Podcasts by Category
- 100 - Precision Medicine in Rare Hematological Diseases: Pyruvate Kinase Activators
Join us on this podcast episode featuring Prof Lucia de Franceschi (Department of Medicine, University of Verona, Italy) as she discusses the latest advances on the use of Pyruvate kinase activators in the treatment of rare hematological diseases.
Learn about the crucial role of Pyruvate kinase (PK) in erythrocyte metabolism and how pyruvate kinase activators are emerging as a new therapeutic option for chronic hemolytic anemias that had previously no other treatment than transfusion or iron chelation.
Discover how two oral pyruvate kinase activators, Mitapivat and Etavopivat, can help improve ineffective erythropoiesis and survival of red cells and therefore are being tested as a new therapeutic scenario for non-transfusion dependent thalassemia patients and sickle cell disease patients.
Discover how PK activators are able to reprogram red cells to a more normal metabolite context, which can have a beneficial effect in a wide range of rare diseases all characterized by an abnormal metabolite profile, which represents the ideal breakthrough in the management of rare diseases, as one drug has the ability to treat multiple disorders.
This is a series of podcasts covering precision medicine across several disorders, more podcasts will be available in the future. Stay tuned!
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Lucia de Franceschi
This is the seventh episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
Matte, Alessandro, Enrica Federti, and Lucia De Franceschi. 2023. ‘Erythrocyte Pyruvate Kinase Activation in Red Cell Disorders’. Current Opinion in Hematology 30 (3): 93. https://doi.org/10.1097/MOH.0000000000000758.
Interested in more content related to Thalassemia? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Wed, 01 May 2024 - 16min - 99 - Precision Medicine in Follicular Lymphoma
Join us for this captivating interview with our guest Prof Stefano Luminari, MD, PhD, from the University of Modena and Reggio Emilia in Italy, as he explores what precision medicine means today for follicular lymphoma.
Together with our host Dr. Isabel Olivera-Martinez, they discuss the current precision medicine approaches to the diagnosis and treatment of follicular lymphoma. They explore the molecular events underlying the disease, the latest targeted therapies, and the future of treatment for follicular lymphoma. Professor Luminari shares his insights on the most promising developments in the field, including T cell engagers, bispecific antibodies, and CAR-T therapies. He also discusses the importance of considering not only the efficacy of these treatments but also their impact on the quality of life and long-term outcomes for patients. This episode provides a comprehensive and enlightening discussion on the current state and future of follicular lymphoma treatment.
This is a series of podcasts covering precision medicine across several disorders, more podcasts will be available in the future. Stay tuned!
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Stefano Luminari
This is the sixth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Fri, 26 Apr 2024 - 19min - 98 - Precision Medicine in Multiple Myeloma
Join us for a captivating discussion with Prof Pieter Sonneveld, MD, PhD, from Erasmus MC Cancer Institute in Rotterdam, the Netherlands, as he explores the evolution of precision medicine in multiple myeloma.
Prof. Sonneveld outlines the improvements in multiple myeloma treatment over the past decade, describing the progressive addition of targeted therapies such as daratumumab and bispecific antibodies, BiTEs, and CAR-T cells to the therapeutic arsenal.
Discover how treatment selection now hinges on whether a one-off or continuous therapy is most suitable, acknowledging the challenges of limited availability in Europe due to cost considerations. Learn about the outstanding findings from the phase III PERSEUS trial, demonstrating the effectiveness of daratumumab combined with lenalidomide for newly diagnosed transplant-eligible patients and transforming their standard of care.
This interview unveils cutting-edge strategies that are reshaping myeloma prognosis and underscores the importance of early adoption of novel therapies for improved patient outcomes.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Peter Sonneveld
This is the fifth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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If you'd like to learn more about Multiple Myeloma, check out the comprehensive EHA - Multiple Myeloma Program on EHA Campus.
Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Fri, 12 Apr 2024 - 17min - 97 - Precision Medicine in Myeloproliferative Neoplasms
Welcome to this podcast episode featuring Prof Claire Harrison (Clinical Director at Guy’s and St Thomas’ NHS Foundation Trust) and Prof Jean-Jacques Kiladjian (Professor at Université Paris-Diderot and Hôpital Saint-Louis).
Join them as they navigate the challenges and opportunities of precision medicine in MPNs, discover how advancements in molecular techniques are reshaping disease diagnosis, patient stratification and treatment tailoring.
Gain insights into the evolving landscape of targeted therapies for MPNs, including JAK inhibitors and emerging strategies for CALR mutation targeting.
Listen as our experts highlight the heterogeneity of clinical needs based on individual patients' molecular profiles and the promise of personalised treatment approaches bringing exciting prospects for improving patient outcomes in this dynamic field.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Claire Harrison and Prof Jean-Jacques Kiladjian
This is the fourth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
If you'd like to learn more about MPN, check out the EHA - Myeloproliferative Neoplasms Program on EHA Campus.
Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Fri, 05 Apr 2024 - 13min - 96 - Precision Medicine and Clonal Hematopoiesis
Join us on this podcast episode featuring Prof Helen Papadaki (University of Crete, Greece) as she discusses the link between clonal hematopoiesis and the risk of developing MDS or AML.
Prof. Papadaki begins by explaining the difference between CHIP (clonal hematopoiesis of indeterminate potential), CCUS (clonal cytopenia of undetermined significance) and ICUS (Idiopathic cytopenia of undetermined significance). She underlines the clinical relevance of the association of clonal hematopoiesis with cytopenias, as a clear indicator of an increased risk of developing hematological malignancies.
Learn how important it is to better characterize by NGS sequencing the specific mutations of the clones, given that the type of mutation, the number of mutations, and the combination of mutations are critical parameters in accurately predicting the risk of developing MDS or AML.
Furthermore, Prof Papadaki explains the importance of discriminating between acquired and germline mutations leading to clonal hematopoiesis and their relationship with age. Finally, she highlights the fact that clonal hematopoiesis is a risk factor for developing not only hematological malignancies but also cardiac diseases.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Helen Papadaki
This is the third episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
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Fri, 29 Mar 2024 - 24min - 95 - Precision Medicine: Hepcidin Mimetics for Polycythemia Vera Treatment
Join us on this podcast episode featuring Prof Domenico Girelli, Professor of Internal Medicine and Director of the Internal Medicine Unit, University Hospital of Verona (Italy), as he discusses the latest advances on the use of Hepcidin mimetics in the treatment of Polycythemia Vera and iron metabolism diseases.
Discover how Hepcidin analogues offer a precise method for managing the overproduction of red blood cells in Polycythemia Vera patients. Explore the potential of Rusfertide, an inhibitor of Hepcidin, in regulating iron availability for erythropoiesis, thereby addressing the characteristic and chronic erythrocytosis seen in Polycythemia Vera. Gain insights into how targeting the Hepcidin-Ferroportin axis is revolutionizing the treatment of various iron metabolism disorders.
Tune in for a comprehensive discussion on these groundbreaking advancements in hematology research.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Domenico Girelli
This is the second in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
To go further: Kremyanskaya M et al. Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera. N Engl J Med. 2024 Feb 22;390(8):723-735. doi: 10.1056/NEJMoa2308809. PMID: 38381675.
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Fri, 15 Mar 2024 - 18min - 94 - Precision Medicine in Inherited Bone Marrow Failure Syndromes
Welcome to another season of EHA Unplugged. In our first episode of 2024, listen to Prof Carlo Dufour, Chairperson of the Paediatric Hemato-Oncology department of G. Gaslini Children’s Hospital in Genova (Italy), as he discusses how classical IBMFs (such as Fanconi Anemia, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, and the telomere disorders) are now being joined by a large number of other diseases included in this category, thanks to the increasing precision of diagnostic genetic tools.
Prof Dufour explains further how crucial precise genetic-based diagnosis is in discriminating between true acquired and constitutional bone marrow failure disorders in order to properly determine the best line of treatment for these rare diseases and to establish a monitoring plan to prevent the occurrence of secondary malignancies.
Tune in to find out how IBMFS patients may benefit from precision medicine and a therapy tailored to their genetic constitution.
This is a series of podcasts covering precision medicine across various disorders, more podcasts will be available in the future. Stay tuned!
