. I think part of it is they don't think that there's any other good options for them." · Seeking FDA Clearance for Over-the-counter Sales, Like Gelesis · Medicare Covers the Device · About 8,000 Customers Have Purchased ELITONE, Elidah's Device · "You have shocked me. I'm not easily shocked. That airline magazines will not talk about urinary incontinence." · "It's not quite the razor blade model. It is definitely about the treatment kit, which cost the $400." · Have Built Sales of $3 MM with Just $750K in Angel Funding Plus $1.8 MM in Grants · "A third of women have the issues, over the age of 30, but then you go to over the age of 50 and it's 1 out of 2." · "It's actually the number one issue of why people entered nursing homes. " · "To women out there, I just encourage them to get treated early." · How You Can Help Podcasts Like Gloria's Be Found · Gloria Kolb Studied Engineering at MIT & Stanford, Worked at Johnson & Johnson then Got Her MBA at Babson · Wife-and-Husband Founding Team · "...over the counter doesn't mean it's less of a product. It is a medical device, regulated product that went through all the hoops."Wed, 31 May 2023 - 46min - 450 - Treating Spinal Fractures Better - Dom Messerli, Founder of Lenoss Medical
Spinal fractures from osteoporosis cause many to lose their independence. Industry veteran Dom Messerli has a better way of fixing the problem than the risky practice of injecting liquid epoxy into the spine. Using engineered human bone, Lenoss Medical is offering a treatment that is safer, effective and easier to administer than the current standard.
Highlights:
· Sal Daher, CFA Introduces Dom Messerli, Founder of Lenoss Medical · "Many times, the patients lose their independence when those fractures happen." · Current Standard of Care is to Inject Liquid Epoxy into the Spine – What Could Go Wrong? · Liquid Epoxy Can Leak into Blood Vessels and Create Blockages · "When it's in the heart, usually what's prescribed is open heart surgery to take out the piece of cured cement out of the heart." · Lenoss Medical's Solution: Engineered Human Bone Material to Build Up the Weakened Spine · Grafting of Same-Species Bone Material Is Decades Old – What's new Is Applying the Approach to Spinal Fractures · "...conducive for new bone formation." · There's No Donor Matching or Donor Rejection Issue Since No Living Cells Are Implanted · Lenoss Medical Was the Subject of Dom's MBA Degree Project · Lenoss Medical Plans to Go to Market Via Distributors Specializing in Products for Spinal Treatments · The Argument for Hospitals Is Reducing Risk and Simplifying the Process · FDA Approval Process Was Relatively Low-Burden, Human Cell and Tissue Product Pathway · Dom Messerli's Immigrant Story · "Eventually, I was affected with the layoff. I was waiting for that day. The next day is when I started Lenoss Medical." · "...I feel we can have a positive impact with these patients with osteoporosis and the spinal fractures. That drives me."Wed, 24 May 2023 - 42min - 449 - Eric Janszen, Co-Founder & CEO of VirZOOM - Virtual Sport
A miserable New England day had avid cyclist Eric Janszen dreaming of better indoor riding. Together with co-founder Eric Malafeew, he launched VirZOOM which now has 40,000 users on its virtual reality platform with great engagement. Fascinating conversation about virtual games becoming sport.
Highlights:
· VirZOOM Gets Grant from Major VR Player for a Joint Development Project · Sal Daher Introduces Eric Janszen, Co-Founder of VirZOOM · Ongoing Crowdfunding Raise on StartEngine · VirZOOM Meets the Challenge of Helping People Enjoy Exercise · Technical Co-Founder Eric Malafeew Worked on Big Hits at Harmonix Music · VirZOOM Tech Lets Users to Do Cool Things Without Getting Motion Sickness · Broke Out of the Limitations Imposed by Being a Bike-Based Platform · "It sounds like you could actually play Quidditch on this." · How the Pivot Came About · "Where we're heading is 100% without a bike." · Making It a Sport Rather than a Game Has Huge Economic Consequences · Sal Speculates on the Possibility of VR Sport Slowing Cognitive Decline · "What gets us up in the morning is all of the reviews that we get from our customers..." · Average VirZOOM Customer Exceeds CDC Recommended Weekly Exercise · The Cost of Getting on VirZOOM Is Modest: $300 for the Quest Headset & $12 per MonthWed, 17 May 2023 - 53min - 448 - Federico Cismondi, Founder - doDoc 2
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Federico Cismondi, co-founder of Sal's portfolio company doDoc, is back on the podcast to talk about the company's acquisition and the lessons he learned from the initial raise to the exit. A charming and instructive conversation with a thoughtful founder.
Why Getting the Best Patent Advice is Indispensable Sal Daher Introduces Federico Cismondi, Co-Founder of doDoc Which Was Recently Acquired The Problem that doDoc Solves "This is the platform for those people who need workarounds because Google Docs just doesn't cut it for them, or Microsoft Word…" Federico, as CEO, Learned He Needed to Delegate More doDocs Pivot from Academic Clients to Pharmaceutical Clients doDoc's Near-Death Experience and What Federico Learned from It doDoc Was Initially Built with Unsuitable Technology - Making a Dog Meow Entrepreneurship in Portugal - What Argentina and Portugal Have in Common How the Exit Came About "...we try to create settings for people to share their ideas, to present them and to run with them. Sometimes they don't even need the validation from a supervisor...in order to run with that idea…" Federico Cismondi Spoke with 1000 people to Get 24 Investors for doDoc Spending More Time with His Co-Founder Than with His Wife Federico Cismondi's Parting Advice to FoundersTopics: co-founders, management, exits, culture, Techstars, software
Wed, 23 Jun 2021 - 35min - 447 - Keith Hearon and Matthew Stellmaker - Good Chemistry
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Two brilliant scholarship kids became friends at Georgia Tech and went on to found a company that could change the world. This is the story of Matthew Stellmaker and Keith Hearon and of the good chemistry manifested in their friendship and in the creation of new polymers friendly to people and nature.
The idea came to Matthew when he was working at a large company that produces 50,000 tons of citrus waste per year. His friend Keith thought that he could do something interesting with the citrus rinds so Matthew got the company to fund the research into creating a use for this natural material.
These two young founders display remarkable self-knowledge and reveal discoveries in the art of founding companies that could help other founders, technical or not. It's a valuable conversation that includes the following topics:
Keith Hearon Bio Matthew Stellmaker Bio Keith Hearon Views Himself as an Entrepreneur Who Uses Science to Commercialize Valuable Products – Inspired by Ken Gall, Founder & Inventor How Keith & Mathew Became Friends How to Find a Job in Architecture in a Down Market Challenge of Langer Lab Further Energized Keith Hearon How Poly6 Got Started How Poly6 Zeroed in on its First Use Case How Poly6 Zeroed in on its First Use Case How Being Co-founders Changed Their Friendship Should You Found a Company with Your Friend? The Risks of Moonlighting The Care & Feeding of Advisors – Busy People Generous with Their Time Other Startups Matthew & Keith AdmireWed, 16 Jun 2021 - 40min - 446 - Tim Spong, Founder - VistaPath Bio
Sponsored by Peter Fasse of Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
To Join Sal's Syndicate: Click Here
A terrible error in a lab led Tim Spong to start a company to improve the reliability and efficiency of pathology labs; big industry players are noticing. This interview was part of my due diligence on Tim's startup, VistaPath Bio. Subsequently, I invested in the company.
Highlights include:
Sal Daher Introduces Tim Spong, Co-Founder of VistaPath Bio "Fast forward a hundred years, even if you walked into some of the best labs in the country, it's still a room full of people cutting tissue and staining tissue and sitting over jars." "…VistaPath is really aiming to do is build the next generation pathology lab using automation, AI, advanced imaging practices, and then put that into every lab in the world…" "The rest of the time and a lot of the costs is spent in these labs, in histology labs, making the slides so that a pathologist can render a diagnosis." The Horror Story that Motivates Tim Spong to Improve the Lab Sample Workflow How Tim Spong Connected with His Co-founder Ben Burley "When I decided to actually quit my job and do it, it was really with him. We made that leap together. Like I said, he is amazing. I couldn't imagine getting this far without him." VistaPath Has Had to Overcome Investors' Lack of Interest in Pathology VistaPath Has a Smart Benchtop for Grossing of Samples that Is Equipped with Cameras to Reduce Error and Automate the Process VistaPath Business Model "What we wanted to do with our business model is make our product something that anybody could have, any lab could afford…" "…our initial evaluations, we're already seeing that we're more accurate than humans, much faster than humans." "We really strove and worked a long time to make our products something that someone can take out of a box, plug into a lab, it's an easy-to-use interface, and they can use it as part of their workflow immediately." Sal Daher Is Considering Making an Investment in VistaPath Bio Sal Daher Invites Accredited Investors to Join His Syndicate List Tim's Entrepreneurial Journey Tim Spong Met His Wife at a Pathology Lab Tim Spong Credits Advisors for Helping Him Decide to Become a Founder "Some people have led us to some of our best advisors and investors were investors that actually turned us down." Tim Spong Encourages Industry Experts to Start Companies to Solve the Problems they See First-HandWed, 09 Jun 2021 - 33min - 445 - Ham Lord, Founder and Super Angel - Launchpad Founder
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
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Writing software never seemed like work to young Ham Lord. In high school and then in college, coding is what got him rolling with his other courses; he loved it. This passion, and the happy coincidence of being at the right place (Brown University) at the right time (early 1980s) led to a brilliantly productive career in computing and entrepreneurship.
Ham's early work in computer graphics would eventually lead to innovation in applying 3D imaging to the creation of new molecules. Later he helped build software with applications in medicine, oil & gas exploration and engineering analysis. He even did work that presaged today's drone technology.
After 16 years as a software engineer and entrepreneur, Ham cashed in his chips and began a hugely consequential career as one of Boston's super angel investors. He was the engine behind the relaunch of Launchpad, one of the country's most respected angel groups. In a frank and accessible interview, Ham discusses the workings of this group, talks about companies that excite him and addresses current trends in the ambit of angel investing.
Topics covered include:
Ham Lord Bio Ham Lord Discovers His Love of Computer Programming How Ham Lord Connected with His First Job After Brown Building a New Display for the F-14 Navy Jet Why Ham Lord Founded His First Startup AVS Rises from the Ashes of Stellar Ham Lord's Transition from Software Development to Marketing After 16 Years Building Startups Ham Lord Takes a Sabbatical Year & Starts Investing Ham Lord Discovers Angel Investing Ham Lord Relaunches Launchpad Ham Lord & Christopher Mirabile Get Together What Does Ham Lord Look for in a Startup? The Ones That Got Away Ham Lord's Favorite Pivot Story Ham Lord & Cambridge Trust Ham Lord Talks About Launchpads' Early-stage Track, the Catalyst Program Two Companies in the Machine Learning Space – Netra.io & Smartvid.io Seraf-investors.com & Seraf Compass Trends: Professionalization of Angel Investing & the Angel Capital AssociationWed, 02 Jun 2021 - 47min - 444 - Vivek Ganesh and Jay Shah - Controlling Epilepsy
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
Sal's Syndicate List: Click to Join
4,000 people per year die in the US from uncontrolled epilepsy, many of them young. Vivek Ganesh and Jay Shah started Neurava to build sensors and algorithms to prevent such deaths. Here's my chat with these doctoral candidates from Purdue trying to bring their tech from the lab to the market.
