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Metabolic Mind

Metabolic Mind

Bret Scher, MD FACC

Metabolic Mind is working to transform the study & treatment of mental disorders by exploring the connection between metabolism & brain health. Metabolic interventions like ketogenic therapy are being used to treat serious mental illnesses like Bipolar Disorder, Schizophrenia, & Major Depressive Disorder. We explore topics that can help you understand how Metabolic Psychiatry might help you or a loved one treat mental disorders Watch our videos at https://www.youtube.com/@metabolicmind Our channel is for information only. Consult your physician before changing your lifestyle or medications.

45 - Solutions to Prevent Early Death in Bipolar Disorder with Dr. Melvin McInnis
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  • 45 - Solutions to Prevent Early Death in Bipolar Disorder with Dr. Melvin McInnis

    People with bipolar disorder are four to six times more likely to die prematurely compared to those without a psychiatric disorder. (In comparison, smokers are two to three times more likely to have a shortened lifespan.) There are several contributing factors, including things like metabolic dysfunction, as well consequences of lifestyle choices influenced by disease burden Science needs to urgently investigate these extremely poor outcomes in search of more effective interventions that will enhance quality of life for people with bipolar disorder. Emerging evidence and clinical experience indicate that ketogenic and metabolic therapies may have a central role in addressing this concerning trend. Dr. Bret Scher interviews Dr. Melvin McInnis, Professor of Bipolar Disorder and Depression at University of Michigan, on these pressing topics. Dr. McInnis is working on a pilot trial that will look at a “ketogenic mimicking diet,” augmenting a low carb diet with exogenous ketones in bipolar disorder. Could this address unwanted metabolic dysfunction in this population? We applaud Dr. McInnins and his team for asking the question. Experts in this episode: Melvin McInnis, M.D., FRCPsych https://medicine.umich.edu/dept/psychiatry/melvin-mcinnis-md https://medicine.umich.edu/dept/prechter-program/melvin-g-mcinnis-md-frcpsych Study The Heinz C. Prechter Longitudinal Study of Bipolar Disorder https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837550/ If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources: https://www.metabolicmind.org/families-and-peers Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#MentalIllness#AlternativeTreatment#MedicalKeto#KetogenicTherapy #KetoForBipolar#Bipolar

    Mon, 22 Apr 2024 - 41min
  • 44 - Trailblazing Stanford Trial Shows Keto Improves Serious Mental Illness - with Dr. Shebani Sethi

    A pioneering, peer-reviewed pilot trial at Stanford, supported by funding from by Baszucki Group and others, investigated a 4-month keto diet intervention for individuals diagnosed with bipolar disorder or schizophrenia who also had metabolic abnormalities such as insulin resistance or impaired glucose tolerance. They saw dramatic psychiatric and metabolic improvements that warrant further research investigations and offer hope to patients looking for new treatment options. Dr. Bret Scher interviews Shebani Sethi, MD, ABOM of Stanford University School of Medicine and Founding Director of the Stanford Metabolic Psychiatry Clinic. She discusses the details of this study which represents a milestone in the field of metabolic psychiatry: It is the first to investigate ketogenic therapy in serious mental illness since 1965. Standard of care treatments for bipolar disorder and schizophrenia typically exacerbate metabolic dysfunction, often leading to increased cardiometabolic risk and comorbidities that shorten lifespan. This trial showed unique outcomes in terms of dual improvements in both metabolic function and psychiatric symptoms Key findings of the single-arm pilot trial include: - 79% of participants showed clinically meaningful psychiatric improvement - 100% of participants who met the criteria for metabolic syndrome were in remission by the end of the study. - Reductions were seen in weight, body mass index (BMI), waist circumference, and visceral adipose tissue. - Improvements were identified across all psychiatric measures. & more Based on the results of Dr. Sethi’s study, along with preliminary data from a University of Edinburgh trial, Baszucki Group has followed its pilot trial grants with the establishment of a new global funding program: ReThink Bipolar: Researching Therapeutic Integration of Nutritional Ketosis in Bipolar Disorder. To date, the program has announced $8M in funding to McLean Hospital and the University of Pittsburgh for randomized controlled trials combining mechanistic explorations with a clinical ketogenic intervention. Experts in this episode: Shebani Sethi MD, ABOM https://med.stanford.edu/profiles/shebani-sethi#bio Twitter: @ShebaniMD Study: https://www.sciencedirect.com/science/article/pii/S0165178124001513?via%3Dihub Stanford news release: https://med.stanford.edu/news/all-news/2024/04/keto-diet-mental-illness.html If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources: https://www.metabolicmind.org/families-and-peers Dive into the research happening on metabolic psychiatry: https://www.metabolicmind.org/research Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#MentalIllness#AlternativeTreatment#MedicalKeto#KetogenicTherapy #KetoForBipolar#KetoForSchizophrenia

    Mon, 15 Apr 2024 - 22min
  • 43 - Are We Biased Toward a Keto Diet?

