The Michael J. Fox Foundation Parkinson's Podcast

Today Parkinson’s treatments are largely focused on helping manage symptoms, but researchers are working towards something more: treatments that address a wider range of symptoms and ultimately slow or stop disease progression. Getting there will likely take many different approaches, reflecting the many ways Parkinson’s can affect people.

In this episode of the MJFF Parkinson’s Podcast,part of its award-winning Parkinson’s Science POV series, host Maggie Kuhl, vice president of patient engagement at MJFF, leads a conversation with MJFF Chief Scientific Officers Brian Fiske, PhD and Mark Frasier, PhD, about how researchers are building a more diverse pipeline of potential treatments. They discuss how learning more about Parkinson’s are opening doors to new approaches, and the importance of centering what really matters for people living with the disease.

Maggie also speaks with Shalini Padmanabhan, PhD, MJFF’s head of translational research, about the Foundation’s Targets to Therapies program and how MJFF is helping discoveries move closer to new treatments.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

A Parkinson’s diagnosis can raise big questions in a family: Was there a genetic link that contributed to developing the disease? How should other family members think about their risk? Should people get genetic testing?

In audio from this month’s MJFF Parkinson’s Webinar, our panel of experts discusses what genetics can tell us about Parkinson’s risk, what to consider around genetic testing, and how studying genetics is helping researchers develop better treatments for everyone living with the disease.

If you’d rather listen on the go, subscribe to The Michael J. Fox Foundation’s Parkinson’s Podcast on iTunes or your preferred podcast app. If you enjoyed what you heard, share it with a friend or leave a review to help others find and support our mission.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinson’s disease can change much more than movement. It can reshape roles and relationships, challenge a person’s sense of identity and alter the future they once imagined. In this podcast, you’ll hear from people living with the disease about how they’ve navigated the big questions that Parkinson’s has raised and the spiritual practices that nurture them, give them hope and keep them grounded. You’ll also hear from experts in Parkinson’s care about the importance of treating the whole person and how tending to spiritual well-being, however that looks for an individual, can be part of living well with the disease.

Learn more about living well with Parkinson’s: https://www.michaeljfox.org/lifestyle-strategies-living-well-parkinsons

Join the Parkinson’s Buddy Network: https://parkinsonsbuddynetwork.michaeljfox.org/v2/

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinsonism is an umbrella term to describe a group of conditions that cause movement symptoms. Parkinson’s disease shares some traits with drug-induced and vascular parkinsonisms, as well as atypical parkinsonisms, but each condition differs in how it progresses and is treated. Listen to audio from this month’s MJFF Parkinson’s Webinar to hear our panel of experts discuss the sometimes-long path to diagnosis and what people with parkinsonism and their families should know. They also cover the latest research into parkinsonisms.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Better treatments for Parkinson’s disease depend on increasing our understanding of why Parkinson’s develops and how it progresses. The Michael J. Fox Foundation’s landmark study, the Parkinson’s Precision Medicine Initiative (PPMI), is expanding to better answer those questions.

In this episode of The Michael J. Fox Foundation Parkinson’s Podcast, Maggie Kuhl, vice president of patient engagement at MJFF, leads a conversation about these efforts with:

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

The Foundation’s landmark study, the Parkinson’s Precision Medicine Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Breakthroughs depend on research volunteers, but many people have questions about what participating in a trial means, and how to select the right trial for their goals, needs and lifestyle. Listen to audio from this month’s Third Thursdays Webinar to hear our panel of experts share what to look for in a trial you’re considering and how to navigate the clinical trial process.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

This webinar received support from BlueRock Therapeutics. Learn more at expditestudy.com.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Constipation is a frequent and troublesome symptom of Parkinson’s disease (PD). It can affect how medication is absorbed and impact daily life. Tune in to audio from this month’s Third Thursdays Webinar to hear our panel of experts discuss why constipation happens in Parkinson’s. They also cover managing and preventing constipation and the latest research on the gut-brain connection.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinson’s isn’t easy to diagnose — everyone’s symptoms differ based on their individual biology, leading to delays in diagnosis and treatment. One of The Michael J. Fox Foundation’s (MJFF) key areas of focus is finding ways to diagnose Parkinson’s disease earlier and more clearly, which could one day lead to more personalized treatments that can improve quality of life.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

There are so many ways to get involved in the research that is leading to clearer disease diagnosis. Learn more about your role in research at: https://www.michaeljfox.org/your-role-parkinsons-research

The Foundation’s landmark study, the Parkinson’s Precision Medicine Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

People living with Parkinson’s disease (PD) and their loved ones develop countless ways to adapt and make daily life easier as symptoms change. Members of The Michael J. Fox Foundation’s Patient Council and their care partners share decades of collective wisdom on living with PD. They came together for a live conversation at MJFF’s New York City offices to discuss what they’ve learned along their own disease journeys, from practical strategies and tools that make daily life easier to the mindsets and mantras that guide and sustain them. In this episode of the MJFF Parkinson’s Podcast, patient council member and guest host Larry Gifford, diagnosed with PD in 2017 and president of PD Avengers, together with his wife and care partner Rebecca, reflect on the advice given.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

The Foundation’s landmark study, the Parkinson’s Precision Medicine Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Many people diagnosed with Parkinson’s and their loved ones wonder what caused the disease. Researchers believe Parkinson’s is caused by a mix of genetic, environmental and age-related factors that may contribute differently to each person. Tune in to audio from this month’s Third Thursdays Webinar to hear our panel of leading Parkinson’s experts discuss the latest efforts to understand what causes the disease so we can better treat and one day prevent it altogether.

Join the movement to end Parkinson’s this Parkinson’s Awareness Month at michaeljfox.org/April

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinson’s disease (PD) is the world’s fastest-growing neurological disease, affecting millions globally. Yet many misconceptions persist about life with the disease, how to treat it and the research going into the search for better therapies. Tune into this episode of The Michael J. Fox Foundation’s Parkinson’s Podcast to listen to our panel of experts including people living with PD, a researcher and movement disorder specialists debunk common myths about Parkinson’s disease and answer community questions.

Discover opportunities to take action and join millions of others moving us closer to a cure. https://www.michaeljfox.org/parkinsons-awareness-month

Like our podcasts? Rate or review the show and share the series with your community. https://apple.co/3p02Jw0

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Sleep is an important part of physical and mental health, but Parkinson’s symptoms and medication side effects can make a good night’s sleep hard to find. Insomnia, nocturia, medication wearing off, REM sleep behavior disorder (RBD) and more can interrupt sleep. Tune into audio from this month’s Third Thursdays Webinar to hear our panel of experts discuss the latest research on the connection between sleep and Parkinson’s disease (PD) and share practical strategies for setting yourself up for the best rest possible.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

A world without Parkinson’s will only be made possible through the work and energy of the Parkinson’s community — people living with the disease and their loved ones, researchers, clinicians, industry leaders, lawmakers and others. Catalyzing that community towards productive action is one of The Michael J. Fox Foundation’s (MJFF) four main areas of research focus in its Strategic Research Agenda, along with more clearly defining Parkinson’s disease, building better treatment pipelines and speeding clinical trial decision-making.