Highlights:
Sal Daher Introduces Vivek Ganesh and Jay Shah of Neurava "looking to develop a wearable device for epilepsy patients at risk for sudden unexpected death" The 40% of Epilepsy Patients with Uncontrolled Epilepsy Are at Risk of Sudden Death People Who Die from Uncontrolled Epilepsy Tend to Be Young The Neurava Algorithm and Device Are Meant to Detect SUDEP as It's Occurring So the Patient Can Get Help Neurava Has Top Advisors on the Technology and on the Clinical Aspects Neurava Is Hoping to Test Its Devices on Patients at Epilepsy Monitoring Units Patients Whose Epilepsy Is Still Uncontrolled After the Administration of Three or More Drugs Are Referred to Surgery Another Strategy to Control Epilepsy Is the Implantation of "Pacemakers" for the Brain Patients with Uncontrolled Epilepsy Have to Wait Months to Get into an Epilepsy Monitoring Unit Founders' Entrepreneurial Journey "My grandfather used to have a toothbrush factory out in India…" "Epilepsy and SUDEP in specific is one area where there really wasn't anything that people are using." "Our relationship is very strong; we work very well together." People with Uncontrolled Epilepsy Should Reach out to Neurava.org Closing Thoughts from Vivek Ganesh and Jay ShahWed, 26 May 2021 - 30min - 443 - Ed Roberts, MIT's Startup Prof
Ed Roberts started the scholarly study of startups. Learn from this brilliant academic pioneer and seasoned investor in Sohu.com and HubSpot about the keys to success in founding a tech company. Along the way you will be entertained and charmed by his most engaging narrative style.
He grew up in working-class Chelsea, Massachusetts. At Chelsea High, he received preparation that would allow him to explore the academic delights offered by MIT's curriculum.
Four MIT degrees later he was on the faculty at MIT's Sloan School of Management studying the impact of NASA's research on the economy. From there it was a short hop to founding the study of tech startups. He also co-founded two successful companies, including Meditech. His course on entrepreneurship incubated Beijing's Sohu.com and Boston's HubSpot. Ed Roberts was an early investor in both.
The oft-cited result that companies founded by MIT alums generate revenues equivalent to the 10th largest economy in the world is one of the products of his scholarship. He also delves into his work on the optimal composition of founding teams.
Among the many topics covered in this bravura interview are:
Ed Roberts Bio High School in Working-class Town of Chelsea Thoroughly Prepared Ed Roberts for Success at MIT Sound Preparation from Chelsea High Allowed Ed Roberts to Explore the MIT Curriculum Ed Roberts Meets Jay Forrester, Co-inventor of the Core Memory and Founder of System Dynamics Research into Entrepreneurship Springs from NASA Project to Measure Impact of Its Technology Ed Roberts Starts His First Company, Pugh-Roberts Associates MIT Faculty Form Consulting Firms, MIT Grads Form Product Companies Ed Roberts Founds Meditech Engineers Debate the Need for a Marketing Person on the Meditech Team – Hired the Only Marketing Person They Knew Sal Daher's Pitch for Listeners to Give Back by Reviewing the Podcast on iTunes and Telling Others About It The Most Significant Results from Ed Roberts' Research It's Important Not to Keep Your Idea Secret but to Talk to Many People About It Eric von Hippel & User Innovation Ideas Are Overvalued – Person Who Has It Gets Too Much Credit – Pivots Are the Norm – Nobody Remembers All the Pivots – Example: Founders of HubSpot Ed Roberts Invests in Founders, Not Ideas Charles Zhang & the Founding of Sohu.com – Ed Roberts Was Surprised Charles Zhang Wanted to Return to China – Amazing Story! "I've always focused on ground zero companies. I do not regard a ground zero company as a frightening and risky thing. I regard it as the place to be because that's where the fun is, that's where you can have impact and, to me, if you've passed my test, that you're passionate, you're dedicated, you're trying to do something that seems worthwhile, you're smart, you're open. I'm going to be able to relate to you. Then, I don't see it as a risky thing". Data on PhDs as Founders? Why Are MIT Students & Alums So Likely to Invest in Startups? 30% of MIT Alumni Go to Work for a Startup – Of Those 25% Go on to Found Their Own Company – Those Companies Outperform the Market Second Companies Outperform First Companies; Third Outperform Second – Studies of Universities as Sources of Innovation – Chuck Easley Did Similar Study at StanfordWed, 19 May 2021 - 1h 31min - 442 - Arrigo Bodda - Startup Italy
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
Italy, an advanced country of 60 million people, gets 20 times less startup money than Boston. My angel investing buddy Arrigo Bodda thinks there's ample room for growth. He is working with 42N, a consultancy focused on bringing Italian startups to the US. At the junction of design and cleantech, Italy has intriguing things to offer.
Highlights:
Sal Daher Introduces Arrigo Bodda, Angel Investor Arrigo's Startups: TireTutor, the Marketplace for Buyers of Tires TireTutor Connects Buyers with Independent Local Suppliers The Startup Scene in Italy Is Beginning to Develop com, a Marketplace for Design Items Sal's Italian Designer Office Chair The 42N Initiative to Mentor Italian Startups Room to Grow: Boston & Cambridge Get 20X the Startup Funding of All Italy "This hunger to succeed is not something that is unique to the United States." com: Design Objects the Generate Solar Power "What if your sculpture could charge your Tesla?" 42N Is Working with Cleantech Open Accelerator to Find Italian Startups Black Soldier Fleas to Break Down Organic Waste in the Home 20 to 1 Weight Reduction for Organic Refuse Self-Adjusting Ecosystem of Black Soldier Fleas in a Small Form Factor 42N Plans to Work with Startups and Private Companies Acquired a Producer of Plant-Based Protein in Latvia Becoming an Advisor as a Prelude to InvestingWed, 12 May 2021 - 43min - 441 - Wan Li Zhu - VC Wisdom
The family of Wan Li Zhu emigrated to America seeking new opportunities. Wan Li benefited from high-quality public education at Bronx High School of Science and went on to a perfect grade-point average at MIT. He studied under renowned quant wiz Andrew Lo and was poised for a career on Wall Street but was lured away by the prospect of hands-on responsibility for product features at Microsoft. After a prodigiously successful stint, during which he was involved in building and marketing Dynamics CRM, Microsoft's fastest-growing product, he went to Harvard Business School. From HBS he was recruited by early-stage VC firm Fairhaven Capital.
The firm, known for its expertise in web security and digital advertising, now sees promise in various applications of artificial intelligence starting with self-driving technology. Wan Li is deeply engaged in bringing on the next generation of winning investments at Fairhaven Capital. Despite a busy professional life, Wan Li Zhu has found time to advise startups and to co-found MIT Angels in Boston. I learned a ton from my conversation with this wise, yet unassuming early-stage VC and angel.
HERE'S A LIST OF THE TOPICS COVERED:
Studied with MIT Professor Andrew Lo – Used Natural Language Processing to Assess Market Sentiment
Why Wan Li Zhu Went to Microsoft – Three Years at MS – Shipped Three Versions of the Product
Wan Li Zhu Connects with Fairhaven Capital through HBS Resume Book
Fairhaven Capital Is Thesis-driven – Attentive to Market Trends that Could Create Large Opportunities
How the Fairhaven Capital Portfolio Is Doing
What Wan Li Zhu Looks for in a Startup Investment
Experienced Founders Can Actually Time Markets
TVision Came Via MIT Angels – Measuring Engagement of TV Viewers
AirFox – Enabling Wireless Carriers to Offer More Affordable Data Plans
MIT Angels Company PathAI's Deep Learning System Is Better at Detecting Tumor Cells than Human Pathologists
Latch – Enterprise-grade Keyless Access System for Apartment Buildings
The Investment Wan Li Zhu Regrets Not Making
Wise VC Wan Li Zhu Continues to Be Very Bullish on AI
Wed, 05 May 2021 - 38min - 440 - Hall Martin, Austin-Based Super Angel Investor - Plan the Exit Before Investing
Sponsored by Peter Fasse of Fish & Richardson, Patent Attorney: https://www.fr.com/team/j-peter-fasse/
Austin-based super angel Hall Martin has an intriguing approach to investing in technology startups that can benefit investors and founders. He's also done quite a bit of equity crowdfunding. This interview was rich in lessons for me. I recommend you listen.
"…my conclusion after looking at it 20 years, it's not that I'm investing in the wrong deals. I'm investing with the wrong deal structure."
Highlights:
Sal Daher Introduces Hall Martin, Super Angel from Texas "Put my money in. In about six months, lost all of it. I started to realize this is harder than it looks and decided I needed to join a group to invest in, rather than do it by myself." "In Austin, we didn't have an angel network until about 2006. When they started it, I was the first member to sign up for it." "We got about 5 million invested in 20 deals and got a 40x return out of one of the deals." "We were in the home of Whole Foods. We started accelerator incubator and we started doing angel investing as well into food and beverage deals, mostly." "I found is that it's very hard to make a return in angel investing. You're in these deals a long time." "Half the deals that are coming through here are good businesses, but they're not really venture businesses. They're not going to sell for 40 or 50x." "I came up with a model called Define the Exit, where I came up with my own term sheet, I discovered that was a key factor of success with angel investing is you don't sign someone else's term sheet; you sign your own." Built in Option to Exit at Year Three "When they go on to market-rate salaries, what they're basically saying is we're not eating ramen noodles anymore, we're going to take our exit out of the salary. You, unfortunately, are not on the payroll, and you don't get that choice." "Seven years later, they exit the business and there was a 50% return to the investors. Well, 50% after 10 years is about a 4% IRR. It's really not much of anything. I went back and looked at it. I estimate this executive team took out about $7 million worth of salaries over those years…" "If the C team is going on the payroll exit, I'm right there with you." Define the Exit versus Revenue-Based Finance "My experience has been, so far that 70% want you to leave all the money in and 30% want you to take all the money out because they want the equity back." "…if in three years I have a choice of pulling 3x my money out, the dynamic is very different." "It's also a Facilities Management A What it is, is we get access to the bank account and to the accounting system. Every month, we go in and pull out the information rights that are owed to the investors and we send it to the investors." "…my conclusion after looking at it 20 years, it's not that I'm investing in the wrong deals. I'm investing with the wrong deal structure." Crowdfunding: "The rule of thumb in that world is you're going to spend 20% of your fundraise on marketing. There's a real expense." "I think a fair number of angel groups I see are moving to later stage to move out of the way of that [crowdfunding]. Some are moving into starting their own funds or going into a syndicate model where they can get carry from those who invest." Scrappy Biotechs: QSM Diagnostics & Hillside BioSciences CSIdentity: Hall Martin's 40X Exit Parting Wisdom from Hall Martin, Super Angel "For every million dollars you want to raise, it'll take you one calendar year to raise it. It's the rule."Wed, 28 Apr 2021 - 35min - 439 - Tivan Amour, Repeat Founder - Growth Rider
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
Tivan Amour, repeat founder, bristles with energy but is also capable of contemplation. He is a growth hacker familiar with the Socratic Dialogue. He is hugely ambitious yet generous with the less fortunate. It was great fun interviewing him and he taught me a bunch of things. Among these were the real value of Techstars to founders and some pointers on growing a customer base.