Guest: Prof Carlo Dufour, G. Gaslini Children’s Hospital in Genova (Italy)
Host: Isabel Olivera-Martinez, PhD, European Hematology Association (EHA)
Learn More
To go further: Miano M, Grossi A, Dell'Orso G, et al. Genetic screening of children with marrow failure. The role of primary Immunodeficiencies. Am J Hematol. 2021; 96(9): 1077–1086. https://doi.org/10.1002/ajh.26242
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Fri, 16 Feb 2024 - 10min - 93 - The Whats in Scientific Publishing
In this episode, join HemaSphere's editor-in-chief, Prof Jan Cools, as he guides you through article publishing. Acquire valuable insights, tips, and new perspectives on often-overlooked considerations. Prof Cools sheds light on the pivotal role of reviewers in the publishing process and provides his insights into the evolving impact of AI on publishing.
Guest: Prof Jan Cools, KU Leuven. Belgium. Editor-in-Chief of HemaSphere
Host: Dr Wilson Lim, European Hematology Association (EHA)
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Fri, 01 Dec 2023 - 20min - 92 - The New Classification of Hemochromatosis: Why and How
Welcome to EHA Unplugged! In this episode, join host Dr Wilson Lim as he delves into the world of hemochromatosis with esteemed Prof Domenico Girrelli from the University of Verona.
Prof Girrelli provides valuable insights into the new classification of hemochromatosis, shedding light on its genetic determinants, clinical manifestations, and recent advancements in its diagnosis and treatment. Discover the complexities of iron metabolism and the impact of this classification on patient management.
Tune in to stay informed about the latest developments in hemochromatosis classification.
Guest: Prof Domenico Girrelli, University of Verona, Italy
Host: Dr Wilson Lim, European Hematology Association (EHA)
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Fri, 17 Nov 2023 - 17min - 91 - Diversity, equity, and inclusion: Why this is important?
In this episode Prof Tarec El-Galaly gives an overview of diversity, equity, and inclusion (DEI). He explains what is DEI in hematology and the work EHA taskforce DEI taskforce is doing for patients benefit. Listen to this great initiative and perhaps it can benefit your practice.
Guest: Prof Tarec El-Galaly, Aalborg University Hospital, Denmark
Host: Dr Wilson Lim, European Hematology Association (EHA)
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Fri, 10 Nov 2023 - 08min - 90 - Unraveling Autoimmune Neutropenia: From Childhood to Adulthood
Join us for this update on Autoimmune Neutropenia (AIN), a rare blood disorder that presents and develops differently in children and adults.
Experts Dr Francesca Fioredda and Prof Helen Papadaki along with our host Dr. Isabel Olivera discuss the diagnostic challenges associated with AIN and the need for a broader definition, based on the latest insights from the different mechanisms underlying AIN’s pathogenesis.
Learn how to adapt the treatment of AIN to the specific form of neutropenia, the patient’s age, evolving needs, and underlying disease. Our experts also emphasize the importance of carefully monitoring AIN patients and of maintaining accurate patient registries.
Read this review article on AIN at HemaSphere or follow the AIN course on the EHA Campus to learn more about AIN.
Host:
Dr. Isabel Olivera
European Hematology Association
Guests:
Dr Francesca Fioredda
Istituito Giannina Gaslini, Italy
Prof Helen Papadaki
University of Crete School of Medicine, Greece
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Fri, 03 Nov 2023 - 21min - 89 - Navigating the World of Hematology Research: from Mentorship to Work-Life Balance
Join us in this enlightening podcast as three experienced researchers, Dr Anastasia Conti, Prof Konstanze Döhner, and Dr Simona Valletta, delve into the dynamic world of scientific research. This discussion moderated by Prof Kirsten Grønbæk offers valuable insights into the pivotal aspects of successful careers in research for hematologists.
The conversation dives deeply into topics relevant to aspiring and established researchers, such as the crucial role of mentorship, and the importance of female mentors in the field, as they may offer valuable guidance to women in science. Choosing the right research lab, the need for a work-life balance, and how to balance clinical work with research endeavors for clinician-scientists are other valuable insights shared by the panel.
The podcast concludes with a focus on fostering a supportive work environment for researchers. They emphasize flexibility, strong communication, and the importance of respecting boundaries to maintain a positive and productive lab atmosphere.
Tune in to gain a wealth of knowledge for navigating in the world of scientific research in hematology.
Host:
Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Denmark
Guests:
Dr Anastasia Conti
San Raffaele Telethon Institute for Gene Therapy, Italy
Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
Dr Simona Valletta
University of Manchester, United Kingdom
Learn More
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Fri, 27 Oct 2023 - 39min - 88 - Myelodysplastic Syndrome (MDS) with Prof Kirsten Grønbæk
Join Prof Kirsten Grønbæk and Prof Konstanze Döhner as they talk about the current landscape in MDS. Prof Grønbæk shares her interest and passion in the disease, the challenges in diagnosis and treatment, and what is on the horizon in research and management of MDS.
Guest: Prof Kirsten Grønbæk, Rigshospitalet and BRIC, Copenhagen, Denmark
Host: Prof Konstanze Döhner, University Hospital of Ulm, Germany
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Fri, 20 Oct 2023 - 19min - 87 - Immune cell therapies and targeted therapies in AML
In this podcast, expert Prof Paresh Vyas and host Dr Enrica Orsini delve into the latest developments in the treatment of Acute Myeloid Leukemia (AML). They discuss new drug targets, new therapies in clinics and the impact of the new treatment on aging patients Moreover, they address existing challenges and provide a glimpse into what the future holds for AML treatment.
Guest: Prof Paresh Vyas, University of Oxford, United Kingdom
Host: Dr Enrica Orsini, EHA
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Fri, 13 Oct 2023 - 10min - 86 - Patient Communication and Self Care
Join us for this insightful podcast where our experts Prof Kirsten Grønbæk, Dr Mirjam Belderbos, Dr Umut Yilmaz, and Prof Konstanze Döhner discuss their experiences, challenges, and strategies for thriving in their demanding and rewarding careers as hematologists. They share valuable insight from effective communication with patients and caregivers to coping with the emotional aspects of their work. Discover how they strike a balance between personal well-being and professional responsibilities.
Host:
Prof Kirsten Grønbæk,
Rigshospitalet and BRIC, Copenhagen, Denmark
Guests:
Dr Umut Yilmaz
İstanbul University-Cerrahpaşa, Istanbul, Turkey
Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
Dr Mirjam Belderbos
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Learn More
If you'd like to continue learning about patient communication, check out the course The Divided Brain: Emotion vs. Logic in Patient Communicationon EHA Campus.
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Mon, 09 Oct 2023 - 35min - 85 - Building prognostic models using big data with Prof Kimmo Porkka
Guest Prof Kimmo Porkka together with host Dr Enrica Orsini talk about using big data to build prognostic models. Based on Prof Porkka’s experience on working with big data, he uses the Harmony Alliance as an example and gives an overview of data collection, the importance of data security and the importance to have the participation of a large network of hospitals or academic centers, and recognising the challenges behind that.
Guest: Prof Kimmo Porka. University of Helsinki, Finland
Host: Dr Enrica Orsini, EHA.
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Fri, 29 Sep 2023 - 10min - 84 - Myeloma - Prof Jorge Sierra
Prof Jorge Sierra provides an overview of myeloma, delving into its clinical aspects and sharing his personal passion for the disease.
Together with host Prof. Konstanze Döhner, they explore myeloma's treatment challenges and advancements. Prof. Sierra also offers valuable advice on initiating myeloma research, making this an engaging podcast for students, trainees, and young hematologists alike.
Guest: Prof Jorge Sierra
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Host: Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
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Fri, 22 Sep 2023 - 23min - 83 - Lymphoma - Dr Umut Yilmaz
In this episode, we talk to Dr. Umut Yilmaz from İstanbul University-Cerrahpaşa. Umut shares his interest in lymphoma, its diversity, and the challenges in his work. He also offers unique advice for inspiring starting hematologists and calls for more people to join the exciting field of lymphoma research and treatment.
Guest: Dr Umut Yilmaz
İstanbul University-Cerrahpaşa, Istanbul, Turkey
Host: Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Copenhagen, Denmark
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Fri, 15 Sep 2023 - 13min - 82 - How to Get Started in Hematology Research - Dr Anastasia Conti, Assoc Prof Maria Paola Martelli and Dr Simona Valletta
Our guests Dr Anastasia Conti, Assoc Prof Maria Paola Martelli and Dr Simona Valletta give an overview on starting research in hematology. They go through their experience, give advice and talk about the challenges they face.