In this episode of The Michael J. Fox Foundation Parkinson’s Podcast, part of its award-winning Parkinson’s Science POVseries, Maggie Kuhl, vice president of patient engagement at MJFF, leads a conversation about these efforts with two veteran scientists: Brian Fiske, PhD, chief scientist, MJFF and Mark Frasier, PhD, chief scientist, MJFF.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

There are so many ways to get involved in Parkinson’s community, whether it’s becoming an advocate, joining Team Fox or participating in research. Learn more at michaeljfox.org

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

How can I show up for my partner with Parkinson’s? How can I best support my parent with PD from afar? How can my loved one and I work together to make decisions as symptoms change?

Our community has many questions about how to best support a loved one with Parkinson’s disease. Tune in to audio from this month’s Third Thursdays Webinar to hear our panel of experts — including care partners, a person living with PD, a social worker and a psychologist — discuss strategies for effective communication and shared decision-making to keep a partnership strong through Parkinson’s.

This webinar received support from Acadia Pharmaceuticals. Learn more at: moretoparkinson’s.com

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Diet is a useful tool to feel and live better, whether you live with Parkinson’s or not. But putting healthy eating into practice can be tricky. In audio from this popular Ask the MDvideo, movement disorder specialist, lifestyle medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, DipABLM, speaks with Erin Presant, DO, movement disorder and culinary medicine specialist. Together, they answer common questions about how diet can support brain health and help manage disease.

Listen now or watch the video. You can also check out our page on lifestyle strategies for living well with Parkinson’s.

Rather listen on the go? Subscribe to our Michael J. Fox Foundation Parkinson’s Podcast wherever you get your podcasts.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

How does research into Parkinson’s and Alzheimer’s overlap, and what insights are being revealed? Tune into audio from this month’s Third Thursdays Webinar to hear our panel of experts discuss what scientists are learning about how these diseases affect the brain and how understanding their links may lead to better care for people living with a disease.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

No matter your age, whether you have Parkinson’s or not, there are steps you can take today to boost your brain health. In this extended version of a popular Ask the MD video, movement disorder specialist, life medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, sits down with Ayesha Sherzai, MD, and Dean Sherzai, MD, PhD, known as The Brain Docs. Together they answer community questions and share tips for using lifestyle medicine to help your brain.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Experiencing some stress is a normal part of life, but many people living with Parkinson’s notice stress may worsen symptoms and make medication less effective. And chronic stress can cause lasting impacts to mental and physical health. Tune into audio from this Third Thursday’s Webinar to hear our panel of experts discuss how stress affects the body and how to reduce its harm.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Earlier this year, The Michael J. Fox Foundation hosted its 2025 Research Roundtable, “Building on Breakthroughs.” Tune into audio from this event to hear Parkinson’s experts and MJFF staff discuss the latest in lifestyle medicine and treatments in the pipeline, as well as the power of advocating for Parkinson’s policy.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

What is AI? How do scientists use it? Where does the data come from? Can AI help find a cure for Parkinson’s?  

As the use of artificial intelligence, or AI, becomes more widespread, our community has asked us many questions about how scientists may be using the technology to further Parkinson’s research. In this episode of The Michael J. Fox Foundation Parkinson’s Podcast, in its award-wining "Parkinson’s Science POV" series, Maggie Kuhl, vice president of patient engagement at MJFF, leads a conversation to answer some of those questions with: 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinson’s research has had a transformative year as researchers have built on breakthroughs to learn more about the disease and how to treat it. Tune into audio from this Third Thursday’s Webinar to hear our panel of experts discuss how Parkinson’s research has advanced in 2025 and what the future could look like.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Read more about this year in research at https://viewer.joomag.com/2025-year-in-review/0030141001760361264

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

As Parkinson’s symptoms change over the years, different treatments may be needed to best manage symptoms and side effects. Since last fall, the U.S. Food and Drug Administration has approved five new options for people living with the disease, including two continuous, under-the-skin infusion pumps. Tune into audio from this Third Thursday’s Webinar to hear our panel of experts discuss these options and other strategies to treat progressing Parkinson’s disease.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Stepping back from the workforce is a milestone event in any life, and Parkinson’s disease (PD) adds an emotional and logistical layer. Many people living with the disease think differently about when and how to retire as they balance symptoms, their financial and health needs and their plans and interests. Tune into this episode of The Michael J. Fox Foundation’s Parkinson’s Podcast to listen to our expert panel of a person living with Parkinson’s, a care partner and people who work with the Parkinson’s community discuss retirement and Parkinson’s. They share advice from their own lives and tips for people entering a new phase of their life.  

Check out our free employment guide. https://www.michaeljfox.org/news/workplace-challenges  

Like our podcasts? Rate or review the show and share the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

While there have been improvements in therapies to treat Parkinson’s symptoms, people living with the disease and their loved ones await a treatment that will slow the progression of Parkinson’s disease (PD) or stop it entirely. These therapies, called disease-modifying therapies, have the potential to change how PD is treated and experienced. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts discuss disease-modifying therapies and the latest in Parkinson’s research. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

This webinar was produced with support from Biohaven. https://www.biohavenclinicaltrials.com/clinical-studies/parkinsons-disease/  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

A Parkinson’s disease (PD) diagnosis can impact many areas of life, including how you get work done and think about your career. It can lead to questions like: Should I disclose my diagnosis to my employer and colleagues? How do I adapt my work around my symptoms? What legal protections do I have?Tune into this episode of The Michael J. Fox Foundation’s Parkinson’s Podcast to listen to our expert panel of people living with PD, a care partner, and an employment consultant discuss employment and Parkinson’s. They share their stories and offer the tips they’ve learned along the way.

Check out our free employment guide. https://www.michaeljfox.org/news/workplace-challenges

Like our podcasts? Rate or review the show and share the series with your community. https://apple.co/3p02Jw0

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Researchers are investigating many options to treat Parkinson’s disease (PD) with stem cells, including reprogramming them to replace lost dopamine-producing neurons and creating supportive brain cells to keep neurons healthy. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts discuss the latest stem cell research and answer audience questions.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

This webinar was produced with support from BlueRock Therapeutics.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

How do I tell my children about my Parkinson’s disease (PD) diagnosis? How do I explain a tremor to my grandkids? How can I support my parent with Parkinson’s from a distance? How can my spouse and I communicate around a symptom of apathy? 

Every year our community submits thousands of questions online and at in-person events. Many are about Parkinson’s symptoms, treatment options and the latest research, but we’re also asked questions about relationships and how to maintain connection with loved ones with Parkinson’s in the picture. In this episode of The Michael J. Fox Foundation’s Parkinson’s Podcast, our expert panel tackles questions on relationships and shares their personal experiences and advice. 

To connect with others for support and community, join the Parkinson’s Buddy Network. https://parkinsonsbuddynetwork.michaeljfox.org/ 

Like our podcasts? Rate or review the show and share the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Technology can offer people living with Parkinson’s disease (PD) much needed support in several areas of life, from apps to keep track of medication timing, wearables to help smooth gait, websites to monitor symptoms and more. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts discuss how tech tools can be incorporated in daily living with PD and how to find your best options. They also share personal tips and experiences and answer audience questions.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Advances in imaging technology offer researchers a window into how Parkinson’s disease affects the brain, which could reshape how the disease is diagnosed and treated. In this episode of The Michael J. Fox Foundation Parkinson’s Podcast, in its award-winning Parkinson’s Science POV series, David Kumbroch, senior science writer at MJFF, lead a conversation with: 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Learn more about the many ways to get involved today at michaeljfox.org

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Having a network of health care professionals, loved ones and community members as part of a care team has shown to improve the quality of life for those living with Parkinson’s disease (PD) and their loved ones. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts discuss how to make the most of your appointments, find specialists and coordinate care to best support the person living with the disease. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Life with Parkinson’s disease (PD) is shaped by myriad factors, including sexual orientation and gender identity that shape access to care, lifestyle decisions and more. In this episode of The Michael J. Fox Foundation’s Parkinson’s Podcast, our expert panel shares their personal stories and discusses the ongoing research into the health concerns and needs of LGBTQ+ people living with PD. 