Here is a list of the topics covered:
Tivan Amour Bio What Effect Did Working for AT&T While Still in College Have in Tivan's Life? Tivan as a Product Manager at Abercrombie & Fitch Tivan Starts His First Company Tivan Decides Boston Is Just Right for Him What Tivan Learned from Volunteering at BUILD How Tivan Structures His Day Tivan's First Company Pivots Genesis of Fortified Bike – New Way to Market to Bike Shops – Cutting Out Distributors Fortified Bike Goes into Techstars The Real Value of Techstars to the Founder Changing Co-founders com Has Won Plaudits from Experts for Its Efficacy – Tivan's Advice on Building a WebsiteWed, 21 Apr 2021 - 52min - 438 - Bill Arnold, Ben Littauer & Sal Daher, CFA - What Angels Do
Bill Arnold of Purdue University's innovation center asked me to put together a panel discussion about what makes Boston's startup ecosystem so strong and how these lessons might translate to other places. Naturally I invited my angel investing buddy Ben Littauer to participate and we had a productive chat which gives founders, and prospective angels, a valuable glimpse into how angel investing works.
Wed, 14 Apr 2021 - 45min - 437 - David Chang, Repeat Founder and Angel, Ex-PayPal and Goldman Sachs
Sponsored by Peter Fasse, Patent Attorney at Fish and Richardson: https://www.fr.com/team/j-peter-fasse/
David Chang seems to have a lifetime of achievement behind him. Six startup exits, stints with TripAdvisor, PayPal and Goldman Sachs as well as close connections in the world of VCs give David a most informed perspective on startups. In this candid and instructive interview, David highlights the dos and don'ts of tech startups in clear and engaging prose. He provides a wealth of suggestions on how to approach markets and technologies.
He immigrated to America from Taiwan as a child and grew up on Long Island. David Chang distinguished himself in computer science as an undergrad at Cornell. Later on he attended Harvard Business School after seven years on Wall Street.
Topics covered in this interview include:
David Chang Bio Came to US from Taiwan with His Family at Age 3 – Grew Up on Long Island Job Market Tight in 1992 – 38 Rejection Letters – 2 Job Offers – Wall Street vs. Silicon Valley Applied to Harvard Business School Thrice - Third Time Lucky – Stays in Boston Working at a Small Startup Dumb Luck Had Brought Him to a Phenomenal Company - edocs Co-founds Mobicious – Just in Time for Financial Crisis Quits Fulltime Stable Job – Decides to Start Company – Daughter Is Born – All in One Weekend! Mobicious Sells for Pennies on the Dollar – Thought Would Never Work in Tech Again – Lands in Where, a Company into Location Awareness – David Beisel of NextView Ventures Decision to Sell Where to PayPal Genesis of Where Angel Fund David Chang's Biggest Failure as a Startup Operator – Lacked Focus on First Startup – Guardrail to Guardrail The Role of Thrift in Startups How David Chang Came to Make His First Angel Investment Great Startups David Chang Passed On Why Is David Chang Not a Full-time VC? David Chang's Advice to Startups Raising Money Be Clear About What's Your Basecamp and What's Your Summit What David Chang Looks for In a Founding Team David Chang's Favorite Pivot – TripAdvisor Stumbles upon the Idea of Doing Reviews Startups David Chang Is Excited About Nightmare Mistakes Founders Make How Do Founders Decide to Raise Another Round or Shut Down? The Value of Knowing Your Place in the Market You ServeWed, 07 Apr 2021 - 47min - 436 - Raza Shaikh, Founder, Angel and Podcaster
Sponsored by Peter Fasse of Fish and Richardson, Top Patent Attorney: https://www.fr.com/team/j-peter-fasse/
A successful founder who has become a respected angel investor in Boston, Raza Shaikh is a pleasure to speak to and to learn from. Raza also has a podcast called On Boards which is great for people who are on boards or would like to be.
Highlights:
Sal Daher Introduces Raza Shaikh, Founder, Angel & Podcaster "I started angel investing actually on AngelList a bunch of years back and realized that that's a little hands-off and you don't connect with the companies for real." Sal Daher Speaks Up for Syndicate Investing Raza Shaikh's Favorite Startups: MentorWorks the Income Sharing Agreements Platform "…the founder, Karthik, is a professor at Northeastern and a Launchpad member, but knowing the higher education space, he really thought that there was an opportunity for an alternative to student loans…" Raza Shaikh's Favorite Startups: KUVA Is a 10X Cheaper Way to Find Gas Leaks Raza Shaikh's Favorite Startups: RaySecur Uses Millimeter Waves to Scan Incoming for Hazards Raza Shaikh Talks About His Fund: Beacon Venture Partners Sal Daher Talks About Peter Fasse of Fish & Richardson Who Sponsors the Podcast Raza Shaikh Bootstraps His First Startup, and His Second What Motivated Raza to Found His First Company Raza's First Angel Investment Raza Shaikh's Parting Thoughts Raul Rosa's Startup, PodSpotWed, 31 Mar 2021 - 46min - 435 - Jay Batson - Open Source Dude
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
Jay Batson is an angel investor's angel investor. He's the kind of guy who people like me, and lots of other people, go to ask really tough questions about angel investing. And, he always has really thoughtful ideas. Whenever I'm puzzling over something, I reach out to Jay. If I can get 10 minutes of his time it's really precious. I really recommend this relaunch of my first interview with Jay Batson.
It is rare to hear reports from the frontiers of technology expressed so lucidly and accessibly by a real insider. This gem of an interview rewards the listener with Jay's sensible and eloquently expressed explanations of the pitfalls of building products and companies. Jay recounts how angel investing taught him things he wishes he had known as a founder. He closes with wise words to recent college grads thinking of founding a startup.
Jay Batson started out as a land man helping oil and gas explorers secure drilling rights. Computerizing part of his work led to his first startup. This made him realize that he loved technology. He would eventually embody this passion for tech in the founding of two venture-backed companies which brought significant innovation by way of the open source movement.
Here are some of the topics included in this podcast:
Sal Daher's Intro: "Jay Batson is an angel investor's angel investor." Jay Batson Bio Born to a Family of Entrepreneurs – Land Man Studying Law at Night – Tech Founder Jay Batson Exits first Startup – Learns UNIX & C - Heads to Job with BBN in Boston – Massively Parallel Computing Jay Batson Goes from Engineering to Product Management At Forrester Research, Jay Batson Foresaw some of the Internet's Potential Desktop Internet Phone – Pingtel – SIP – Bits of Code We still Use Today The Story of Acquia Open Source Primer Jay Batson Gets into Angel Investing What Jay Batson Looks for In a Startup What Jay Batson Has Learned from Being an Angel Investor Technique Jay Batson Uses in Mentoring Startups What Do Startups Most Frequently Not Do Well? Jay Batson Relates the Story of Pingtel's Pivot Jay Batson's Eloquent Statement of the Value of a Working Board of Directors Jay Batson's Advice to Recent College Grads Thinking of Founding a CompanyTopics: software, product, management, exits, boards, discovering entrepreneurship, founding story
Wed, 24 Mar 2021 - 45min - 434 - Joe Falcão, CFO and Employee #5 at Thrasio
Sponsored by Peter Fasse, Patent Attorney at Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
Joe Falcão is the CFO of Boston-based unicorn Thrasio. Learn the secrets of this uniquely successful startup. Retrace my friend's exciting journey which started in Kenya and led to Boston via Brazil and other interesting places.
Highlights:
Sal Daher Introduces Joe Falcão, CFO & #5 Employee at Boston-based Unicorn Thrasio "Always be open to meet people." "…we are playing within the Amazon ecosystem by acquiring Amazon third-party sellers." "…what we are buying is basically a proven customer experience and a proven supply chain that they can use in our platform and build in scale." "…from that point, onward it becomes very time-consuming or capital onerous for them to grow and scale. And that's a sweet spot where Thrasio can acquire these companies." "And we want to make sure that they feel pride in what we are growing and helping them out." "…we've got a unicorn status in the summer." "…what we want to do is provide awesome products for the customers." "One other element I will suggest for the founders of companies is to understand their numbers, the flow very well. How the company makes money, the business model." "…create a strong relationship with investors, because investors can help you." "Your mom may be more interested in your success, but your investors are second, a very close second." "…doing the right thing and build up strong trust and relationships. That's the cornerstone of everything I do." "Vasco da Gama went to India, and that was the startup of 500 years ago." "…every company I joined, I tried to pick up a corner of the company, which had problems that needed to be fixed." How Joe Met His Wife Cheryl on a Trip to IndiaWed, 17 Mar 2021 - 34min - 433 - José Falcão, Chefe de Finanças da Thrasio
Patrocinado pelo Peter Fasse, advogado de patentes da Fish & Richardson: https://www.fr.com/team/j-peter-fasse/
José Falcão, Chefe de Finanças da Thrasio explica o que motiva esta companhia que adquire comércios na Amazon.com. Falamos também sobre a jornada de sua vida pela Africa, Asia e o Brasil.
Wed, 17 Mar 2021 - 28min - 432 - Arrigo Bodda, International Angel Investor
Sponsored by Peter Fasse, Prominent Patent Attorney at Fish & Richardson (https://www.fr.com/team/j-peter-fasse/)
Growing up in Northern Italy, Arrigo Bodda dreamed of becoming an architect. He chose instead to study law, a handy pre-requisite for a career in human resources in a country where staffing involves a lot of legal work. His corporate career neatly coincided with the emergence of the European Union, a phenomenon that deeply influenced his work and life. After much success in the executive suites of global enterprises, Arrigo now has the opportunity to pursue his passion for design and architecture as an angel investor with Walnut Venture Associates and as an entrepreneur.
In this lighthearted interview, Arrigo shares some of the valuable wisdom gained in navigating large multinational enterprises across cultures and across disciplines. He offers valuable suggestions for founders of startups seeking to do business with multinational companies. He also provides an appealing model of finding the right balance between following your passions and making concessions to reality.
Topics discussed in this podcast include:
Sal Daher's Intro of International Angel Investor Arrigo Bodda Arrigo Bodda Bio Living & Working in Europe vs. in the United States The Secrets of Successful Cross-cultural Relations in the Workplace How Arrigo Bodda found His Career Path – Deep Wisdom on Career Development from an HR Specialist "The suggestion that I have for everyone that is listening now, and that they are thinking where I should make my first move, my recommendation is make your first move in a place where the people around you are better than you." European Union 2.0 Tips for Startups Navigating Huge Multinationals The Value of an MBA from IMD Starting a Company in Thailand What Kind of Companies Arrigo Bodda Likes to Invest In What Does Arrigo Bodda Look for in a Founding Team? Don't Invest in Startups Alone – Join a Group, It will Save you Money & Be More Fun than Investing AloneWed, 10 Mar 2021 - 51min - 431 - Bill Hetzel - Clean Tech Exec and Angel Investor - Startup Success in Maine
Podcast Sponsored by Peter Fasse of Fish & Richardson
Dropping prices for solar panels sank many American clean tech companies. PIKA Energy, however, was able to benefit from the trend by innovating. Generac acquired them in 2019 because of their uniquely efficient home energy storage system. Bill Hetzel, former COO, tells the compelling story of this Maine Angel (and Sal)-backed success and more.