The podcast starts with the basics of how to get started in hematology research, starting how to come up with research ideas and how to develop these ideas into projects. Our guests continue with their view on PhD programmes, where they give advice to those who want to start a PhD or a research focused career. Anastasia, Maria and Simona recollects how rewarding their PhD experience was and emphasizes the importance of motivation, resilience and persistence in research. A PhD shapes you Simona says. Last but not least, they delve into the topic of research funding and their experiences in writing grants.
Guests:
Dr Anatasia Conti
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Assoc Prof Maria Paola Martelli
University of Perugia, Perugia, Italy
Dr Simona Valletta
University of Manchester, Manchester, United Kingdom
Host: Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Copenhagen, Denmark
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Fri, 08 Sep 2023 - 43min - 81 - Pediatric Hematology - Dr Mirjam Belderbos
Listen as guest Dr Mirjam Belderbos talk to our host Prof Kirsten Grønbæk about her own experience in pediatric hematology, how she interacts with her patients and their family, the challenges in the field and how it differs from adult hematology. She also indulge us in the fun annual custom her pediatric unit does and how rewarding her role is to her. She ends by giving some advice to trainees and medical students who are interested in the field of pediatric hematology.
Guest: Dr Mirjam Belderbos. Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Host: Prof Kirsten Grønbæk. Rigshospitalet and BRIC, Copenhagen, Denmark
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Fri, 01 Sep 2023 - 16min - 80 - Iron metabolism: physiology and pathology
This week, we have guest Prof Laura Silvestri from Vita-Salute San Raffaele University who gives an amazing overview of iron regulation from the perspective of the protein hepcidin.
Prof Silvestri illustrates the mechanism behind hepcidin regulation and how is transcription effected by proinflammatory cytokines in certain hematological disorders.
Host: Dr Enrica Orsini; Guest: Prof Laura Silvestri
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Fri, 25 Aug 2023 - 13min - 79 - Pathogenesis and Management of Acute Chest Syndrome (ACS) in SCD
In this episode, Prof David Rees gives an overview of acute chest syndrome (ACS) in SCD.
Prof Rees and host Dr Enrica Orsini talk about epidemiology, the clinical picture, patient management, and the importance of recognizing this disease.
Host: Dr Enrica Orsini; Guest: Prof David Rees
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Fri, 11 Aug 2023 - 11min - 78 - EHA Unplugged: MDS Classification and Risk Assessment
In this episode, Prof Maria Teressa Voso talks about MDS classification and risk assessment. She explains the different risk scores, the importance of molecular genetics in classification, risk stratification and management in MDS patients.
Guest: Prof Maria Teressa Voso ; Host: Dr Enrica Orsini
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Fri, 04 Aug 2023 - 15min - 77 - New Treatment of Iron Metabolism Defects: A Focus on Anemia of Inflammation
Listen as our guest Prof. Martina Muckenthaler and host Dr. Isabel Olivera Martinez give an overview on anemia of inflammation. They discuss the pathogenesis of the disease and the current treatment landscape in particular with HIF-PH inhibitors, and hepcidin as a target in certain disease entities.
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Guest: Prof. Martina Muckenthaler ; Host: Dr. Isabel Olivera Martinez
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Fri, 28 Jul 2023 - 20min - 76 - Latest Innovations and Future Perspectives in CAR-T Therapy
Listen as Dr. Maria Themeli and Dr. Ciprian Tomuleasa provide an overview of the latest developments and novel ideas in CAR-T therapy.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
Guests: Dr. Maria Themeli and Dr. Ciprian Tomuleasa
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Fri, 21 Jul 2023 - 13min - 75 - Current CAR-T Treatment for Lymphomas Focusing on DLBCL
Listen as Dr. Anna Sureda explains the available CAR-T treatments for lymphomas, focusing on DLBCL (diffuse large B cell lymphoma) and the challenges of CAR-T therapy in the current treatment landscape. She also considers the possibility of using CAR-T cells in 2nd line treatment (or earlier) and in combination with other drugs.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Guest: Dr Anna Sureda
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Fri, 14 Jul 2023 - 13min - 74 - Clinical Management of CAR-T Therapy in Myeloma
In this episode Dr Wilson Lim interviews our guest Prof. Carlos Fernández de Larrea on CAR-T toxicities and how to control or avoid adverse reactions to CAR-T therapies in patients with myeloma.
Guest: Prof. Carlos Fernández de Larrea ; Host: Dr Wilson Lim
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Fri, 07 Jul 2023 - 07min - 73 - Challenges in receiving CAR-T treatment: Patient's perspective
Listen as Dr. Anna Sureda discusses CAR-T therapy from a patients perspective and the steps that physicians can take to help patients overcome the challenges that comes with CAR-T treatment.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Guest: Dr Anna Sureda ; Host: Dr Wilson Lim
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Fri, 30 Jun 2023 - 06min - 72 - Ph+ acute lymphoblastic lymphoma and the immune system in hematological neoplasms.
Listen as Emeritus Prof Robin Foà brings you on the journey of Ph+ ALL management together with our host Dr Enrica Orsini. With a long career in ALL, Prof Foà runs through the history of Ph+ ALL, his experience in patient management, and then brings you up to date on the current picture in patient management.
Tune in as Prof Foà describes the breakthrough in treatment with TKI inhibitors and the introduction of the immunotherapeutic drug blinatumomab in Ph+ ALL.
Guest: Emeritus Prof. Robin Foà
Host: Dr. Enrica Orsini
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Fri, 23 Jun 2023 - 23min - 71 - CAR-T Treatment in Myeloma: State of the Art
Join us for another episode of EHA Unplugged. We have Prof. Herman Einsele here talking about the current landscapes of CAR-T therapy in myeloma, results achievable today, and the future perspectives for these patients.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Guest: Prof Herman Einsele
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Fri, 02 Jun 2023 - 07min - 70 - Reasons for Failure and Relapse and Mechanisms of Resistance in CAR-T
Join us here at EHA Unplugged with another episode on CAR-T updates. Listen as our guest Prof. Chiara Bonini and host Dr. Wilson Lim discuss the reasons for CAR-T therapy failure and relapse after treatment.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
Guest: Prof. Chiara Bonini ; Host: Dr. Wilson Lim
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Fri, 26 May 2023 - 14min - 69 - Economic Aspects of CAR-T: Challenges and Solutions
Listen as Prof. Christian Chabannon provides an overview of the challenges and obstacles raised by the economic aspects of CAR-T treatment. He examines different solutions and proposes a way forward to address these issues.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
Guest: Prof. Christian Chabannon ; Host: Dr. Olivera Martinez
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Thu, 18 May 2023 - 19min - 68 - Update on CAR-T Therapies in Acute and Chronic Leukemias
Listen as Prof. John Gribben provides an update on where we are with CAR-T in acute and chronic leukemias.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
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If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
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Fri, 12 May 2023 - 07min - 67 - Spotlight Talks: How I Treat Absolute Iron Deficiency in Inflammatory Disorders
Prof Günter Weiss, from the University of Innsbruck, Germany, provides in this podcast a comprehensive pathogenetic and clinical overview of a relevant and frequent medical problem: Absolute Iron Deficiency, defined as the combination of anemia of chronic disease (ACD) and iron deficiency anemia (IDA) in people suffering from inflammatory disorders.
The complex functional mechanisms and underlying diseases at work in these patients make the diagnostic work-up and treatment choices difficult and may require careful analysis. Prof Weiss’s clear explanation of the different issues associated with this condition provides a useful guide to clinicians in their daily practice.
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If you liked this podcast and would like to explore related content, you can check out our EHA Diagnosing And Treating Iron Deficiency Program on the EHA Campus.
EHA Social Learning
Explore our social media microlearning: https://ehaedu.org/SM_Learning
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Fri, 28 Apr 2023 - 18min - 66 - Overview of the Current CAR-T Landscape
Listen as Prof. Carl June provides an overview of the past and current landscape and challenges in CAR-T therapy, along with a summary of the innovations being introduced to lower the cost of CAR-T and improve CAR-T treatment and access.
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Fri, 21 Apr 2023 - 09min - 65 - Papers Unplugged: Precision Medicine and Myeloid Neoplasms
In this podcast, Hartmut Döhner, Hematologist-Oncologist and Professor of Medicine in Germany, discusses with Dr. Nathalie van Havre the role of genomic characterization in the classification, prognosis and treatment of myeloid neoplasms.