To connect with others for support and community, join the Parkinson’s Buddy Network. https://parkinsonsbuddynetwork.michaeljfox.org/ 

Like our podcasts? Rate or review the show and share the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

The beliefs and perceptions that friends, family, employers and even strangers hold about Parkinson’s disease (PD) shape the experience of living with the disease. Facing misperceptions and stigma can cause isolation and worsen symptoms. Tune into audio from this Third Thursdays Webinar to listen to our panel of experts have a candid and compassionate conversation about times they’ve faced stigma, how they’ve navigated it and how they’re working to change misperceptions of Parkinson’s to improve life for everyone living with the disease.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.    

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

There are so many ways to get involved with Parkinson’s disease, from community building to advocacy, research participation to fundraising. Taking that first step toward involvement can be daunting, but many people say it’s a critical part of living well with the disease. In this episode of The Michael J. Fox Foundation Parkinson’s Podcast, members of the Foundation’s Patient Council share stories of their own first steps, explore how engagement has impacted their journeys and offer advice and perspective to others who are looking for ways to make meaningful change. Tune in to hear guest hosts Jimmy Choi, diagnosed with Parkinson’s in 2003, and Hadley Ferguson, diagnosed with multiple system atrophy (MSA-P), an atypical Parkinsonism in 2014, reflect on those stories, recorded live in the MJFF offices.  

Learn more about the many ways to get involved today at michaeljfox.org. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Life with Parkinson’s comes with a vast range of emotions, wherever you are in your disease journey. Shock, grief, optimism, fear, denial, hope, humor and more can all be a part of the emotional landscape for people living with the disease and their loved ones. Tune into audio from this special edition Third Thursdays Webinar to listen to our panel of experts have a frank and deep conversation about how they’ve navigated their feelings over the years, how they’ve managed challenging emotions and what lifts them up and brings them hope. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Smell loss can be among the earliest signs of Parkinson’s disease (PD) and other neurodegenerative diseases, signaling changes in the brain years before other symptoms are noticeable. Because of the link between smell and brain health, researchers are very interested in understanding more about how people with smell loss go on to either develop a disease or not, and why some people with PD still are able to smell. To learn more about the latest research, tune into audio from this Third Thursdays Webinar and listen to expert panelists discuss the science of smell and what scientists are learning about its connection to disease.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

You could take any two humans on earth and their genetic code will be roughly 99 percent the same — it’s the small differences in code that lead to different experiences and outcomes, including the risk of developing diseases like Parkinson’s. Scientists are learning more about which genetic changes are linked to Parkinson’s disease, revealing important insights into disease biology and progression. Tune into this episode of our award-winning “Parkinson’s Science POV” series to learn how researchers are using genetics to better understand the disease and work toward better treatments for all.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

This episode was made possible byPrevail Therapeutics. Partner support allows us to furnish high-quality educational content to the Parkinson's community while maintaining our commitment to allocate donor dollars to high-impact research. Editorial control of all Michael J. Fox Foundation-published content rests solely with the Foundation. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

With three new Parkinson’s treatments approved in the last year, there are more options than ever before for people living with the disease. Tune into audio from this Third Thursdays Webinar to hear movement disorder specialists, research experts and a person living with Parkinson’s answer community questions about the new treatments available, explain how therapies make it through FDA approval and share the latest on treatments in the pipeline.   

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Movement disorder specialist, lifestyle medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, shares tips on medication management for people at every stage of the disease journey.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

It is widely known that a healthy diet can provide essential nutrients and lead to a multitude of benefits, but growing evidence has highlighted important links between diet, nutrition, and brain health, particularly related to neurodegenerative disease. In this episode, Dr. Puja Agarwal discusses her research investigating the role that diet and nutrition may play in Parkinson’s disease and other neurodegenerative conditions. Evidence from her studies and the work of others suggests that certain diets, including the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, are associated with brain health and may have the potential to delay the onset or slow progression of Parkinson's disease or other neurodegenerative conditions. We hear more about her ongoing MJFF-funded research project examining the role of diet in the progression of parkinsonian signs and its association with Lewy body pathologies, as well as future directions for this exciting line of research. Puja is an Assistant Professor in the Department of Internal Medicine at Rush University.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Parkinson's disease significantly impacts various aspects of communication, and this can make it challenging for people with the disease to communicate effectively, be understood by others, and engage in social situations. Dr. Gemma Moya-Galé joins this episode to talk about her work on voice and communication in people with Parkinson’s disease. In particular, she discusses a novel app she and her team are developing, with funding from The Michael J. Fox Foundation, to help people with Parkinson’s improve how well their speech is understood. The app uses evidence-based principles from speech therapy and noise-augmented automatic speech recognition to provide speech training and feedback. She also shares her recent research on linguistically and culturally responsive methods for addressing communication challenges in both English- and Spanish-speaking individuals with Parkinson's disease, and how this approach has the potential to improve clinical care. Gemma is an Assistant Professor of Communication Sciences and Disorders, as well as the Director of the Communication, Technology, and Language Diversity Lab at Teachers College, Columbia University.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Certain populations are disproportionately affected by neurological diseases, including Parkinson's and other neurodegenerative diseases. A lot of work remains to be done to improve brain health outcomes and promote healthy brain aging across the lifespan, particularly for minoritized, underrepresented populations. Including participants from diverse backgrounds in research helps ensure that the results from studies and clinical trials in the field are valid, generalizable, and representative of all individuals affected by these diseases. 

In this episode, Dr. Monica Rivera-Mindt discusses brain health inequities in neurodegenerative diseases, her work using culturally informed community-engaged research methods to improve representation in research studies, important gaps in the literature, lessons learned from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Diversity Task Force that could be applied in Parkinson's disease research, and more. Monica is Professor of Psychology, Latinx studies, and African and African American studies at Fordham University, and she has a joint appointment as Professor of Neurology at the Icahn School of Medicine at Mount Sinai. She is also a board-certified neuropsychologist.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Alpha-synuclein plays a key role in the pathophysiology of Parkinson's disease, and researchers have been investigating this protein as a therapeutic target and also as a potential biomarker for the disease. The alpha-synuclein seed amplification assay, developed by Dr. Claudio Soto and colleagues, leverages the self-replicating nature of the misfolded alpha-synuclein proteins that form aggregates in Parkinson's disease. Amplifying misfolded alpha-synuclein can allow researchers and clinicians to detect the presence of the pathological form of the protein in biospecimens, even when the amount of misfolded alpha-synuclein in a sample is very low. In this episode, Claudio discusses his work in this area and how it has opened the doors for a variety of potential uses of the alpha-synuclein seed amplification assay, including applications in diagnosis, clinical trials, and drug development for Parkinson's disease.