Highlights:
Sal Daher Introduces Bill Hetzel, Clean Tech Exec & Angel Investor "The original idea behind Pika Energy was to make the world's lowest cost, highest efficiency home/residential wind turbine." "His wind turbines sold for around $10,000. They were sized to power part of your home." "Every year, as we developed our wind turbine, the price of solar dropped faster, and that means one thing to a startup, pivot." "…one of the great things about Pika Energy…were these power electronics and the power electronics we had had a special capability. It meant that each part of the system controlled itself without some fancy engineer coming in and programming it." "You mean you had a more elegant design than Elon Musk's design?" "Well, our batteries, too, didn't come in one big, five-person carry Powerwall-sized monolith. Our models came part by part and you built them on-site for the battery as well. A solar installer felt very comfortable." "The business community in Maine is really human-scale... I mean, you can get to know everybody and it's very supportive. I've invested in three Maine" "I just got on the phone and I called up Ben [Ben Polito, co-founder of PIKA] and said, "I'm interested in learning more about your company." Ben and Joshua, who are like all good entrepreneurs, were willing to open up their network." "Pika Energy stood out as it was a small, but a seriously well-run company. Did things well, took care of investor money. It was serious about that." "I think one of Pika's big strengths was the ability to listen to advice, and Ben Polito, the CEO, was really good at this." Excellent Monthly Reporting to Investors Made Follow-On Rounds Much Easier "And we cycled and got better with each cycle." "We got better at what we did and that made a huge difference when we were ready to pivot because we already had a foundation of business processes, and so our pivot wasn't the entire company." "We showed them [Generac] a demonstration of our product and they were just thrilled. They'd been working on it in-house to build it themselves. They had looked at competitors and they were sophisticated enough and far enough along in their own investigation of this that they recognized our patented power electronics were special." Angel Investing in Maine – A Strong Statewide Ecosystem "Maine Angels tend to go out of their way to support the company, not just in terms of money, but also in terms of advice, connections, providing all of the resources that the companies need." Eighty Percent of Success Is Showing Up During a Maine Snow Storm ORONO Spectral Solutions – Highly Efficient Water Screening HighByte – Making Information from the Industrial Floor Easily Available for Analysis Junora – Tech for Depositing Thin Film of Different Elements on Architectural Materials VETRO – Mapping Optical Fiber Networks "…I can say that there's a certain pride that Maine has, and the Maine Angels have that same feeling and it makes for a really close-knit community. It's really a joy to work with this group of people."Wed, 03 Mar 2021 - 41min - 430 - Peter Fasse, Patent Attorney and Angel Investor - Patents 101
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Peter Fasse comes from a family of patent attorneys. He is a highly respected partner at Fish & Richardson, the storied Boston-based (now global) firm that represented Alexander Graham Bell, Thomas Edison and the Wright Brothers. Peter's work continues that tradition by representing some of the leading technological innovators of today. Peter also invests as an angel in technology companies. In this practical and accessible conversation he revealed valuable insights and resources for founders and investors in technology companies. He also relayed some interesting and instructive stories of intellectual property success and calamity.
Among the topics covered were:
Introduction by Sal Daher of the Interview with Peter Fasse, Patent Attorney Peter Fasse Bio Young Cornell Grad in Textiles & Fabrics Becomes Patent Office Examiner Peter Fasse's Practice In What Areas Is it Important to Have Patents and Why? Software Patents, Why Have Them and Why Not? Supreme Court Taking Harsh Views on Patents Patent Attorney Horror Stories – Theft, Suicide, Rogue Wave, Bear Mauling & Hasty Firing How Institutions Can Claim Intellectual Property of Employees Freedom to Operate – Should Be a Big Concern for Tech Startup Founders & Investors "There's a common misconception that if you have a patent on something, that it allows you to practice and commercialize that invention, but that's not true." Different Levels of Freedom to Operate Analysis Two Extreme Freedom to Operate Cases & Outcomes Strong IP Position a Vital Ingredient in Sale of Tech Startups Mass Tech Transfer Center (MTTC) Is a Great Resource for Technology Startups Transcytos & SQZ Biotech Most Patents Are Not Commercially Viable, But Fish & Richardson Has a Special Package for Highly Promising Startups – Fish Steps Unsolicited Client Testimonial for Peter Fasse! Why Investing Through a Vehicle Rather than Directly Can Make Sense Trade Secrets – Formula for Coca Cola Trademarks – Frequently Overlooked Trouble with Chinese Partners – Capital Controls & Theft of Intellectual PropertyWed, 24 Feb 2021 - 56min - 429 - Meng Deng, PhD and Karen Wurster - Convert Fat to Cure Diabetes
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What if an injection could cure your diabetes? Meng Deng, PhD and Karen Wurster were on the podcast to talk about Adipo Therapeutics' ambitious plan to remake the metabolism of diabetic people. Informative and accessible.
Highlights include:
Sal Daher Introduces the Founder and the CEO of Adipo Therapeutics "…we're talking about having too much white fat and not enough brown fat." "…transform that energy-storing white fat into energy-burning brown fat." "…a nanoparticle that you inject into the white fat and it converts the white fat into brown fat…" "…you can eat the same amount and continue to lose weight." "…because the sizes are so small that the particles are easily uptaken by the fat cells…" Adipo Will Need Five to Six Million Dollars in Funding to Get to a Deal with a Strategic Player "…it's a large market that has a proven, well understood regulatory pathway." Purdue's Entrepreneurial Infrastructure Was Vital to Getting Adipo Off the Ground, According to Founder Meng Deng, PhD The Podcast Is Sponsored by Pater Fasse of Fish & Richardson Karen Wurster Took Early Retirement at Eli Lilly and Was Looking for an Entrepreneurial ActivityWed, 17 Feb 2021 - 33min - 428 - Frank Ferguson - Practical Dreamer
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Frank Ferguson had a knack for building companies. He headed Bose at a time of rapid growth and built Curriculum Associates into a great success. Frank Ferguson's angel investing was unusual in that he invested in just a few startups but lavished support on those few. The results were great. Frank was active well into his nineties but passed away recently; this relaunch of an interview I recorded with him is a memorial for his life of achievement and passion. It's loaded with lessons for angels and founders. Rest in peace, Frank Ferguson.
My favorite observation from the conversation with Frank Fergusson neatly encapsulates his recipe for success as an investor:
"You can get sucked in and fall in love with a lot of things, but then you have to ask, "Are these the guys who can actually make it happen?" What are the odds that these guys can keep together, not fight, get over it, be successful, run things correctly, not fall in love with their own things so much that they lose track of the financial realities of the business? Can they sell?"
Click Here to read the transcript of the interview.
TOPICS DISCUSSED INCLUDE:
Yes, That Bose Corporation! Curriculum Associates, Which Frank Ferguson Built, Continues to Be Hugely Successful Scraping Chicken Droppings in an Iowa Farm From Iowa State University to Teheran Courtesy of Syracuse University & the US State Department Frank Ferguson Thinks about Business School at MIT or Harvard Thanks to a Friendly Psychologist With an MIT Sloan MBA in Hand, Frank Ferguson Goes to Work at Baird Atomic Near Harvard Square Frank Ferguson Meets his Co-founders at Curriculum Associates Just as He Starts Work at the Bose Corporation Frank Ferguson Invests $80,000 in Today's Dollars in Curriculum Associates Circa 1959 - Money Saved through Frugal Living in Iran How Frank Ferguson Connected with Amar Bose, Founder of the Bose Corporation Frank Ferguson Invests in the Bose Corporation Amar Bose Invites Frank Ferguson to Be President of the Bose Corporation in 1969 Frank Ferguson Moonlighted at Curriculum Associates while Running the Bose Corporation Frank Ferguson Left the Bose Corporation When it Was Experiencing Growth of 70% per Year to Get Curriculum Associates off the Ground Amar Bose, Brilliant but Difficult at Times Frank Ferguson Succeeds in Educational Publishing, a Notoriously Tough Business, by Finding a Niche – Differentiated Instruction Curriculum Associates Succeeds but Discord Arises Over the Purchase of a Water Cooler! Competition Gets Rough in the World of Educational Publishing Curriculum Associates' i-Ready Succeeds by Measuring Progress of Individual Student to Help Teachers Better Support Students – Teacher Training a Pivotal Element of i-Ready's Success Before Teacher Training Was Required i-Ready Saw No Gains – With Teacher Training Student Gains Are Dramatic! Ugly Truth – Fifth-grade Teacher Has Three to Five Year Grade Span in Her Classroom Lev Vygotsky, Seneca The Younger & Andrew Bell of Madras College – "By Teaching We Learn" "Talk to Me Baby – How You Can Support Young Children's Language Development" by Betty Bardige Visionary Entrepreneurs Need to Hire Grunts Who Are Really Good at Execution – Frank Ferguson Was the Grunt & Amar Bose Was the Visionary How Amar Bose Hired the Smartest of the Smartest for the Bose Corporation Family with 11 Children Uses the Madras Method Whereby the Elder Learn by Teaching the Younger Sign Up at AngelInvestBoston.com to Hear About Upcoming Free, In-person Events – do Review Us on iTunes Frank Ferguson, Practical & Involved Philanthropist – Lionheart Foundation – Robin Casarjian Frank Ferguson Does Nothing in Half Measures – Elon Musk Would Approve Frank Ferguson - Angel Investor in the Bose Corporation and Curriculum Associates – Participated in the Baird Atomic IPO Hugh Stoddard, Father & Son, Piali De & Senscio Systems Amos Tversky & Daniel Kahneman, "Thinking Fast & Slow", "Nudge" by Cass Sunstein and Richard Thaler Frank Ferguson Connects with Will Graylin, Invests in Loop Pay Now Samsung Pay Will Graylin and ONvocal Frank Ferguson's Approach to Angel Investing – Invests Where He Finds the People and Technologies Compelling – Few Enough Companies So He Can Make a Real Difference People Come up with Great Ideas, Great Markets but Sometimes Forget that there Is Friction in the World Lessons from Iran for Angel InvestorsWed, 10 Feb 2021 - 1h 10min - 427 - Matt Breen, Founder - Rahoo Baby
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The hardships faced by parents of babies with developmental problems led Matt Breen and his co-founder / fiancée, Erica Costa, both pediatric occupational therapists, to start Rahoo Baby to make it easier for parents to support their baby's development.Their first product is now at buybuy BABY and Target. A fun chat with a down-to earth founder.
Highlights:
Sal Daher Introduces Matt Breen, Founder of Rahoo Baby "…how acutely aware parents have become about how important brain development is from birth to three years old…" "…something's happened to them or they've just fallen behind in one category of development." "…he's not rolling independently at five months old, but quite literally within two minutes of this session starting with this baby, by implementing just the most simple fundamental therapy technique, this baby was rolling over independently from his back to his belly once, twice, three times." "We can be curating education for parents that gives them the ability to help their own baby reach these developmental milestones…" "…not only is tummy time important for strengthening, but it also reduces pressure on the back off the baby's head." "The way it supports tummy time is because it makes far more engaging for the baby and the parent together." "We are in buybuy BABY which is the number one premium baby wear We're launching with Target in just a couple of months." "One of those advisors… he has hands-on experience in this industry working directly with factories, overseas, going all the way from the design phase to the supply chain phase, to your own warehouse." "…we're really going after is building a brand that's really synonymous with early childhood development, early childhood well-being…" "We want parents to feel comfortable around this idea that their baby is working towards developmental milestones." "We're trying to make sure that all parents can have access to these tools, this information that sparks early childhood development." "We know the bumps in the road where babies tend to stumble developmentally." Matt's Co-Founder Is His Fiancée "Erica and I together, we are a really, really strong team, but separate. We wouldn't have had any success so far, I'm sure of that." Matt Breen Points to Valuable Advice from Ed BeloveWed, 03 Feb 2021 - 47min - 426 - Nick Zeckets - Growing Revenue
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Founder and revenue consultant Nick Zeckets and I discussed his first startup and what he learned from it. Then we talked about the best ways for startups to build revenues. Instructive and inspiring.