Discover the main methods of genomic testing, the kind of relevant information they can provide, and the essential techniques that should currently be available for hematology centers. The podcast also explores the significance of germline variants and the need for their investigation, and the challenges associated with the implementation of a comprehensive genomic assessment in routine clinical practice.
The podcast is based on the paper: "Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia", by Duncavage EJ, et al. Blood. 2022;140:2228-2247. (https://pubmed.ncbi.nlm.nih.gov/36130297/)
Host: Dr Nathalie van Havre; Guest: Prof Hartmut Döhner
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Fri, 14 Apr 2023 - 14min - 64 - Papers Unplugged: Precision Medicine in AML
In this podcast, hear from Prof Hartmut Döhner, Hematologist-Oncologist and Professor of Medicine in Germany, as he discusses the growing roles of precise treatments based on the characteristics of the leukemic cells in acute myeloid leukemias. Discover the clinical developments of targeted treatments such as IDH1/2 inhibitors and venetoclax, and learn about the importance of combination treatment to improve results.
The podcast also explores the use of epigenetic agents as part of standard care in older patients and how the proportion of patients treated with targeted agents is increasing. Tune in to find out how more AML patients may benefit from precision medicine and targeted therapy.
The podcast is based on the paper: "Towards precision medicine for AML", by Döhner H, et al. Nat Rev Clin Oncol. 2021;18:577-590. (https://pubmed.ncbi.nlm.nih.gov/34006997/)
Host: Dr Nathalie van Havre; Guest: Prof Hartmut Döhner
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To learn more about AML and updated classification and prognostic recommendations, check out QR Case 19 on AML on the EHA Campus.
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Fri, 10 Mar 2023 - 11min - 63 - Debate: Gene Addition or Gene Editing for Hemoglobinopathies?
In this podcast about gene therapy for hemoglobinopathies, our experts Dr. Evangelia Yanaki and Professor Franco Locatelli discuss the most effective approach for treating patients with these conditions, considering the safety concerns and potential complications associated, as well as the need for long-term monitoring of patients.
In this debate recorded during the EHA22 Annual Congress, Dr. Yanaki advocates for gene addition therapy, while Professor Locatelli favors genome editing as a more precise approach. Despite their differing opinions, both speakers concur that additional research is necessary to fully comprehend the potential benefits and risks of both approaches.
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If you liked this podcast and would like to explore related content, you can check out our EHA Gene Therapy Techniques Programon the EHA Campus.
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Fri, 07 Apr 2023 - 41min - 62 - What's in Store for Lymphoid Malignancies?
In this episode, guest Prof Martin Dreyling and host Dr Nathalie van Havre discuss the latest developments in lymphoid malignancies and the research roadmap that has been put in place to guide future research.
Professor Dreyling highlights the move away from traditional chemotherapy towards non-cytostatic approaches and discusses the long-term complications of traditional treatments and the need for precision therapy.
Host: Dr Nathalie van Havre; Guest: Prof Martin Dreyling
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Fri, 31 Mar 2023 - 18min - 61 - Spotlight Talks: Postpartum Hemorrhage (PPH)
In this episode of EHA Unplugged, Prof Beverly Hunt discusses the global consequences of postpartum hemorrhage (PPH) and the unacceptable PPH-related mortality rate in developed countries. The discussion continues on the challenges faced in the identification of PPH and the primary causes of PPH. Prof Hunt further talks about the consequences of PPH on children and emphasizes the need for more research in PPH and campaigns to improve maternal health.
Guest: Prof Beverly Hunt
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available. Stay tuned.
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If you liked this podcast and would like to explore related content, you can check out our Women with Bleeding Disorder course on the EHA Campus. A multidisciplinary team of experts has developed this accredited micro e-learning program to increase awareness, knowledge, and understanding of bleeding disorders and their management among healthcare professionals who are the first to see women and girls with signs and symptoms of bleeding disorders.
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Fri, 24 Mar 2023 - 22min - 60 - Papers Unplugged: The Perspectives of Doctors and Patients in the Treatment of CLL
Join Prof Paolo Ghia and our host Dr Enrica Orsini as they discuss the treatment of Chronic Lymphocytic Leukemia (CLL) from the perspectives of patients and doctors.
In this episode, they discuss the factors that influence the decision of treatment choices from the perspectives of patients and doctors and how both parties have different perspectives on the subject. They further highlight the importance of understanding the differing priorities between these two groups and the need for shared decision-making in the treatment process.
The podcast is based on the paper: "What Are the Attributes Prioritized in the Choice of Therapy in Chronic Lymphocytic Leukemia? A Patient-physician Cross-matching Analysis of a Discrete Choice Experiment", by Laurenti L et al., published on HemaSphere in 2022.
Host: Dr Enrica Orsini; Guest: Prof Paolo Ghia
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To learn more about CLL and updated treatment recommendations, check out our comprehensive CLL Program on the EHA Campus.
Discover more of EHA's social media microlearning here.
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Fri, 17 Mar 2023 - 09min - 59 - Debate: Should Low Risk PV-MF Patients be Treated?
Treatment of low-risk patients with polycythemia vera (PV) and myelofibrosis (MF) is still a matter of debate. Although traditionally these patients were managed exclusively with supportive treatment, more recent guidelines suggest the opportunity of identifying subgroups of patients eligible for cytoreduction.
In this debate recorded during the EHA22 Annual Congress, experts Claire Harrison and Christen Lykkegaard Andersen support opposite statements on this topic, discussing the pros and cons of cytoreductive treatment in low-risk PV and MF patients, with the aid of representative clinical cases.
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If you liked this podcast and would like to explore related content, you can check out our Polycythemia Vera course on the EHA Campus.
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Fri, 03 Mar 2023 - 38min - 58 - Health Technology Assessment (HTA)
Join our guest Dr Martin Kaiser and host Dr Nathalie van Havre, as they talk about Heath Technology Assessment (HTA) in hematology and in Europe’s public healthcare landscape.
Our speakers discuss the relevance of HTA for hematologists and how it aims to standardize access to new health technologies for patients across Europe. Furthermore, they examine the challenges in generating solid evidence to support these assessments, particularly in the case of rare diseases, and whether HTAs are likely to cause new delays for new health technologies to reach the patients.
Next, the social and economic implications of HTA are discussed, in particular costs, limited resources, and equality in access to treatment. Dr Kaiser concludes this podcast by emphasizing the importance of HTA education and awareness in medical education.
Host: Dr Nathalie van Havre; Guest: Dr Martin Kaiser
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Wed, 01 Mar 2023 - 20min - 57 - Spotlight Talks: New Agents for the Treatment of Thalassemia
In this podcast, you will listen to Prof Antonis Kattamis summarizing the last developments in the treatment of patients with thalassemia. While the life expectancy of these patients has considerably improved in the last decades, quality of life and disease burden is still a relevant issue.
However, new classes of drugs, with action of the pathophysiologic mechanisms of the disease, are entering the clinics—drugs able to improve globin chain imbalance or ineffective erythropoiesis, or decrease hemolysis. Prof Kattamis will discuss the efficacy of these treatments and of innovative gene therapy approaches, not neglecting economic evaluations on the sustainability of new treatments in thalassemia.
Guest: Prof Antonis Kattamis
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
View this podcast on EHA Campus for key slides related to this episode.
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If you liked this podcast and would like to explore related content, you can check out our EHA Thalassemia Program on the EHA Campus.
For more social media microlearning from EHA, visit https://ehaedu.org/SM_Learning.
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Fri, 17 Feb 2023 - 16min - 56 - Papers Unplugged: What's New in the Treatment of CLL?
In this podcast, Prof Paolo Ghia discusses the current treatment landscape of Chronic Lymphocytic Leukemia (CLL), providing a guide for clinicians faced with an ever-growing number of therapeutic alternatives.
Within targeted therapies, a special focus is dedicated to BTK inhibitors and their different characteristics, and to the long-term results of the ASCEND trial. The management of CLL is changing rapidly, and Prof Ghia's expertise can help hematologists to choose the right treatment for their patients, even in high-risk cases, such as the ones with TP53mutation or del(17p).
The podcast is based on the paper: "Acalabrutinib Versus Investigator's Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results", by Ghia P et al., published on HemaSphere in 2022.
Host: Dr Enrica Orsini; Guest: Prof Paolo Ghia
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To learn more about CLL and updated treatment recommendations, check out our comprehensive CLL Program on the EHA Campus.