This year, Claudio received the 2024 Robert A. Pritzker Prize for Leadership in Parkinson’s Research for his substantial contributions to research and his commitment to mentoring the next generation of scientists in the field. Claudio is the Huffington’s Distinguished University Chair, Professor of Neurology, and Director of the George and Cynthia Mitchell Center for Alzheimer’s Disease and Related Brain Disorders at The University of Texas Medical School in Houston. He is also the Founder, Vice-President, and Chief Scientific Officer at AMPRION Inc.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

To help meet the growing global need for more movement disorders specialists, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders in collaboration with longtime partner the Edmond J. Safra Foundation. This program supports the training of movement disorders specialists who will provide expert care and drive advances in Parkinson's research. The program is positively impacting early-career clinician-researchers, as well as the centers where they train. These impacts will continue to grow over the years as more fellows are trained. In this episode, Dr. Marcelo Merello and Dr. Sergio Castillo-Torres share their insights and perspectives as a Fellowship Director and a Fellow in the program, respectively. 

Marcelo is Director of the Department of Neurosciences and Chief of the Movement Disorders Clinic at the Institute for Neurological Research or Fleni Hospital. He is fellowship Director at Fleni and the University of Buenos Aires. In addition, Marcelo is Principal Investigator with the National Council for Scientific and Technical Research and Professor of Neurodegenerative Diseases at the Pontifical Catholic University of Argentina. Sergio is an Associate Professor in Neurology and Internal Medicine at the Dr. Jose E. Gonzales University Hospital of the Autonomous University of Nuevo Leon. He was an Edmond J. Safra Fellow in Movement Disorders at Fleni Hospital. Visit michaeljfox.org/fellowship to learn more about the Edmond J. Safra Fellowship in Movement Disorders.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Stem cell models derived from patients with Parkinson’s disease are valuable tools that are helping researchers around the world to better understand the underlying causes of neurodegeneration and to develop biomarkers and new therapies. To maximize the potential impacts of these tools, it is critical that they are developed and shared according to the principles of open science. In her interview, Dr. Birgitt Schüle discusses her work developing alpha-synuclein cell lines, challenges and opportunities in the field, and important considerations surrounding open science. She goes in-depth on how the cell lines were developed, characterized, and deposited with the American Tissue and Cell Collection (ATCC) with funding support from The Michael J. Fox Foundation, as well as how these cells can be used to fuel future discoveries. Birgitt is an Associate Professor in the Department of Pathology at Stanford University School of Medicine and Co-Director of the Alzheimer’s Disease Research Center, Neuropathology, and Induced Pluripotent Stem Cell (iPSC) Core. 

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

New qualitative and quantitative tools are being developed to measure and track changes in proteins relevant for neurodegenerative disease, and these tools have the potential to accelerate drug discovery and clinical trials. In this episode, Dr. Judith Steen discusses her work creating novel qualitative and quantitative tools and workflows at the interface of proteomics and transcriptomics, including their novel FLEXI platform. This platform uses targeted, high- throughput quantitative mass spectrometry to isolate, quantify, and identify molecular changes in proteins. She describes her ongoing project, funded by The Michael J. Fox Foundation, to develop FLEXISyn, which aims to track post-translational changes in alpha-synuclein to better understand how the protein becomes dysfunctional and begins misfolding and forming toxic aggregations in Parkinson's disease. Judith is Associate Professor of Neurology at Harvard Medical School, a member of the Harvard Stem Cell Institute, and Director of the Neuroproteomics Laboratory in the F.M. Kirby Neurobiology Center at Boston Children's Hospital.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Substantial research has focused on identifying biomarkers for the diagnosis of Parkinson's disease (PD) as well as monitoring progression of the disease. In developing these biomarkers, it is critical for scientists to consider how the biomarkers will ultimately be used in the clinic and in clinical trials research. In this interview, Dr. Charles (Chuck) Adler shares his perspectives on how biomarkers are currently being used in clinical and research contexts, and what it would take for him to use them more often in clinical practice. He also discusses how groundbreaking collaborative research studies, including the Arizona Study of Aging and Neurodegenerative Disorders and the Parkinson's Progression Markers Initiative (PPMI), are having major impacts on the field. Chuck is Consultant and Professor of Neurology in the Department of Neurology and The Wayne and Kathryn Preisel Professor of Neuroscience Research at the Mayo Clinic Alix School of Medicine at the Mayo Clinic in Arizona.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Sleep disturbances, such as insomnia, sleep fragmentation, excessive daytime sleepiness, and REM sleep behavior disorder are common in people with Parkinson's disease (PD). Poor sleep quality can also impact other domains of function, including motor function. Prior research has shown that a type of photoreceptor cell in the retina, called melanopsin cells, provide the main light signals to the brain to initiate sleep, and function of these cells is impaired in PD. Dr. Beatix Feigl and her colleagues developed a novel light therapy intervention that selectively activates the melanopsin photoreceptor cells, and in this episode, she discusses the results of a recent randomized controlled trial evaluating the efficacy of this melanopsin photoreceptor-directed light therapy on sleep and circadian rhythm, as well as motor behaviors. She also discusses her earlier work on melanopsin cells that led to the development of standard measures to assess their function. Beatrix is an Ophthalmologist and an Associate Professor in the School of Biomedical Sciences and Center for Vision and Eye Research, as well as the Faculty of Health, at the Queensland University of Technology.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson’s Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Evidence supports that dysfunction in the homeostasis of iron and other elements likely contributes to the pathophysiological mechanisms of Parkinson's disease, but we have yet to develop suitable elemental biomarkers for use in diagnosing and monitoring the progression of Parkinson's disease. Dr. Paul Lingor discusses his work in this area to identify patterns of bioelements in CSF that could serve as PD biomarkers. Beyond CSF, he is also examining tear fluid as a potential biomarker source that is easier to collect. In addition to work on biomarkers, Paul has been involved in developing and evaluating new treatments for Parkinson's disease. In this episode, he discusses an ongoing phase II clinical trial evaluating the ROCK inhibitor Fasudil, as well as research examining combinations of advanced therapies for people with later-stage Parkinson's disease. Paul is Professor of Neurology at the Technical University of Munich and head of the outpatient clinics for motor neuron disease and co-head of the outpatient clinics for Parkinson’s disease.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson’s Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Prior studies have established links between poor olfaction and Parkinson's disease, and impaired sense of smell is a common prodromal symptom of Parkinson's disease. The causes and mechanisms of prodromal neurodegeneration are actively being researched. However, environmental exposure to pesticides or other chemicals may trigger or modify the course of neurodegeneration, potentially leading to the development of Parkinson's disease over time. In this episode, Dr. Honglei Chen shares his research on environmental causes of neurodegenerative diseases, focusing particularly on evidence linking olfaction, environmental exposure, and Parkinson’s disease. Better understanding how environmental factors may contribute (alone or in combination with genetic factors) to the pathogenesis of Parkinson's disease may lead to new approaches to prevent or slow the progression of neurodegeneration. Honglei is the MSU Research Foundation Professor of Epidemiology and Biostatistics at Michigan State University.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Gait impairments such as slow speed, small steps, and high variability from step to step are common in people with Parkinson's disease, and these changes begin to occur early in the course of disease. Freezing of gait may develop later for some individuals, and it has been linked to falls and other adverse outcomes. When the quality of walking declines, it can lead to a reduction in the quantity of walking and overall physical activity, which is also related to poorer health outcomes. To prevent this cascade of events, Dr. Gammon Earhart is developing and evaluating interventions to improve gait and increase physical activity in People with Parkinson's disease. In this episode, she discusses how she and collaborators are conducting studies on different approaches, including a mobile health application, self-generated rhythmic cues in the form of singing, and mindfulness training, to improve aspects of walking and physical activity in people with Parkinson's disease. Gammon is Professor of Physical Therapy, Neurology, and Neuroscience, Associate Dean for Physical Therapy, and Director of the Program in Physical Therapy at Washington University School of Medicine in St. Louis.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Improving our understanding of the complex neural circuits involved in normal function of the basal ganglia and other parts of the brain impacted by Parkinson's disease is critical for developing more targeted and more effective treatment approaches. In this episode, Dr. Aryn Gittis discusses her research examining how the activity of specific basal ganglia circuits relates to motor control in both health and pre-clinical models of movement disorders like Parkinson's disease. She describes new research on basal ganglia circuits that expands upon existing theoretical frameworks and provides important insights that can be leveraged to improve current therapies for Parkinson's disease by better targeting specific cell types in relevant circuits. Aryn also shares details about her ongoing project evaluating the impacts of stimulus location for a novel pattern of deep brain stimulation (DBS) that has been shown to provide long-lasting therapeutic effects in pre-clinical models. Aryn is Professor of Biological Sciences and the Neuroscience Institute at Carnegie Mellon University.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Demand for movement disorder specialists continues to grow, but not enough neurologists are receiving focused training in Parkinson’s and related conditions in order to meet the current and projected needs in the U.S. and around the world. In collaboration with longtime partner the Edmond J. Safra Foundation, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders with the goal of growing the global base of movement disorders specialists. In this episode Dr. Rachel Dolhun shares more about this fellowship program, the application process, and how the program supports the training of movement disorders clinician-researchers who will become leaders in Parkinson's care and advance science in the field. Rachel is Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research. Visit michaeljfox.org/funding to learn more about the Edmond J. Safra Fellowship in Movement Disorders. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Trichloroethylene (TCE) and related chemicals like perchloroethylene (PCE) have been used widely for a variety of commercial purposes over the past century, and these chemicals are prevalent in the air, water, and soil. Over the past several decades, mounting evidence has been published linking exposure to TCE/PCE with adverse health effects, including cancer and Parkinson's disease. In this episode, Dr. Sam Goldman discusses his research on environmental risk factors for Parkinson’s disease, focusing on recently published studies examining Parkinson's disease risk in Veterans at Camp Lejeune and also a cluster analysis investigating parkinson's disease diagnoses in people who worked near a contaminated site. Sam is a Professor in the Division of Occupational, Environmental, and Climate Medicine and the Departments of Medicine and Neurology at the University of California, San Francisco (UCSF). He is also a Principal Investigator in the San Francisco Veterans Affairs Medical Center.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