Highlights include:
Sal Introduces Nick Zeckets, Founder & Revenue Consultant What Quadwrangle Does "What is already out there that I can make better? I don't want to replace it, at least not on day one." "…first and foremost, and I heard it 1,000 times and I never really got it, but it was to fall in love with the problem and not the solution." "The sales process was there… the product wasn't ready." "Oftentimes, it's just like any good advisor, it's just asking some really concrete questions." "Because everything's a referral economy at this point." "Her trick was that she was the most methodical person you could imagine… Bottom line was that she had a sales process." "…the founder's out there doing the selling. The founder is the one picking up the cash. And it is almost impossible… to templatize that passion." "…remarkably common amongst startups is a real... In small companies in general, is a lack of belief in their own value." "there's a lot of this stuff that between software and freelancers and on-demand services, you can look like an absolute marketing juggernaut." "And otherwise, these on-demand services are incredible. It just doesn't cost that much, and so I love modeling that out for companies." "…I was a fairly prolific hustler in high school, and even in elementary school." "…if we shine a light on the bad stuff as soon as we can identify that we've got bad stuff, it's going to kill that mold." "Follow the process." "Again, it's the truth will set you free in all things."Wed, 27 Jan 2021 - 46min - 425 - K. Woodman-Maynard - The Business of Being an Artist
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Artist K. Woodman-Maynard discusses her gorgeous graphic novel interpretation of The Great Gatsby, the business of being a graphic artist and other engrossing matters. A delightfully different interview with a charming guest.
Highlights include:
Sal Introduces K. Woodman-Maynard, Creator of The Great Gatsby Graphic Novel "Color is gorgeous. The drawings are extremely expressive and interesting… the style of the period is displayed." "…I think it's a good way to get people who might not otherwise read The Great Gatsby, the prose book, interested." Cashflow from a Graphic Novel Is Inconsistent – Good to Have Steady Income from Graphic Design "…it was very painful for me to cut out specific lines, because I love those lines." "I'm in complete agreement that you shouldn't dismiss somebody's whole life's work just based on certain philosophies. It's a balance." "…it started by a very intense deep reading of the text…" "The whole book took about 1500 hours. That's actively time tracked hours." "…the first thing for a beginner that they need to know is that they can do it. You can make a living as a graphic artist." "I was encouraged to go into architecture because that was considered to be more stable for artists. I'm so glad I didn't, because I graduated college in 2008." "One thing that's been key for me has been diversifying my income. I have income from graphic novels. I have income from graphic design work, from illustration." "I think it's an important thing for yourself as a graphic artist to be able to pivot and to be able to work in different ways." "…finding good mentors. That's something that I would encourage your niece to do." "Going to Harvard has really helped me with asking stupid questions." "You can be a good business person and also be good at your craft." "The Great Gatsby was a commercial flop at the time that it was published." "He was making a huge amount. He would just spend it before he even got it, which is the direct opposite of me." "…a captive audience of troops who read The Great Gatsby and then returned and spread the word about it." "I'm wondering what's going to happen once the vaccine is out. Will we experience another Roaring Twenties in a different way?" "I do the Pomodoro method. …You work for 25 minutes; you take 5 minutes off. Then every two hours, you take a half an hour break." "In high school, we had to take career placement tests. I had equal likelihood artist and military officer." The Importance of Story Telling Addressing Mental Health Issues with Kids via Comics: TKAMI.org "I decided not to go into architecture because it wasn't my calling. Also, because I could see that it wouldn't be good for my mental health." "It's just gorgeous. I highly recommend this work."Wed, 27 Jan 2021 - 40min - 424 - Kristen Overly - Life Science Financing
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Kristen Overly works as management consultant and is a leader at MIT Life Science Angels. Kristen and I discussed various aspects of the funding of life science startups. She, like me, is intrigued by the opportunities in what Jeff Behrens called the scrappy biotechs in his doctoral thesis. Highlights include:
Sal Daher Introduces Kristen Overly of MIT Life Science Angels & Back Bay Advisors "…MITLifeSciAngels.com. And we look for companies that have some sort of affiliation with MIT, whether that's a founder or a board member or maybe a scientific founder or maybe the technology came out of MIT." "Who's invited to the [MIT Life Science Angels] meetings as potential investors?" "…. I remember it was kind of in the beginning times of Rubius Therapeutics because that was a similar-ish platform play to Remora." "I suspect he had a hard time raising money, not having had a Ph.D. He's a brilliant guy, he could have done it but in the life sciences, it's almost like joining a holy priesthood or something. You have to have your Ph.D." "… the increase in the number of SPACs recently. I think it just shows how different the life sciences industry is from the tech." "…you just have to believe in the people, sign a blank cheque and hope that they can do their jobs right." "But still the [SPAC] model is untested…. Acquisitions are hard. Most acquisitions fail…" "So basically 97% of the funding go to either life science companies that are created by the venture capital firms themselves or companies that have some kind of a star player, right?" "…when I was at MIT, I found myself frustrated because there were so many amazing technologies just kind of stuck in a lab." "The number of scrappy biotechs is about to skyrocket." "And there's a lot of not great AI technologies. People are just taking the open-source code and applying it and calling it a product and starting a company and getting money." An Intro to Radio Pharmaceuticals "…my senior year, I got a really bad concussion, freak accident." "Yeah, it was the hardest decision I had ever had to make in my life to take the year off at school. I mean, I was on this set path since I was born." I'm passionate about is that only about two percent of all VC funds overall go to female founded companies.Wed, 20 Jan 2021 - 49min - 423 - Chuck Donnelly and Julie Morrison - SaaS for Pre-Clinical Trials
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RockStep Solutions improves efficiency by 70% according to one client. This is why the startup is getting word of mouth traffic from clients running in vivo drug trials. Founders Chuck Donnelly and Julie Morrison tell their story and share valuable wisdom about this intersection of software and bio.
Highlights include:
Sal Daher Introduces Chuck Donnelly and Julie Morrison, the Founders of RockStep Solutions RockStep Provides a SaaS Solution for a Sector of the Drug Discovery Space That Is Poorly Served by Existing Vendors "The problem that we're solving is data chaos in drug discovery." "…we have one of our customers that's projecting a 70% efficiency gain." "We bring value to the pharmaceutical companies by speeding up that pipeline, reducing the number of errors that happen." "While I was at Jackson Lab… We recognized that there was this gap, if you will, that we just talked about. The NIH actually funded us." "One full day of my work week was designed to take all my data out of paper and put it into Excel even." "But they don't actually have any money." I said, "I'm not sure it matters at this point because I'm so passionate about the problem they're solving." "I can tell you that these equity-only deals work very rarely…" On co-founders: "You have to be aligned on your personal values because this is a marriage. In very many ways it's similar." "There's no question, your family is part of this company. You will not have a work-life balance." "Ultimately, if we don't get the pricing right, we're not going to succeed. You have to get your pricing right." "…they're just academic customers paying, I think our cheapest is $50 a user. Right now, in industry we're getting $1,800 per user. That's how different our pricing has scaled up." "We spent about a year and a half, two years, perfecting the product that we have out in our biopharmas today." "After a year and a half of doing that, we ended up with a product that is totally, uniquely positioned in the market…" "…if she had gone in thinking that she already knew it and she just was trying to validate it, she would be coming in with her own biases, almost telling the people, "This is how it should be done."" "If you have a toxic person or persons in the company, that goes through the entire company. You cannot; it will kill your company." "…a hire that almost tore the company apart, to be honest. It was a salesperson forced on us by an investment firm." "...we can teach anyone anything for the most part…But you can't really change someone's culture or their personality, their willingness to dig in." "First thing is that it takes a lot longer to raise capital than you might think. The other thing is that you're going to probably need more money than you think." Deep Wisdom on Grants: "All told we got three grants, total of 1.85 million… from the NIH. That was all great non-dilutive funding and life is good. But I would caution anybody who wants to continue living off of grants, don't do it." "We could have written another grant, but it's not going to be a market-driven product anymore, it's going to be a grant-driven product." "The market still needs to stop using paper and spreadsheets." "…it's hard. I spend a lot of my time raising money." "…our sweet spot really is the small, mid, to large biotech and global pharmaceutical companies." "…it feels good when you start seeing people coming to you on word of mouth." "…there are fires burning every day. It's overwhelming. The big mistake you can make is just trying to put every fire out because you're not going to make any progress." "…don't do it unless you're ready. This is the hardest thing you will ever do." "…manage burnout. Burnout is very real." "I would say another really important tip is you can't do this alone."Wed, 13 Jan 2021 - 51min - 422 - Entrepreneurs Journey - Ham Lord - C Mirabile - Joe Mandato
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Launchpad, Boston's leading angel group, has published a polished collection of stories that illustrate the success and failure of their portfolio companies over two decades. It is titled "The Entrepreneur's Journey". Listen to my interview of authors Ham Lord, Christopher Mirabile and Joe Mandato to learn more about this valuable resource for angels and founders.
Highlights from the interview:
Peter Fasse of Fish & Richardson Sponsors the Angel Invest Boston Podcast Boston's Answer to The Three Tenors, The Three Super-Angels "…back in 2012, started working with some of the members within Launchpad to understand why some of our companies succeeded and why some of them failed." "But there was something about that team that we just couldn't disengage." "…it was one of these software purchases ... unlike a lot of enterprise software ... that immediately paid for itself." "…if we had looked at Mobius and said, "No, hardware company, we're not investing," we would have lost out on an investment that ultimately is going to be a 35x return." "…Intuitive Surgical, where it violated every principle of venture investing. Right?" "…it was a 10 year, 35x. That is a beautiful, beautiful investment." "…I could sort of hear myself in some of these stories, and I've changed the approach that I'm taking in certain areas." "We included as much failure as success in this book. Every theme is illustrated by both companies that got lucky and got it right, and companies that didn't." "…One of the challenges is the timeline. For VC, the timeline, it's so long with the biotech's and that's really become problematic."Wed, 06 Jan 2021 - 43min - 421 - Ham Lord and Christopher Mirabile - Winning Collaboration
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The collaboration of Ham Lord and Christopher Mirabile, two of Boston's most consequential super angels, is widely admired. Its most visible fruit is the success of Launchpad Venture Group, which they manage together. In the relaunch of this revealing interview, they let us in on how this winning collaboration came to be and what keeps it productive as it approaches the end of its first decade.
Christopher Mirabile and Ham Lord are already familiar to our listeners. Each has been interviewed individually on earlier episodes of the Angel Invest Boston Podcast. In the current episode, the two different personalities interact and give us a glimpse into what drives their working relationship.
Click here to read the full episode transcript.