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Fri, 10 Feb 2023 - 11min - 55 - Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms—Myelodysplastic Syndromes
In this podcast, Prof Mario Cazzola illustrates the genesis of the new ICC classification of myeloid neoplasms, published in 2022 (Arber DA et al, Blood 2022), with a special focus on MDS, and the new nosological entities that have been defined in it.
The new entities, namely SF3B1-mutant MDS, TP53 multi-hit MDS, and clonal cytopenia of undetermined significance (CCUS), underline the importance of gene sequencing for the diagnosis and risk stratification of myeloid neoplasms and MDS in particular.
Guest: Prof Mario Cazzola
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
View this podcast on EHA Campus for key slides related to this episode.
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If you liked this podcast and would like to explore related content, you can check out our MDS Flashcards on the EHA Campus.
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Fri, 03 Feb 2023 - 13min - 54 - Papers Unplugged: TIF Guidelines for the Management of Patients with Transfusion-Dependent Thalassemia (TDT)
What are the latest guidelines for the management of patients with Transfusion-Dependent Thalassemia (TDT)?
In 2022, the fourth edition of the TIF (Thalassemia International Federation) guidelines for the management of patients with transfusion-dependent thalassemia (TDT) was published.
In this podcast, Prof Ali Taher discusses with our host, Dr Nathalie van Havre, the main news of this edition, including genetic work-up, chelation therapy, and prevention and management of complications.
Furthermore, Prof Taher illustrates the innovative gene therapy approaches and new drugs (such as luspatercept, the most recently approved drug for TDT) currently available for the treatment of these patients and how they can impact the management of TDT.
The podcast is based on the paper "2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia", by Farmakis D et al., published in HemaSphere in 2022 (HemaSphere. 2022;6:e732).
Host: Dr Nathalie van Havre; Guest: Prof Ali Taher
This is the sixth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Fri, 27 Jan 2023 - 16min - 53 - Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms—Lymphoid Diseases
Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms: Lymphoid Diseases
In this podcast, Prof John Gribben, former President of EHA, discusses the new ICC lymphoid malignancies classification (Campo E, et al. Blood, 2022), highlighting the main novelties introduced for specific entities and explaining the new criteria guiding the diagnosis and prognosis of lymphoproliferative diseases.
Listen to this podcast to gain an overview of the most innovative findings in the field, while waiting for the updated WHO classification to be published in 2023.
Guest: Prof John Gribben
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
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Fri, 20 Jan 2023 - 13min - 52 - Papers Unplugged: Is CAR-T Economically Sustainable?
Is CAR-T economically sustainable?
Join our guest Prof Martin Dreyling and host Dr Nathalie van Havre as they discuss the costs of CAR-T cell therapy for the treatment of blood disorders at an individual level and whether it is economically sustainable for health systems.
Listen along as they consider the financial challenges of patient selection for this costly life-saving therapy, based on Prof Dreyling’s experience with relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL) patients. Challenges touched upon include reimbursement policies, time lags and associated costs of personalized therapy, and choosing the indications to include.
Prof Dreyling further offers his insights into the overall financial burden for health systems based on his participation on a recent Budget Impact Analysis (BIA) carried out in DLBCL patients in Germany. Finally, our guests contemplate cancer immunotherapy perspectives for the coming years, including bispecific antibodies as a potentially cost-effective alternative in development.
The details of the BIA were recently described in the article Budget Impact Analysis of CAR T-cell Therapy for Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma in Germany published in HemaSphere by Skalt D, Moertl B, von Bergwelt-Baildon M, Schmidt C, Schoel W, Bücklein V, Weiglein T, Dreyling M, and Berger K.
Host: Dr Nathalie van Havre; Guest: Prof Martin Dreyling
This is the fifth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Fri, 13 Jan 2023 - 17min - 51 - Papers Unplugged: What Ever Happened to Plan S?
What is Plan S and what has happened to it?
Join our guest Dr Nuno Borges and host Dr Christian Scharenberg as they talk about the core principles, goals, and challenges of Plan S.
Listen along as Dr Borges discusses the controversies aroused by Plan S and the “publish or perish” paradigm faced by early career scientists. Dr Borges ends this podcast on a positive note where he believes that slowly, but surely, and thanks to social media, we are heading towards a future where scientific publications will be open access and freely available to everyone.
This discussion is based on the recently published article Change is Coming: Plan S From the Early Career Scientist Perspective in HemaSphere by Dr Nuno Borges.
Host: Dr Christian Scharenberg; Guest: Dr Nuno Borges
This is the fourth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Fri, 09 Dec 2022 - 07min - 50 - Papers Unplugged: CHIP and Associated Risk in Elderly Patients
What is clonal hematopoiesis of indeterminate potential (CHIP) and its associated risks in elderly patients? Join our guest Prof Kirsten Gronbaek and host Dr Christian Scharenberg as they discuss CHIP and its association with epigenetic age, mutations, patient survival, and the current landscape for CHIP treatment. This discussion is based on the recently published article Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins in HemaSphere by Professor Kirsten Gronbaek.
Fri, 25 Nov 2022 - 08min - 49 - Papers Unplugged: EHA and War in Ukraine
What can a not-for-profit NGO do for patients in a time of war? Join our guests, Prof Konstanze Döhner, Prof Elizabeth Macintyre, and Dr Nathalie van Havre as they discuss what the European Hematology Association (EHA) has done in favor of Ukraine and the Ukrainian hematological community.
Fri, 11 Nov 2022 - 12min - 48 - Papers Unplugged: Precision Medicine and Hemoglobinopathies
What is precision medicine and how can this concept be applied to Sickle cell disease? How can precision medicine impact disease management, what is the difference in precision medicine between low- and high-income countries, and what is the future in SCD treatment? In this podcast episode, Prof David Rees shares his view on these issues with host Dr Christian Scharenberg.
Fri, 28 Oct 2022 - 11min - 47 - Naive CLL
How did CLL lose its role of "Cinderella" in hematology in the last decades, thanks to the introduction of entirely new classes of drugs, and came under the spotlight of clinical research in hematology?
Prof Jennifer Woyach discusses the fundamentals of CLL genetics and treatment in this podcast, as well as the selection of patients for therapy, the different, and somewhat unpredictable, clinical course the disease can follow, together with the last evidence from CLL clinical trials.
Host: Prof Shaun McCann; Guest: Prof Jennifer Woyach
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Fri, 10 Jun 2022 - 13min - 46 - Thrombosis - Bleeding in Cancer
The links between thrombosis and cancer have been known for a long time and are associated with the type of cancer (pancreatic and lung carcinomas, for example, are particularly prone to give this complication), its localization, and the anti-neoplastic treatment used to fight the cancer itself.
Prof Jan Marie Connors, in this podcast, explains how a thrombotic episode may represent the first indication of a cancer diagnosis, and how guidelines should be critically used to manage these patients, taking into account the concurrent anti-cancer therapy and potential drug interactions.
Host: Prof Shaun McCann; Guest: Prof Jean Marie Connors
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Fri, 03 Jun 2022 - 16min - 45 - The Microbiome in HCT
In this podcast, Prof Tessa Andermann, an expert in infectious diseases, provides an overview of the role of the microbiome in the homeostasis of the human body and how it has been implicated in the development of complications after allogeneic transplantations, including acute graft-versus-host-disease, infections, mortality, and disease relapse.
Some of the relationships observed between changes in the microbiome and clinical outcome might in the next future be better characterized and exploited to drive therapeutic choices.
Host: Prof Shaun McCann; Guest: Prof Tessa Andermann
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Fri, 27 May 2022 - 12min - 44 - Diagnosing Erythrocytosis
How do you make a diagnosis of erythrocytosis? Is full blood count enough or do you need more specific tests? How is the classification in primary and secondary erythrocytosis linked to EPO levels? Is idiopathic erythrocytosis really a vanishing entity?
These are some of the questions Prof Mary-Frances McCullin answers in this podcast, giving listeners the key information necessary to understand erythrocytosis in clinical practice.
Host: Prof Shaun McCann; Guest: Prof Mary-Frances McMullin
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Fri, 20 May 2022 - 17min - 43 - Clinical Trials of the Future (Clinical Trial)
In the seventh and final episode of the Clinical Trial podcast series, you can hear Prof. Konstanze Döhner and Prof. Antonio Almeida exchanging ideas and thought-provoking opinions about how investigator-initiated clinical trials and new trial designs can provide patients early access to novel drugs.