For over a century, different surgical interventions have been explored to address symptoms of Parkinson's disease, and researchers are continuing to innovate and improve surgical treatments today. With new technology and an ever-expanding understanding of the function of the nervous system and the pathophysiology of Parkinson's disease, neurosurgical interventions are becoming more effective and more personalized. Dr. Doris Wang joins us in this episode to discuss her work using focused ultrasound and deep brain stimulation (DBS) as treatments for Parkinson’s disease and other movement disorders. She discusses some of the benefits and limitations of focused ultrasound treatment, comparisons of traditional versus asleep interventional MRI-guided deep brain stimulation surgery, advances in adaptive deep brain stimulation, and the development of gait-related biomarkers that could drive adaptive DBS. Doris is a neurosurgeon and Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF). 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

The Michael J. Fox Foundation for Parkinson's Research established its Research Tools Program to address gaps in the field and common challenges surrounding the development of reagents and models that slowed the initial stages of promising research projects. In collaboration with many partners and stakeholders, the Research Tools Program helps ensure that scientists around the world have access to high-quality reagents, models, and more. These tools have been instrumental in launching novel research projects to better understand Parkinson's disease and to develop promising new treatment strategies. This episode features Dr. Nicole K. Polinski, Director of Research Resources at The Michael J. Fox Foundation for Parkinson’s Research. In our conversation, she discusses her role in the organization, the wide variety of tools available through the Research Tools Program, and how academic and industry researchers can share their insights and feedback on current tools and future directions for tool development.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Increasing evidence supports the presence of sex and gender differences in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. There is a critical need to more closely examine sex and gender differences in all stages of research, therapeutic development, and clinical treatment to enable better outcomes through precision medicine approaches. This episode focuses on the relevance of sex and gender factors in Parkinson's disease and efforts to transform scientific research, policy, and healthcare to identify and address needs based on sex and gender. Our guest Dr. Antonella Santuccione Chadha discusses her work with the Women’s Brain Project, their recent roundtable on enhancing care in Parkinson’s disease, and the organization's goals for the future. Antonella is a medical doctor with experience spanning positions in clinical care, academic research, the Swiss Agency for Therapeutic Products (regulatory), and industry leadership and consultation for large pharmaceutical companies and smaller start-up companies. She is currently Co-Founder and Pro Bono Chief Executive Officer of the Women’s Brain Project, an international non-profit organization studying sex and gender determinants to brain and mental health.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Atypical Parkinsonian Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies are often initially diagnosed as Parkinson's disease. Incorrect, incomplete, or delayed diagnoses are barriers to beginning the most appropriate treatment early in the disease course. More research is needed to facilitate early diagnoses, understanding of disease pathogenesis, and monitoring of disease progression. However, largescale, collaborative initiatives are making meaningful progress in understanding genetic contributors to disease pathology and progression in Parkinson's disease. Our guest in this episode, Dr. Huw Morris, has spent more than twenty five years researching Parkinson's disease and parkinsonian syndromes, and he shares highlights from recent work, including studies on the genetics and pathogenesis of Parkinson’s disease and other parkinsonian syndromes. Huw is Professor of Clinical Neuroscience at University College London Institute of Neurology, as well as an Honorary Consultant Neurologist at the Royal Free Hospital and the National Hospital for Neurology and Neurosurgery Queen Square. 