TOPICS COVERED INCLUDE:
Christopher & Ham's Remarkable Collaboration How They Connected Division of Labor Lucky to Have Jody Collier as Operations Manager Complementary Skills & Creative Tension What They Enjoy in Working Together What Motivates Christopher and Ham How Christopher & Ham Differ in their Investing Gene Gregerson, an Engineer's Engineer & Mobius Imaging – Astonishing Feat of Entrepreneurship Blind Spots: How Having a Partner Helps Avoid Them Integrity in the Founding Team is Essential – Due Diligence Screens Out Frauds Geographic Focus Makes It Possible to Add Value Dos & Don'ts for a Winning Collaboration How Ham and Christopher Work Things Out When Problems Arise Co-CEOs Raise a Red Flag but Can Work Trends Christopher & Ham See A Business Semyon Dukach Would Like!Wed, 30 Dec 2020 - 56min - 420 - Christopher Mirabile - Angel with a PlanWed, 23 Dec 2020 - 47min
- 419 - Mike Singer, MD/PhD - Polymath FounderWed, 16 Dec 2020 - 1h 01min
- 418 - Patrick Rivelli, Founder and Angel Investor - How to Invest In Biotech
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Repeat biotech founder and angel investor Patrick Rivelli talks about his career and about how to approach the daunting challenge of investing in biotech as an angel.
Family considerations drove several of Patrick Rivelli's career choices but did not prevent him from having brilliant triumphs. Success as a consultant was followed by success as an executive. This led him to found his first company and to fund another startup. The most eloquent evidence of his achievements was exiting two biotech startups in eleven years. If you are a seasoned biotech investor, I'm sure that grabbed your attention. Patrick was also instrumental in founding MIT Angels of the Bay Area and now leads the life science track at MIT Angels in Boston.
I learned a lot from this fun chat with Patrick. I hope it will be entertaining and instructive for you as well.
Note: When Sal talked about biotech booming circa 1996 he actually meant to say the internet. Biotech was still a backwater then.
TOPICS DISCUSSED INCLUDE: Patrick Rivelli's Bio Love Drives the Choice of Patrick Rivelli's First Job Family & Luck Steer One's Career Consulting at Bain Leads to Private Equity Bain Paid for Sloan MBA Work at Bain Was Different After Patrick Rivelli Graduated from Sloan Patrick Rivelli Gets Involved in the Life Sciences – Pharma Companies Had Medical Device Businesses Then Biology Was a Backwater in the 1990s – Then Human Genome Was Sequenced by 2003 Consulting Was Taking a Toll on Patrick's Family Life So He Took a Corporate Position Patrick Rivelli Goes to Work at a Medical Device Company in 1996 – First Internet Wave Just Starting Then Netscape IPO & "The Nudist on the Late Shift" Target Therapeutics Is Sold – Mass Firings Ensue Patrick Rivelli Has a Tough Period in His Career – Growth & More Self-knowledge Patrick Rivelli Gets Involved with a Startup for the First Time Patrick Rivelli Founds Smart Therapeutics "…Nobody Wanted Medical Devices. Everybody Wanted Pets.com and Whatever.com" "You Went from Nerd to Cool Dude" Markets Always Overshoot Boston vs. Bay Area How Boston Has Changed Since the 1960s Patrick Rivelli Gets Into Angel Investing Chestnut Medical Technologies Is Acquired in 2007 Patrick Rivelli Gets MIT Angels Moving in the Bay AreaWed, 09 Dec 2020 - 1h 14min - 417 - Brian Mahon, Investor and Advisor - Expert DOJO
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Expert Dojo is the international accelerator based in Southern California. Founder Brian Mahon and team look for great founders with profitable businesses that can grow. Brian's a delightfully articulate guest. Don't miss this outstanding interview.
Highlights:
Sal Daher Introduces Brian Mahon of Expert Dojo, the International Accelerator in Southern California "…we'll invest as easily and as happily in Boston, as we will do in Bosnia…" "…we wanted to be able to give ordinary people the ability to be able to grow extraordinary companies…" "Actually, we have 70 investments in our companies now. Being part of that journey and watching them while they're at that stage is just absolutely beautiful…" "…I'm over in our location, which is 10,000 square-foot facility on top of the mall in Santa Monica…" "It cost me money. So, I'm not falling for it again." "…we copy the people who I don't necessarily admire what they do, but I admire how they acquire users." AdLaunch – Squarespace for Videos Irish Nun Stories "This is my point about entrepreneurship. It grew here. I could reread and re-watch the movie about the great Edison and Tesla battle a hundred times because this is where virtually all of it began." Making Mass Spectrometry Easily Accessible "…these people have actually built an entire machine learning algorithm that goes deep into the scans themselves, it's not looked at by the naked eye…" "…tuberculosis is a killer, but it's a stupid killer. This should have been eradicated years ago." "They're fighting the mutation day by day." Sal Daher Does a Pitch for His Investment Syndicate "I remember two things with my dad. The first thing is he never complained." "It meant that you had a beautiful office right on the corner. You made it, no matter what you were working or how many hours you were there." "To the investors, they are incredibly fortunate to be part of your syndicate group. This is not a solo sport." "Suddenly, their foosball tables are not quite such enticing as a recruitment offer because they've just fired 30% of their staff."Wed, 02 Dec 2020 - 1h 06min - 416 - Ed Belove, Founder and Angel Investor
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Ed Belove is a very active angel investor. He's a successful founder in software and hardware. Just a very thoughtful person. Very, very smart, very observant, very committed. Founders would be very lucky to have Ed Belove in their corner. I really enjoyed this interview, which I recorded in the first season of the podcast. And it is a very, very meaty interview. Full of interesting stories. For example, helping build Lotus with Mitch Kapor and all sorts of other things. So, it's a little bit of history of the software industry. A lot of wisdom about building a company and an introduction to just a tremendous, tremendous angel investor and person. I highly recommend the conversation with Ed Belove.
As an undergrad at Harvard, Ed Belove hung out with people at the campus radio station that liked to play with computers. This eventually led to a brilliant career that included building software products with the visionary Mitch Kapor at Lotus Development. Ed co-founded a company that greatly expanded the Apple II's ability to communicate. The company would eventually pivot to supplying the hardware for early Internet services such as CompuServe and AOL. This successful trajectory allowed Ed to dedicate his time to building early-stage companies and doing philanthropic work. As a much sought-after angel investor, Ed puts his capital and energy to work on behalf of promising startups. If you are building a software startup, you would be well served to listen to the thoughts Ed expresses in this podcast.
HERE ARE SOME OF THE TOPICS COVERED IN OUR CONVERSATION:
Ed Belove's Bio Data General in the Early 1970's Was a Hotbed of Entrepreneurship – Many Startups Came Out of Data General Software As It Was Before It Ate the World Data General Gave Away Software to Sell Hardware Space War Video Game on PDP-10 Computers "Soul of a New Machine" by Tracy Kidder Now There Is a Huge Number of Software Building Blocks That Anybody Can Put Together – This Did Not Exist in the 1970s Telex and TWX Emulation for the Apple II – Got Around Apple II's Inability to Multitask Ed Belove Went to Work Lotus Development – Mitch Kapor Was a Real Visionary Ed Belove Runs into People Who Are Still Using Lotus Agenda WorkFlowy! Ed Belove, Lessons from Fetchnotes – Alex Horak & Alex Schiff "Ease of use can't be overestimated" Interchange Online – Put the First Major Paper Online, The Washington Post – Ziff Davis AT&T Still Had a Monopoly Mindset despite Deregulation & Divestiture – No Hurry to Make Decisions in Fast-moving Market "The Innovator's Dilemma" by Clayton Christensen "The Road Ahead" by Bill Gates, Nathan Myhrvold and Peter Rinearson How Ed Belove Got into Angel Investing Do Help Get the Word out About Angel Invest Boston by Leaving a Review on iTunes What Ed Belove Looks for in a Startup Knowing What You Don't Know CEOs Need to Have People to Talk to In & Out of the Startup – There Are Now Many More Resources than in the Past CEO, Don't "Manage" Your Board, Work with Your Board CEO, Founder, Know Thyself Shares, Notes and SAFEs, Oh My!Wed, 25 Nov 2020 - 1h 12min - 415 - SQZ's IPO bears out Armon Sharei's vision of empowering cells to change lives.
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SQZ's successful IPO validates the vision laid out by Armon Sharei, PhD in this interview recorded two years ago. In accessible language, this genius founder explains the approach that has big strategic players excited. SQZ is the model I have in mind when I invest in biotech companies. Find out why.
Armon Sharei wants to train our immune system to fight cancer. We hear a lot of claims like this, however when a mega-pharmaceutical company like Roche inks a $500 million deal to work on it, we pay attention. At age 29, Armon convinced not only Roche but gimlet-eyed VCs to back him. How did he do this? How did he go from a boy living in Iran to being one of the stars of MIT's storied Langer Lab?
Part of Armon's secret is the ability to explain thickly complex ideas in accessible language that does not over simplify. He is that rarest of creatures, a scientist of the first rank who speaks lucidly and acts practically. I am grateful that Armon took time out from curing cancer to share his experiences with us in this inspiring interview.
If you are a scientist thinking of founding a company or an investor thinking of investing in a biotech startup you could learn a lot by listening to this interview with Armon Sharei and then going to AngelInvestBoston.com searching under the biotech topic.
Among the topics covered are:
Armon Sharei Bio Childhood Spent in Iran & Dubai, Finished High School in Marin County Why Armon Sharei Wanted to Be a Scientist Why Leave Edenic Bay Area for Purgatorial Boston? SQZ Technology Comes from Failed Attempt to Shoot Genetic Materials into Cells How the Idea of Starting a Company Came About "I think one of the main examples, which is kind of the subject we've been pursuing most deeply at the company in two different projects, is the idea of telling the immune system what to target in the context of cancer". SQZ Technology Excels at Getting Protein Fragments into Cells – Very Promising Method of Training Our Immune System to Fight Cancer Sal Asks Listeners to Subscribe & Review on iTunes – Podcast Has Great Guests & Sound Biotech Fundraising Is Hard – Armon Sharei's Advice on Fundraising Armon Sharei Finds a Lead Investor for His Angel Round SQZ Biotech's Pivot from Selling their Tech as a Tool to Looking for Therapies "…over 70 or 80% of scientists want to put stuff into cells for some reason. I think aside from looking under a microscope there's nothing that they want to do more". Therapy Research Is Risky, But Tool Business Was Harder Than It Looked, Besides Armon Really Wanted to Do Science The Board Was Essential in the Pivot from Being a Tool Company to Becoming a Therapy Company How Does a 29-Year-old Negotiate a $500 Million Deal with a Major Corporation? Hiring the Right People Is the Most Important Thing a Founder Does, Look for Cultural FitWed, 11 Nov 2020 - 46min - 414 - Senan Ebrahim, Founder - Hikma Health
The disrupted life of refugees keeps them from having good medical records. Med student Senan Ebrahim decided to do something about it and succeeded. Listen to the story of Hikma Health and of its promising founder.
Senan Ebrahim grew up in Silicon Valley but he experienced the Syrian refugee crisis via his grandmother. When he became interested in the problem of refugee health his initial solution was laughably unsuited to real life. Contact with health care workers serving the refugee population allowed Senan to zero in on a high-impact solution that is now serving 50,000 displaced people and is set to grow.
Wed, 04 Nov 2020 - 39min - 413 - Beth Marcus - Startup DocWed, 28 Oct 2020 - 1h 03min
- 412 - Wade Lange - Startups at Purdue
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Purdue wants to be Startup U. They are already the #3 university in the US for producing startups, right behind MIT and Columbia. One of my favorite companies, Savran Technologies, came out of Purdue. I spoke with Wade Lange of Purdue Foundry, responsible for promoting startups at Purdue. Several interesting Purdue startups were discussed.