They discuss the importance of large collaborative groups, the complexity of current requirements that must be in place, and the impact that these challenges may have, along with the relevant issues that could be changed in order to enable more uncomplicated participation and conduction of clinical studies.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Konstanze Döhner; Prof. Antonio Almeida
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Mon, 16 May 2022 - 46min - 42 - Cutaneous T Cell Lymphoma (CTCL) Episode 2: Treatment
This series of two podcasts leads you on a journey through the main clinical and therapeutical aspects of Cutaneous T Cell Lymphomas (CTCLs), a heterogeneous group of lymphoid neoplasms characterized by primary cutaneous localization. Albeit rare, CTCLs have peculiar clinical characteristics, requiring a multidisciplinary approach and a strict collaboration between different specialists, allowing for a timely and precise diagnosis, critical for the good outcome of these patients.
Join dermatologist Prof Maarten Vermeer (Dept. of Dermatology, Leiden University Medical Center) and hematologist Dr Erik Marijt (Head of the Central Laboratory of Clinical Hematology and the Interdivisional Flowcytometry Core Facility, Leiden University Medical Center) as they exchange their views and expertise on the diagnosis and management of patients with CTCLs.
In this second episode, listen to Prof Vermeer and Dr Marijt discussing how CTCL patients with localized and diffuse disease can be effectively treated, and how new targeted agents and allogeneic transplantation can be integrated into the management algorithm.
Hosts: Prof Maarten Vermeer; Dr Erik Marijt
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Fri, 13 May 2022 - 25min - 41 - Cutaneous T Cell Lymphoma (CTCL) Episode 1: Presentation and Diagnosis
This series of two podcasts leads you on a journey through the main clinical and therapeutical aspects of Cutaneous T Cell Lymphomas (CTCLs), a heterogeneous group of lymphoid neoplasms characterized by primary cutaneous localization. Albeit rare, CTCLs have peculiar clinical characteristics, requiring a multidisciplinary approach and a strict collaboration between different specialists, allowing for a timely and precise diagnosis, critical for the good outcome of these patients.
Join dermatologist Prof Maarten Vermeer (Dept. of Dermatology, Leiden University Medical Center) and hematologist Dr Erik Marijt (Head of the Central Laboratory of Clinical Hematology and the Interdivisional Flowcytometry Core Facility, Leiden University Medical Center) as they exchange their views and expertise on the diagnosis and management of patients with CTCLs.
In this first episode, listen to Prof Vermeer and Dr Marijt illustrating the dermatologic and hematologic approaches to the diagnosis and staging of CTCLs, including the different clinical presentation and prognosis of the most common types of CTCLs.
Hosts: Prof Maarten Vermeer; Dr Erik Marijt
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Fri, 13 May 2022 - 22min - 40 - Circulating Tumor DNA
Dr David Kurtz discusses in this podcast the most recent technical developments and practical applications of circulating tumor DNA and liquid biopsies, an active area of research in the last 25 years, which is now gaining more importance and translational application in the clinic. In tumors like B-cell non-Hodgkin lymphomas, for example, somatic mutations can now be tracked and diagnosed using these techniques. Other fields of active investigations include CLL and solid tumors, as well as disease monitoring and early diagnosis on relapses.
Host: Shaun McCann; Guest: Dr. David Kurtz
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Fri, 08 Apr 2022 - 16min - 39 - Treating CML in Developing Countries
The whole world of CML changed in the early 2000s with the introduction of imatinib and TKIs, however, the situation in developing countries can be significantly different from Europe and USA, as discussed by Prof Hemant Malhotra in this podcast.
Short-backs may encompass the molecular diagnosis and monitoring of the disease (not everywhere available) as well as the cost of drugs and medical expense coverage. On the other hand, the relative affordability of generic TKIs may cause skipping of expensive diagnostic procedures before starting treatment, whereas their current prolonged life expectancy is making the number of CML patients increasingly high. A complex picture that is worth listening to in order to better understand medicine across different regions in the world.
Host: Shaun McCann; Guest: Prof. Hemant Malhotra
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Fri, 01 Apr 2022 - 14min - 38 - Less is More - Transfusion
Transfusion processes have changed significantly in recent years, at the same time changing the guidelines for blood cell replacement therapy. Listen to Prof. Michael Murphy in this podcast as he provides an overview of the most up-to-date topics in transfusion, including the relevant risk of over-transfusion, restricted transfusion practices, and also the issues of delayed transfusion and transfusion-related infections.
"Don't give two when one will do," should remain the bottom line criterion in transfusion decisions in stable patients.
Host: Shaun McCann; Guest: Prof. Michael Murphy
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Fri, 25 Mar 2022 - 14min - 37 - Chronic Myeloid Leukemia (Naomi)
This podcast follows a short discussion between two young hematologists on a clinical case review of a chronic myeloid leukemia patient called Naomi. In this discussion, the hematologists go through Naomi’s case while addressing the management of CML patients in complete molecular response and the requirements for discontinuation of tyrosine kinase treatment in CML patients.
This podcast is rendered from QR Case 5 - Chronic Myeloid Leukemia (Naomi) on the EHA Campus.
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Fri, 04 Mar 2022 - 07min - 36 - All Good Things Must Come to an End: How and When to End a Clinical Trial (Clinical Trial)
In the sixth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the different reasons that lead to the end of a trial – especially when it is earlier than planned. He also gives us a summary of what happens after the trial; the importance of some steps involving the data and their availability, and the writing of reports for the appropriate regulatory authorities.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Robert Hills
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Tue, 22 Feb 2022 - 22min - 35 - Iron Deficiency: Perioperative
In the fourth episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Antonio Almeda discuss the diagnostic and therapeutic management of iron deficiency and anemia in the perioperative setting, a clinical situation where having inadequate iron stores carries significant clinical consequences on mortality and morbidity outcomes. They also address the conclusions of different studies that have investigated the impact of repleting patients with iron on the incidence of complications, mortality, or long-term health. They also disclose how they are monitoring their patients’ iron levels following surgery and why it is important.
Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeda
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the EHA Diagnosing And Treating Iron Deficiency Program.
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Fri, 18 Feb 2022 - 28min - 34 - Documentation and authorization: Safeguarding the Credibility of Clinical Trials (Clinical Trial)
In the fifth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the documentation of clinical trials and how it represents a safeguard for the credibility of the trial. He points out the importance of finding a good balance between too many documents and not enough of them. In addition, he highlights the multitude of different groups working on a clinical trial, which ultimately renders documentation an insurance to a smooth process.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Robert Hills
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
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Tue, 15 Feb 2022 - 19min - 33 - Ethical Issues Associated with Treating Hematological Malignancies in Older Adults (Aging Patient: Dispelling Myths)
In the fifth and final episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest experts Prof Raul Cordoba, Dr Ulrich Wedding, and Dr Dominique Bron discuss the ethical issues associated with treating hematological malignancies in older adults. They raise different points regarding treatment decisions made with (and not without) the patient and amongst other parameters, how much of an impact costs have in the choice of treatment.
Dr Bron also reminds us of the 4 principles of healthcare (nonmaleficence, beneficence, autonomy, and justice) – and that age is not a criterion in deciding whether a patient should be treated or not. Finally, they address the impact of COVID-19 on the current clinical practice and whether it has exacerbated ethical issues.
Host: Gareth Tucker; Guest: Prof Raul Cordoba, Dr Ulrich Wedding, Prof Dominique Bron
In the second episode of the Aging Patient: Dispelling Myths podcast series, the importance of medical decision making based on a patient’s ‘fitness’ rather than their age will be stressed, and the impact of good diet and exercise in maintaining fitness and delaying sarcopenia highlighted.
Host: Gareth Tucker; Guest: Prof Alessandra Tucci, Prof Sergio Storti
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the Aging Patient: Dispelling Mythsprogram.
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Fri, 11 Feb 2022 - 37min - 32 - Sponsor: A Role to Take Seriously (Clinical Trial)
In the fourth episode of the Clinical Trial podcasts, Dr. Eleftheria Hatzimichael gives us an overview of the sponsor's role and responsibilities in investigator-initiated clinical trials. The different meaning of "sponsor" and "funder", the importance for physicians to be involved in the design of clinical trials, the eight overarching responsibilities of the sponsor, are all key topics discussed in this podcast.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Dr. Eleftheria Hatzimichael
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Tue, 08 Feb 2022 - 17min - 31 - Hematological Changes in Older Adults (Aging Patient: Dispelling Myths)
In the fourth episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest expert Prof Monica Engelhardt discuss how comprehensive geriatric assessment can guide treatment decisions and improve patient outcomes.