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

For many years, Parkinson's disease and dementia with Lewy bodies have been defined using clinical features. With recent advances in biomarkers, particularly the alpha-synuclein seed amplification assay that allows us to detect misfolded and aggregated alpha-synuclein in cerebrospinal fluid, it is now possible to identify the presence of pathological neuronal alpha-synuclein in living patients. With input from diverse stakeholders, a new biological definition of neuronal alpha-synuclein disease (NSD) has been proposed, along with an integrated staging system (NSD-ISS). In this interview, we discuss the development of this biologic definition for Parkinson’s disease and the staging system with Dr. Lana Chanine, one of the lead authors of the recently published manuscript in The Lancet Neurology that describes this work. It is important to note that the NSD and NSD-ISS are for research purposes only right now, and they are not ready to be implemented in the clinic. Lana is a Movement Disorders Neurologist and Associate Professor of Neurology at the University of Pittsburgh.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

There is a pressing need to develop safe and effective disease-modifying and symptomatic treatments for Parkinson's disease. Through improvements in our understanding of the pathophysiology of the disease, as well as genetic risk factors, new potential treatment targets have emerged. However, bringing a promising new compound from the lab through all of the steps of drug development is a long, difficult, and resource-intensive process. In recent years, collaborative efforts and advances in biomarkers have led to important breakthroughs that have the potential to facilitate the development of new drugs for Parkinson's disease. In this episode, Dr. Kalpana Merchant draws from over two decades of pharmaceutical industry experience to share progress in drug discovery and development for Parkinson’s disease and other neurodegenerative conditions. Kalpana is President and Chief Scientific Officer at TransThera Consulting, which provides guidance on drug discovery and translational strategies to biopharma startup companies. She is also an Adjunct Professor at Northwestern University’s Feinberg School of Medicine, a member of the Oregon Innovation Council, a Scientific Advisor at The Michael J. Fox Foundation, and she serves on advisory panels at the National Institutes of Health.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

In neurodegenerative conditions such as Parkinson's disease (PD), patients often do not receive a diagnosis until the hallmark motor symptoms begin to manifest. This can be a decade or more after substantial changes start occurring in the brain. A major goal of the PD research field has been to develop methods for earlier detection and intervention. Over the years, there have been substantial advances in neuroimaging techniques and biological biomarkers that have allowed us to more accurately identify patients with Parkinson's disease, including the recent development of the alpha-synuclein seed amplification assay. In this episode, Dr. John Seibyl discusses his early work on neuroimaging in Parkinson's disease through to the groundbreaking, large-scale clinical trials he is involved with for assessing the impacts of neuroprotective drugs for Parkinson's disease as well as Alzheimer's disease. He also shares his perspectives as a researcher and a patient with Parkinson's disease. John is Chairman of the Board, Co-Founder, and Senior Scientist of the Institute for Neurodegenerative Disorders in New Haven, Connecticut. He is also a board-certified physician in both Psychiatry and Nuclear Medicine, and he is an Adjunct faculty member in Neurology at Yale University School of Medicine.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

A substantial portion of people with Parkinson's disease (PD) have a family history of the disease, and new findings continue to improve our understanding of relevant genetic variants. These discoveries are key for clarifying the mechanisms that lead to Parkinson's disease as well as the development of new therapies. The Global Parkinson's Genetics Program (GP2) was established to gather and integrate genetic and clinical data from diverse participants around the world to expand our knowledge of the genetic architecture of PD. In this episode, Dr. Christine Klein discusses her experiences as Co-Leader of the Monogenetic Network of GP2, including the early days of setting up this large-scale collaboration, important achievements to date, and priorities and considerations going forward. She also shares recent findings from her own research on genetic variants related to Parkinson's disease. Christine is Director of the Institute of Neurogenetics and of the Section of Clinical and Molecular Neurogenetics at the Department of Neurology, as well as the Schilling Professor of Neurology at the University of Lübeck in Germany. She is also Co-Director of the Monogenetic Network of GP2. 

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

A growing body of evidence is expanding our understanding of the links between inflammation, our immune responses, brain health, and neurodegeneration. In particular, several genes associated with Parkinson's (including LRRK2) are known to be involved in inflammation, and peripheral inflammation has been shown to influence brain function and contribute to the development of neurodegenerative diseases. Better understanding the roles of inflammation and our immune responses in Parkinson's disease is important for developing new treatments and strategies to slow or prevent disease progression. In this episode, Dr. Malú Gámez Tansey talks about her research at the intersection of immunology, neuroscience, and genetics. She describes new findings and current projects in her lab, discusses advances in neuroimmunology, and shares her insights on important areas of opportunity in the field. Malú is the Norman and Susan Fixel Chair in Parkinson's Disease, Professor of Neuroscience and Neurology, and Director of the Parkinson's Foundation Research Center of Excellence at the University of Florida College of Medicine. She's also editor-in-chief of Nature Partner Journal Parkinson's Disease.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

Mutations in the LRRK2 gene were first linked to Parkinson's disease (PD) risk in 2004. Since then, researchers from around the world have advanced our understanding of the mechanisms through which LRRK2 may contribute to PD, leading to the development of three potential LRRK2-targeted therapies that are now being evaluated in clinical trials. Along with colleagues and collaborators, Dr. Dario Alessi has pioneered new research and approaches that have aided in the development of drugs to inhibit LRRK2 and potentially treat people with Parkinson's disease. In this episode Dario discusses his work developing the LRRK2 kinase assay, LRRK2 Ser935 dephosphorylation assay, and Rab phosphorylation assay, as well as future directions and opportunities in the field. This year, Dario received the 2023 Robert A. Pritzker Prize for Leadership in Parkinson’s Research for his substantial research contribution and his commitment to mentoring the next generation of Parkinson’s scientists. Dario is the Professor of Signal Transduction and Science Director of the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

For decades, researchers, clinicians, and industry professionals have continued to study and optimize deep brain stimulation (DBS) with the goal of providing the best possible personalized treatment for Parkinson’s disease (PD) and other neurological conditions. In this episode, Dr. Michael Okun joins us to discuss his research and some of the recent advances in deep brain stimulation and other areas. He draws from his extensive research and clinical experience applying DBS and neuromodulation therapies for patients with PD, Tourette syndrome, tic disorders, dystonia, essential tremor, and obsessive-compulsive disorder. Michael is co-founder and co-director of the Norman Fixel Institute for Neurological Diseases at the University of Florida, as well as Medical Advisor for the Parkinson’s Foundation. He is a board-certified neurologist, movement disorders specialist, neuroscientist, author, and an expert on deep brain stimulation and neuromodulation for movement disorders. 

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Sleep impacts our lives in many different ways, and Dr. Amy Amara joins us in this episode to discuss her career and findings from her research on sleep in Parkinson’s disease (PD). She shares her insights on the characteristics of sleep in people with Parkinson’s disease, how sleep can be impacted by exercise, medications, and deep brain stimulation, and how studying rapid eye movement (REM) sleep behavior disorder may be important for developing early treatments before PD motor symptoms manifest. Amy is a Professor of Neurology at CU Anschutz School of Medicine who is an expert on quantitative electroencephalography, sleep disorders, and neurodegenerative disease. 

This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In this episode, serial entrepreneur Dr. Karoly Nikolich shares his perspectives on the industry side of the state of neuroscience, as well as areas of opportunity and the role of industry in advancing the field. He also discusses recent major breakthroughs, the importance of industry partnerships, including collaborations with The Michael J. Fox Foundation (MJFF), and how he is working to advance Parkinson's disease research through his work at Alkahest and other endeavors. Karoly is a scientific advisor at Bayshore Global Management and at Pivotal Bioventures. In addition, he is Chairman and Executive Advisor at Alkahest Inc., and also an Adjunct Professor of Psychiatry at Stanford University. Karoly has extensive expertise in the biotech and neuro-therapeutics industries, and he also manages his foundation, the Scholar Nikolich Foundation. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

New research advances are expanding our knowledge of Parkinson's disease and bringing us closer to the ultimate goals of new treatments, effective cures, and disease prevention. In this introductory episode, you'll hear from Dr. Brian Fiske and Dr. Mark Frasier, Co-Chief Scientific Officers at The Michael J. Fox Foundation for Parkinson's Research (MJFF). During the conversation, they provide their perspectives on the state of the field of Parkinson's disease research, describe new advances in biomarkers for Parkinson's disease, and discuss progress in the development of novel therapeutics. They also share insights on resources and tools being developed to advance Parkinson's research, MJFF's research strategy, and what it could mean for your research.