Highlights:
Sal Daher Welcomes Listeners and Introduces Wade Lange from Purdue Foundry Wade Lange Was Introduced by Çağrı Savran of "One Cell in a Billion" Fame On Savran Tech: "It's a promising technology. I mean, it's all about capturing really, really rare cells." Purdue, being a Land Grant College Combines and Excellent School of Agriculture with a Top Engineering Program "…good news for Purdue. We were ranked number three in the country in the number of startup companies in the period of 2008 to 2018 behind your own MIT and Columbia…" "We called it Firestarter, it's a nine week-long program, pretty intense, but it really is kind of the basics of business." DDX Accelerator Program – All About Identifying & Removing Obstacles "Marc Andreessen said it some years ago that software is eating the world. It actually now is biotech that's eating the world." Professor Phillip Low, Founder of Endocyte, Launching an Antiviral Company SpeechVive Helps Patients with Parkinson's Disease Communicate Reliably Spensa Technologies Is Applying Machine Vision to Identifying Insects, Weeds and Other Problems in Agriculture Perceive Inc. Helps Retailers Identify Patterns in Stores Sal Daher Talks About His Investment Syndicate Wade Lange's Entrepreneurial Journey "I would rather be a big fish in a small pond was my thinking. So, I joined a startup was started by a couple of faculty members, at Purdue." How Wade Lange Came to the Purdue Foundry "Purdue's President Daniels wants Purdue to be known as startup U, okay." Sal Daher Makes a Plug for Purdue as a Great Place to Be an Undergrad "…my connection to Çağrı came because of my brother-in-law. My brother-in-law is a patent attorney at Fish and Richardson." "…founding entrepreneurs who have deep relationships with 25 other founders, 10 industry experts, and eight investors. They had double the revenue growth of founders who didn't." Wade Lange on the Advantages of Growing Your Startup Near PurdueWed, 21 Oct 2020 - 36min - 411 - Jeff Behrens, PhD - Why You're Wrong About Biotech Funding
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Jeff Behren's doctoral dissertation suggests that life science startups are not funded the way we all think. Listen to our discussion of his work and learn why he believes we have to revise what is taught to founders about raising money.
Highlights:
Sal Daher Welcomes Jeff Behrens Back on the Podcast to Discuss His Findings on Biotech Funding "We published papers. We had a world class SAB, and ultimately, we sold these drugs. So, during that, you'd think, "Well, we should be able to raise venture capital." We never could." The Conventional Wisdom about How Life Science Startups Are Funded Casma Therapeutics as an Example of a Startup Born Inside a Venture Firm "There was no Lisa and Joe… There [was] no outside founders. This was born inside the venture firm." Jeff's Research Result: Only 8% of All Startups Follow Path of Angel Funding Then VC Funding Jeff's Research Result: For Biotech Startups, 4.5% of those that Started with Angel Money Got VC Funding "So, it's almost like these are two distinct entrepreneurial streams that don't intermingle very much." Angel Investors Should Not Expect Future Rounds to Come from VCs – Should Think About How to Fund Future Rounds in the Absence of VC Money "Well, we want to have fewer new companies and more companies that we invest longer and heavier and over time." Jeff's Research Result: In a Decade VC-Started Biotechs Went from Taking 20% of Funded Deals to Taking 80% The Big Biotech VCs Don't Take Pitches from Outside Companies Anymore Only 3% Funding Goes to the Scrappy Biotechs Who Were Not VC-Founded or Did Not Have Famous Founders Scrappy Biotech Startups Need to Draw a Credible Path that Does Not Include VC Funding Corporate Venture Groups Created to Allow Big Players to Look at New Technologies Being Funded by a Corporate VC Does Not Seem to Increase the Chances of a Venture Being Acquired Trends Among Life-Science VCs Vary Geographically: Boston, NY vs. West Coast "We never take pitches" – Dave Berry - Partner - Flagship Pioneering Accelerators, Business Schools, Advisors Need to Revise their Ideas about Funding of Biotech Startups "So, it is true that Polaris is probably... Of these companies that are doing venture creation, they're probably more balanced than the others." Path Dependency of Funding "…unfortunately, great science can languish unfunded." Parting Thoughts from Jeff Behrens, PhDWed, 14 Oct 2020 - 40min - 410 - Eilon Shalev - Elphi: Hacking Mortgages
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Mortgage origination is a massive business deeply stuck in the past. Proof: in 2020 it still takes an average of 45 days to approve a mortgage. Israeli founder Eilon Shalev and his buddies from MIT Sloan School aim to change all that with their startup Elphi.
Highlights:
Sal Daher Welcomes Listeners & Introduces Eilon Shalev of Elphi What Elphi Does The Non-Linearity of Mortgage Applications Is a Huge Problem – Average Time to Approval: 45 Days "We have a paying customer and the software is live today with that lender. That lender is a non-depository mortgage lender, which means it is not a bank." The Current State of the Mortgage Origination Business A Shout out to Sonal Singh of Spatio Metrics for Connecting Sal Daher and Eilon Shalev The Founding Story of Elphi Why University Tuition Is So Astronomically High How Eilon Shalev Shifted His Focus from Student Financing to Mortgages "I was obligated to just try to choose the most problematic problem I can find from that large industry and try to solve it." The Elphi Team Sal Daher Plugs His Investment Syndicate Eilon Shalev's Entrepreneurial Journey Parting Thoughts from Eilon Shalev "…one of the main reasons that there was no innovation in that particular space for those particular problems is the high barriers to entry. Once you overcome those barriers to entry, you are that kid in a candy shop…"Wed, 07 Oct 2020 - 36min - 409 - Matt Fates, VC & Angel Investor
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Tech VC Matt Fates of Ascent Venture Partners talks about his portfolio and his investing career and ponders becoming more active as an angel investor. A frank and informative conversation with a delightful guest.
Highlights:
Sal Daher Welcomes Listeners & Introduces Matt Fates, Venture Capitalist Matt Fate's VC Portfolio: Connected2Fiber "The power of connectivity is becoming strategic again as most of your software applications reside outside of your four walls. The need for this intelligence, the need for this data has just become absolutely mission critical for that industry. So, they're growing rapidly." Vee24 "I would say Vee24 is really that next level of very professional interaction…" Augmented Reality (AR) as a Tool for Online Engagement Matt Fates' and Sal Daher's Investment in Streamroot The VC Industry Is Focusing on Fewer & Bigger Deals – Leaving Many Interesting Companies Behind Finding the Holy Grail Sal Daher Makes a Pitch for His Syndicate List "That wasn't luck. That was Ernie, my boss, telling me, "There's nothing you're going to be able to do to convince me to make another investment in this environment. It's too crazy." Paths to Becoming a VC Parting Thoughts from Matt FatesWed, 30 Sep 2020 - 52min - 408 - David Glazer - Biotech Deal Wiz
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Unlike software startups that can scale with minimal resources, biotech startups need frequently to rely on collaborations with big strategic players to get to scale. This is an interview with one of the top attorneys in arranging such deals, David Glazer of Morgan Lewis. I learned much from David; I hope you will too.
Highlights:
Sal Daher Introduces David Glazer of Morgan Lewis, the Biotech Deal Wiz Why Collaborations with Strategic Partners Are So Necessary for Biotech Startups Sal Connected with David by Courtesy of Armon Sharei of SQZ Biotech; David Advised SQZ on the $1.3 Billion Roche Deal Collaborations May Last Ten or Twenty Year; Picking the Right Partner is Crucial A Strategic Partner Can Be Immensely Valuable with Dealing with the Complexities & Cost of Getting a Compound of Technology to Market Strategics Offer Clinical, Regulatory & Commercial Expertise Startups Lack "You got one partner signed up and then the dominoes start to fall, it provides a validation." The Topics that Dominate the Discussions Between Biotech Startups and Strategic Partners The Tradeoffs Central to the Negotiations An Important Metric of Biotech Deals Is Elucidated Picking Mechanisms Determine Who Takes the Lead in Which Circumstance Reward Follows Risk in Biotech Deals "Careful what you ask for when you're the biotech company…" – The Law of Unintended Consequences Collaborations Can Give Startups the Capacity to Develop Their Own Internal Projects Resources from Collaborations Can Help Startups Mature Their Tech "I would say I spend about 50% of my time with the pharmaceutical, the strategic players, and about 50% with biotechs." Since They Represent both Biotechs & Strategics, Morgan Lewis Has a Good Sense of What Motivates the Players and What Deals Can Get Done How Deals Go Awry Sal Daher Puts in a Plug for His Syndicate List How David Glazer Became a Biotech Deal Maker "…then in 2000, the [tech] bubble popped and I ended up spending almost all of my time working for the pharmaceutical and biotech companies back in the day." How the Acquisition of One of His Clients Expanded David Glazer's Network Morgan Lewis Has Afforded David Glazer the Opportunity to Do Interesting Pro Bono Work David Glazer's Closing Advice to Biotechnology Companies Thinking About Collaborations "…I've always found it helpful to have a champion at the pharmaceutical company who is very interested in your deal."Wed, 23 Sep 2020 - 41min - 407 - Fred Bamber - Tech VC Becomes an Angel
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As a venture capitalist Fred Bamber helped build such successful companies as Interleaf, Q1 Labs and Volt Server. Now working as an angel investor Fred is invested such exciting companies as SQZ Biotech, Pixability, ViralGains and Streamroot (exited). In his self-effacing and modest way, Fred reveals deep wisdom gained from 75 investments in his career as a VC.
Topics include:
Fred Bamber Finds His Career Path Avoiding the Military Draft Led Him to Work for His First Startup Fred Bamber & Friend Found a Venture Fund – Consulting vs. Venture Capital IPOs Then & Now Investment in Interleaf Makes His First Fund a Success! Two Ways of Connecting in the World of Venture Capital – Via Success & Via Failure Several Losing Investments in Companies Seeking to Exploit the Piezoelectric Effect Themes In Angel Investing – Investing in Brand New Fields i.e. White Spaces '…Oracle has a huge go-to-market cost, and engineering is a tiny bit of it.' Technology Causing Convergence of Consumer & Enterprise Businesses Startups with Jeff Weiss - The Perils of Being Early – Early Augmented Reality (AR) Rich Lane & Reflection Technology – Augmented Reality-like – Projecting Text into the Eye Progress of Technology Is Painful – "Thread Across The Ocean" by John Steele Gordon Michael Lewis & Drama in Business – Paul English & "A Truck Full of Money" Paul English Finds His Inner Entrepreneur after Interleaf Robert P. Smith & "Riches Among the Ruins" – Not Made for Working In Large Companies VCs Should Be Humble Fred Bamber Talks About His Investment in Volt Server Uber & Washington, D.C. Cabs Peter Thiel's Critique of Entrepreneurship – "We Were Promised Flying Cars and We Got 140 Characters" SQZ Biotech & Massachusetts Materials Technology What Fred Bamber Looks For In a Startup – Technology, Coachability, Tenacity, Openess – VC vs Angel Startups Should Report Frequently – Reports Should Tie In to Previous Reports i.e. Close the Loop Angel Investor Should Be Father Confessor without the Ave Marias Bettina Hein & Pixability – Example of Determination Combined with Openess Beth Marcus' Test For Listening Fred Bamber's Suggestion of the Perfect Number of Angel Investments in a Portfolio Why Sal Daher Is Invested In About 42 Companies The Role of a Board of Directors – Father Confessor Fred Bamber's Favorite Pivot – Q1 Labs (IBM) Fred Bamber Also Like Streamroot's Pivots Q1 Labs Pivot Runs Counter the Received Wisdom of Startups Needing a Narrow Focus to Succeed "Crossing the Chasm" by Geoffrey A. Moore "Why Knowledge Matters" by E.D. Hirsch, Jr.Wed, 16 Sep 2020 - 1h 10min - 406 - Derek Canton, Founder and CEO - Paerpay: Contactless Pay at the Table"
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Young founder Derek Canton was obsessed with making restaurant payments frictionless. COVID scrambled his product plans but opened up a huge opportunity to provide contactless payment. Throughout lockdown Paerpay has gotten traction for its text-driven payment system which is a perfect fit for the times.