Dr Engelhardt gives us an insight into her clinical practice and how elderly hematology patients are receptive - or not - to this testing. You will also learn what are the parameters to consider when treating elderly patients for hematologic malignancies, e.g., how frailty can influence the outcomes of the treatment. Finally, Dr Engelhardt addresses the current pandemic situation regarding these patients: are older patients more vulnerable to COVID-19 when they are already suffering from hematological malignancies and under treatment?
Host: Gareth Tucker; Guest: Prof Monika Engelhardt
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the Aging Patient: Dispelling Mythsprogram.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Fri, 04 Feb 2022 - 33min - 30 - Patient Support: Relate and Create (Clinical Trial)
In the third episode of the Clinical Trial podcasts, Prof. Martin Dreyling from the University of Munich makes several points about standards of care in clinical studies, also mentioned as GCPs (Good Clinical Practices). He gives us a historical perspective on the establishment of these standards 20 years ago, and how they need an update through what he calls a ‘reality check’. Prof. Dreyling is part of the coalition Reducing Bureaucracy in Clinical Trials and explains what they are proposing to update and improve GCPs in 2021.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Martin Dreyling
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Tue, 01 Feb 2022 - 17min - 29 - Treatment of Hematological Malignancies in Older Adults (Aging Patient: Dispelling Myths)
In the third episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and experts Prof Antonio Almeida, Prof Valentin Goede, and Dr Annamaria Brioli discuss the treatment of hematological malignancies in older adults, involving polypharmacy in most cases. They describe how patients commonly react to polypharmacy and how challenging it can be to have all the information about a patient’s full list of medication, and to keep them compliant. They also address the step of deprescribing, a critical point in the therapy of these patients.
Host: Gareth Tucker; Guest: Prof Valentin Goede, Prof Antonio Almeida, Dr Annamaria Brioli
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the Aging Patient: Dispelling Mythsprogram.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Fri, 28 Jan 2022 - 32min - 28 - The Paper Trail (CRO) (Clinical Trial)
In the second episode of the Clinical Trial podcasts, former EHA President Prof. John Gribben gives us an overview of the role(s) of CROs (Contract Research Organizations) in clinical investigation. He discusses how they can help, notably with the paper trails associated with clinical trials, and how they should be constructive partners in the process of clinical research.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. John Gribben
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
Facebook: https://e-h-a.link/facebook
LinkedIn: https://www.linkedin.com/company/eha/
Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Tue, 25 Jan 2022 - 18min - 27 - Patient Assessment In Older Adults (Aging Patient: Dispelling Myths)
In the second episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker discusses with experts Prof Alessandra Tucci and Prof Sergio Storti the definition and importance of patient assessment (including frailty, comorbidity, and polypharmacy), in older adults with hematological conditions and how it can be used to determine the overall ‘fitness’ of a patient. They also discuss the critical role of interactions between HCPs, patients, and their entourage in the assessment.
You will listen to clinical examples showing how a complete geriatric assessment can help direct treatment for older patients with specific hematological malignancies and how a benefit can be obtained from more effective, novel treatments.
Host: Gareth Tucker; Guest: Prof Alessandra Tucci, Prof Sergio Storti
Additional information (in order of mention):
HCP: Healthcare ProfessionalCLL: Chronic Lymphocytic Leukemia11q minus: deletion of a portion of the long arm (q) of chromosome 11SF3B1 gene: Splicing Factor 3B1POT1 gene: Protection of Telomeres 1 AML: Acute myeloid leukemiaIPSS: International Prognostic Scoring SystemADL: Activities of Daily LivingIADL: Instrumental Activities of Daily LivingWhat did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the Aging Patient: Dispelling Mythsprogram.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
Facebook: https://e-h-a.link/facebook
LinkedIn: https://www.linkedin.com/company/eha/
Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Fri, 21 Jan 2022 - 31min - 26 - Multiple Myeloma in Underserved Populations (Episode 3)
In this podcast, the last of a series dedicated to Multiple Myeloma in underserved patient populations with, Prof Sonja Zweegman focuses on the challenges associated with MM treatment in older patients, namely the assessment of frailty and how to adapt treatment in this population. The podcast also addresses the specific characteristics of MM in the elderly, including the incidence of genetic mutations and the role of comorbidities.
Speaker: Prof Sonja Zweegman; Host: Prof Pieter Sonneveld
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
Facebook: https://e-h-a.link/facebook
LinkedIn: https://www.linkedin.com/company/eha/
Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Thu, 20 Jan 2022 - 22min - 25 - What matters in a trial design? (Clinical Trial)
In the first episode of the Clinical Trial podcasts, Amsterdam UMC researcher and author of “A Quick Guide on How to Conduct Medical Research” Dr. Marieke Ter Wee points out the importance of formulating a research question at the beginning of any clinical trial. What models are used to formulate the question and answer to it? She unravels the main parts of a research proposal that should be elaborated by the authors of clinical studies.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Dr. Marieke ter Wee
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
Facebook: https://e-h-a.link/facebook
LinkedIn: https://www.linkedin.com/company/eha/
Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Tue, 18 Jan 2022 - 17min - 24 - Aging and Clonal Diseases (Aging Patient: Dispelling Myths)
In the Aging Patient: Dispelling Myths podcast series, Prof Raul Cordoba kicks off a series of podcasts that will offer you up-to-date information about hematology in older adults.
For the first interview, he welcomes guest expert Dr Kristina Kirschner to discuss aging and clonal disease. You will learn how clonal hematopoiesis increases with advancing age and how the accumulation of some clonal mutations have been linked with hematological cancers.
Dr Kirschner answers questions - asked by patients - about the definition of aging by hematologists, or the relation of aging and susceptibility to clonal cancers. They also address the mechanisms of epigenetic mutations in aging hematopoietic stem cells and the impact of genes drivers of myeloid malignancies in the elderly population.
Host: Dr Raul Cordoba; Guest: Dr Kristina Kirschner
Additional information (in order of mention):
AML (disease): Acute Myeloid LeukemiaMDS (disease): Myelodysplastic SyndromesDNMT3A gene (DNA Methyltransferase 3 Alpha)TET2 gene (Tet Methylcytosine Dioxygenase 2)ASXL1 gene (ASXL Transcriptional Regulator 1)CHIP (disease): (Clonal Hematopoiesis of Indeterminate Potential)PPM1D gene: Protein Phosphatase, Mg2+/Mn2+ Dependent 1DWhat did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the Aging Patient: Dispelling Mythsprogram.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Fri, 14 Jan 2022 - 19min - 23 - Iron Deficiency: Women
In the third episode of the Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Dr Noemi Roy review the many important functions iron plays in the body, providing the background for the high prevalence of iron deficiency in women, particularly in their fertile life and during pregnancies. They address different strategies of treatment, including IV, oral treatment, and nutrition recommendations. Finally, they also highlight the importance of treating iron deficiency after childbirth when the mother comes back home.
Host: Prof Gunnar Birgegård; Guest: Dr Noemi Roy
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the EHA Diagnosing And Treating Iron Deficiency Program.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
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Fri, 31 Dec 2021 - 40min - 22 - Iron Deficiency: Chronic Kidney Disease
In the second episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Christopher Winearls highlight the high prevalence of iron deficiency anemia in patients with CKD, together with its association with poor long-term outcomes. They discuss the importance of monitoring iron on top of monitoring erythropoietin and treating the deficiency prior to the use of erythropoietin. Overall, Prof Winearls discloses how to evaluate ferritin and Hb levels in CKD patients and how to treat iron deficiency and monitor outcomes in this special population. Host: Prof Gunnar Birgegård; Guest: Prof Christopher Winearls
Fri, 24 Dec 2021 - 29min - 21 - Iron Deficiency: Heart Failure
In the first episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, Prof Gunnar Birgegård and host expert Prof Antonio Almeida define what is iron deficiency and more precisely functional iron deficiency. They discuss the prevalence of anemia in cardiac failure patients and the relation between severity of the heart disease and incidence of iron deficiency. They also highlight the importance of monitoring potential renal symptoms for better treatment outcomes.
Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeida
This episode was produced with the support of the World Heart Federation.
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the EHA Diagnosing And Treating Iron Deficiency Program.