    There are many biases both for and against a keto diet. At Metabolic Mind, an organization focused on ketogenic therapy for psychiatric conditions like bipolar, schizophrenia, and chronic depression, we acknowledge our own pro-keto bias; however, we also are proactive about taking a measured approach, grounding our understanding and content in scientific evidence. Often, an anti-keto bias may be prevalent among traditional doctors due to limited education on therapeutic ketosis. You can recognize these red flags indicating an anti-keto bias: - Referring to keto as one “diet”: Keto is not a “diet,” but a physiologic state - Confounding studies on an incorrect definition of “low-carb” and ketogenic diets: They are not the same thing - And others Similarly, here are some claims that show a pro-keto bias and are unsubstantiated claims: - A keto diet is super easy for everyone to follow: The perceived difficulty of a keto diet will vary for individuals - All carbs are evil and dangerous: Fibrous carbs can be part of a balanced diet for individuals who have good metabolic health - And others At Metabolic Mind, we encourage everyone to take a balanced approach and to think critically about the current scientific evidence to make informed healthcare decisions. If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources: https://www.metabolicmind.org/families-and-peers Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#MentalIllness#AlternativeTreatment#MedicalKeto#KetogenicTherapy #KetoDiet#AntiKeto

    Mon, 08 Apr 2024 - 07min
  • 42 - Collaborative Science: How Individuals are Enhancing Research - with Dave Feldman

    Dave Feldman is a citizen scientist and founder of Citizen Science Foundation. In this interview, he sits down with us to discuss the success of the 2024 Collaborative Science (CoSci) Conference and how one community is helping make research better. All proceeds from this year’s CoSci Conference are being used to help fund further research for lean mass hyper-responders. This year’s events included presentations from medical experts, researchers and individuals with their own citizen scientist journeys. The conference was a groundbreaking gathering that highlighted the spirit of scientific discovery. Dave Feldman, Citizen Scientist CitizenScienceFoundation.org X: @realDaveFeldman More about CoSci: https://cosci.org/ Watch our interview with Dave about his lean mass hyper-responder study: https://youtu.be/hNqqr5mqSU4 If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources: https://www.metabolicmind.org/families-and-peers Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#MentalIllness#AlternativeTreatment#MedicalKeto#KetogenicTherapy #CoSci#CollaborativeScience

    Mon, 01 Apr 2024 - 23min
  • 41 - Why Keto for Mental Health May Not Be Working for You - with Dr. Bret Scher

    Ketogenic therapy can be a powerful intervention for many people with mental illness, including those with serious conditions like bipolar disorder, schizophrenia and major depression. Initial data indicates that individual response to ketogenic therapy for mental health may vary. Research is ongoing and needs to further investigate underlying mechanisms and how metabolism impacts brain function in individual patients. While keto may not be an effective treatment for everyone, there are a number of ways patients can troubleshoot their ketogenic therapy strategy before deciding this treatment option doesn’t work for them. In this practical video, Dr. Bret Scher shares seven common reasons why ketogenic therapy may not be yielding results: - Ketone levels might not be high enough - The timeframe may not be long enough–for some patients, it can take up to 3-4 months to see optimum results All of these factors can also impair results: - Vitamin & nutrient deficiencies - Concurrent medical conditions - Abusing drugs and alcohol - Some medications make it harder to get into ketosis - Other lifestyle factors such as poor sleep or too much stress It is important to note that ketogenic therapy is more than simply following a keto diet. We recommend that anyone attempting to use a keto diet to treat a mental health condition work with a trained clinician. Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ More helpful resources related to this episode: What is the difference between a keto diet and ketogenic therapy? - with Dr. Bret Scher: https://youtu.be/BK99A_bhn6Y Labs to Check Before Starting Ketosis for Mental Health: https://youtu.be/tSkOw3l8OoQ Find helpful resources, like how to find a clinician and the labs recommended for ketogenic therapy on this page of our website: https://www.metabolicmind.org/families-and-peers About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#MentalIllness#AlternativeTreatment#KetoForDepression#KetoForBipolar#DepressionTreatment#MedicationSideEffects#MedicialKeto#KetogenicTherapy

    Mon, 25 Mar 2024 - 08min
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