Highlights:
Sal Introduces Founder Derek Canton of Paerpay What Paerpay Does How Paerpay Makes Money The Competition is Device-Centric, Paerpay Is Software that Runs on Legacy Devices How the Paerpay Solution Is Implemented A Possible Collaboration with Squadle? Derek Canton Has Ambitions Beyond the Restaurant Space for Paerpay Sal's Pitch for His Investment Syndicate Derek Canton's Discovery that He Was an Entrepreneur Derek's Dad Gives Him "The Talk" About Entrepreneurship "But I tell people it's the most rewarding, most painful experience you can have, being an entrepreneur, but candidly I'm addicted to it, man. I love it." "…on a personal side was as simple as do what you love and if your dream doesn't scare you, it's not big enough." "…the first times in history where operators are thinking about contactless payments being the number one way of form of accepting payments, period, period. That's never happened before." "…a few months from now the world is going to be completely different. And so, for the first time in history, we have this opportunity to really help shape what that world looks like. And our tech is doing it already and it's been incredible." How Derek Canton Got His Co-Founder Alan Inacio – How They Seized the Opportunity for Contactless Payments Created by COVID "…, if you are a founder and you're looking for a problem to solve, now's the perfect time to be able to do that. The world is quickly changing…"Wed, 09 Sep 2020 - 36min - 405 - Ben Littauer, Founder and Angel Investor - #1 Fundraising Mistake
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Ben Littauer travelled an unlikely path from philosophy to communications technology. He brings to life the exciting turns in his careers as founder and angel investor. In his light-hearted style, Ben provides a thoughtful tour of Boston's angel scene in this episode that ranges over many topics including equity crowdfunding. In particular, he explains what leads founders to make the worst fund-raising mistake of all. The philosopher's clarity of thought and the engineer's practicality are in evidence.
Wed, 02 Sep 2020 - 1h 03min - 404 - Klaudyne Hong, Founder - AI Improving Clinical Outcomes
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The sense of purpose and focus that led Klaudyne Hong to do her PhD at MIT in two years helped her turn a chance comment during a fly-fishing trip into a groundbreaking startup. Peach IntelliHealth is building AI for acute medical care. Her project was seeded by the Government of Singapore where she found great help in building her data set. She's now seeking FDA approval.
Highlights include:
Sal Daher Introduces Klaudyne Hong, PhD, Founder of Peach Intellihealth What Peach Intellihealth Does Peach Intellihealth's AI Can Predict a Patient's Response to Treatment The Founding Story of Peach Intellihealth "So, if you don't remember anything about what I say today, remember the next point. It's the highlight of the show, okay? I actually caught two striped bass that morning." "And we started then doing a historical analysis, and we realized that our algorithms actually fit that data very nicely." Peach's AI Got Regulatory Approval in Singapore – Now Replicating Pivotal Study in the U.S. "Sepsis, by the way, is the most expensive health care condition, hospitalized condition, in the U.S." "If someone's going to go into cardiac arrest, and you know it several hours in advance, you can make a huge difference." Current Status of Peach Intellihealth Funding for Peach Intellihealth – the Government of Singapore Came in as a Seed Investor "I grew up in Singapore, and I left when I was relatively young. So, I was as an undergrad in California." Her Favorite Show "Cheers" Showed Boston in Such a Good Light that Klaudyne Chose to Apply to MIT "…my thesis…was about controlling gene expression for gene therapy applications." Klaudyne's Two-Year PhD "I drew him a picture of this DNA that was wearing cowboy boots, and somehow told him it's all about the cowboy boot being a gene therapy vector. And somehow, he understood what I was saying. He said, "Yeah, come join me in the lab."" Klaudyne Hong's Entrepreneurial Journey After J&J Klaudyne Consulted but Found It Unrewarding, Lacking Ownership – Enter Entrepreneurship Peach Benefitted from the Entrepreneurial Ecosystem in Singapore that Allowed the Rapid Acquisition of Patient Data "But I find that the larger the company, sometimes the slower things can be, because I think they call way too many meetings that you have to attend." "They see that you have this passion. And they see that look, if it's that crazy, why do you have so many good people embarking on this journey with you?" "It is the most robustly supported result in the study of entrepreneurship that more co-founders, better chance of success." Where the AI Will Fit in the Clinic "I also see AI in a sense of helping make informed choices about the kinds of medicine we take." Sal Talks About Portfolio Company Leuko Klaudyne Hong's Closing CommentsWed, 26 Aug 2020 - 46min - 402 - Amanda Drobnis and Jess McLear - Duet for Founder and Board Member
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Vets have known for a century that injecting extract from fetal tissue helps wounds heal faster However, the procedures required were arduous. Hilltop Bio is taking the hassles out of this time-tested therapy and creating a new revenue stream for clinics. Amanda Drobnis, founder and Jess McLear, board member update us on the company's progress.
Interview highlights include:
Sal Daher Introduces Amanda Drobnis and Jessica McLear What Hilltop Biosciences Does and What Pain Points It Addresses How Jess McLear Came to be an Investor in Amanda Drobnis' Company "…they tend to be leaders. If Launchpad signs up for a deal, other angels tend to follow." "But what we can patent is how we collect the tissue, how we process the tissue, the methods that we're going to use the tissue for." "…even through COVID we've had repeat sales." "So, she's right on track with what she said she was going to do again on track on budget. We don't see those very often either." "Our big breakthrough that we've been working towards is having our room temperature regenerative therapies available that are off the shelf and ready for our vets to use." Jess McLear: "I kind of grew up around startups. My father has been investing in startups over 30 years, so I've grown up around startups…" "That's an interesting collection of companies. Hilltop Biosciences, Knip Bio, 99Degrees…" Angel Investor Jess McLear's Advice to Founders Angel Investor Jess McLear's Advice to Founders about Fundraising "Female entrepreneurs, I find it definitely takes much longer for a lot of them, which is a really sad state of affairs." "I can't stress that enough. My board members, Jess, and all my other board members, they really make a difference…" "…you are always fundraising. It never ends. And when you think it's over, it's not over." "You also want to update the people that didn't invest, but might be on the fence because they may invest at some point too. That's one thing that a lot of people don't do." "I salute Amanda as a really stellar founder and she's got a board, she's got a product. She keeps her investors updated. She keeps even the ones that said no updated. Well done."Wed, 12 Aug 2020 - 31min - 401 - Ralph Wagner, Angel Investor and Founder - Flunk Calculus, Ace Life
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Ralph Wagner recalls his journey of self-discovery that led from failure in engineering to incandescent success in marketing and sales. The man who could not do calculus or write code excelled at identifying and exploiting opportunities created by computer technology. In this interview one sees that Ralph's captivating personality is firmly ballasted by good sense and common decency. It is made evident how his interest in people was vital to the success of his many ventures.
Wed, 12 Aug 2020 - 1h 04min - 400 - Joe Selvaggi, Entrepreneur and Podcaster - "HubWonk"
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Joe Selvaggi, entrepreneur and podcaster straddles the worlds of business and policy in his podcast HubWonk, one of two podcasts from Boston's Pioneer Institute. Joe and I talked about compelling interviews of founders and how they relate to the work of the free-market think tank. Fun & Instructive.
Highlights include:
Sal Daher's Introduction of Joseph Selvaggi The Pioneer Institute and Entrepreneurship Joe Selvaggi's Business – Plaster Fun Time "It could be easier. Our tax regime, our regulation regime." Everything has an effect on your clients, your business, your employees. You kind of become an honorary policy wonk…" "My ingenuity, my hard work, makes you richer." COVID-19 Highlights the Bounty Brought to Us by Free Markets that We Take for Granted – The Fish Counter at Whole Foods Buoy Health – HubWonk Podcast Buoy Health's AI Interviews Patients and Advises Them on What Type of Care to Seek & Where Joe Selvaggi Addresses Issues Such Education and Transportation that Are Crucial to Entrepreneurs "I just think that the retirement homes have to do a whole lot better about protecting the elderly from transmission of diseases." Gauss Medical – Machine Vison in the Operating Room Joe Selvaggi Talks about His Interview with the Founder of Telehealth Firm Amwell Joe Selvaggi's Entrepreneurial Journey "What I love about HubWonk and really the podcast medium is, you get to eavesdrop on a conversation with people who are really making hard decisions…" Example of Podcast Candor: Russ Wilcox – Frank Conversation about All His Mistakes as a Founder "To the superficiality of Twitter? Oh, no doubt. Marshall McLuhan said "the medium is the message.""Wed, 05 Aug 2020 - 45min - 399 - Michael Mark, Super Angel Investor and Founder - Best Pivots Ever
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Super angel investor Michael Mark tells fascinating stories that take us from the precocious founding of his first startup straight out of MIT to his being a highly-prized investor in hundreds of startups today. The narratives are interwoven with valuable lessons on how tech startups are built in Boston's vibrant entrepreneurial ecosystem. They include entertaining observations of subjects ranging from comedians to co-founders. Some of the most interesting pivots (radical changes of business plan) are elucidated. Michael's dry wit and unassuming manner make his deep wisdom accessible to all of us.
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Topics we touched on:
The best pivots ever! Need for focus When to pivot How frequently business plans work out Hiring a CEO Qualities of the founders Role of luck in startups What a board of directors can do for the startup How Michael got started in entrepreneurship Pixability Exos Loop Pay Bettina Hein Beth Marcus Will Graylin Progress Software Cadmus Interleaf Netegrity UnderwareWed, 29 Jul 2020 - 57min - 398 - Jenny Ro, PhD, Founder and CEO - AI Connecting Humans
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Curious Reactor, the AI built by founder Jenny Ro, PhD, helps participants at life science conferences figure out who to meet. It's only the first step in a promising road map. Loved the chat with this compelling founder.
Wed, 22 Jul 2020 - 34min - 397 - Gillian Isabelle - COVID-19 Update
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Founder Gillian Isabelle, Ph.D. returns to give us an update on how her startup Enlivity is navigating the COVID crisis.
Here is Gillian's origin story: Gillian Isabelle's Full Interview
Wed, 15 Jul 2020 - 17min
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Les grands dossiers de l'Histoire par Franck Ferrand Radio Classique
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Enquêtes criminelles RTL
Entrez dans l'Histoire RTL
Le grand récit RTL
Les Grosses Têtes RTL
Les histoires incroyables de Pierre Bellemare RTL
L'Heure Du Crime RTL
El Larguero SER Podcast
SER Historia SER Podcast
Todo Concostrina SER Podcast
Un Libro Una Hora SER Podcast
HISTORIAS DE LA HISTORIA VIVA RADIO