Mentioned in this episode:

This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience.  These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

If depression, anxiety or apathy occur as part of a Parkinson’s journey, it can be easy to feel alone, isolated or unsure of what might bring relief. But there are ways to manage these symptoms. Tune into audio from this Third Thursdays Webinar to hear people living with Parkinson’s share their stories of coping with mood changes as well as a movement disorder specialist and psychiatrist discuss pharmacological and non-pharmacological treatments options. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Movement disorder specialist, lifestyle medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, answers community questions on Parkinson’s and exercise with physical therapist and rehab scientist Cristina Colón-Semenza, PhD. 

Listen to the audio or watch the video. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Being a care partner to someone with Parkinson’s disease (PD) can be a shifting and complex role, as symptoms and life circumstances change. And sometimes, this can lead to stress and even burnout for the care partner. Tune into audio from this Third Thursdays Webinar to hear expert panelists discuss how to navigate care partnership, including everyday strategies to de-stress and find supportive community.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Understanding the biology of Parkinson’s disease (PD) and turning that knowledge into better treatments is a complex undertaking. In this episode of the award-winning Parkinson’s Science POV series, scientists at The Michael J. Fox Foundation (MJFF) discuss how they are tackling this problem from every angle. Whether it’s using cutting-edge imaging to get a picture of the disease in the brain or working with the community to develop better options to treat walking difficulties, our researchers are collaborating to discover the next wave of treatment options and close in on a cure. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Watch our webinar or read our Year in Review at michaeljfox.org.

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

With two new drugs approved by the FDA, a National Plan signed into law and many advances in our understanding of Parkinson’s disease, 2024 has been a transformative year in Parkinson’s research. Tune into audio from this month’s Third Thursdays Webinar to hear research experts from industry and academia talk with MJFF staff about the latest research on disease biology and emerging therapies.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0   

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Each person living with Parkinson’s disease (PD) will have a unique journey with their treatments, including the decision to have deep brain stimulation (DBS), which is a surgical procedure to treat Parkinson’s motor symptoms. While DBS isn’t suitable for everyone, it can be helpful in the right person, and it’s a complex, lifelong choice. And although the experience goes far beyond surgery day, brain surgery often looms large in people’s minds as they are contemplating DBS. In this episode, our expert panelists tackle community-sourced questions on DBS surgery day: what to wear, how loved ones can support, what it feels like to be awake during brain surgery and more. Tune in to hear from two people who have had DBS, a neurosurgeon and a movement disorder specialist and learn more about the realities of surgery day.  

For more information on deep brain stimulation, download our newly updated, comprehensive guide or check out our webinar at michaeljfox.org.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community: https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. People from all backgrounds with and without Parkinson’s can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Troubles with gait – slow walking, shuffling steps and foot dragging and more – can be symptoms of Parkinson’s. In audio from this Third Thursdays Webinar, our experts explore the robust research efforts underway to understand and treat gait issues, from physical rehab interventions to deep brain stimulation modifications to wearable robots designed to smooth gait.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0  

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In this podcast, four people from different backgrounds have a candid conversation on race, stigma and Parkinson’s. They share their experiences trying to find culturally competent medical professionals, overcoming the barriers to research participation, and communicating with their communities about their diagnosis. And they offer tips and advice on finding empowerment through education and advocacy.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community: https://apple.co/3p02Jw0  

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. People from all backgrounds with and without Parkinson's can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Parkinson’s disease brings with it many potential symptoms, including hallucinations (seeing things that are not there) and delusions (believing things that are not true). Not everyone will experience these symptoms and not everyone who does will find them bothersome, but it can be a source of uncertainty and concern for people living with the disease. In audio from this Third Thursdays Webinar, our expert panel discusses navigating life with these symptoms and medication and non-medication strategies to manage them.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0

The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Finding the right Parkinson’s treatment plan can be a trial-and-error process. The kind of medication, the dosage, the timing and lifestyle factors are all important pieces of the puzzle. In audio from this Third Thursdays Webinar, our expert panel made up of people living with Parkinson’s disease (PD), a movement disorder specialist and a researcher discuss different medication options, practical tips for finding what works best for you and the latest research on emerging treatments.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Research shows mindfulness and meditation can improve some Parkinson’s (PD) symptoms and help people live a better life with the disease, but it can be tricky to put into practice. In this podcast, you’ll hear from people whose lives have been touched by PD and who use mindfulness to reduce symptoms and stress, and from a researcher who is studying how mind-body strategies can be used to treat Parkinson’s. Tune in for practical tips, advice and a guided meditation you can try at home.  

You can find links to the resources mentioned in the episode on our website:  michaeljfox.org/podcast/breathing-through-mindfulness-parkinsons-treatment-tool 

You can also download our free guide on exercise and Parkinson’s disease, which includes tips for incorporating meditation into your daily routine at michaeljfox.org/exerciseguide 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

The decision-making process around deep brain stimulation (DBS) to treat Parkinson’s motor symptoms can be a complex and emotional journey. People often have questions about when – and whether – to have the procedure and what the experience is like, from the months of evaluation pre-surgery to surgery day to life with the device. In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s disease (PD) and a movement disorder specialist share their DBS stories and answer audience questions about their choices and experiences.   

Learn more about deep brain stimulation and download our free guide on our website: https://bit.ly/4cTOT52

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community.  

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Just over a year ago, there was a major breakthrough in Parkinson’s disease (PD) research – a tool that could detect abnormal alpha-synuclein protein in the spinal fluid of people living with PD even before onset of symptoms. This discovery is already impacting the ways scientists conduct and think about Parkinson’s research. Tune into this episode of our award-winning “Parkinson’s Science POV” series to learn  how researchers are using the test to better understand disease biology and what the future holds.    

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

You might be interested in stepping forward for science to play a role in the next breakthrough in Parkinson’s research, but still have questions about how to actually participate. How do you pick the right study for you? How do you balance your life logistics and your medical care considerations? What rights do you have when you participate in a study? In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s and research experts discuss the practicalities and benefits of volunteering for research.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Many people living with Parkinson’s disease (PD) experience pain as a non-motor symptom. Pain can arise from stiff muscles, dystonia, nerve pain and even the disease progression itself. It’s a symptom that some find difficult to talk about, but there are options for people to find relief. In audio from this Third Thursdays webinar, listen to our expert panel of people living with PD, movement disorder specialists, and an integrative pain specialist discuss pain and Parkinson’s – why it happens, treatments to reduce it, and practical tips you can start incorporating today.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In this episode, hosted by Larry and Rebecca Gifford, members of The Michael J. Fox Foundation’s Patient Council and their care partners share their honest reactions to their diagnosis — from panic and denial to sadness and loneliness. This group of men and women of different ages and backgrounds offers words of wisdom about what to consider, what they’ve lost and what they’ve gained – and you’ll be surprised to hear how, for some, what they’ve gained is more than what they lost. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

If you or a loved one was recently diagnosed and you’re wondering where to start, visit https://www.michaeljfox.org/newlydiagnosed to find helpful resources, including an educational guide, support groups and videos. 

Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org.  

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In this raw and emotional conversation, four women with Parkinson’s living in four different countries discuss the challenges faced because of delayed diagnosis, hormonal changes, lack of information and treatment, research inequity and gender biases. They share how they live better with the disease by advocating for themselves with their health care team and how they empower other women through awareness and activism. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Connect with other women who share your experiences with Parkinson’s. The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org. 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Living with Parkinson’s comes with a variety of symptoms, some of which can be unexpected, and frankly, embarrassing. Drooling, bladder issues and sexual dysfunction are hard to talk about, even with loved ones or your doctor – and can affect your self-image,  your intimate relationships or the way you move through the world.  In audio from this Third Thursdays webinar, listen to our expert panel of people living with Parkinson’s, a care partner and a movement disorder specialist discuss Parkinson’s taboo topics and ways that you can navigate hard conversations and embarrassment.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 

Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org.  

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

The biology behind what causes Parkinson’s is complex, with only about a quarter of cases with clear genetic drivers. The environment – where you live, the air you breathe, the food you eat, the world around you – plays a key role in PD. Emerging research is showing environmental exposures to things like pesticides and pollution may interact with a person’s genetics and contribute to the disease. And there’s a myriad of other factors still being investigated, from the forces that drive your access to neighborhoods with clean air and water, good doctors and healthy living opportunities to psychosocial factors like stress and discrimination. In audio from this Third Thursdays Webinar, listen to our expert panel discuss the latest research and ways you can get involved to end preventable exposures and advocate for Parkinson’s policy.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

The drug development pipeline is key to bringing new therapies to people with Parkinson’s disease (PD). With major breakthroughs in research in the past year, including a new biomarker for PD, The Michael J. Fox Foundation’s Parkinson’s Progression Markers Initiative (PPMI) study and other initiatives can be leveraged to create better designed trials. This audio from our Third Thursdays Webinar features a conversation about all the ways clinical trial design is changing, and why leaders in the space believe those changes will lead to better treatments. The webinar includes contributions from a person with PD, a researcher and an industry leader.     

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0   

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Dating and beginning new relationships with Parkinson’s involve distinct challenges, joys and fears. In this frank and funny podcast, our experts discuss how they face considerations like building and maintaining confidence, disease disclosure, and the importance of self-knowledge and self-care in new relationships. They remind us all that no matter what we’re facing, dating and finding love can be fun and fulfilling. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Whether you’ve been newly diagnosed or have been living with Parkinson’s for many years, The Michael J. Fox Foundation’s Parkinson’s Buddy Network is a free, online platform that helps you find new connections, access educational resources and engage in important dialogue. Join our community today at parkinsonsbuddynetwork.org. 

The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

We know exercise is important for people with Parkinson’s. Once you’ve decided to move more, what next? In this audio from our Third Thursdays Webinar, our experts discuss strategies for making exercise a meaningful part of your life. They present ways to make time for exercise and to make the most of it, including being aware of different types, frequencies and intensities. This discussion will help you find a way to get moving and stay motivated. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 

Join a Foundation-hosted run/walk event. Or register for the Unity Walk. Every mile moves us one step closer to a cure for Parkinson's. Learn more at michaeljfox.org. 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.  

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

One key pillar of The Michael J. Fox Foundation’s research strategy is a focus on “de-risking" potential treatments for Parkinson’s disease. This episode of our award-winning “Parkinson’s Science POV” series explains how lowering the risk associated with developing new therapies leads to a more robust pipeline of treatments. The episode details several recent successes of the strategy. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 

Join a study today to help speed progress toward better treatments and a cure for Parkinson’s disease. To search for studies in your area, visit Fox Trial Finder at foxtrialfinder.org. 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Doctors have been using DaTscan brain imaging as a tool to help diagnose the Parkinson’s disease (PD) for more than a decade, but even people who know a lot about the disease often still have questions about its role — and the role of other imaging tools — in diagnosis and care. What’s a DaTscan, and how does it relate to PET, SPECT and MRI? When is a DaTscan or other brain imaging tool used in PD? Are there any risks? 

In this audio from our Third Thursdays Webinar, experts and people with PD offer listeners an impromptu course in Brain Imaging 101. You’ll learn to differentiate the different types of imaging used to visualize the brain and how they are used in PD research and care. You’ll also learn the latest in efforts to visualize alpha-synuclein, the protein that misfolds and clumps in Parkinson’s, and what its selective imaging in the living brain will mean for PD clinical trials and care. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

The holidays can be a time of joyful celebration with those we love. They may also come with the stress of travel, disruptions to your regular routine or even loneliness.  For those living with Parkinson’s disease (PD), or those taking care of someone they love with the disease, these feelings can be intensified. This podcast offers tips to people living with PD, as well as their care partners, friends and family, for how to prepare — mind, body and suitcase — to make your holidays happy.  

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In a year of remarkable progress for the Parkinson’s field, we’re entering a new era for better understanding the biology of the disease, with the identification of a breakthrough biomarker accelerating new therapeutics through the clinical pipeline and legislators on Capitol Hill moving toward legislation that unites the federal government on a mission to treat, prevent and cure Parkinson’s disease. 

What does this progress mean for researchers studying Parkinson’s and for those living with the disease? And what will come next? 

Tune in as scientists and staff from The Michael J. Fox Foundation (MJFF) answer these questions and share insights in our latest Third Thursdays Webinar. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Join a study today to help speed progress toward better treatments and a cure for Parkinson’s disease. To search for studies in your area, visit Fox Trial Finder at foxtrialfinder.org.  

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi. 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

In a groundbreaking discovery earlier this year, a global consortium founda new variant in the GBA gene that is associated with a higher risk of Parkinson’s disease (PD) for people of African ancestry. The finding marks the first African ancestry-specific genetic risk factor for Parkinson’s disease. In this podcast, researchers share the human stories behind the discovery, which underscores the importance of international collaboration and the participation of underrepresented communities in research.  

Themes covered in this discussion: 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network.https://apple.co/3p02Jw0 

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi 

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

People with Parkinson’s disease (PD) have lots of questions about probiotics, prebiotics, laxatives and fiber. That’s because constipation and bloating are some of the more bothersome but less talked about symptoms of PD. In this audio from our Third Thursdays Webinar, experts and people with PD discuss effective ways for managing constipation and other gut-related symptoms. You’ll also learn about emerging treatments for constipation, the gut-brain connection and why the gut is linked to Parkinson’s. 

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0  

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit

Shock, doubt, anxiety — a diagnosis of Parkinson’s can trigger these and many other difficult emotions. This replay of audio from our Third Thursdays Webinar features a conversation among people with Parkinson’s about how they processed the emotional aftermath and navigated the early years following their diagnosis. We also hear from a psychologist who specializes in Parkinson’s about what she’s learned about how people deal with this life-changing diagnosis and ways to manage the emotions in a positive way.

Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0

Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.

Mentioned in this episode:

All Grit. No Quit. is our bold Campaign to raise $2.5 billion by 2028. This is our biggest push yet toward a world without Parkinson's and we need to bring the full force of our community to meet this moment. Whatever brings you here, you can be a part of accelerating what comes next. michaeljfox.org/campaign/all-grit-no-quit