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Fri, 17 Dec 2021 - 31min - 20 - HSCT in Multiple Myeloma
In episode 9 of "EHA Unplugged", Prof. Shaun McCann describes the importance of general medical management in multiple myeloma (MM) patients and the application of the principles of treatment in different subpopulations of patients. He also explains how to diagnose MM and assess the response to treatment.
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the course "EHA Unplugged - Hematological Diseases, HSCT and More".
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
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Fri, 10 Dec 2021 - 23min - 19 - Multiple Myeloma in Underserved Populations (Episode 2)
This podcast, the second of a series dedicated to Multiple Myeloma in underserved populations, addresses clinical challenges in MM, with a focus on high-risk disease and cytogenetics. Prof Weisel describes the established genetic prognostic markers in MM, and the new abnormalities that are becoming important, besides the role and impact of Minimal Residual Disease (MRD) on risk status and classification of MM patients. Speaker: Prof Katja Weisel; Host: Prof Pieter Sonneveld
Tue, 07 Dec 2021 - 28min - 18 - Chronic Lymphocytic Leukemia (CLL)
In episode 8 of "EHA Unplugged", Prof. Shaun McCann details the diagnostic and prognostic criteria of CLL and the correct diagnostic work-up. He also describes the increasing array of treatments available for CLL patients and outlines the role of allogeneic transplantation in this disease.
Fri, 03 Dec 2021 - 27min - 17 - Chronic Myeloid Leukemia (CML)
In episode 7 of "EHA Unplugged", Prof. Shaun McCann describes the clinical and genetic features of chronic myeloid leukemia (CML), discusses the best therapeutic options, and characterizes the changes that occur in the natural history of the disease after the introduction of tyrosine-kinase inhibitors (TKIs).
Fri, 26 Nov 2021 - 28min - 16 - SCD: What Physicians Can Learn From Patients And Carriers (Episode 3)
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this closing discussion, Dr Jo Howard and Professor Léon Tshilolo reflect on what they have learned from their conversations with people affected by sickle cell disease and sickle cell trait, and discuss the present and future of sickle cell disease treatment across the world. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Interview with: Dr Jo Howard and Professor Léon Tshilolo Host: Mandi Watty-Miller
Tue, 16 Nov 2021 - 31min - 15 - Multiple Myeloma in Underserved Populations (Episode 1)
In this podcast, the first of a series dedicated to Multiple Myeloma in underserved patient populations, Prof Terpos illustrates the impact of renal disease on MM outcomes and how it should best be managed. Follow the podcast to learn about assessment and monitoring of renal function in MM patients, the available treatment options for this population, and the role and outcomes of kidney transplantation. Speaker: Prof Evangelos Terpos; Host: Prof Pieter Sonneveld
Mon, 15 Nov 2021 - 1h 06min - 14 - SCD: What Physicians Can Learn From Patients And Carriers (Episode 2)
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In the second episode, a mother and daughter affected by sickle cell are joined by hematologist Professor Léon Tshilolo for an interview with Mandi Watty-Miller, an individual with sickle cell trait. They discuss the experience of raising a child with sickle cell disease, navigating the world of online misinformation about the condition, and how to improve communication and trust between doctors and patients. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Interview with: Prof Léon Tshilolo Host: Mandi Watty-Miller
Wed, 10 Nov 2021 - 43min - 13 - BCR-ABL1-like ALL
In this podcast, Dr. Rijneveld discusses BCR-ABL1-like acute lymphoblastic leukemia (ALL), a specific subgroup of ALL characterized by an expression profile similar to Ph+ ALL, albeit lacking the BCR-ABL1 rearrangement, and by sensitivity to TKIs. She highlights how TKIs were game-changing for the prognostic of these patients, although their cost and associated toxicities (usually low but fatiguing in the long-term), may still be issues in the clinical practice. Interview with: Anita Rijneveld. Host: Shaun McCann
Tue, 09 Nov 2021 - 14min - 12 - ALL Hope For The Future
Listen to this expert interview to discover characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults and children. Dr Advani guides us in the biology and genetics of the disease in these two categories of patients, dedicating a special focus to Philadelphia-like ALL and to the clinical and prognostic role of measurable residual disease (MRD). Finally, as CAR-T therapies are becoming available to adult ALL patients, challenges and promises of this approach are discussed in the concluding part of the podcast. Interview with: Anjali Advani. Host: Shaun McCann
Fri, 05 Nov 2021 - 13min - 11 - Iron Homeostasis in Host Defense and Inflammation
In this podcast, Dr Nemeth reminds us that iron is not only necessary for hematopoiesis and red cell production. A complex relationship exists between iron levels and susceptibility to infections, which involves the different sensibility of microbes to iron as well as the association between iron deficiency and poor response to immunization, as you will discover in this clear overview on the role of iron in host defence.
Interview with: Elizabeta Nemeth. Host: Ayan Panjan
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Would you like to receive EBAH CME credit points for listening to podcasts? Please visit the EHA Campus and check out the EHA Unplugged catalog.
https://ehacampus.ehaweb.org/
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Email us: education@ehaweb.org
Subscribe to receive the EHA Educational Updates via https://eha.news/subscribe
Fri, 29 Oct 2021 - 07min - 10 - SCD: What Physicians Can Learn From Patients And Carriers (Episode 1)
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. In this first episode, consultant hematologist Dr Jo Howard has a conversation with two individuals affected by sickle cell disease (SCD) and sickle cell trait (SCT). They discuss the impact that the condition has on their personal and family lives, common misconceptions about the SCD experience, areas where treatment frequently falls short, and how to raise awareness further. SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education. Host: Dr Jo Howard
Thu, 28 Oct 2021 - 45min - 9 - Impact of Social Stigma on Coping with SCD
Listen to this podcast to hear a psychologist’s point of view on sickle cell disease (SCD), and how to address the psychological as well as the hematological needs of SCD patients. The importance of specific psychological support services for SCD patients, the concept of social stigmatization as a true complication of the disease, and its consequences for physicians dealing with these patients are discussed in this podcast. Interview with: Kofi Anie. Host: Ayan Panjan
Fri, 22 Oct 2021 - 16min - 8 - Interventions in Adolescent SCD
This podcast focuses on the social aspects of SCD, in particular on the challenges confronting adolescents with SCD and their treating physicians. Prof. Hankins speaks about the delicate transition from pediatric to adult care, the use of technology in improving the care of these patients, and the issues associated with access to new treatments. Interview with: Jane Hankins. Host: Shaun McCann
Fri, 15 Oct 2021 - 16min - 7 - Sickle Cell Disease in Pregnancy
In this podcast, Dr Smith-Whitley illustrates the many different aspects and possible pregnancy complications for mother and fetus in women with SCD. Practical aspects dealt within the clinical practice, such as the management of pain in the pregnant woman, use of transfusions and HU, and reproductive education for SCD patients, are also discussed in the podcast. Interview with: Kim Smith-Whitley. Host: Shaun McCann
Fri, 08 Oct 2021 - 14min - 6 - HSCT in Paroxysmal Nocturnal Hemoglobinuria
In episode 6 of "EHA Unplugged", Prof. Shaun McCann discusses Paroxysmal Nocturnal Hemoglobinuria. You will hear him describe the etiology and the clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH), apply the correct diagnostic work-up if the disease is suspected, and discuss the principles of treatment in these patients, including monoclonal antibodies and HCT.
Fri, 01 Oct 2021 - 20min - 5 - HSCT in Severe Aplastic Anemia
In episode 5 of "EHA Unplugged", Prof. Shaun McCann discusses HSCT in Severe Aplastic Anemia. You will hear him detail the diagnostic criteria of severe aplastic anemia (SAA) and the current therapeutic approaches for this disease. He will also characterize the results of HCT, the best conditioning options and different source of hemopoietic cells for SAA patients.
Fri, 24 Sep 2021 - 25min - 4 - Engraftment and Chimerism following HSCT
In episode 4 of "EHA Unplugged", Prof. Shaun McCann discusses the phenomenon of engraftment and chimerism following hemopoietic cell transplantation (HCT) and the main techniques used to determine the origin of the cells in the recipient.
Fri, 17 Sep 2021 - 11min - 3 - Infections in HSCTMon, 06 Sep 2021 - 19min
- 2 - Graft-versus-Host Disease in HSCT
In episode 2 of "EHA Unplugged", Prof. Shaun McCann explains the relationship between HSCT and graft-versus-host disease.
Fri, 03 Sep 2021 - 14min - 1 - The History of HSCTWed, 01 Sep 2021 - 17min
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